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Curated summaries of microbiome research, grouped by topic.

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Alzheimer’s Dementia (2)

Anemia (3)

Autism spectrum disorder (ASD) (1)

Autoimmune Diseases (94)

The role of zinc and nutritional immunity in Clostridium difficile infection

Dec 15, 2025
This review examines the impact of dietary zinc on gut microbiota and its role in Clostridium difficile infection. Excess zinc is shown to alter microbiota composition and increase disease severity,…

Epithelial barrier dysfunction and microbial dysbiosis in Crohn’s disease

Dec 7, 2025
This review explores the role of epithelial barrier dysfunction and microbial dysbiosis in the pathogenesis of Crohn’s disease, highlighting the impact of genetic, environmental, and microbiota…

The Link between Ankylosing Spondylitis, Crohn’s Disease, Klebsiella, and Starch Consumption

Dec 8, 2025
This article investigates the relationship between ankylosing spondylitis, Crohn’s disease, Klebsiella pneumoniae, and starch consumption, suggesting that high starch intake may trigger the growth of…

Primary sclerosing cholangitis and inflammatory bowel disease comorbidity: an update of the evidence

Dec 8, 2025
This review updates the current understanding of PSC-IBD, discussing its unique clinical features, the increased risk of malignancies, and the challenges in managing this comorbidity.

Mendelian Randomization Reveals Causal Gut Microbiota Signatures in Six Thyroid Diseases

Jul 23, 2025
Mendelian‑randomization of 18,340 MiBioGen participants and > 349k FinnGen controls identifies 32 gut genera with causal roles—some protective, others harmful—across six thyroid diseases,…

Extraintestinal Manifestations in Inflammatory Bowel Disease: From Pathophysiology to Treatment

Dec 7, 2025
This review explores the pathophysiology, prevalence, and treatment strategies for extraintestinal manifestations (EIMs) in Crohn’s disease and ulcerative colitis, emphasizing the role of immune…

Ocular Manifestations of IBD: Pathophysiology, Epidemiology, and Iatrogenic Associations of Emerging Treatment Strategies

Dec 8, 2025
This review explores ocular manifestations in IBD, including episcleritis, uveitis, and scleritis, discussing their pathophysiology, epidemiology, and management, with an emphasis on the role of IBD…

Novel Insights into the Pathogenesis of Inflammatory Bowel Diseases

Dec 7, 2025
This review focuses on the complex pathogenesis of Crohn’s Disease, exploring the roles of microbiome dysbiosis, immune system dysregulation, and environmental factors in disease progression, while…

Psoriasis as a Potential Risk Factor for Inflammatory Bowel Disease (IBD)

Dec 8, 2025
This study finds that psoriasis is associated with an increased risk of developing inflammatory bowel disease, particularly ulcerative colitis, emphasizing the importance of early gastrointestinal…

Graves’ Disease Gut Microbiota Signature: Key Microbial Changes in Autoimmune Thyroid Disease

Jul 29, 2025
Graves’ disease patients display a distinct gut microbiota signature, characterized by reduced diversity and altered abundance of key microbial taxa, including increased Bacilli, Prevotella, and…

Intestinal Microbiota Changes in Graves’ Disease: Microbial Signatures and Clinical Impact

Jul 28, 2025
This study found that Graves’ disease is associated with reduced gut microbial diversity and specific increases in Bacilli, Lactobacillales, Prevotella, Megamonas, and Veillonella, alongside…

Osteoporosis Complications in Crohn’s Disease Patients: Factors, Pathogenesis, and Treatment Outlines

Dec 9, 2025
This review discusses the pathogenesis of osteoporosis in Crohn’s disease, focusing on the role of cytokines, glucocorticoids, and malnutrition. It emphasizes the importance of early detection and…

Graves & Crohn: Genetic Evidence for Microbiome-Mediated Crosstalk

Jul 23, 2025
Mendelian-randomization of East-Asian GWAS data shows Crohn disease genetics raise Graves disease risk, while ulcerative colitis genetics are protective, highlighting microbiome-immune pathways…

Graves’ Disease Gut Microbiome Signatures: Key Genera and Clinical Implications

Jul 29, 2025
This study reveals distinct gut microbiome alterations in Graves’ disease, identifies 12 key bacterial genera as diagnostic signatures, and shows microbiota recovery after antithyroid therapy,…

Thromboembolic Events in Patients with Inflammatory Bowel Disease: A Comprehensive Overview

Dec 9, 2025
This review explores the link between IBD and thromboembolic events, highlighting the increased risks, particularly in patients with active disease, corticosteroid treatment, and post-surgery. It…

The relationship between serum calprotectin levels and disease activity in patients with subacute thyroiditis.

Jun 20, 2025
The study demonstrated that serum calprotectin is significantly elevated during acute subacute thyroiditis and drops with recovery, offering a novel, independent marker for disease activity, though…

Graves’ Disease Gut Microbiota Signatures: Key Microbial Shifts and Clinical Implications

Jul 29, 2025
This study reveals that Graves’ disease patients exhibit distinct gut microbiota signatures, with increased Bacteroidetes and Prevotellaceae and decreased Firmicutes and Lachnospiraceae, strongly…

Graves’ Disease Gut Microbiota: Distinct Microbial Signatures and Clinical Associations

Jul 29, 2025
Graves’ disease patients show distinctive gut microbiota profiles, with increased Bacteroidetes and specific pro-inflammatory bacteria, despite no difference in overall diversity. Key taxa correlate…

Alteration in gut microbiota is associated with immune imbalance in Graves’ disease

Jul 29, 2025
This study reveals distinct compositional changes in the gut microbiota of Graves’ disease patients, notably increased Bacteroidetes and Prevotellaceae and decreased Firmicutes and Lachnospiraceae,…

Graves’ Disease and Depression: Immunity, Hormones & Microbiome Explained

Jul 23, 2025
Graves Disease potentiates depression via autoimmune cytokines, hormonal excess and gut‑microbiome shifts. This review consolidates epidemiology and mechanisms, highlighting microbial signatures…

Incidence of and Risk Factors for Paradoxical Psoriasis or Psoriasiform Lesions in Inflammatory Bowel Disease Patients Receiving Anti-TNF Therapy

Dec 8, 2025
This systematic review and meta-analysis examines the incidence and risk factors for paradoxical psoriasis or psoriasiform lesions in IBD patients treated with anti-TNF therapy, providing crucial…

Microbial dysbiosis in the gut drives systemic autoimmune diseases

Dec 13, 2025
This review examines how microbial dysbiosis in the gut contributes to systemic autoimmune diseases like type 1 diabetes, MS, RA, and SLE. It emphasizes microbial influences on immune responses and…

Bidirectional Causality Between Graves’ Disease and the Gut Microbiome Revealed by Mendelian Randomization

Jul 23, 2025
This bidirectional Mendelian Randomization (MR) study establishes a causal link between Graves’ disease and gut microbiome alterations, confirming thyroid–gut axis interactions and identifying key…

Succinate metabolism: underlying biological mechanisms and emerging therapeutic targets in inflammatory bowel disease

Dec 15, 2025
This review discusses succinate’s role in IBD pathogenesis, focusing on its dual role in inflammation and tissue repair. The review underscores the importance of microbiota-driven succinate…

Metabolic Influences of Gut Microbiota Dysbiosis on Inflammatory Bowel Disease

Dec 15, 2025
This review investigates how gut microbiota dysbiosis impacts metabolic functions and immune responses in inflammatory bowel disease (IBD), highlighting key microbial changes and therapeutic…

Artificial intelligence-assisted capsule endoscopy for detecting lesions in Crohn’s disease

Dec 14, 2025
This study systematically reviews the use of AI-assisted capsule endoscopy for detecting lesions in Crohn’s disease. AI showed high diagnostic accuracy with a sensitivity of 94% and specificity of…

Genetic and Epigenetic Etiology of Inflammatory Bowel Disease: An Update

Dec 13, 2025
This review focuses on the genetic and epigenetic factors that contribute to Inflammatory Bowel Disease (IBD), highlighting key genes and microbiome interactions, and their role in disease…

Nephrolithiasis in Crohn’s Disease Patients: A Review of the Literature

Dec 9, 2025
This review discusses nephrolithiasis in Crohn’s disease patients, highlighting the increased risk, pathophysiology, and preventative measures. It emphasizes dietary interventions and fluid intake to…

Advancements in Immunomodulatory Therapies for IBD and Their Interplay With the Gut–Brain Axis

Dec 11, 2025
This review explores immunomodulatory therapies for IBD, focusing on their impact on the gut-brain axis. It evaluates conventional and emerging treatments like biologics, FMT, and probiotics,…

Molecular Alteration Analysis of Human Gut Microbial Composition in Graves’ disease Patients

Jul 23, 2025
This study identified a microbiome signature in Graves’ disease marked by reduced microbial richness and elevated Prevotella_9 and Haemophilus, with losses in Faecalibacterium and Alistipes,…

New developments in our understanding of ankylosing spondylitis pathogenesis

Dec 8, 2025
This review discusses the pathogenesis of ankylosing spondylitis, highlighting the role of Type 17 immune responses, gut microbiome dysbiosis, and metabolic factors in disease development. It also…

Gut Microbiota: Role in Pathogen Colonization, Immune Responses and Inflammatory Disease

Dec 15, 2025
The review explores the role of gut microbiota in immune regulation and pathogen resistance, particularly in inflammatory diseases like IBD. It highlights the effects of microbiota dysbiosis and the…

Intestinal Stricture in Crohn’s Disease

Dec 7, 2025
This review explores the pathophysiology, risk factors, and management of intestinal strictures in Crohn’s Disease, emphasizing genetic, environmental, and imaging factors, as well as current…

Relationship between the gut microbiota and bile acid composition in the ileal mucosa of Crohn’s disease

Dec 15, 2025
This study links gut microbiota dysbiosis with bile acid composition changes in Crohn’s disease. The altered microbial and bile acid profiles may play a significant role in disease progression,…

Viral Microbiome Signatures in Graves’ Disease: A Comprehensive Review

Jul 23, 2025
This review links genetics, hormones, environment and especially viral exposures—EBV and HCV—to the Th1‑centric immunopathology of Graves’ disease, highlighting chemokine signatures relevant to…

Homeostasis and Inflammation in the Intestine

Dec 14, 2025
This study highlights the complex relationship between the gut microbiota, the immune system, and intestinal health. It emphasizes how disruptions to this balance can lead to chronic diseases like…

Long-term risk of inflammatory bowel disease in autoimmune hepatitis: Over a 20-year population-based study

Dec 9, 2025
This study explores the long-term risk of developing IBD in AIH patients, identifying smoking as a significant risk factor and showing that while IBD increases cirrhosis prevalence, it does not…

Siderophore-mediated iron acquisition and modulation of host-bacterial interactions

Dec 15, 2025
This review explores siderophore-mediated iron acquisition in the gut, its role in bacterial growth, and its impact on microbial community dynamics and host immunity, with implications for IBD,…

Microbiome in Graves Disease Hypothyroidism: Insights from Integrated Analysis for Clinicians

Jul 29, 2025
Integrated microbiome-metabolome study reveals dysbiosis and metabolic shifts in Graves’ disease and hypothyroidism, highlighting potential biomarkers like depleted Bacteroides for thyroid…

Graves’ Disease Gut Microbiome Signature: Key Genera and Clinical Implications

Jul 29, 2025
This prospective study identifies a unique gut microbiome signature in Graves’ disease, characterized by decreased SCFA-producing bacteria and increased pro-inflammatory taxa, which partially…

Microbiome-metabolome generated bile acids gatekeep infliximab efficacy in Crohn’s disease

Dec 15, 2025
This study reveals the significant role of gut microbiome and metabolome signatures in predicting infliximab response in Crohn’s Disease, suggesting that microbiome-based biomarkers could guide…

Phage therapy: Targeting intestinal bacterial microbiota for the treatment of liver diseases

Dec 15, 2025
This review explores phage therapy as a promising treatment for liver diseases linked to gut microbiota imbalances. It highlights key findings on how phages target harmful bacteria, restoring…

The effect of iron therapy on oxidative stress and intestinal microbiota in inflammatory bowel diseases: A review on the conundrum

Dec 15, 2025
This review examines the impact of iron therapy on oxidative stress and the intestinal microbiota in IBD, highlighting the complexities of managing iron deficiency in these patients. It emphasizes…

Copper in infectious disease: Using both sides of the penny

Dec 15, 2025
Copper’s dual role as both an antimicrobial and essential micronutrient plays a significant part in the host-pathogen interaction, with pathogens evolving resistance mechanisms while hosts leverage…

Clinical Features of Intra-Abdominal Abscess and Intestinal Free-Wall Perforation in Korean Patients with Crohn’s Disease

Dec 7, 2025
This study examines the clinical features, risk factors, and treatment outcomes of intra-abdominal abscesses (IA) and intestinal free-wall perforations (IP) in Korean patients with Crohn’s disease,…

Prevalence and Bidirectional Association Between Autoimmune Liver Disease and Inflammatory Bowel Disease

Dec 7, 2025
This study provides a comprehensive meta-analysis on the prevalence and bidirectional association between inflammatory bowel disease (IBD) and autoimmune liver disease (AILD), shedding light on the…

Iron Deficiency Anemia: An Overlooked Complication of Crohn’s Disease

Dec 15, 2025
This study highlights the high prevalence of iron deficiency anemia (IDA) in Crohn’s disease patients and its association with worse hospitalization outcomes, including longer stays, higher costs,…

Pyoderma gangrenosum and inflammatory bowel disease: Recent insights into epidemiology, pathogenesis, and therapeutic approaches.

Dec 9, 2025
This review explores the relationship between pyoderma gangrenosum and inflammatory bowel disease, focusing on epidemiology, clinical features, and treatment approaches. It emphasizes the need for…

Succinate’s Dual Roles in Inflammatory Bowel Disease

Dec 15, 2025
This narrative review explores succinate’s dual immunoregulatory roles in IBD, examining how its concentration affects inflammation and tissue repair. The study discusses potential therapeutic…

NOD2 in Crohn’s Disease—Unfinished Business

Dec 11, 2025
This review explores the genetic complexities of NOD2 in Crohn’s disease, emphasizing its role in the stricturing phenotype and the need for deeper research into rare variants and their…

Environmental risk factors of inflammatory bowel disease: toward a strategy of preventative health

Dec 7, 2025
This review explores environmental risk factors for Crohn’s disease and ulcerative colitis, highlighting modifiable exposures such as smoking, diet, and early-life antibiotic use, and their impact on…

The Prevalence of Zinc Deficiency in Crohn’s Disease Patients

Dec 15, 2025
The study reveals a higher prevalence of zinc deficiency in Crohn’s disease patients compared to healthy controls. While serum zinc levels did not differ significantly between groups, the increased…

Correlations between serum cytokines and gut microbiota in patients with Graves’ disease: A case-control study

Jul 28, 2025
What was studied? This case–control observational study investigated the associations between peripheral blood cytokine profiles and gut microbiota composition in patients with Graves’ disease (GD),…

Targeted Therapies and Microbiome Insights in Graves’ Disease: A Clinical Review

Dec 23, 2025
This review maps the immune‑microbial mechanisms driving Graves’ disease and evaluates next‑generation biologics, small molecules and tolerance‑inducing peptides that may replace conventional…

The Role of Gut Microbiota in Intestinal Inflammation with Respect to Diet and Extrinsic Stressors

Dec 11, 2025
The review examines the relationship between gut microbiota, diet, and extrinsic stressors in promoting intestinal inflammation, with implications for managing IBD. It emphasizes the potential…

Extraintestinal Manifestations of Inflammatory Bowel Disease

Dec 9, 2025
This review discusses the extraintestinal manifestations of IBD, focusing on the pathophysiology, prevalence, and associations with treatment. It emphasizes the role of immune system dysfunction,…

Beneficial Effects of a Low-Nickel Diet on Relapsing IBS-Like and Extraintestinal Symptoms of Celiac Patients during a Proper Gluten-Free Diet: Nickel Allergic Contact Mucositis in Suspected Non-Responsive Celiac Disease

Nov 27, 2025
A study of celiac patients revealed that persistent symptoms during gluten-free eating may stem from nickel allergic contact mucositis. A low-nickel diet significantly improved gastrointestinal and…

Nutritional Status and Its Detection in Patients with Inflammatory Bowel Diseases

Dec 7, 2025
This paper explores the nutritional status of IBD patients, highlighting common nutrient deficiencies, the importance of early screening, and the role of therapies like infliximab in improving…

Effects of Trace Elements on Endocrine Function and Pathogenesis of Thyroid Diseases—A Literature Review

Jun 30, 2025
This review summarizes current evidence on how trace elements influence thyroid hormone synthesis, metabolism, and the development of thyroid diseases, highlighting mechanistic links, clinical…

The Copper/Zinc Ratio Correlates With Markers of Disease Activity in Patients With Inflammatory Bowel Disease.

Dec 15, 2025
This study links the Cu/Zn ratio with markers of disease activity in IBD, suggesting it as a potential biomarker for disease monitoring. It emphasizes the role of zinc and copper deficiencies in IBD…

The effects of hyperbaric treatment on perianal fistula activity in patients with Crohn’s disease

Dec 15, 2025
This study demonstrates the promising role of hyperbaric oxygen therapy (HBOT) as an adjunct treatment for perianal fistulas in Crohn’s disease. It shows substantial improvements in fistula healing,…

Gut Microbiome Signatures in Graves’ and Hashimoto’s Disease: Microbial Markers and ABC Transporter Pathway Insights

Jul 29, 2025
This study demonstrates that Graves’ disease and Hashimoto’s thyroiditis patients share distinct gut microbiome signatures—particularly involving Bacillus, Blautia, and Ornithinimicrobium—and a…

Environmental Influences on the Onset and Clinical Course of Crohn’s Disease

Dec 14, 2025
This review explores environmental factors such as smoking, diet, and air pollution that influence the onset and progression of Crohn’s disease. It highlights the importance of smoking…

Psoriasis and inflammatory bowel disease: links and risks

Dec 8, 2025
This review examines the genetic, immune, and microbiological links between psoriasis and inflammatory bowel disease, focusing on shared pathophysiological mechanisms and treatment strategies.

Comprehensive Review: Genetic Architecture and Clinical Implications in Graves’ Disease

Jul 24, 2025
A multi‑ethnic review summarising >80 genetic loci underlying Graves’ disease, their clinical correlates and emerging precision‑medicine applications.

Altered fecal bile acid composition in active ulcerative colitis

Dec 15, 2025
This study reveals altered fecal bile acid composition in IBD patients, especially UC, suggesting the potential of bile acids as biomarkers for disease severity and differentiation between UC and CD.

Gut Microbiome in Graves’ Disease and Orbitopathy: Distinct Signatures and Clinical Implications

Jul 29, 2025
This study demonstrates that gut microbiome composition and function differ significantly between Graves’ disease and Graves’ orbitopathy, with specific taxa correlating with thyroid autoimmunity.…

Gut Microbiota in Graves’ Disease and Graves’ Orbitopathy: Distinct Microbial Signatures and Implications

Jul 29, 2025
This study identified distinct alterations in gut microbiota composition and function in Graves’ disease and Graves’ orbitopathy patients compared to healthy controls, highlighting specific microbial…

Gut Microbiota Signatures in Graves’ Disease: Key Associations and Biomarker Potential

Jul 29, 2025
This study reveals that Graves’ disease is linked to distinct gut microbiota alterations, particularly increased Ruminococcus and Lactobacillus and decreased Synergistetes and Phascolarctobacterium,…

Genome sequences of copper resistant and sensitive Enterococcus faecalis strains isolated from copper-fed pigs in Denmark

Dec 15, 2025
This study examines the genome sequences of copper-resistant Enterococcus faecalis strains isolated from copper-fed pigs. It identifies key resistance genes, highlighting the potential for…

Mycobacterium avium subspecies paratuberculosis (MAP) and Crohn’s disease: the debate continues

Dec 14, 2025
The study examines the debate surrounding Mycobacterium avium subspecies paratuberculosis (MAP) in Crohn’s disease, with conflicting data on its role as a causative factor. Anti-MAP therapies show…

Graves’ Disease Gut Microbiome Signature: Diagnostic and Pathogenic Insights

Jul 29, 2025
This cross-sectional study found that Graves’ disease patients have distinctly altered gut microbiota—lower Firmicutes, higher Bacteroidetes, and reduced butyrate-producers—suggesting a role for the…

Gut Microbiota in Graves’ Disease: Microbial Signatures and Diagnostic Potential

Jul 29, 2025
This study identified distinctive alterations in gut microbiota in Graves’ disease, including reduced diversity and specific taxonomic shifts. Key microbial signatures correlated with thyroid…

Mycobacterium avium subspecies paratuberculosis and its relationship with Crohn’s disease

Dec 14, 2025
This review investigates the ongoing debate over the potential role of Mycobacterium avium subspecies paratuberculosis in Crohn’s disease. Despite frequent detection in patients, MAP’s…

Epidemiological studies of migration and environmental risk factors in the inflammatory bowel diseases

Dec 14, 2025
This review examines how migration and environmental risk factors influence the onset and course of inflammatory bowel diseases (IBD), with a focus on migrant populations transitioning from…

Genetic and environmental factors influencing Crohn’s disease

Dec 9, 2025
This review highlights the genetic and environmental factors influencing Crohn’s disease, including the role of NOD2 mutations, smoking, diet, and vitamin D deficiency. It underscores the need for…

Crohn’s disease and clinical management today: How it does?

Dec 14, 2025
This review examines the environmental and genetic factors influencing Crohn’s disease, offering insight into how these factors contribute to disease onset, progression, and management. The…

A comparative study of the gut microbiota in immune-mediated inflammatory diseases-does a common dysbiosis exist?

May 24, 2025
This study reveals that gut microbiota dysbiosis in immune-mediated inflammatory diseases includes shared enrichment of pro-inflammatory taxa like Streptococcus and Eggerthella, alongside depletion…

Alterations of the Gut Microbiota in Hashimoto’s Thyroiditis Patients

Mar 18, 2025
Gut microbiota analysis in Hashimoto’s thyroiditis patients identified significant dysbiosis, with increased pro-inflammatory taxa and reduced beneficial microbes, correlating with thyroid…

Analysis of subgingival microbiome of periodontal disease and rheumatoid arthritis in Chinese: A case-control study

May 23, 2025
This study on the subgingival microbiome in rheumatoid arthritis and periodontitis identified Treponema enrichment in RA. Despite similar microbial richness across groups, specific dysbiotic shifts…

Assessment of Thyroid Function and Oxidative Stress State in Foundry Workers Exposed to Lead

Mar 18, 2025
What was studied? The study assessed thyroid function and oxidative stress in foundry workers occupationally exposed to lead (Pb) dust and fumes. It investigated the correlation between blood lead…

Comparative Analysis of Taxonomic and Functional Gut Microbiota Profiles in Relation to Seroconversion of Thyroid Peroxidase Antibodies in Euthyroid Participants.

Mar 18, 2025
What was studied? This study investigated the taxonomic and functional gut microbiota profiles of euthyroid individuals with and without thyroid peroxidase antibodies (TPOAb), a marker for autoimmune…

Elevated Lactoferrin and Anti-Lactoferrin Antibodies in Endometriosis: Autoimmune and Microbiome Insights

Mar 18, 2025
This study confirms elevated lactoferrin and anti-lactoferrin antibody levels in endometriosis, suggesting autoimmune involvement. Anti-lactoferrin drops post-surgery, hinting at a biomarker role,…

Exploring the Bidirectional Link Between Graves’ Disease and Gut Microbiome: New Insights Into the Thyroid–Gut Axis

Mar 18, 2025
This study confirms a bidirectional causal relationship between Graves’ Disease and the gut microbiome. Key taxa like Deltaproteobacteria elevate GD risk, while others, such as Anaerostipes, are…

Integrative analysis of gut microbiome and host transcriptome reveal novel molecular signatures in Hashimoto’s thyroiditis

Mar 18, 2025
This study revealed novel molecular signatures linking gut microbiota and transcriptome in Hashimoto’s thyroiditis, advancing diagnostic and therapeutic approaches.

Mercury and nickel allergy/ Risk factors in fatigue and autoimmunity

May 24, 2025
Hypersensitivity to mercury and nickel was significantly more common in fatigued and autoimmune patients than in healthy controls. Removal of dental metals reversed symptoms and immune activation,…

Meta-analysis of gut microbiome studies identifies disease-specific and shared responses

Mar 18, 2025
What was studied?The meta-analysis focused on the human gut microbiome’s association with various diseases by analyzing 28 published case-control gut microbiome studies covering ten diseases. The…

Molecular Alteration Analysis of Human Gut Microbial Composition in Graves’ disease Patients

Mar 18, 2025
What was studied?The study investigated the gut microbial composition in patients with Graves’ disease (GD) compared to healthy controls. Who was studied?The study involved 27 GD patients and 11…

Molecular estimation of alteration in intestinal microbial composition in Hashimoto’s thyroiditis patients

Mar 18, 2025
This study identifies significant gut microbiota alterations in Hashimoto’s thyroiditis, with reduced beneficial microbes and increased pathogens.

Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls

Mar 18, 2025
This case-control study investigates the gut microbiota’s role in multiple sclerosis (MS) pathogenesis by comparing the fecal microbiota of relapsing-remitting MS patients to healthy controls.…

Role of Cholestyramine in Refractory Hyperthyroidism: A Case Report and Literature Review

Mar 18, 2025
The study investigates the role of cholestyramine for refractory iodine-induced hyperthyroidism, showing rapid FT4 reduction in 12 days.

Serendipity in Refractory Celiac Disease: Full Recovery of Duodenal Villi and Clinical Symptoms after Fecal Microbiota Transfer

Mar 18, 2025
A patient with refractory celiac disease type II achieved complete duodenal villi recovery and symptom resolution after fecal microbiota transfer.

The Comorbidity of Endometriosis and Systemic Lupus Erythematosus: A Systematic Review

Mar 18, 2025
This review explores the significant comorbidity between systemic lupus erythematosus (SLE) and endometriosis, emphasizing shared pathological pathways.

The gut microbiota and endometriosis: From pathogenesis to diagnosis and treatment

Mar 18, 2025
What was reviewed? The study reviewed the relationship between the gut microbiota and endometriosis, focusing on how the gut microbiota may influence the pathogenesis, diagnosis, and potential…

Bacterial Vaginosis (59)

Medical-Grade Honey as a Potential New Therapy for Bacterial Vaginosis

Jul 4, 2025
What was reviewed? This review article examines current evidence on the use of medical-grade honey (MGH) as a novel therapy for bacterial vaginosis (BV), a prevalent condition among women of…

Relationships between female infertility and female genital infections and pelvic inflammatory disease

Jun 27, 2025
A large-scale Taiwanese study found that upper and lower genital tract infections, but not comorbidities or bacterial vaginosis, independently increased infertility risk. PID and lower genital tract…

Bacterial vaginosis and its association with infertility, endometritis, and pelvic inflammatory disease

Jun 27, 2025
This review details the links between bacterial vaginosis, endometritis, pelvic inflammatory disease, and infertility, highlighting the role of vaginal and endometrial microbiota disruptions and…

Effects of dietary quercetin on female fertility in mice: implication of transglutaminase 2

Jul 4, 2025
What was studied? This original research investigated the long-term effects of dietary quercetin supplementation on female fertility and ovarian physiology in mice, with a specific focus on the role…

Microbiota and Pelvic Inflammatory Disease

Jun 19, 2025
This review highlights how vaginal microbiota imbalance, particularly bacterial vaginosis, significantly increases the risk of pelvic inflammatory disease. Advanced molecular methods have identified…

A Multi-Omic Systems-Based Approach Reveals Metabolic Markers of Bacterial Vaginosis and Insight into the Disease

Apr 3, 2025
This study used a multi-omic approach to reveal key microbial and metabolic markers of bacterial vaginosis. It identified two distinct symptomatic BV metabotypes, each defined by unique microbial and…

An Integrated Efficacy and Safety Analysis of Single-Dose Secnidazole 2 g in the Treatment of Bacterial Vaginosis

Apr 7, 2025
This study confirms secnidazole’s efficacy and safety as a one-dose treatment for BV, improving outcomes while supporting microbiome restoration.

Antimicrobial activity of bovine lactoferrin against Gardnerella species clinical isolates

Apr 3, 2025
Bovine lactoferrin shows promise as an adjunctive treatment for bacterial vaginosis, inhibiting metronidazole-resistant G. vaginalis strains and potentiating the effects of clindamycin. Its ability…

Association Between Dietary Patterns and Bacterial Vaginosis

Apr 3, 2025
A diet high in processed foods and sugar increases bacterial vaginosis (BV) risk, while a plant-based diet lowers it. This study highlights the importance of dietary choices in vaginal health,…

Association Between Heavy Metal Exposure and Bacterial Vaginosis

Apr 3, 2025
This cross-sectional study identified a strong link between elevated serum lead and cadmium levels and increased risk of bacterial vaginosis. It suggests that heavy metal exposure may disrupt vaginal…

Bacterial biota of women with bacterial vaginosis treated with lactoferrin

Apr 3, 2025
This study explored the effects of lactoferrin on the vaginal microbiota in women with bacterial vaginosis, showing its potential as a non-antibiotic treatment option.

Bacterial Communities in Women with Bacterial Vaginosis:

Apr 3, 2025
This study used high-resolution sequencing to analyze bacterial communities in women with BV. Findings reveal distinct microbial associations, diagnostic inconsistencies, and racial differences in BV…

Bacterial Vaginosis – A Brief Synopsis of the Literature

Apr 3, 2025
This review explores bacterial vaginosis, emphasizing its recurrence, microbial associations, and treatment challenges. It highlights the need for microbiome-based therapies, standardized diagnostic…

Bacterial vaginosis and biofilms: Therapeutic challenges and innovations

Apr 3, 2025
This review links BV recurrence to resilient biofilms formed by Gardnerella vaginalis. Probiotics and biofilm disruptors (e.g., Astodrimer gel) improve outcomes by restoring Lactobacillus dominance.…

Bacterial Vaginosis and Chlamydia in Tubal Infertility

Apr 3, 2025
Study links BV and past chlamydial infection to tubal infertility, with 87.5% of BV-positive women having tubal damage. Both infections were often asymptomatic. IVF pregnancy rates were unaffected,…

Bacterial Vaginosis and its Association with Infertility, Endometritis, and Pelvic Inflammatory Disease

Apr 3, 2025
BV disrupts Lactobacillus dominance, increasing infertility risk via inflammation, PID, and endometritis. L. crispatus probiotics reduce BV recurrence; CE treatment boosts IVF success. Early…

Bacterial Vaginosis Biofilms: Challenges to Current Therapies and Emerging Solutions

Apr 3, 2025
This review discusses bacterial vaginosis, biofilm formation, and emerging therapies targeting biofilms for more effective BV treatments.

Bacterial Vaginosis Is Associated with Variation in Dietary Indices

Apr 28, 2025
A high glycemic load diet increases bacterial vaginosis (BV) risk, while nutrient-rich diets lower it. This study highlights the link between diet quality and vaginal microbiome balance, providing…

Bacterial Vaginosis Recurrence: Drivers, Challenges, and Treatment

Apr 3, 2025
This review explores bacterial vaginosis recurrence, emphasizing microbial persistence, reinfection, and partner treatment. It highlights the need for improved therapeutic strategies, including…

Bacterial Vaginosis: Current Diagnostic Avenues and Future Opportunities

Apr 3, 2025
This review explores bacterial vaginosis diagnostics, highlighting traditional limitations and emerging molecular solutions. Advances in sequencing, metabolomics, and AI-driven analysis offer…

Bacterial Vaginosis: What Do We Currently Know?

Apr 3, 2025
This review explores bacterial vaginosis (BV), emphasizing microbial shifts, diagnostic challenges, and treatment strategies. It highlights the role of biofilms, emerging molecular diagnostics, and…

Boric Acid for the Treatment of Vaginitis: New Possibilities Using an Old Anti-Infective Agent

Apr 3, 2025
Boric acid offers promising results for treating resistant vulvovaginal candidiasis, bacterial vaginosis, and trichomoniasis. It shows comparable efficacy to oral itraconazole, with fewer adverse…

Cannabidiol (CBD) Acts as an Antioxidant on Gardnerella vaginalis

Apr 3, 2025
CBD shows antibacterial and antibiofilm activity against Gardnerella vaginalis, suggesting its potential as a novel treatment for bacterial vaginosis, particularly in biofilm-related infections.

Clinicians’ use of Intravaginal Boric Acid Maintenance Therapy for Recurrent Vulvovaginal Candidiasis and Bacterial Vaginosis

Apr 3, 2025
This study evaluates the use of intravaginal boric acid for recurrent vulvovaginal candidiasis and bacterial vaginosis, highlighting its long-term tolerability, high patient satisfaction, and rare…

Combatting antibiotic resistance in Gardnerella vaginalis: A comparative in silico investigation for drug target identification

Apr 3, 2025
This study identifies phospho-2-dehydro-3-deoxyheptonate aldolase as a drug target in Gardnerella vaginalis and highlights five FDA-approved compounds as potential treatments for bacterial vaginosis.

Computational approach for drug discovery against Gardnerella vaginalis

Apr 3, 2025
This study identifies DAHP synthase as a promising drug target for Gardnerella vaginalis in the treatment of bacterial vaginosis, presenting potential inhibitors with favorable pharmacokinetics.

Contribution of Essential Oils to the Fight against Microbial Biofilms—A Review

Apr 3, 2025
This review explores the antimicrobial potential of essential oils (EOs) in combating microbial biofilms, highlighting their effectiveness against pathogens like S. aureus and C. albicans. EOs can…

Current Treatment of Bacterial Vaginosis—Limitations and Need for Innovation

Apr 3, 2025
This review reveals high BV recurrence rates after metronidazole or clindamycin treatment due to microbial biofilms and potential sexual transmission. While both antibiotics show similar short-term…

Dietary Intake of Selected Nutrients Affects Bacterial Vaginosis in Women

Apr 3, 2025
Higher dietary fat intake increases the risk of bacterial vaginosis (BV), while folate, vitamin E, and calcium may lower severe BV risk. This study suggests dietary interventions could play a role in…

Dietary Patterns and Bacterial Vaginosis: is there any association?

Apr 3, 2025
A nutrient-rich diet lowers bacterial vaginosis (BV) risk, while processed foods increase it. This study highlights the importance of dietary choices in vaginal microbiome balance, offering insights…

Diversity of Vaginal Microbiota Associated with Bacterial Vaginosis

Apr 3, 2025
This study analyzed vaginal microbiota diversity in women with BV using molecular techniques. It identified key BV-associated bacteria and emphasized the need for molecular diagnostics and…

Dynamics of Vaginal Microbiota Before, During and After Episodes of Bacterial Vaginosis

Apr 3, 2025
This study analyzed daily changes in vaginal microbiota before, during, and after BV episodes. Findings highlight microbial instability, early dysbiosis markers, and the need for microbiome-focused…

Efficacy and Safety of Different Drugs for the Treatment of Bacterial Vaginosis

Apr 3, 2025
This meta-analysis compared BV treatments, identifying ornidazole as the most effective oral drug and sucrose/probiotics as top non-antibiotic options. Restoring Lactobacillus dominance is key, with…

Efficacy of Vitamin C Vaginal Tablets in Preventing Recurrence of Bacterial Vaginosis: A Randomized Controlled Trial

Apr 3, 2025
This study demonstrates that 250 mg vitamin C vaginal tablets reduce the recurrence of bacterial vaginosis, offering an effective and safe prophylactic treatment.

Fighting polymicrobial biofilms in bacterial vaginosis

Apr 3, 2025
This review examines how polymicrobial biofilms contribute to bacterial vaginosis (BV) treatment failure and explores alternative strategies for improved therapy.

Guidelines for the treatment of bacterial vaginosis: focus on tinidazole

Apr 3, 2025
This review evaluates the use of tinidazole in treating bacterial vaginosis, highlighting its efficacy, favorable pharmacokinetics, and reduced side effects compared to metronidazole, especially for…

Identifying Bacterial Vaginosis-Associated Bacteria

Apr 3, 2025
This study identifies bacterial vaginosis-associated species, improving BV diagnostics and treatment strategies through metagenomic sequencing.

Impact of oral metronidazole treatment on the vaginal microbiota and correlates of treatment failure

Apr 3, 2025
This study assesses the impact of metronidazole on the vaginal microbiota, revealing that high G. vaginalis and pathobionts correlate with treatment failure, suggesting a need for biofilm-disrupting…

Improved cure of bacterial vaginosis with single dose of tinidazole (2g), Lactobacillus rhamnosus GR-1, and Lactobacillus reuteri RC-14

Apr 29, 2025
This study shows that oral probiotics significantly boost cure rates of bacterial vaginosis when used with tinidazole, restoring a healthy vaginal microbiome.

Lactobacillus crispatus inhibits growth of Gardnerella vaginalis and Neisseria gonorrhoeae on a porcine vaginal mucosa model.

Apr 3, 2025
The study shows that Lactobacillus crispatus inhibits the growth of Gardnerella vaginalis and Neisseria gonorrhoeae by lowering pH and producing lactic acid, offering insights into…

Metabolic Signatures of Bacterial Vaginosis

Apr 3, 2025
This study revealed how bacterial vaginosis alters vaginal metabolism, linking specific microbial shifts with distinctive metabolite profiles. It showed that BV-associated bacteria drive metabolic…

Microbiota in vaginal health and pathogenesis of recurrent vulvovaginal infections: a critical review

Jun 6, 2025
This review clarifies the role of vaginal microbiota in health and recurrent infections, highlighting Lactobacillus complexity, pathogen interactions, and the need for personalized diagnostic and…

NMR Metabolomics of Symbioses Between Bacterial Vaginosis Associated Bacteria

Apr 3, 2025
This study highlights metabolic interactions between Gardnerella vaginalis and Prevotella bivia, revealing their role in bacterial vaginosis and preterm birth risk. Using NMR metabolomics, it…

Pathogenesis of Bacterial Vaginosis: Discussion of Current Hypotheses

Apr 3, 2025
This review explores the competing hypotheses behind bacterial vaginosis (BV), emphasizing microbial shifts, racial disparities, and sexual transmission. Key findings suggest BV may be sexually…

Prebiotic Maltose Gel Can Promote the Vaginal Microbiota From BV-Related Bacteria Dominant to Lactobacillus in Rhesus Macaque

Apr 3, 2025
This study explores the impact of prebiotic maltose gel on the vaginal microbiota of rhesus macaques, showing its potential to shift microbial balance from BV-related bacteria to Lactobacillus…

Probiotics are a Good Choice for the Treatment of Bacterial Vaginosis

Apr 3, 2025
This meta-analysis reviewed 12 randomized controlled trials and found that probiotics significantly improve the clinical cure rate of bacterial vaginosis. Probiotic use restored beneficial…

Recurrent Bacterial Vaginosis Following Metronidazole Treatment is Associated with Microbiota Richness at Diagnosis

Apr 3, 2025
This study links high pre-treatment vaginal microbiota diversity to BV recurrence after metronidazole. Women with sustained clearance had lower richness. Lactobacillus iners improved immune markers…

Recurrent bacterial vaginosis–an old approach to a new problem

Apr 3, 2025
The study finds that hydrogen peroxide vaginal washout effectively alleviates recurrent bacterial vaginosis symptoms, restoring pH and eliminating pathogens in most cases, though it does not fully…

Saccharomyces cerevisiae–based Probiotic as Novel Anti-microbial Agent for Therapy of Bacterial Vaginosis

Apr 3, 2025
This study evaluated a Saccharomyces cerevisiae-based probiotic for bacterial vaginosis treatment. The probiotic selectively inhibited BV-associated pathogens like G. vaginalis without harming…

Secnidazole for the Treatment of Bacterial Vaginosis

Apr 3, 2025
This systematic review analyzed six trials evaluating secnidazole for bacterial vaginosis treatment. Secnidazole at 2 g significantly improved clinical and microbiologic cure rates, showing…

Single-Dose, Bioadhesive Clindamycin 2% Gel for Bacterial Vaginosis: A Randomized Controlled Trial

Apr 3, 2025
This study evaluates the efficacy and safety of a single-dose 2% clindamycin vaginal gel for treating bacterial vaginosis, demonstrating significant clinical and bacteriologic cure rates compared to…

The Human Microbiome during Bacterial Vaginosis

Apr 3, 2025
This review explores bacterial vaginosis, focusing on microbial imbalances, immune responses, and diagnostic challenges. It highlights the need for microbiome-based treatments and improved…

The interplay between microbiota, metabolites, immunity during BV

Apr 3, 2025
This review explains how microbial shifts, metabolite production, and immune responses interact in bacterial vaginosis. It highlights the roles of Gardnerella, Atopobium, and other anaerobes in…

The right bug in the right place: opportunities for bacterial vaginosis treatment

Apr 3, 2025
This review explores the role of vaginal microbiota in bacterial vaginosis and highlights emerging microbiome-informed treatments. It emphasizes microbial signatures of BV, the limitations of…

Tinidazole in the treatment of bacterial vaginosis

Apr 3, 2025
This review assesses the use of tinidazole for treating bacterial vaginosis, comparing its efficacy, side effects, and cost to metronidazole. It highlights tinidazole’s favorable side effect profile…

Treatment of Bacterial Vaginosis with Topical Clindamycin or Metronidazole

Apr 3, 2025
This study compares the microbiological effects of metronidazole and clindamycin in treating bacterial vaginosis, highlighting differences in antimicrobial resistance and efficacy in eliminating…

Unveiling Resistance and Virulence Mechanisms under Darwinian Positive Selection for Novel Drug Discovery for Gardnerella vaginalis

Apr 3, 2025
The study analyzed the genetic evolution of Gardnerella vaginalis, focusing on its resistance and virulence under Darwinian positive selection. It identifies new drug targets and emphasizes the…

Vaginal Microbiome Recovery After Bacterial Vaginosis Treatment

Apr 3, 2025
This study examines vaginal microbiome recovery after metronidazole treatment for BV. Findings show delayed microbiota stabilization, L. iners dominance post-treatment, and the need for improved…

Vaginal Microbiota Molecular Profiling in Women with Bacterial Vaginosis

Apr 3, 2025
This study assessed vaginal microbiota in BV-positive women using real-time PCR. It found reduced Lactobacillus crispatus, biofilm-associated pathogens, and high diagnostic accuracy for molecular…

Brain Health (6)

Breast Cancer (17)

A systematic review of randomised clinical trials – The safety of vaginal hormones and selective estrogen receptor modulators for the treatment of genitourinary menopausal symptoms in breast cancer survivors

Aug 21, 2025
This review assesses the safety of vaginal hormones and SERMs in treating genitourinary menopausal symptoms in breast cancer survivors. It finds no significant rise in serum estrogen levels or an…

The Role of Lead and Cadmium in Gynecological Malignancies

Aug 9, 2025
This study explores the role of lead and cadmium in gynecological malignancies, focusing on their ability to mimic estrogen and induce oxidative stress, contributing to cancer development. It…

Probiotics as Anti-Tumor Agents: Insights from Female Tumor Cell Culture Studies

Aug 7, 2025
Probiotics were shown to significantly reduce cancer cell proliferation, promote apoptosis, and inhibit migration in breast and ovarian cancer cells, suggesting their potential as adjunctive cancer…

Physical Activity and Breast Cancer Risk: Evidence, Mechanisms, and Clinical Implications

Nov 16, 2025
This review summarizes evidence linking physical activity to reduced breast cancer risk, with significant benefits for postmenopausal women. Mechanisms include hormonal modulation, reduced…

Breast tissue, oral and urinary microbiomes in breast cancer

Jul 23, 2025
This study explores the differences in microbiomes across breast tissue, oral, and urinary sites in women with and without breast cancer. Key findings suggest distinct microbiomic patterns in…

Gut microbiome associations with breast cancer risk factors and tumor characteristics: a pilot study

Jul 23, 2025
This pilot study links gut microbiome diversity with breast cancer risk factors and tumor characteristics, particularly in HER2+ tumors and those with early menarche. It suggests microbial…

A comprehensive analysis of breast cancer microbiota and host gene expression

Mar 18, 2025
The study analyzed breast tumor and adjacent tissues, linking microbiota composition to cancer pathways. Key findings implicate specific microbes in breast cancer progression.

Association between Gut Microbiota and Breast Cancer: Diet as a Potential Modulating Factor

Mar 18, 2025
This study links reduced gut microbial diversity and specific taxa (e.g., Acidaminococcus, Hungatella) to breast cancer, influenced by diet. Findings suggest microbiome-targeted interventions and…

Breast cancer but not the menopausal status is associated with small changes of the gut microbiota

Aug 11, 2025
This study shows that breast cancer, rather than menopausal status, drives subtle gut microbiota changes. Dysbiosis in BC patients included reduced Blautia obeum and Bifidobacterium. Functional…

Breast cancer in postmenopausal women is associated with an altered gut metagenome

Mar 18, 2025
The study revealed altered gut microbiota in postmenopausal breast cancer patients, with enriched inflammation-associated species and depleted butyrate producers. Functional gene changes suggest…

Breast cancer patients from the Midwest region of the United States have reduced levels of short-chain fatty acid-producing gut bacteria

Mar 18, 2025
This study identifies gut dysbiosis in breast cancer patients, highlighting reduced SCFA-producing bacteria and altered microbial pathways. Findings suggest microbiome-targeted interventions could…

Composition and Functional Potential of the Human Mammary Microbiota Prior to and Following Breast Tumor Diagnosis

Mar 18, 2025
This study explores the mammary microbiota’s composition and function before and after breast cancer diagnosis, revealing dysbiosis and metabolic shifts as early markers.

Comprehensive profiles and diagnostic value of menopausal-specific gut microbiota in premenopausal breast cancer

Aug 11, 2025
What was studied? This study investigated the gut microbiota profiles, diagnostic value, and functional pathways specific to premenopausal breast cancer patients. It aimed to identify unique gut…

Gut and oral microbial compositional differences in women with breast cancer, women with ductal carcinoma in situ, and healthy women

Mar 18, 2025
This study reveals distinct gut microbiota profiles in breast cancer and DCIS patients, with reduced alpha diversity and functional shifts linked to inflammation. Major microbial associations,…

Intestinal microbiota influences clinical outcome and side effects of early breast cancer treatment

Mar 18, 2025
Gut microbiota influences early breast cancer prognosis and treatment side effects, with specific commensals correlating to outcomes. Chemotherapy alters microbiota, favoring beneficial species and…

Microbial Dysbiosis Is Associated with Human Breast Cancer

Mar 18, 2025
Microbial dysbiosis, marked by reduced bacterial load and altered species composition, is linked to breast cancer progression. Enrichment of Methylobacterium radiotolerans in tumors and depletion of…

The oral microbiome and breast cancer and non-malignant breast disease, and its relationship with the fecal microbiome in the Ghana Breast Health Study

Mar 18, 2025
The study linked reduced oral microbiome diversity and altered microbial profiles to breast cancer and non-malignant breast disease, highlighting strong correlations between oral and fecal…

Cadmium (Cd) (1)

Cardiovascular Health (13)

The Impact of Arsenic, Cadmium, Lead, Mercury, and Thallium Exposure on the Cardiovascular System and Oxidative Mechanisms in Children

Jan 7, 2026
The review examines how exposure to arsenic, cadmium, lead, mercury, and thallium impacts the cardiovascular system and oxidative mechanisms in children, highlighting long-term health risks and…

Hyperuricemia in chronic kidney disease: Emerging pathophysiology and a novel therapeutic strategy

Nov 28, 2025
This review outlines how hyperuricemia in chronic kidney disease arises from distinct filtration and tubular reabsorption defects, driving inflammation, endothelial dysfunction, and renal decline…

Role of Probiotics in Modulating and Managing Metabolic Diseases

Dec 27, 2025
This review highlights the beneficial role of probiotics in managing metabolic diseases like obesity, type 2 diabetes, and hypertension. It explores how probiotics improve gut health, regulate…

The potential of prebiotics, probiotics, and synbiotics for ameliorating intestinal barrier dysfunction

Dec 28, 2025
What Was Reviewed? This paper reviews the potential effects of prebiotics, probiotics, and synbiotics in managing diabetes mellitus (DM), focusing on their ability to restore intestinal barrier…

Menopause-Induced Metabolic Shifts: Implications for Cardiovascular and Metabolic Risk

Jul 9, 2025
What was studied? The study examined the metabolic changes that occur during menopause, focusing on how menopause modulates circulating metabolites in midlife women. Researchers specifically analyzed…

Susceptibility to environmental heavy metal toxicity among Americans with kidney disease

Nov 28, 2025
CKD increases blood lead and cadmium concentrations while reducing urinary elimination, heightening susceptibility to heavy metal toxicity in CKD, with disproportionately greater effects in Black…

Heavy Metals Toxicity: Mechanism, Health Effects, and Therapeutic Interventions

Jan 7, 2026
This review addresses the health effects, toxicity mechanisms, and therapeutic interventions related to heavy metals, highlighting the importance of further research and improved treatment strategies.

A metabolic view on menopause and ageing

Jul 9, 2025
This study reveals significant metabolic changes in postmenopausal women, including a pro-atherogenic lipid profile and increased amino acids linked to cardiovascular and metabolic risk, emphasizing…

Altered Gut Microbiota in Chronic Heart Failure: A Pathway to New Therapies

Mar 18, 2025
This review emphasizes the significant alterations in gut microbiota in severe chronic heart failure (CHF) patients and suggests that gut microbiota modulation could be a promising avenue for…

Evidence of a causal and modifiable relationship between kidney function and circulating trimethylamine N-oxide

Mar 18, 2025
This study shows that kidney function is the key regulator of TMAO levels, linked to cardiovascular risk. Reno-protective therapies, like GLP-1 receptor agonists, may lower TMAO levels, offering new…

Gut microbiota in heart failure and related interventions

Mar 18, 2025
This review explores the gut-heart axis, highlighting how gut microbiota alterations and metabolites like TMAO and SCFAs contribute to heart failure (HF). It evaluates the gut hypothesis, emphasizing…

The Association between Zinc and Copper Circulating Levels and Cardiometabolic Risk Factors in Adults: A Study of Qatar Biobank Data

Mar 18, 2025
This study evaluated the associations of zinc, copper, and Zn/Cu ratio with cardiometabolic risk factors in Qatari adults, revealing copper’s protective role and Zn/Cu ratio’s adverse implications…

TMAO: how gut microbiota contributes to heart failure

Mar 18, 2025
This review underscores the critical role of gut microbiota and TMAO in heart failure pathophysiology and opens up new avenues for therapeutic interventions targeting the gut–TMAO–HF axis. The…

Chronic Kidney Disease (CKD) (8)

Causes of Death in End-Stage Kidney Disease: Comparison Between the United States Renal Data System and a Large Integrated Health Care System

Dec 3, 2025
This study compared causes of death in ESRD patients between USRDS and KPSC sources, finding low concordance and highlighting limitations in mortality attribution for clinical and translational…

Toxic microbiome and progression of chronic kidney disease: insights from a longitudinal CKD-Microbiome Study

Nov 29, 2025
This study shows how a toxic gut microbiome enriched in uraemic toxin-producing species drives CKD progression, validated across cohorts and animal models, with diet emerging as a modifiable factor.

Gut microbiome alterations precede graft rejection in kidney transplantation patients

Nov 29, 2025
Gut microbiome dysbiosis precedes kidney transplant rejection, marked by loss of SCFA-producing taxa, reduced diversity, and enrichment of disease-associated bacteria. This prerejection signature…

Association of low-level heavy metal exposure with risk of chronic kidney disease and long-term mortality

Nov 28, 2025
This study links low-level heavy metal exposure to increased CKD risk and higher cadmium-associated mortality, with synergistic toxicity when both metals are elevated.

Lactulose Improves Fecal Microflora in CKD Patients

Dec 4, 2025
Lactulose improved fecal microflora in CKD patients by significantly increasing Bifidobacteria and Lactobacilli while stabilizing renal function. These microbiome shifts counteract…

KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease

Dec 3, 2025
The KDIGO 2012 CKD guideline synthesizes global evidence to refine CKD definition, staging, prognosis, and management, emphasizing albuminuria and GFR as core predictors of progression and mortality.

Lactulose Improves Renal Function and Gut Microbiota in CKD

Dec 4, 2025
Lactulose improved renal function in adenine-induced CKD rats by lowering uremic toxins, decreasing indole-producing taxa, and enriching Bifidobacterium and Lactobacillales. These microbiome shifts…

Characterization of metal(loid)s and antibiotic resistance in bacteria of human gut microbiota from chronic kidney disease subjects

Nov 28, 2025
Study of chronic kidney disease microbiome resistance showing metal–antibiotic co-resistance, early-stage enrichment of Firmicutes/Proteobacteria, and progressive loss of resistance genes as CKD…

Chronic Pelvic Pain (CPP) (2)

Clindamycin (3)

Copper (Cu) (1)

Crohn’s Disease (3)

Dimethylglyoxime (DMG) (2)

Drug Repurposing (4)

End-Stage Renal Disease (ESRD) (1)

Endometriomas (1)

Endometriosis (64)

Does Physical Exercise Lower Endometriosis Risk? Systematic Review Insights

Jul 22, 2025
This systematic review found insufficient evidence to confirm that physical exercise reduces endometriosis risk or symptoms, though some data suggest a potential protective effect. Well-designed…

Elevated levels of whole blood nickel in a group of Sri Lankan women with endometriosis: a case control study

Nov 27, 2025
This study examined blood nickel and endometriosis, revealing significantly higher nickel levels in affected Sri Lankan women, supporting a potential metalloestrogenic role.

Endometriosis and Ovarian Cancer: An Integrative Review (Endometriosis and Ovarian Cancer)

Aug 12, 2025
This review explores the link between endometriosis and ovarian cancer, focusing on genetic mutations like ARID1A, oxidative stress, and estrogen receptor loss, which contribute to the development of…

Metformin as a Potential Treatment Option for Endometriosis

Jun 24, 2025
Metformin shows potential in treating endometriosis through anti-inflammatory, anti-angiogenic, anti-proliferative effects, and modulation of the gut microbiome. It could be a safe, effective…

Endometriosis-associated infertility: From pathophysiology to tailored treatment

Jun 27, 2025
This review synthesizes evidence on the multifactorial mechanisms underlying endometriosis-associated infertility, emphasizing inflammatory, hormonal, anatomical, and molecular drivers. It highlights…

Metformin, the Rise of a New Medical Therapy for Endometriosis? A Systematic Review of the Literature

Jun 24, 2025
Metformin emerges as a promising non-hormonal therapy for endometriosis, showing potent anti-inflammatory, anti-angiogenic, and fertility-enhancing effects, with significant symptom relief in limited…

Altered Follicular Fluid Metabolic Pattern Correlates with Female Infertility and Outcome Measures of In Vitro Fertilization

Jun 30, 2025
This study identified 27 follicular fluid metabolites differentiating infertile from fertile women, developed a predictive Biomarker Score, and demonstrated strong correlations with IVF outcomes,…

Endometriosis-Associated Ovarian Cancer: From Molecular Pathologies to Clinical Relevance

Aug 12, 2025
This review explores the molecular pathogenesis of endometriosis-associated ovarian cancer, highlighting key genetic mutations, hormonal imbalances, and microRNA dysregulation that contribute to the…

Bacterial vaginosis and its association with infertility, endometritis, and pelvic inflammatory disease

Jun 27, 2025
This review details the links between bacterial vaginosis, endometritis, pelvic inflammatory disease, and infertility, highlighting the role of vaginal and endometrial microbiota disruptions and…

Endometriosis and Infertility: A review of the pathogenesis and treatment of endometriosis-associated infertility

Jun 27, 2025
This review details the multifactorial pathogenesis of endometriosis-associated infertility, emphasizing molecular, genetic, and inflammatory mechanisms, and evaluates current and emerging…

Metabolic risk factors and fertility disorders: A narrative review of the female perspective

Jun 30, 2025
This review explores how metabolic risk factors—obesity, the female athlete triad, and oxidative stress—contribute to female infertility, highlighting associations with PCOS, endometriosis, and…

Physical Activity and Exercise Improve Quality of Life in Endometriosis: A Systematic Review

Jul 7, 2025
This review found that physical activity and exercise significantly improved pain, emotional well-being, and perceived control in women with endometriosis, supporting their use as safe and effective…

Low-Nickel Diet in Endometriosis: Symptom Relief and Nickel Mucositis Evidence

Oct 14, 2025
Nickel allergic contact mucositis was identified in over 90% of endometriosis patients with IBS-like symptoms. A low-nickel diet significantly reduced gastrointestinal, extra-intestinal, and…

How does chronic endometritis influence pregnancy outcomes in endometriosis associated infertility? A retrospective cohort study

Jun 26, 2025
This study shows chronic endometritis significantly increases pregnancy complications in women with endometriosis-associated infertility. Placenta previa, gestational hypertension, and cesarean…

Fusobacterium Infection: A New Pathogenic Insight into Endometriosis and Microbiome-Targeted Therapy Potential

Nov 15, 2025
Fusobacterium infection significantly contributes to endometriosis pathogenesis, activating fibroblast inflammation and lesion formation. Antibiotics like metronidazole show promise.

Elevated Lead, Nickel, and Bismuth Levels in the Peritoneal Fluid of a Peritoneal Endometriosis Patient without Toxic Habits or Occupational Exposure following a Vegetarian Diet

Nov 27, 2025
This case report describes markedly elevated lead, nickel, and bismuth in the peritoneal fluid of a young woman with endometriosis, highlighting dietary and environmental exposure considerations and…

1H NMR- based metabolomics approaches as non-invasive tools for diagnosis of endometriosis

Jun 6, 2025
This study demonstrates the potential of ¹H-NMR metabolomics to diagnose endometriosis non-invasively by identifying metabolic biomarkers and disrupted pathways. Quadratic Discriminant Analysis…

A metabonomics approach as a means for identification of potentialbiomarkers for early diagnosis of endometriosis

Mar 18, 2025
This study used 1H-NMR metabonomics to identify serum biomarkers for early endometriosis diagnosis. Elevated lactate, alanine, and reduced glucose levels highlight metabolic disruptions, offering a…

A More Diverse Cervical Microbiome Associates with Better Clinical Outcomes in Patients with Endometriosis: A Pilot Study

Mar 18, 2025
This study links cervical microbiome diversity with endometriosis severity. Findings reveal microbial imbalances, particularly in advanced stages, correlate with pain, infertility, and inflammatory…

Altered Composition of Microbiota in Women with Ovarian Endometrioma: Microbiome Analyses of Extracellular Vesicles in the Peritoneal Fluid

May 26, 2025
This study identifies microbiota alterations in ovarian endometrioma, showing distinct microbial shifts in peritoneal fluid extracellular vesicles. Enrichment of Pseudomonas and Acinetobacter,…

Anti-Endometriotic Effects of Pueraria Flower Extract: A Novel Therapeutic Approach

Apr 1, 2025
Pueraria flower extract (PFE) inhibits endometriotic cell adhesion, migration, and MMP expression, reducing lesions in a mouse model, offering potential for non-hormonal therapies.

Antibiotic therapy with metronidazole reduces endometriosis disease progression in mice: a potential role for gut microbiota

May 19, 2025
This study shows that antibiotic therapy with metronidazole reduces endometriotic lesion growth and inflammation in mice by targeting the gut microbiota, particularly Bacteroidetes. Findings suggest…

Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case–control studies

Mar 18, 2025
Endometriosis significantly increases the risk of clear-cell, low-grade serous, and endometrioid ovarian cancers. This study highlights the need for subtype-specific ovarian cancer surveillance and…

Associations Between Endometriosis and Gut Microbiota

May 17, 2025
This study examines the association between endometriosis and gut microbiota, highlighting significant differences in microbial diversity and composition. Women with endometriosis showed altered gut…

Causal effects of gut microbiome on endometriosis: a two-sample Mendelian randomization study

Aug 11, 2025
What was studied? This study investigated the causal relationship between gut microbiome composition and endometriosis using a two-sample Mendelian randomization (MR) approach. The researchers aimed…

Correlation of calprotectin serum levels with degrees of endometriosis: A cross-sectional study

May 24, 2025
This study found no significant correlation between serum calprotectin levels and the severity of endometriosis. Despite its known role as an inflammatory biomarker, calprotectin did not…

Correlation of fecal metabolomics and gut microbiota in mice with endometriosis

May 19, 2025
This study identifies gut microbiota and metabolomic shifts in endometriosis, with altered bile acid biosynthesis and ALA metabolism. Elevated CDCA and UDCA levels, coupled with microbial changes,…

Does Exposure of Lead and Cadmium Affect the Endometriosis?

Mar 18, 2025
The study links lead and cadmium exposure to increased endometriosis risk, emphasizing lead’s role at low blood levels and synergistic effects with cadmium. It advocates for strict monitoring…

Effect of endometriosis on the fecal bacteriota composition of mice during the acute phase of lesion formation

May 19, 2025
This study found that endometriosis does not induce significant changes in the fecal bacteriota composition during the acute phase of lesion formation. Findings suggest that gut microbial shifts in…

Elevated Lactoferrin and Anti-Lactoferrin Antibodies in Endometriosis: Autoimmune and Microbiome Insights

Mar 18, 2025
This study confirms elevated lactoferrin and anti-lactoferrin antibody levels in endometriosis, suggesting autoimmune involvement. Anti-lactoferrin drops post-surgery, hinting at a biomarker role,…

Endometriosis induces gut microbiota alterations in mice

May 19, 2025
This study demonstrates that endometriosis induces gut microbiota alterations in a murine model, particularly increasing the Firmicutes/Bacteroidetes ratio and enriching Bifidobacterium and…

Exploring the link between dietary zinc intake and endometriosis risk: insights from a cross-sectional analysis of American women

Mar 18, 2025
This study links higher dietary zinc intake with increased endometriosis risk among American women, highlighting zinc’s complex role in immune modulation and estrogen-related pathways. Findings…

Fruit and vegetable consumption and risk of endometriosis

Mar 18, 2025
What Was Studied This study explored the potential link between the consumption of fruits and vegetables and the risk of laparoscopically confirmed endometriosis. Using data collected from the…

Gut microbiota imbalance and its correlations with hormone and inflammatory factors in patients with stage 3/4 endometriosis

May 17, 2025
This study explores the gut microbiota imbalance and its correlations with hormone and inflammatory factors in stage 3/4 endometriosis. Key findings reveal distinct microbial shifts linked to…

I Am the 1 in 10—What Should I Eat? A Research Review of Nutrition in Endometriosis

Mar 18, 2025
This review explores how dietary modifications impact endometriosis progression. Antioxidants, omega-3s, and anti-inflammatory diets show promise in symptom relief and hormonal regulation.…

Identification of distinct stool metabolites in women with endometriosis for non-invasive diagnosis and potential for microbiota-based therapies

Mar 18, 2025
This study identifies stool-based biomarkers for endometriosis diagnosis and highlights the therapeutic potential of 4-hydroxyindole, a microbiota-derived metabolite, in reducing inflammation and…

Iron Overload and Endometriosis: Mechanisms, Implications, and Therapeutic Targets

Mar 18, 2025
Iron overload in endometriosis contributes to oxidative stress, inflammation, and tissue damage, driving lesion persistence and subfertility. Ferroptosis resistance and dysregulated iron metabolism…

Lactoferrin: a secret weapon in the war against pathogenic bacteria

Mar 18, 2025
This review definitively showcases lactoferrin’s antimicrobial prowess against resistant bacteria, detailing its mechanisms, effects on virulence factors like biofilms, and potential to restore…

Metabolomics reveals perturbations in endometrium and serum of minimal and mild endometriosis

Mar 18, 2025
This study highlights metabolic alterations in endometrial tissue and serum of minimal and mild endometriosis patients, identifying amino acid biomarkers with diagnostic potential. A combined serum…

Microbiome of the lower genital tract in Chinese women with endometriosis by 16s-rRNA sequencing technique: a pilot study

May 19, 2025
This study identifies microbiome shifts in the lower genital tract of Chinese women with endometriosis, marked by Atopobium enrichment and changes in ribosome biogenesis and immune modulation.…

Microbiome Profile of Deep Endometriosis Patients: Comparison of Vaginal Fluid, Endometrium and Lesion

May 19, 2025
This study reveals a distinct microbiome profile in deep endometriosis, with unique bacterial communities in lesion sites, suggesting a role in inflammation and disease progression. Potentially…

Microbiota composition and distribution along the female reproductive tract of women with endometriosis

Aug 11, 2025
This study maps the microbiota composition along the reproductive tract in endometriosis patients, revealing microbial dysbiosis, reduced Lactobacillus, and increased Pseudomonas and Sphingobium in…

Molecular detection of intrauterine microbial colonization in women with endometriosis

Mar 18, 2025
What was studied? The research focused on investigating microbial colonization in women’s intrauterine environment and cystic fluid, utilizing a molecular approach to detect bacterial presence. This…

Molecular detection of intrauterine microbial colonization in women with endometriosis

May 19, 2025
This study reveals that intrauterine microbial colonization is prevalent in women with endometriosis, particularly with Streptococcaceae, Staphylococcaceae, and Enterobacteriaceae. Findings suggest…

Molecular detection of microbial colonization in cervical mucus of women with and without endometriosis

Aug 11, 2025
This study identifies intrauterine microbial colonization in endometriosis, with enriched Streptococcaceae, Staphylococcaceae, and Enterobacteriaceae. GnRHa therapy exacerbated microbial imbalances,…

Nickel Allergy as a Risk Factor for Endometriosis

Mar 18, 2025
This study identifies nickel allergy as an independent risk factor for endometriosis, highlighting shared immune dysregulation and estrogenic pathways. Using a population-based cohort, researchers…

Oral, Vaginal, and Stool Microbial Signatures in Patients With Endometriosis as Potential Diagnostic Non-Invasive Biomarkers: A Prospective Cohort Study

Aug 11, 2025
This study explores oral, vaginal, and stool microbial signatures in patients with endometriosis, highlighting their potential as non-invasive diagnostic biomarkers. Findings suggest distinct…

Overlap Between Irritable Bowel Syndrome Diagnosis and Endometriosis in Adolescents

Mar 18, 2025
The study links endometriosis with a fivefold increased risk of IBS in adolescents, emphasizing the role of acyclic pelvic pain severity and inflammation as shared mechanisms. Early screening for IBS…

Persistent Organic Pollutants and Endometriosis

Mar 18, 2025
This study links persistent organic pollutants to metabolic alterations in deep endometriosis, identifying trans-nonachlor and 2-hydroxybutyrate as key markers.

Plants as source of new therapies for endometriosis: a review of preclinical and clinical studies

Mar 18, 2025
This review highlights the potential of plant-derived therapies for endometriosis. Key findings include anti-inflammatory, anti-proliferative, and anti-angiogenic effects of herbal extracts and…

Plants as source of new therapies for endometriosis: a review of preclinical and clinical studies

Mar 18, 2025
This review assesses plant-derived agents for endometriosis therapy, focusing on mechanisms like inflammation, angiogenesis, and apoptosis. Key agents such as resveratrol and curcumin show…

Presence of metalloestrogens in ectopic endometrial tissue

Mar 18, 2025
This study quantified metalloestrogens—cadmium, nickel, and lead—in ectopic endometrial tissue, suggesting their role in endometriosis persistence.

Remission of Endometriosis by Hyperbaric Oxygen Treatment in Rats

Mar 18, 2025
This study demonstrates hyperbaric oxygen therapy (HBOT) achieves complete remission of endometriotic lesions in a rat model by reducing hypoxia, inflammation, and TNF-α levels. While HBOT shows…

The bidirectional relationship between endometriosis and microbiome

Mar 18, 2025
This review highlights the bidirectional relationship between endometriosis and the microbiome, showcasing dysbiosis as a key factor in inflammation and estrogen metabolism. Emerging…

The Comorbidity of Endometriosis and Systemic Lupus Erythematosus: A Systematic Review

Mar 18, 2025
This review explores the significant comorbidity between systemic lupus erythematosus (SLE) and endometriosis, emphasizing shared pathological pathways.

The effect of hyperbaric oxygen therapy in the inflammatory response in a mouse model of endometriosis: An experimental study

Mar 18, 2025
This study highlights hyperbaric oxygen therapy’s (HBOT) role in reducing inflammation and NFκB expression in a mouse model of endometriosis. The findings suggest HBOT as a promising…

The Endobiota Study: Comparison of Vaginal, Cervical and Gut Microbiota Between Women with Stage 3/4 Endometriosis and Healthy Controls

May 19, 2025
This study reveals distinct microbiome shifts in the vaginal, cervical, and gut microbiota of women with stage 3/4 endometriosis. The absence of Atopobium and elevated Gardnerella in reproductive…

The impact of endometriosis on dietary choices and activities of everyday life: a cross-sectional study

Mar 18, 2025
This review highlights how gluten-free, Mediterranean, and anti-inflammatory diets improve pain perception in endometriosis by reducing inflammation and modulating the gut microbiome. Probiotics and…

The Influence of Lactoferrin in Plasma and Peritoneal Fluid on Iron Metabolism in Women with Endometriosis

May 24, 2025
This study demonstrates that peritoneal fluid-to-plasma ferritin and lactoferrin ratios distinguish endometriosis stage and severity. Iron overload and shifting iron-binding protein profiles reveal a…

The Main Theories on the Pathogenesis of Endometriosis

Mar 18, 2025
This review synthesizes key theories on endometriosis pathogenesis, emphasizing immune, hormonal, and epigenetic interactions in its progression.

The role of gut and genital microbiota and the estrobolome in endometriosis, infertility and chronic pelvic pain

Mar 18, 2025
This review highlights the gut and genital microbiome’s roles in estrogen-driven conditions like endometriosis, infertility, and CPP, emphasizing dysbiosis’ impact on inflammation and…

The role of the vaginal microbiome in distinguishing female chronic pelvic pain caused by endometriosis/adenomyosis

May 17, 2025
This study examines the role of the vaginal microbiome in distinguishing chronic pelvic pain caused by endometriosis and adenomyosis. Findings highlight specific microbial signatures associated with…

The Vaginal Microbiome as a Tool to Predict rASRM Stage of Disease in Endometriosis: a Pilot Study

May 19, 2025
This study identifies the vaginal microbiome as a predictor of endometriosis severity, highlighting microbial shifts that correlate with rASRM staging. Anaerococcus emerged as a key biomarker for…

Trace Elements and Endometriosis: Insights into Oxidative Stress and Novel Therapies

Mar 18, 2025
This review explores the role of trace elements and oxidative stress in endometriosis, highlighting their potential as therapeutic targets. It underscores the need for further research into the trace…

Escherichia coli (E. coli) (1)

Essential Oils (2)

Estrogen (4)

Fecal Microbiota Transplantation (FMT) (2)

Female Infertility (36)

The Effects of Toxic Heavy Metals Lead, Cadmium and Copper on the Epidemiology of Male and Female Infertility

Jun 30, 2025
This review synthesizes evidence linking lead, cadmium, and copper exposure to male and female infertility, detailing mechanisms of reproductive toxicity, epidemiological patterns, and the potential…

POI: Premature Ovarian Insufficiency/Pregnancy or Infertility?

Jun 27, 2025
This case report describes a young woman with premature ovarian insufficiency who, despite infertility and diagnostic confirmation of POI, experienced spontaneous conception. The case underscores the…

Contraceptive potential of Hibiscus rosa-sinensis (Linn.)

Jul 27, 2025
Hibiscus rosa-sinensis shows potent antifertility effects through antiovulatory, antiimplantation, and antispermatogenic mechanisms in animal studies, supporting its development as a safe, natural…

The Application of Complementary and Alternative Medicine in Polycystic Ovary Syndrome Infertility

Jul 3, 2025
This review summarizes clinical and mechanistic evidence for complementary and alternative medicine in PCOS infertility, highlighting TCM, acupuncture, nutrient supplementation, and lifestyle…

Pelvic inflammatory disease and infertility

Jun 27, 2025
This review details the polymicrobial pathogenesis of PID, its major microbial culprits—including both classical STIs and vaginal anaerobes—and underscores the high risk of infertility. Early…

Potential biomarkers of infertility associated with microbiome imbalances

Jun 27, 2025
Microbiome dysbiosis and elevated miR-21-5p and miR-155-5p levels are strongly linked to unexplained infertility, suggesting their role as biomarkers. Correcting these microbiome imbalances could…

Herbal contraceptives: Evaluation of antifertility potential of Hibiscus rosa-sinensis (Linn.)

Jul 15, 2025
Hibiscus rosa-sinensis exhibits significant antifertility effects in animal models through antiovulatory, antiimplantation, and spermatogenic disruption mechanisms, highlighting its potential as a…

Relationships between female infertility and female genital infections and pelvic inflammatory disease

Jun 27, 2025
A large-scale Taiwanese study found that upper and lower genital tract infections, but not comorbidities or bacterial vaginosis, independently increased infertility risk. PID and lower genital tract…

Alterations of Vaginal Microbiota in Women With Infertility and Chlamydia trachomatis Infection

Jun 27, 2025
This study identified vaginal microbiota dysbiosis, marked by Lactobacillus iners dominance, in infertile women infected with Chlamydia trachomatis. Post-antibiotic recovery suggested microbiome…

Endometriosis-associated infertility: From pathophysiology to tailored treatment

Jun 27, 2025
This review synthesizes evidence on the multifactorial mechanisms underlying endometriosis-associated infertility, emphasizing inflammatory, hormonal, anatomical, and molecular drivers. It highlights…

Association between heavy metals exposure and infertility among American women aged 20-44 years: A cross-sectional analysis from 2013 to 2018 NHANES data

Jun 30, 2025
This cross-sectional study in American women found that higher urinary arsenic—and, to a lesser extent, cadmium—were associated with increased infertility risk, with lead exposure linked to…

Microbiota and Human Reproduction: The Case of Female Infertility

Jun 26, 2025
This review summarizes the essential role of balanced reproductive microbiota, particularly Lactobacillus dominance, in fertility and IVF success, linking microbial dysbiosis to infertility and…

Female Infertility Associated with Blood Lead and Cadmium Levels

Jun 30, 2025
What was studied? This original research article investigated the association between blood levels of lead and cadmium (two common environmental heavy metals) and self-reported infertility among…

Female Fertility and Environmental Pollution

Jun 30, 2025
Environmental pollution—including heavy metals, air pollutants, and endocrine disruptors—negatively impacts female fertility through hormonal disruption, oxidative stress, and epigenetic changes. The…

Perception prevalence of the relationship between PID and infertility amongst women of reproductive age: A Nigerian study

Jun 27, 2025
A Nigerian study found only 10% of reproductive-age women recognized the link between PID and infertility, despite high education levels. The findings emphasize the need for improved public health…

Altered Follicular Fluid Metabolic Pattern Correlates with Female Infertility and Outcome Measures of In Vitro Fertilization

Jun 30, 2025
This study identified 27 follicular fluid metabolites differentiating infertile from fertile women, developed a predictive Biomarker Score, and demonstrated strong correlations with IVF outcomes,…

The Role of Genital Tract Microbiome in Fertility: A Systematic Review

Jun 26, 2025
This review underscores the importance of genital tract microbiome composition in fertility, particularly Lactobacillus crispatus dominance, which is linked to better fertility outcomes. Dysbiosis…

Bacterial vaginosis and its association with infertility, endometritis, and pelvic inflammatory disease

Jun 27, 2025
This review details the links between bacterial vaginosis, endometritis, pelvic inflammatory disease, and infertility, highlighting the role of vaginal and endometrial microbiota disruptions and…

Association between co-exposure to phenols and phthalates mixture and infertility risk in women

Jul 1, 2025
This study explores the relationship between co-exposure to phenols and phthalates and infertility risk in women of reproductive age, highlighting significant associations with BPA and DEHP…

Endometriosis and Infertility: A review of the pathogenesis and treatment of endometriosis-associated infertility

Jun 27, 2025
This review details the multifactorial pathogenesis of endometriosis-associated infertility, emphasizing molecular, genetic, and inflammatory mechanisms, and evaluates current and emerging…

Metabolic risk factors and fertility disorders: A narrative review of the female perspective

Jun 30, 2025
This review explores how metabolic risk factors—obesity, the female athlete triad, and oxidative stress—contribute to female infertility, highlighting associations with PCOS, endometriosis, and…

Characterizing the gut microbiota in females with infertility and preliminary results of a water-soluble dietary fiber intervention study.

Jun 27, 2025
This study shows gut microbiota differences between fertile and infertile women, highlighting improved fertility outcomes with dietary fiber (PHGG) supplementation that enhances beneficial gut…

Comparative Effect of Nigella Sativa+ Black Pepper and Letrozole + Tamoxifen on Female Infertility in Women with Polycystic Ovarian Syndrome: A Randomized Clinical Trial

Jul 4, 2025
A randomized clinical trial found Nigella sativa plus black pepper significantly improved pregnancy rates and reproductive parameters versus letrozole plus tamoxifen in infertile women with PCOS,…

Protective Roles of Honey in Reproductive Health: A Review

Jul 4, 2025
Honey exerts protective effects in reproductive health by modulating oxidative stress, supporting hormonal balance, and selectively inhibiting pathogens while preserving beneficial microbiota, making…

Characterization of the Vaginal Microbiome in Women with Infertility and Its Potential Correlation with Hormone Stimulation during In Vitro Fertilization Surgery

Jun 27, 2025
This study shows women with secondary infertility have persistently altered, less diverse vaginal microbiomes unresponsive to IVF hormone stimulation. Increased Atopobium and decreased Lactobacillus…

Post-Coital Antifertility Activity of Hibiscus rosa-sinensis Linn. roots

Jul 15, 2025
The ethanolic root extract of Hibiscus rosa-sinensis shows potent, reversible post-coital antifertility effects in rats via estrogenic mechanisms, supporting its potential as a safe herbal…

Female Fertility and the Nutritional Approach: The Most Essential Aspects

Jul 5, 2025
A narrative review examining how dietary patterns, nutrients, and gut microbiota impact female fertility, highlighting the Mediterranean diet’s benefits, the risks of Western diets, key…

Differential Composition of Vaginal Microbiome Is Associated With Successful Intrauterine Insemination in Couples With Idiopathic Infertility

Jun 26, 2025
This study links the vaginal microbiome, particularly Lactobacillus crispatus dominance, to successful IUI outcomes in idiopathic infertility. Dysbiosis, with an increase in Bifidobacterium, was…

Relationship between risk factors for infertility in women and lead, cadmium, and arsenic blood levels: a cross-sectional study from Taiwan

Jun 30, 2025
Infertile women in Taiwan showed higher blood lead and arsenic levels than pregnant women, mainly linked to frequent Chinese herbal medicine use. Physical activity may help lower lead accumulation,…

How does chronic endometritis influence pregnancy outcomes in endometriosis associated infertility? A retrospective cohort study

Jun 26, 2025
This study shows chronic endometritis significantly increases pregnancy complications in women with endometriosis-associated infertility. Placenta previa, gestational hypertension, and cesarean…

Endometrial microbiota composition is associated with reproductive outcome in infertile patients

Jun 26, 2025
This study links endometrial microbiota composition to reproductive success in ART, showing that Lactobacillus dominance is associated with better outcomes, while dysbiosis with pathogens like…

Human genital tracts microbiota: dysbiosis crucial for infertility

Jun 26, 2025
This review connects genital microbiota dysbiosis to infertility, highlighting the role of Lactobacillus dominance in female fertility and microbial imbalances in seminal fluid affecting male…

A two-sample mendelian randomization analysis investigates associations between gut microbiota and infertility

Jun 26, 2025
This study demonstrates a causal link between specific gut microbiota and infertility risks, identifying protective and harmful bacterial taxa in both men and women. It highlights the…

Probiotics and the envisaged role in treating human infertility

Jul 3, 2025
This review details how probiotics modulate the human microbiome to support fertility, addressing mechanisms, clinical evidence, and implications for male and female reproductive health, with…

Effects of vaginal microbiota on in vitro fertilization outcomes in women with different infertility causes

Jul 23, 2025
This study explores the impact of vaginal microbiota on IVF outcomes in women with infertility. It highlights how specific bacteria like Lactobacillus iners and Pseudomonas spp. can predict IVF…

Causal Effects of Gut Microbiota on Female Reproductive Tract Inflammation and Infertility: A Mendelian Randomization Study

Jun 26, 2025
The study confirmed causal links between specific gut microbiota and female reproductive tract inflammation and infertility. Notably, Lachnospiraceae and Ruminococcus increased inflammation risks,…

Gram-Negative Bacteria (2)

Graves’ Disease (GD) (23)

Mendelian Randomization Reveals Causal Gut Microbiota Signatures in Six Thyroid Diseases

Jul 23, 2025
Mendelian‑randomization of 18,340 MiBioGen participants and > 349k FinnGen controls identifies 32 gut genera with causal roles—some protective, others harmful—across six thyroid diseases,…

Graves’ Disease Gut Microbiota Signature: Key Microbial Changes in Autoimmune Thyroid Disease

Jul 29, 2025
Graves’ disease patients display a distinct gut microbiota signature, characterized by reduced diversity and altered abundance of key microbial taxa, including increased Bacilli, Prevotella, and…

Intestinal Microbiota Changes in Graves’ Disease: Microbial Signatures and Clinical Impact

Jul 28, 2025
This study found that Graves’ disease is associated with reduced gut microbial diversity and specific increases in Bacilli, Lactobacillales, Prevotella, Megamonas, and Veillonella, alongside…

Graves & Crohn: Genetic Evidence for Microbiome-Mediated Crosstalk

Jul 23, 2025
Mendelian-randomization of East-Asian GWAS data shows Crohn disease genetics raise Graves disease risk, while ulcerative colitis genetics are protective, highlighting microbiome-immune pathways…

Graves’ Disease Gut Microbiome Signatures: Key Genera and Clinical Implications

Jul 29, 2025
This study reveals distinct gut microbiome alterations in Graves’ disease, identifies 12 key bacterial genera as diagnostic signatures, and shows microbiota recovery after antithyroid therapy,…

Graves’ Disease Gut Microbiota Signatures: Key Microbial Shifts and Clinical Implications

Jul 29, 2025
This study reveals that Graves’ disease patients exhibit distinct gut microbiota signatures, with increased Bacteroidetes and Prevotellaceae and decreased Firmicutes and Lachnospiraceae, strongly…

Graves’ Disease Gut Microbiota: Distinct Microbial Signatures and Clinical Associations

Jul 29, 2025
Graves’ disease patients show distinctive gut microbiota profiles, with increased Bacteroidetes and specific pro-inflammatory bacteria, despite no difference in overall diversity. Key taxa correlate…

Alteration in gut microbiota is associated with immune imbalance in Graves’ disease

Jul 29, 2025
This study reveals distinct compositional changes in the gut microbiota of Graves’ disease patients, notably increased Bacteroidetes and Prevotellaceae and decreased Firmicutes and Lachnospiraceae,…

Graves’ Disease and Depression: Immunity, Hormones & Microbiome Explained

Jul 23, 2025
Graves Disease potentiates depression via autoimmune cytokines, hormonal excess and gut‑microbiome shifts. This review consolidates epidemiology and mechanisms, highlighting microbial signatures…

Molecular Alteration Analysis of Human Gut Microbial Composition in Graves’ disease Patients

Jul 23, 2025
This study identified a microbiome signature in Graves’ disease marked by reduced microbial richness and elevated Prevotella_9 and Haemophilus, with losses in Faecalibacterium and Alistipes,…

Viral Microbiome Signatures in Graves’ Disease: A Comprehensive Review

Jul 23, 2025
This review links genetics, hormones, environment and especially viral exposures—EBV and HCV—to the Th1‑centric immunopathology of Graves’ disease, highlighting chemokine signatures relevant to…

Microbiome in Graves Disease Hypothyroidism: Insights from Integrated Analysis for Clinicians

Jul 29, 2025
Integrated microbiome-metabolome study reveals dysbiosis and metabolic shifts in Graves’ disease and hypothyroidism, highlighting potential biomarkers like depleted Bacteroides for thyroid…

Graves’ Disease Gut Microbiome Signature: Key Genera and Clinical Implications

Jul 29, 2025
This prospective study identifies a unique gut microbiome signature in Graves’ disease, characterized by decreased SCFA-producing bacteria and increased pro-inflammatory taxa, which partially…

Correlations between serum cytokines and gut microbiota in patients with Graves’ disease: A case-control study

Jul 28, 2025
What was studied? This case–control observational study investigated the associations between peripheral blood cytokine profiles and gut microbiota composition in patients with Graves’ disease (GD),…

Targeted Therapies and Microbiome Insights in Graves’ Disease: A Clinical Review

Dec 23, 2025
This review maps the immune‑microbial mechanisms driving Graves’ disease and evaluates next‑generation biologics, small molecules and tolerance‑inducing peptides that may replace conventional…

Effects of Trace Elements on Endocrine Function and Pathogenesis of Thyroid Diseases—A Literature Review

Jun 30, 2025
This review summarizes current evidence on how trace elements influence thyroid hormone synthesis, metabolism, and the development of thyroid diseases, highlighting mechanistic links, clinical…

Gut Microbiome Signatures in Graves’ and Hashimoto’s Disease: Microbial Markers and ABC Transporter Pathway Insights

Jul 29, 2025
This study demonstrates that Graves’ disease and Hashimoto’s thyroiditis patients share distinct gut microbiome signatures—particularly involving Bacillus, Blautia, and Ornithinimicrobium—and a…

Comprehensive Review: Genetic Architecture and Clinical Implications in Graves’ Disease

Jul 24, 2025
A multi‑ethnic review summarising >80 genetic loci underlying Graves’ disease, their clinical correlates and emerging precision‑medicine applications.

Gut Microbiome in Graves’ Disease and Orbitopathy: Distinct Signatures and Clinical Implications

Jul 29, 2025
This study demonstrates that gut microbiome composition and function differ significantly between Graves’ disease and Graves’ orbitopathy, with specific taxa correlating with thyroid autoimmunity.…

Gut Microbiota in Graves’ Disease and Graves’ Orbitopathy: Distinct Microbial Signatures and Implications

Jul 29, 2025
This study identified distinct alterations in gut microbiota composition and function in Graves’ disease and Graves’ orbitopathy patients compared to healthy controls, highlighting specific microbial…

Gut Microbiota Signatures in Graves’ Disease: Key Associations and Biomarker Potential

Jul 29, 2025
This study reveals that Graves’ disease is linked to distinct gut microbiota alterations, particularly increased Ruminococcus and Lactobacillus and decreased Synergistetes and Phascolarctobacterium,…

Graves’ Disease Gut Microbiome Signature: Diagnostic and Pathogenic Insights

Jul 29, 2025
This cross-sectional study found that Graves’ disease patients have distinctly altered gut microbiota—lower Firmicutes, higher Bacteroidetes, and reduced butyrate-producers—suggesting a role for the…

Gut Microbiota in Graves’ Disease: Microbial Signatures and Diagnostic Potential

Jul 29, 2025
This study identified distinctive alterations in gut microbiota in Graves’ disease, including reduced diversity and specific taxonomic shifts. Key microbial signatures correlated with thyroid…

Hashimoto’s Thyroiditis (5)

Alterations of the Gut Microbiota in Hashimoto’s Thyroiditis Patients

Mar 18, 2025
Gut microbiota analysis in Hashimoto’s thyroiditis patients identified significant dysbiosis, with increased pro-inflammatory taxa and reduced beneficial microbes, correlating with thyroid…

Comparative Analysis of Taxonomic and Functional Gut Microbiota Profiles in Relation to Seroconversion of Thyroid Peroxidase Antibodies in Euthyroid Participants.

Mar 18, 2025
What was studied? This study investigated the taxonomic and functional gut microbiota profiles of euthyroid individuals with and without thyroid peroxidase antibodies (TPOAb), a marker for autoimmune…

Integrative analysis of gut microbiome and host transcriptome reveal novel molecular signatures in Hashimoto’s thyroiditis

Mar 18, 2025
This study revealed novel molecular signatures linking gut microbiota and transcriptome in Hashimoto’s thyroiditis, advancing diagnostic and therapeutic approaches.

Molecular estimation of alteration in intestinal microbial composition in Hashimoto’s thyroiditis patients

Mar 18, 2025
This study identifies significant gut microbiota alterations in Hashimoto’s thyroiditis, with reduced beneficial microbes and increased pathogens.

Molecular estimation of alteration in intestinal microbial composition in Hashimoto’s thyroiditis patients

May 28, 2025
This study found that gut microbiota in Hashimoto’s thyroiditis patients differs markedly from healthy controls, with enriched Escherichia coli and depleted Prevotella. These microbial shifts support…

Heart Failure (1)

Hormone Replacement Therapy (HRT) (16)

Long-term postmenopausal hormone therapy and endometrial cancer

Aug 21, 2025
Long-term use of estrogen and estrogen-progestin therapies significantly increases the risk of endometrial cancer, particularly for women with lower BMI. The risk is dose-dependent, with…

Hormone therapy and the risk of stroke: Perspectives ten years after the Women’s Health Initiative trials

Aug 21, 2025
This review investigates the stroke risk associated with hormonal therapies in postmenopausal women, comparing oral and transdermal estrogen formulations and highlighting the need for individualized…

Hormone replacement therapy for women previously treated for endometrial cancer

Aug 21, 2025
This review highlights the lack of conclusive evidence on the safety of hormone replacement therapy (HRT) in women treated for early-stage endometrial cancer. While a small study found no significant…

Hormone therapy for first-line management of menopausal symptoms: Practical recommendations

Aug 20, 2025
This review sets a simple plan for menopausal hormone therapy first-line management, favors transdermal routes when risk exists, and backs local therapy for genitourinary symptoms with clear links to…

A systematic review of randomised clinical trials – The safety of vaginal hormones and selective estrogen receptor modulators for the treatment of genitourinary menopausal symptoms in breast cancer survivors

Aug 21, 2025
This review assesses the safety of vaginal hormones and SERMs in treating genitourinary menopausal symptoms in breast cancer survivors. It finds no significant rise in serum estrogen levels or an…

Role of menopausal hormone therapy in the prevention of postmenopausal osteoporosis

Aug 20, 2025
The review shows that menopausal hormone therapy osteoporosis prevention lowers fractures when started near menopause, favors transdermal routes for safety, and maps RANKL–OPG and cytokine shifts…

Rethinking Menopausal Hormone Therapy: For Whom, What, When and How long?

Aug 21, 2025
This review offers updated guidance on the use of menopausal hormone therapy, highlighting its benefits when started early, particularly for women with low cardiovascular risk. It stresses the…

Risks, Benefits, and Treatment Modalities of Menopausal Hormone Therapy: Current Concepts

Aug 21, 2025
The study emphasizes the risks and benefits of menopausal hormone therapy in managing vasomotor symptoms, osteoporosis, and cardiovascular health. It highlights the importance of timing, formulation,…

Vasomotor Symptoms During Menopause: A Practical Guide on Current Treatments and Future Perspectives

Aug 21, 2025
The review defines menopause vasomotor symptoms treatment and microbiome relevance, favors timely hormone therapy and transdermal routes, details effective nonhormone options, and highlights…

Menopausal hormone therapy and menopausal symptoms

Aug 21, 2025
This review emphasizes the benefits and risks of MHT in managing menopause symptoms, including the prevention of long-term conditions. It advocates for individualized treatment plans, especially…

Optimizing menopausal hormone therapy: For treatment and prevention, menstrual regulation, and reduction of possible risks

Aug 20, 2025
This review links menopausal hormone therapy and vaginal microbiome care to safer symptom relief, bleeding control, and prevention. It favors transdermal estradiol and physiologic progestogens, and…

Progesterone: The ultimate endometrial tumor suppressor

Aug 20, 2025
The review defines progesterone endometrial tumor suppressor mechanisms, links receptor biology to therapy response, and outlines immune and barrier changes with clear microbiome relevance despite no…

Treatment of Symptoms of the Menopause: An Endocrine Society Clinical Practice Guideline

Aug 21, 2025
This guideline on menopausal symptom treatment prioritizes early initiation of hormone therapy, safe routes like transdermal estradiol, and vaginal care for genitourinary symptoms. It promotes a…

The 2020 Menopausal Hormone Therapy Guidelines

Aug 20, 2025
The guideline links menopausal hormone therapy guidelines and vaginal microbiome care to safer symptom control, better GSM outcomes, and lower UTI risk through local estrogen, with timing and route…

Menopausal hormone therapy increases the risk of gallstones: Health Insurance Database in South Korea (HISK)-based cohort study

Aug 21, 2025
This study shows that menopausal hormone therapy increases the risk of gallstones, especially with topical estrogen and tibolone. However, no increased risk for gallbladder cancer was found. These…

Hormonal therapies and venous thrombosis: Considerations for prevention and management

Aug 21, 2025
This review explores the thrombosis risks of hormonal therapies, comparing various estrogen formulations and progestins. It emphasizes the need for personalized treatment based on thrombophilic risk…

Hyperbaric Oxygen Therapy (HBOT) (1)

Infertility (9)

The Effects of Toxic Heavy Metals Lead, Cadmium and Copper on the Epidemiology of Male and Female Infertility

Jun 30, 2025
This review synthesizes evidence linking lead, cadmium, and copper exposure to male and female infertility, detailing mechanisms of reproductive toxicity, epidemiological patterns, and the potential…

Lactobacilli–lactoferrin interplay in Chlamydia trachomatis infection

Jun 24, 2025
The study found a potent inhibitory effect against Chlamydia trachomatis infection using Lactobacillus brevis combined with lactoferrin, notably reducing bacterial adhesion, invasion, and…

Microbiota and Human Reproduction: The Case of Female Infertility

Jun 26, 2025
This review summarizes the essential role of balanced reproductive microbiota, particularly Lactobacillus dominance, in fertility and IVF success, linking microbial dysbiosis to infertility and…

Differential Composition of Vaginal Microbiome Is Associated With Successful Intrauterine Insemination in Couples With Idiopathic Infertility

Jun 26, 2025
This study links the vaginal microbiome, particularly Lactobacillus crispatus dominance, to successful IUI outcomes in idiopathic infertility. Dysbiosis, with an increase in Bifidobacterium, was…

Human genital tracts microbiota: dysbiosis crucial for infertility

Jun 26, 2025
This review connects genital microbiota dysbiosis to infertility, highlighting the role of Lactobacillus dominance in female fertility and microbial imbalances in seminal fluid affecting male…

A two-sample mendelian randomization analysis investigates associations between gut microbiota and infertility

Jun 26, 2025
This study demonstrates a causal link between specific gut microbiota and infertility risks, identifying protective and harmful bacterial taxa in both men and women. It highlights the…

A More Diverse Cervical Microbiome Associates with Better Clinical Outcomes in Patients with Endometriosis: A Pilot Study

Mar 18, 2025
This study links cervical microbiome diversity with endometriosis severity. Findings reveal microbial imbalances, particularly in advanced stages, correlate with pain, infertility, and inflammatory…

Iron Overload and Endometriosis: Mechanisms, Implications, and Therapeutic Targets

Mar 18, 2025
Iron overload in endometriosis contributes to oxidative stress, inflammation, and tissue damage, driving lesion persistence and subfertility. Ferroptosis resistance and dysregulated iron metabolism…

The role of gut and genital microbiota and the estrobolome in endometriosis, infertility and chronic pelvic pain

Mar 18, 2025
This review highlights the gut and genital microbiome’s roles in estrogen-driven conditions like endometriosis, infertility, and CPP, emphasizing dysbiosis’ impact on inflammation and…

Intratumoural Microbiota (11)

Role of Fungi in Tumorigenesis: Promises and Challenges

Aug 19, 2025
This review explores the role of fungi in cancer progression, highlighting their impact on tumor development and immune responses. It emphasizes the potential for mycobiome-based cancer diagnostics…

Spatial Heterogeneity of Intratumoral Microbiota: A New Frontier in Cancer Immunotherapy Resistance

Aug 19, 2025
This review investigates the spatial heterogeneity of intratumoral microbiota and its impact on cancer immunotherapy resistance. It highlights how microbial distribution within tumors influences…

The intratumoral microbiota: A new horizon in cancer immunology

Aug 18, 2025
This review explores the role of intratumoral microbiota in cancer progression and immunity. It discusses how microbiota influence tumor behavior and therapy outcomes, suggesting potential…

The microbial landscape of tumors: A deep dive into intratumoral microbiota

Aug 19, 2025
This review examines the role of intratumoral microbiota in cancer progression, immune modulation, and therapy resistance. It highlights microbial species involved in tumor growth and discusses the…

Unveiling the intratumoral microbiota within cancer landscapes

Aug 19, 2025
The review highlights the role of intratumoral microbiota in cancer initiation, progression, and therapy. It discusses the dual effects of these microbiota on immune responses, emphasizing their…

Intratumoral Microbiota: Insights from Anatomical, Molecular, and Clinical Perspectives

Aug 19, 2025
What was studied? This review article explores the role of intratumoral microbiota in cancer initiation, progression, and therapeutic responses. It highlights the complex interactions between…

The role of the microscopic world: Exploring the role and potential of intratumoral microbiota in cancer immunotherapy

Aug 19, 2025
This review explores the complex role of intratumoral microbiota in cancer, emphasizing their influence on immune responses and the potential for microbiome-based therapies in cancer immunotherapy.…

Intratumoral microbiome: Implications for immune modulation and innovative therapeutic strategies in cancer

Aug 19, 2025
This review explores the dual role of the intratumoral microbiome in cancer, highlighting its impact on immune modulation and its potential as a target for innovative therapeutic strategies,…

Intratumoral microbiota: Roles in cancer initiation, development and therapeutic efficacy

Aug 18, 2025
This review explores how intratumoral microbiota influence cancer initiation, progression, and therapy. It highlights their roles in immune modulation, tumor growth, and therapeutic resistance,…

Intratumoural microbiota: a new frontier in cancer development and therapy

Aug 18, 2025
This review discusses how intratumoral microbiota influence cancer progression and therapy. It explores their roles in immune modulation, inflammation, and treatment resistance, and suggests…

Tumour-resident oncolytic bacteria trigger potent anticancer effects through selective intratumoural thrombosis and necrosis

Aug 19, 2025
This study demonstrates the potent anticancer effects of a tumor-resident bacterial consortium in both immunocompetent and immunocompromised mice. The consortium induces tumor remission through…

Iron (Fe) (7)

Plasma Iron Infection Risk: Role of TSAT and HFE C282Y in Immune Defense

Aug 22, 2025
This review summarizes evidence that both low and high plasma iron increase infection risk, particularly in individuals with HFE C282Y homozygosity. Maintaining stable transferrin saturation is vital…

Iron Supplementation and Infant Gut Microbiota: Meta-Analysis Reveals Bifidobacterium Loss

Aug 23, 2025
Iron supplementation in infants reduces Bifidobacterium abundance by 6.37%, as confirmed by meta-analysis. While critical for anemia prevention, oral iron may disrupt the infant gut microbiota,…

Role of Iron in Bacterial Pathogenesis: Clinical Takeaways from an Editorial

Aug 22, 2025
What was reviewed? This editorial synthesizes evidence on the role of iron in bacterial pathogenesis, emphasizing how iron scarcity and host nutritional immunity shape virulence, metabolic strategy,…

Commensal iron acquisition and nutritional immunity during Salmonella infection

Aug 22, 2025
XusB in Bacteroides thetaiotaomicron binds enterobactin in OMVs, sustains commensal fitness, and creates a lipocalin 2 resistant iron pool that Salmonella can recapture, redefining…

The battle for iron between bacterial pathogens and hosts: clinical microbiome implications

Aug 22, 2025
This review maps the battle for iron between bacterial pathogens and hosts, detailing nutritional immunity, bacterial siderophores and heme uptake, siderocalin defense, stealth siderophores, and…

Iron Supplementation and Microbiome in Preterm Infants: Risks of Dysbiosis and Pathogen Enrichment

Aug 22, 2025
High-dose enteral iron supplementation in VLBW infants was associated with reduced microbial diversity, Proteus enrichment, and increased microbial potential for ferroptosis and epithelial invasion,…

Staphylococcus aureus Metal Acquisition and Nutritional Immunity: Virulence Insights

Aug 22, 2025
This review outlines how Staphylococcus aureus overcomes host nutritional immunity by acquiring iron, manganese, and zinc, underscoring the critical role of metal transport systems in virulence and…

Irritable Bowel Syndrome (IBS) (25)

Graves & Crohn: Genetic Evidence for Microbiome-Mediated Crosstalk

Jul 23, 2025
Mendelian-randomization of East-Asian GWAS data shows Crohn disease genetics raise Graves disease risk, while ulcerative colitis genetics are protective, highlighting microbiome-immune pathways…

Low-Nickel Diet in Endometriosis: Symptom Relief and Nickel Mucositis Evidence

Oct 14, 2025
Nickel allergic contact mucositis was identified in over 90% of endometriosis patients with IBS-like symptoms. A low-nickel diet significantly reduced gastrointestinal, extra-intestinal, and…

Beneficial Effects of a Low-Nickel Diet on Relapsing IBS-Like and Extraintestinal Symptoms of Celiac Patients during a Proper Gluten-Free Diet: Nickel Allergic Contact Mucositis in Suspected Non-Responsive Celiac Disease

Nov 27, 2025
A study of celiac patients revealed that persistent symptoms during gluten-free eating may stem from nickel allergic contact mucositis. A low-nickel diet significantly improved gastrointestinal and…

Alterations in composition and diversity of the intestinal microbiota in patients with diarrhea-predominant irritable bowel syndrome

May 18, 2025
The study investigated gut microbiota in diarrhea-predominant irritable bowel syndrome (D-IBS), revealing distinct microbial shifts, including increased Enterobacteriaceae and reduced…

Altered Gut Microbiota in Irritable Bowel Syndrome and Its Association with Food Components

May 18, 2025
This study explores the altered gut microbiota in IBS and its association with caffeine and dietary fiber. Findings indicate that high caffeine intake is linked to increased microbial diversity and…

Altered profiles of intestinal microbiota and organic acids may be the origin of symptoms in irritable bowel syndrome

May 19, 2025
This study reveals that altered microbiota and elevated organic acids in IBS patients correlate with increased symptom severity, poorer quality of life, and heightened negative emotions. The findings…

Alternation of the gut microbiota in irritable bowel syndrome: an integrated analysis based on multicenter amplicon sequencing data

May 18, 2025
This study explores the alteration of the gut microbiota in IBS patients, revealing distinct microbial shifts linked to IBS subtypes. Findings highlight potential for microbiome-based therapies and…

Association of aberrant brain network dynamics with gut microbial composition uncovers disrupted brain-gut-microbiome interactions in irritable bowel syndrome: Preliminary findings

May 19, 2025
This study identifies disrupted brain-gut-microbiome interactions in IBS patients, revealing altered brain network dynamics and microbial shifts linked to symptom severity and cognitive dysfunction.…

Differences in gut microbial composition correlate with regional brain volumes in irritable bowel syndrome

May 18, 2025
This study identified two distinct IBS subgroups based on gut microbiome profiles, revealing correlations with regional brain volumes. The findings highlight the role of gut dysbiosis in structural…

Fecal Microbiota in Patients with Irritable Bowel Syndrome Compared with Healthy Controls Using Real-Time Polymerase Chain Reaction: An Evidence of Dysbiosis

May 18, 2025
The study identifies significant fecal microbiota dysbiosis in IBS patients, marked by increased Pseudomonas aeruginosa and Bacteroides thetaiotamicron, highlighting their potential as microbial…

Functional dysbiosis within the gut microbiota of patients with constipated-irritable bowel syndrome

May 18, 2025
The study highlights functional dysbiosis in constipated-irritable bowel syndrome, with increased sulfate-reducing bacteria and disrupted SCFA profiles.

Gastrointestinal microbiome signatures of pediatric patients with irritable bowel syndrome

May 18, 2025
This study identifies distinct microbiome signatures in pediatric IBS, revealing unique microbial imbalances linked to disease subtypes.

Global and deep molecular analysis of microbiota signatures in fecal samples from patients with irritable bowel syndrome

May 19, 2025
This study identifies global microbiota signatures in IBS patients, revealing distinct microbial imbalances that differentiate them from healthy controls. Key findings include a 2-fold increase in…

Gut microbiome signatures reflect different subtypes of irritable bowel syndrome

May 18, 2025
This study explores gut microbiome signatures across IBS subtypes, highlighting distinct microbial and metabolic shifts. Findings reveal subtype-specific dysbiosis, with implications for personalized…

Gut microbiota composition and functional prediction in diarrhea-predominant irritable bowel syndrome

Aug 11, 2025
This study reveals that gut microbiota in IBS-D patients is characterized by reduced Firmicutes, Fusobacteria, and Actinobacteria, alongside elevated Proteobacteria. Functional predictions indicate…

IBS-associated phylogenetic unbalances of the intestinal microbiota are not reverted by probiotic supplementation

May 18, 2025
This study found that while probiotics may relieve IBS symptoms, they do not revert the gut microbiota imbalances associated with the disorder.

Increase in fecal primary bile acids and dysbiosis in patients with diarrhea-predominant irritable bowel syndrome

May 18, 2025
The study identified significant shifts in fecal bile acid composition and gut microbiota in IBS-D patients. Elevated primary bile acids and dysbiosis were linked to stool frequency and consistency,…

Irritable Bowel Syndrome and Nickel Allergy:What Is the Role of the Low Nickel Diet?

May 19, 2025
What was studied? This pilot study evaluated the prevalence of nickel (Ni) allergy in individuals diagnosed with irritable bowel syndrome (IBS) and investigated the clinical efficacy of a low-nickel…

Lower Bifidobacteria counts in both duodenal mucosa-associated and fecal microbiota in irritable bowel syndrome patients

May 19, 2025
This study reveals that IBS patients have significantly lower bifidobacteria counts in both fecal and duodenal samples compared to healthy controls. The marked reduction in Bifidobacterium…

Molecular analysis of the luminal- and mucosal-associated intestinal microbiota in diarrhea-predominant irritable bowel syndrome

May 19, 2025
This study reveals that diarrhea-predominant IBS (D-IBS) is linked to reduced microbial diversity and niche-specific dysbiosis in the gut.

More than constipation – bowel symptoms in Parkinson’s disease and their connection to gut microbiota

May 18, 2025
IBS-like symptoms in Parkinson’s disease are linked to distinct gut microbiota changes, particularly Prevotella depletion, implicating the microbiota-gut-brain axis in non-motor symptoms.

Multi-omics profiles of the intestinal microbiome in irritable bowel syndrome and its bowel habit subtypes

May 17, 2025
This study explores multi-omics profiles of the intestinal microbiome in IBS subtypes, revealing distinct microbial and metabolic signatures. Findings highlight potential for microbiome-based…

Overlap Between Irritable Bowel Syndrome Diagnosis and Endometriosis in Adolescents

Mar 18, 2025
The study links endometriosis with a fivefold increased risk of IBS in adolescents, emphasizing the role of acyclic pelvic pain severity and inflammation as shared mechanisms. Early screening for IBS…

The microbiome of the oral mucosa in irritable bowel syndrome

May 18, 2025
The study identified distinct oral microbiome profiles in IBS patients, particularly in those overweight, highlighting its potential as a non-invasive diagnostic tool for visceral pain severity and…

Understanding of the Site-Specific Microbial Patterns towards Accurate Identification for Patients with Diarrhea-Predominant Irritable Bowel Syndrome

May 18, 2025
This study identifies site-specific microbial patterns in IBS-D patients, highlighting Bacteroides, Prevotella, and Oscillospira in the rectal mucosa as biomarkers. Findings suggest that rectal…

Lactoferrin (1)

Lead (Pb) (3)

Lipopolysaccharide (LPS) (3)

Low‑Nickel Diet (LNiD) (1)

Menarche (4)

Menopausal Hot Flashes (16)

Prevalence of hot flushes and night sweats around the world: a systematic review

Jul 19, 2025
This systematic review explores the global prevalence of hot flashes and night sweats, revealing significant cultural and regional variations. It emphasizes the need for personalized, region-specific…

User Outcomes for an App-Delivered Hypnosis Intervention for Menopausal Hot Flashes: Retrospective Analysis.

Jul 21, 2025
The study assessed the effectiveness of the Evia app, a smartphone-based hypnotherapy intervention, in reducing hot flash frequency and severity in menopausal women.

Severe hot flashes are associated with chronic insomnia

Jul 19, 2025
This study links severe hot flashes to chronic insomnia in perimenopausal and postmenopausal women, suggesting that managing hot flashes could improve sleep quality and reduce the health risks…

What’s in a name: are menopausal “hot flashes” a symptom of menopause or a manifestation of neurovascular dysregulation?

Jul 19, 2025
The article redefines menopausal hot flashes as signs of underlying neurovascular dysregulation, linking them to chronic conditions like cardiovascular disease and cognitive decline. It advocates for…

The Effect of Salvia Officinalis on Hot Flashes in Postmenopausal Women

Jul 21, 2025
This systematic review and meta-analysis found that Salvia officinalis significantly reduces the frequency of hot flashes in postmenopausal women, making it a promising non-hormonal alternative.

The effect of dietary intake on hot flashes in menopausal women

Jul 21, 2025
This study examines how dietary intake affects hot flash frequency in postmenopausal women. It finds that stable blood glucose levels, achieved through regular meals, reduce hot flash occurrences,…

Urinary phthalate metabolite concentrations and hot flashes in women from an urban convenience sample of midlife women

Jul 19, 2025
The study links urinary phthalate metabolite levels with increased risk and frequency of hot flashes in midlife women, suggesting environmental exposure as a contributing factor. Associations varied…

Menopausal hot flashes: mechanisms, endocrinology, treatment

Jul 19, 2025
The review explores the physiological mechanisms behind menopausal hot flashes, including thermoregulatory changes, sympathetic nervous activation, and estrogen depletion. It also examines treatments…

Dietary advanced glycation end-products and postmenopausal hot flashes

Jul 21, 2025
This study shows that reducing dietary advanced glycation end-products (AGEs) through a plant-based diet significantly reduces hot flashes in postmenopausal women, offering a non-hormonal alternative…

Phthalate metabolite levels and menopausal hot flashes in midlife women

Jul 19, 2025
This study links higher levels of phthalate metabolites, particularly from personal care products, to an increased risk and severity of hot flashes in midlife women, suggesting that phthalate…

The effect of herbal tea capsule on menopause hot flashes

Jul 21, 2025
This study demonstrates that herbal tea capsules significantly reduce the frequency, duration, and severity of hot flashes in postmenopausal women, offering a promising natural alternative to hormone…

High Physical Activity Level May Reduce Menopausal Symptoms

Aug 22, 2025
This study reveals that higher levels of physical activity, especially during leisure time, are linked to reduced severity of menopausal symptoms, particularly urogenital and somato-vegetative…

Menopause hot flashes and molecular mechanisms modulated by food-derived nutrients

Jul 21, 2025
This review discusses how food-derived nutrients modulate molecular mechanisms related to hot flashes in menopause, identifying dietary compounds that may offer effective, natural alternatives to…

Neurokinin 3 receptor antagonism as a novel treatment for menopausal hot flushes

Jul 21, 2025
This study demonstrates that MLE4901, an NK3R antagonist, significantly reduces hot flash frequency, severity, and interference in menopausal women, offering a non-hormonal treatment alternative.

SSRIs for hot flashes: a systematic review and meta-analysis of randomized trials.

Jul 21, 2025
This meta-analysis reveals that SSRIs are effective in reducing hot flashes in menopausal women, with escitalopram showing the highest efficacy. These results support SSRIs as a non-hormonal…

Diet quality, body weight, and postmenopausal hot flashes: a secondary analysis of a randomized clinical trial

Jul 21, 2025
This study suggests that a low-fat vegan diet, particularly one supplemented with soybeans, significantly reduces hot flashes in postmenopausal women, with improvements linked to higher plant-based…

Menopause (59)

Diagnosis of the menopause: NICE guidance and quality standards

Aug 24, 2025
NICE guidance recommends diagnosing menopause in women over 45 clinically, not with lab tests, while FSH measurement is reserved for suspected POI in women under 40, streamlining care and reducing…

Prevalence of hot flushes and night sweats around the world: a systematic review

Jul 19, 2025
This systematic review explores the global prevalence of hot flashes and night sweats, revealing significant cultural and regional variations. It emphasizes the need for personalized, region-specific…

Black cohosh (Cimicifuga spp.) for menopausal symptoms.

Jul 14, 2025
This review finds insufficient evidence that black cohosh effectively reduces menopausal symptoms. Hormone therapy outperforms black cohosh, which appears safe but needs further study for efficacy…

Drugs for the treatment of menopausal symptoms.

Jul 14, 2025
Estrogen therapy remains the most effective treatment for menopausal symptoms, with transdermal delivery preferred for safety. Non-hormonal options offer moderate relief; emerging therapies like…

Ospemifene for the treatment of menopausal vaginal dryness, a symptom of the genitourinary syndrome of menopause

Aug 22, 2025
Ospemifene is an effective and safe treatment for menopausal vaginal dryness and dyspareunia, particularly in women with contraindications for estrogen therapy. It improves vaginal health without…

Hormone therapy for first-line management of menopausal symptoms: Practical recommendations

Aug 20, 2025
This review sets a simple plan for menopausal hormone therapy first-line management, favors transdermal routes when risk exists, and backs local therapy for genitourinary symptoms with clear links to…

Compositional and functional features of the female premenopausal and postmenopausal gut microbiota

Jul 7, 2025
Menopause is linked to reduced gut microbiome diversity, loss of beneficial Firmicutes and Roseburia, and increased risk-associated taxa and metabolic pathways. These changes may contribute to higher…

The gut microbiota in menopause: Is there a role for prebiotic and probiotic solutions?

Jul 14, 2025
Menopause alters gut microbiota composition and estrogen metabolism, contributing to symptoms and disease risks. Prebiotic and probiotic interventions show promise for symptom relief and metabolic…

Comparison of Gabapentin with Estrogen for treatment of hot flashes in post-menopausal women

Aug 22, 2025
This study demonstrates that gabapentin 300 mg/day is as effective as estrogen 0.625 mg/day for reducing hot flashes in post-menopausal women. It provides a viable non-hormonal alternative with fewer…

Complementary and Alternative Medicine for Menopause

Jul 14, 2025
Mind-body therapies like hypnosis effectively reduce menopausal hot flashes; natural products and whole-system CAM approaches show mixed evidence. More high-quality research is needed.

Onset of natural menopause in African American women

Jul 7, 2025
This prospective study of 17,070 African American women found smoking most strongly predicts earlier menopause, while higher BMI and oral contraceptive use are protective. Perceived racism showed…

Assessing the Impact of (Poly)phenol-Rich Foods on Cardiometabolic Risk in Postmenopausal Women

Jul 14, 2025
Dietary intake of (poly)phenol-rich foods modestly improves cardiometabolic risk factors and reduces oxidative stress in postmenopausal women, with gut microbiome variability influencing outcomes.

Interaction of metals, menopause and COVID-19: A review of the literature

Jul 9, 2025
This review details how environmental metal exposures influence menopause onset, symptoms, and COVID-19 outcomes, emphasizing the potential for trace mineral supplementation and the need for…

Rethinking Menopausal Hormone Therapy: For Whom, What, When and How long?

Aug 21, 2025
This review offers updated guidance on the use of menopausal hormone therapy, highlighting its benefits when started early, particularly for women with low cardiovascular risk. It stresses the…

Menopausal Changes in the Microbiome—A Review Focused on the Genitourinary Microbiome

Jul 7, 2025
Menopause alters the gut, vaginal, and urinary microbiomes, decreasing Lactobacillus and increasing microbial diversity. These changes contribute to GSM, rUTI, and urinary symptoms. Hormone therapy…

Socioeconomic and Lifestyle Factors Affecting Age at Natural Menopause: Global Systematic Review

Jul 7, 2025
What was reviewed? This systematic review and meta-analysis synthesized data from 46 community-based studies across 24 countries, assessing the influence of socioeconomic position (SEP) and lifestyle…

Risks, Benefits, and Treatment Modalities of Menopausal Hormone Therapy: Current Concepts

Aug 21, 2025
The study emphasizes the risks and benefits of menopausal hormone therapy in managing vasomotor symptoms, osteoporosis, and cardiovascular health. It highlights the importance of timing, formulation,…

Primary ovarian insufficiency: Update on clinical and genetic findings

Jul 30, 2025
This review explores the genetic and clinical factors contributing to primary ovarian insufficiency (POI), highlighting key genes and the importance of early diagnosis, fertility preservation, and…

Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause

Jul 14, 2025
This review details the estrogenic activity, neuroprotective effects, and clinical relevance of medicinal plants for menopausal women, highlighting their potential to prevent cognitive decline and…

What’s in a name: are menopausal “hot flashes” a symptom of menopause or a manifestation of neurovascular dysregulation?

Jul 19, 2025
The article redefines menopausal hot flashes as signs of underlying neurovascular dysregulation, linking them to chronic conditions like cardiovascular disease and cognitive decline. It advocates for…

What’s in a name: are menopausal ‘hot flashes’ a symptom of menopause or a manifestation of neurovascular dysregulation?

Jul 7, 2025
This review challenges the labeling of hot flashes as mere menopausal symptoms, proposing they signal underlying neurovascular dysregulation linked to chronic disease risk, and calls for new clinical…

Ospemifene, a novel selective estrogen receptor modulator for treating dyspareunia associated with postmenopausal vulvar and vaginal atrophy

Aug 22, 2025
Ospemifene (60 mg/day) significantly reduces dyspareunia and improves vaginal health in postmenopausal women with vulvar and vaginal atrophy. It offers a non-estrogenic treatment option, especially…

Premenopausal Bone Health: Osteoporosis in Premenopausal Women

Jul 8, 2025
This review outlines the evaluation and management of osteoporosis in premenopausal women, emphasizing secondary causes, appropriate BMD interpretation, and tailored treatment—highlighting the…

Spotlight on the gut microbiome in menopause: current insights

Jul 7, 2025
Menopause reduces gut microbiome diversity and shifts composition toward a male-like profile, likely due to declining estrogen and progesterone. These changes may impact postmenopausal health and…

Vasomotor Symptoms During Menopause: A Practical Guide on Current Treatments and Future Perspectives

Aug 21, 2025
The review defines menopause vasomotor symptoms treatment and microbiome relevance, favors timely hormone therapy and transdermal routes, details effective nonhormone options, and highlights…

A dietary intervention for postmenopausal hot flashes: A potential role of gut microbiome

Jul 14, 2025
A plant-based diet with soy reduces hot flashes in postmenopausal women, potentially by modulating gut bacteria linked to inflammation and estrogen metabolism.

Urinary metals and metal mixtures and timing of natural menopause in midlife women

Jul 9, 2025
The study links higher urinary arsenic and lead concentrations to earlier menopause, suggesting that exposure to these metals accelerates ovarian aging. Women with higher environmental risk scores…

Exposure to heavy metals and hormone levels in midlife women

Jul 9, 2025
This study links urinary heavy metal exposure (arsenic, cadmium, mercury, lead) to altered sex hormone levels in midlife women, with stronger effects during the perimenopausal transition. It suggests…

Menopausal hormone therapy and menopausal symptoms

Aug 21, 2025
This review emphasizes the benefits and risks of MHT in managing menopause symptoms, including the prevention of long-term conditions. It advocates for individualized treatment plans, especially…

Menopausal hot flashes: mechanisms, endocrinology, treatment.

Jul 7, 2025
This review elucidates the neuroendocrine and thermoregulatory mechanisms of menopausal hot flashes, evaluating objective measurement and treatment strategies, with a focus on central sympathetic…

Menopausal hot flashes: mechanisms, endocrinology, treatment

Jul 19, 2025
The review explores the physiological mechanisms behind menopausal hot flashes, including thermoregulatory changes, sympathetic nervous activation, and estrogen depletion. It also examines treatments…

Menopause-Induced Metabolic Shifts: Implications for Cardiovascular and Metabolic Risk

Jul 9, 2025
What was studied? The study examined the metabolic changes that occur during menopause, focusing on how menopause modulates circulating metabolites in midlife women. Researchers specifically analyzed…

Pause menopause with Rhodiola rosea, a natural selective estrogen receptor modulator

Jul 14, 2025
Rhodiola rosea shows promise as a natural selective estrogen receptor modulator, offering neuroprotective, cardiovascular, and bone health benefits for menopausal women with fewer risks than…

Estrogen and Thrombosis: A Bench to Bedside Review

Aug 21, 2025
This study explores estrogen’s effects on thrombosis risk in hormonal contraceptives and HRT, highlighting mechanisms of action, the role of different estrogen doses, and the importance of…

The Gut Microbiome Is Altered in Postmenopausal Women With Osteoporosis and Osteopenia.

Jul 7, 2025
This study identifies distinct gut microbiome and functional gene signatures associated with osteoporosis and osteopenia in postmenopausal women, highlighting key microbial taxa and metabolic…

Associations of the fecal microbiome with urinary estrogens and estrogen metabolites in postmenopausal women

Jul 7, 2025
Greater fecal microbiome diversity in postmenopausal women correlates with urinary estrogen metabolite profiles linked to lower breast cancer risk. Specific taxa, notably Clostridiales, are…

Treatment of Symptoms of the Menopause: An Endocrine Society Clinical Practice Guideline

Aug 21, 2025
This guideline on menopausal symptom treatment prioritizes early initiation of hormone therapy, safe routes like transdermal estradiol, and vaginal care for genitourinary symptoms. It promotes a…

The effect of herbal tea capsule on menopause hot flashes

Jul 21, 2025
This study demonstrates that herbal tea capsules significantly reduce the frequency, duration, and severity of hot flashes in postmenopausal women, offering a promising natural alternative to hormone…

Intermittent Fasting and Weight Management at Menopause

Jul 14, 2025
Intermittent fasting improves weight, insulin sensitivity, and cardiovascular health in postmenopausal women, offering a promising non-pharmacological strategy for managing metabolic disorders.

Menopausal Hot Flashes: A Concise Review

Jul 19, 2025
This review synthesizes current evidence on menopausal hot flashes, focusing on neuroendocrine mechanisms, genetic factors, and a stepwise, personalized treatment approach, emphasizing new targets…

The 2020 Menopausal Hormone Therapy Guidelines

Aug 20, 2025
The guideline links menopausal hormone therapy guidelines and vaginal microbiome care to safer symptom control, better GSM outcomes, and lower UTI risk through local estrogen, with timing and route…

Menopausal Hot Flashes: A Review of Physiology and Biosociocultural Perspective on Methods of Assessment

Jul 19, 2025
What was reviewed? The article presents a detailed review of menopausal hot flashes, examining both the physiological and biosociocultural factors that contribute to this common menopausal symptom.…

Menopause Alters Gut Microbiome and Increases Cardiometabolic Risk in Hispanic Women

Jul 7, 2025
Menopause in Hispanic/Latina women is linked to distinctive gut microbiome and estrobolome alterations, resembling those in men, and these microbial changes are associated with increased…

A metabolic view on menopause and ageing

Jul 9, 2025
This study reveals significant metabolic changes in postmenopausal women, including a pro-atherogenic lipid profile and increased amino acids linked to cardiovascular and metabolic risk, emphasizing…

Menopause-Associated Lipid Metabolic Disorders and Foods Beneficial for Postmenopausal Women

Jul 9, 2025
This review synthesizes evidence on menopause-related lipid metabolic disorders, emphasizing estrogen deficiency, dietary interventions, and the role of probiotics and microbiome modulation in…

The Importance of Nutrition in Menopause and Perimenopause—A Review

Aug 22, 2025
This review underscores the importance of nutrition in managing menopausal symptoms and preventing chronic diseases. It highlights key nutrients such as calcium, vitamin D, and protein and promotes a…

Menopause hot flashes and molecular mechanisms modulated by food-derived nutrients

Jul 21, 2025
This review discusses how food-derived nutrients modulate molecular mechanisms related to hot flashes in menopause, identifying dietary compounds that may offer effective, natural alternatives to…

Actaea racemosa L. Is More Effective in Combination with Rhodiola rosea L. for Relief of Menopausal Symptoms

Jul 14, 2025
Combining Rhodiola rosea and Actaea racemosa extracts significantly improves menopausal symptoms and quality of life, outperforming black cohosh alone with good safety.

Do SSRIs and SNRIs reduce the frequency and/or severity of hot flashes in menopausal women

Aug 22, 2025
This review confirms that SSRIs and SNRIs, particularly paroxetine and venlafaxine, are effective for managing hot flashes in menopausal women. These therapies provide an alternative to hormone…

Systemic and local effects of vaginal dehydroepiandrosterone (DHEA): NCCTG N10C1 (Alliance)

Aug 22, 2025
What was studied? This study examined the systemic and local effects of vaginal dehydroepiandrosterone (DHEA) in postmenopausal women, particularly those with a history of breast or gynecologic…

Insights into estrogen impact in oral health & microbiome in COVID-19

Jul 23, 2025
This study examined the impact of estrogen on oral health and microbiome composition in COVID-19 patients, showing that postmenopausal women and men experience poorer oral health, which correlates…

The relationship between menopausal syndrome and gut microbes

Jul 7, 2025
This study found that menopausal syndrome is linked to gut microbiota dysbiosis, with reduced Bifidobacterium animalis and altered metabolic pathways, suggesting microbiome-targeted interventions may…

Study on gut microbiota and metabolomics in postmenopausal women

Jul 7, 2025
This study reveals how FSH-driven changes in perimenopausal women associate with distinct gut microbiota and metabolomic profiles, linking specific bacteria and metabolic pathways to symptoms like…

Health disorders in menopausal women: microbiome alterations, associated problems, and possible treatments

Jul 14, 2025
Menopause disrupts multiple microbiomes, elevating risks for infections, metabolic and cardiovascular diseases, and osteoporosis. Targeted interventions including probiotics, diet, and hormone…

Gut microbiota signatures and fecal metabolites in postmenopausal women with osteoporosis

Jul 7, 2025
This study demonstrates significant alterations in gut bacteria, fungi, and metabolites in postmenopausal women with osteoporosis, revealing microbial and metabolic signatures closely linked to bone…

The Effects of Environmental Contaminant Exposure on Reproductive Aging and the Menopause Transition

Jul 19, 2025
This study explores how exposure to environmental contaminants like PFAS, BPA, and phthalates accelerates reproductive aging and leads to early menopause, with significant health risks.

Connecting microbiome and menopause for healthy ageing

Jul 7, 2025
This review details how menopause-driven hormonal changes alter the vaginal and gut microbiome, emphasizing the clinical implications for symptoms and therapies, and advocating for more inclusive,…

Menopausal shift on women’s health and microbial niches

Jul 7, 2025
Menopause drives profound shifts in the oral, gut, and vaginal microbiome, decreasing protective species and increasing disease risk. Understanding these hormone-microbe interactions is crucial for…

Menopause modulates the circulating metabolome: Evidence from a prospective cohort study

Jul 9, 2025
Menopause is linked to significant metabolic shifts, including a proatherogenic lipid profile and altered amino acid levels, which may increase cardiovascular and metabolic disease risks in women.…

Metabolomic Signature (3)

Metal Homeostasis (1)

Metallomic Signatures (1)

Metals (295)

Factors affecting the absorption and excretion of lead in the rat

Aug 28, 2025
An in vivo radiotracer study defines lead absorption and excretion in the rat: duodenal, bile-modulated uptake; competition with Fe/Zn/Ca; iron deficiency–enhanced absorption; erythrocyte transport;…

Cadmium transport in blood serum

Sep 24, 2025
This study explores how cadmium binds to human serum transferrin, albumin, and citrate, revealing key insights into cadmium transport and bioavailability in the bloodstream. It also highlights the…

TRANSPORT OF INORGANIC MERCURY AND METHYLMERCURY IN TARGET TISSUES AND ORGANS

Jan 23, 2026
This review explains how inorganic mercury and methylmercury enter the gut, kidney, liver, brain, and placenta by binding to thiols and mimicking nutrients that use amino acid and organic anion…

Assessing Acute and Chronic Risks of Human Exposure to Arsenic

Sep 12, 2025
This study assessed acute and chronic arsenic exposure in an Ethiopian population, finding significant health risks associated with contaminated groundwater and cigarette smoking. Biomarkers like…

Cysteine coordination of Pb(II) is involved in the PbrR-dependent activation of the lead-resistance promoter, PpbrA, from Cupriavidus metallidurans CH34

Aug 27, 2025
This study sheds light on the molecular mechanisms through which Cupriavidus metallidurans CH34 regulates lead resistance, highlighting the role of the PbrR protein and its interaction with the PpbrA…

GPX4 in cell death, autophagy, and disease

Jan 18, 2026
What Was Studied? The research paper reviewed the roles of GPX4 (Glutathione Peroxidase 4) in cell death, particularly focusing on its function in ferroptosis, autophagy, and disease. GPX4, a key…

Elevated levels of whole blood nickel in a group of Sri Lankan women with endometriosis: a case control study

Nov 27, 2025
This study examined blood nickel and endometriosis, revealing significantly higher nickel levels in affected Sri Lankan women, supporting a potential metalloestrogenic role.

Microbial Diversity of Mer Operon Genes and Their Potential Rules in Mercury Bioremediation and Resistance

Jan 24, 2026
What was reviewed? This review explained how mercury cycles through air, water, and soil and how microbes control key steps that change mercury toxicity. It focused on mercury-resistant bacteria and…

The Extracellular Metallometabolome: Metallophores, Metal Ionophores, and Other Chelating Agents as Natural Products

Sep 3, 2025
The extracellular metallometabolome links secreted metallophores and ionophores to metal control at mucosa, explaining microbiome shifts, pathogen fitness, and host defense, with clear genomic…

ZntA maintains zinc and cadmium homeostasis and promotes oxidative stress resistance and virulence in Vibrio parahaemolyticus

Sep 26, 2025
This study investigates the role of ZntA in zinc and cadmium homeostasis, oxidative stress resistance, and virulence in Vibrio parahaemolyticus. ZntA protects against metal toxicity and promotes…

Potential role of Mercury pollutants in the success of Methicillin-Resistant Staphylococcus aureus USA300 in Latin America

Jan 25, 2026
This study shows that trace mercury exposure can favor the USA300-LV MRSA lineage in South America. Mercury reverses the fitness cost of COMER, helps USA300-LV outcompete other strains, and increases…

Mechanistic insights into staphylopine-mediated metal acquisition

Feb 3, 2026
This study reveals how S. aureus uses staphylopine (StP) to acquire transition metals, with CntA playing a central role in metal recognition and transport. The findings highlight new potential…

Higher incidence of zinc and nickel hypersensitivity in patients with irritable bowel syndrome

Nov 27, 2025
Study identifying significantly higher zinc and nickel hypersensitivity in IBS patients, suggesting metal-induced immune activation as a contributor to mucosal inflammation and symptom generation.

Understanding How Minerals Contribute to Optimal Immune Function

Jan 28, 2026
This review explains how magnesium, zinc, copper, iron, and selenium shape innate and adaptive immunity and long-term inflammation. It highlights that magnesium deficiency can weaken the gut barrier…

Lead(II) Binding in Natural and Artificial Proteins

Aug 28, 2025
This review defines how lead binding in proteins drives host enzyme inhibition and signaling errors while microbial operons export and precipitate Pb(II), reshaping niche metal availability and…

Disulfiram and Copper Ions Kill Mycobacterium tuberculosis in a Synergistic Manner

Sep 6, 2025
This study shows that disulfiram, in combination with copper ions, significantly enhances the bactericidal effects against M. tuberculosis, especially against drug-resistant strains. The…

Impact of occupational exposure on human microbiota

Jan 25, 2026
This review explains how workplace microbes, chemicals, metals, and air pollution can change the adult human microbiome. It highlights links to colonization, gut permeability, and immune effects, and…

Correlation of Heavy Metal Content in the Blood of Patients with Ovarian Cancer by Place of Residence

Aug 8, 2025
This study explores how the concentration of heavy metals, particularly zinc and copper, in the blood of ovarian cancer patients correlates with their recurrence-free survival. It highlights the…

Specific Histidine Residues Confer Histatin Peptides with Copper-Dependent Activity against Candida albicans

Sep 2, 2025
Copper-dependent activity against Candida albicans rises when histatin peptides bind copper via a proximal bis-His site, lowering EC50 and improving killing in vitro; copper chelation reverses this…

Chronic arsenic exposure perturbs gut microbiota and bile acid homeostasis in mice

Sep 15, 2025
This study explores the effects of chronic arsenic exposure on the gut microbiota and bile acid metabolism in mice, revealing significant changes in microbial composition and bile acid homeostasis,…

Multi-Omics Reveals that Lead Exposure Disturbs Gut Microbiome Development, Key Metabolites and Metabolic Pathways

Aug 27, 2025
This study demonstrates that lead exposure disrupts the gut microbiome, reducing microbial diversity and impairing key metabolic pathways related to vitamin E, bile acids, nitrogen metabolism, and…

Bacterial Metallostasis: Metal Sensing, Metalloproteome Remodeling, and Metal Trafficking

Jan 7, 2026
This review examines bacterial metallostasis, focusing on metal sensing, metalloproteome remodeling, and metal trafficking. It highlights key regulatory mechanisms and implications for therapeutic…

Lead exposure in relation to gut homeostasis, microbiota, and metabolites

Aug 29, 2025
This study explores how lead exposure disrupts gut microbiota, leading to compromised gut health and systemic issues. It highlights the potential of probiotics and other interventions to restore…

Oral Administration of Probiotics Inhibits Absorption of the Heavy Metal Cadmium by Protecting the Intestinal Barrier

Sep 28, 2025
This study highlights the protective effects of Lactobacillus plantarum CCFM8610 probiotics against cadmium toxicity by preserving intestinal barrier function and reducing oxidative stress, offering…

Silver(I), Mercury(II), Cadmium(II), and Zinc(II) Target Exposed Enzymic Iron-Sulfur Clusters when They Toxify Escherichia coli

Sep 26, 2025
The study investigates how soft metals like silver, mercury, cadmium, and zinc damage bacterial dehydratases by targeting their [4Fe-4S] clusters, revealing insights into the molecular mechanisms of…

Lead Precipitation by Vibrio harveyi: Evidence for Novel Quorum-Sensing Interactions

Aug 28, 2025
This study demonstrates that Vibrio harveyi regulates lead precipitation through quorum-sensing systems, particularly AI1, AI2, and a newly discovered AI3, with implications for environmental…

Dietary copper-fructose interactions alter gut microbial activity in male rats

Sep 2, 2025
Dietary copper-fructose interactions in rats depleted Akkermansia, shifted Firmicutes families, weakened tight junctions and goblet cells, and raised liver injury signals, defining a…

Determination of Manganese in Urine and Whole Blood Samples by Electrothermal Atomic Absorption Spectrometry: Comparison ofChemical Modifiers

Feb 3, 2026
This study optimizes electrothermal atomic absorption spectrometry (ETAAS) for detecting manganese in urine and blood samples, demonstrating high sensitivity and precision, and providing insights…

Bacterial Mg2+ Homeostasis, Transport, and Virulence

Jan 28, 2026
This review explains how bacteria sense magnesium outside and inside the cell, switch among Mg2+ transporters, and remodel their envelope to survive low Mg2+. It shows how Mg2+ limitation and host…

Transition metals and virulence in bacteria

Dec 8, 2025
What was reviewed? This review article examines how transition metals shape bacterial virulence through three interconnected processes: acquisition, limitation, and intoxication. It emphasizes the…

The Role of Lead and Cadmium in Gynecological Malignancies

Aug 9, 2025
This study explores the role of lead and cadmium in gynecological malignancies, focusing on their ability to mimic estrogen and induce oxidative stress, contributing to cancer development. It…

Molecular Mechanisms of Zinc as a Pro-Antioxidant Mediator: Clinical Therapeutic Implications

Sep 6, 2025
This review links the molecular mechanisms of zinc as a pro-antioxidant mediator to lower oxidative stress, restrained inflammation, and clinical signals in elders and chronic disease, with clear…

Effects of Hydrogen Sulfide on the Microbiome: From Toxicity to Therapy

Sep 24, 2025
The review examines the complex role of hydrogen sulfide in modulating the gut microbiome, highlighting its potential as a therapeutic agent to stabilize microbiota biofilms and reduce inflammation…

Arsenate replacing phosphate – alternative life chemistries and ion promiscuity

Sep 11, 2025
This review explores the potential for arsenate to replace phosphate in biochemical reactions, examining enzyme promiscuity, arsenate esters’ instability, and the implications for arsenic-based…

Metallophores Drive Staphylococcus aureus Virulence and Pathogenicity

Jul 8, 2025
Metallophores in S. aureus enable metal acquisition and virulence; disrupting these systems may offer novel antimicrobial strategies.

Metallothionein and Cadmium Toxicology—Historical Review and Commentary

Sep 26, 2025
This study explored the role of metallothionein in cadmium toxicity, focusing on its protective and transport roles, particularly in the kidneys. It emphasizes the potential of MT-related biomarkers…

Zinc in Human Health and Infectious Diseases

Sep 6, 2025
This review maps zinc in human health and infectious diseases, linking host zinc control to pathogen survival, clinical trial signals, and simple gene and protein markers that explain microbiome…

Heavy Metal–Gut Microbiota Interactions: Probiotics Modulation and Biosensors Detection

Sep 22, 2025
This review highlights how heavy metals alter the gut microbiota and discusses the potential of probiotics to mitigate these effects. It also emphasizes the role of advanced biosensors in detecting…

Plasma Iron Infection Risk: Role of TSAT and HFE C282Y in Immune Defense

Aug 22, 2025
This review summarizes evidence that both low and high plasma iron increase infection risk, particularly in individuals with HFE C282Y homozygosity. Maintaining stable transferrin saturation is vital…

MOLECULAR MECHANISMS OF LEAD NEUROTOXICITY

Aug 26, 2025
This review explores the molecular mechanisms of lead neurotoxicity, focusing on ion mimicry, mitochondrial dysfunction, oxidative stress, and neuroinflammation. The findings emphasize the long-term…

Exposure to mercury from dental amalgam: actual contribution for risk assessment

Jan 22, 2026
This study measured mercury in urine and hair in dental workers and controls and linked urine mercury to the number of amalgam fillings. Levels stayed below occupational limits, but fillings still…

Mercury(II) Binding to Metallothionein in Mytilus edulis revealed by High Energy-Resolution XANES Spectroscopy

Jan 24, 2026
This study shows that mussel metallothionein binds mercury in two main forms: a dominant linear Hg–thiolate complex and a substantial clustered Hg–thiolate structure with Hg–Hg pairing. The clustered…

Cadmium toxicity and treatment: An update

Sep 24, 2025
This review explores the toxic effects of cadmium exposure on multiple organ systems and its link to various diseases, including cancer and kidney dysfunction. It also discusses treatment options,…

Arsenic Binding to Proteins

Sep 11, 2025
This review examines how arsenic binds to proteins, disrupting their function and contributing to toxicity and resistance mechanisms. It highlights key proteins like thioredoxin and pyruvate…

Undiagnosed Wilson’s Disease and Fibromyalgia Masking Bowel Perforation

Sep 5, 2025
This case study highlights the difficulty of diagnosing Wilson’s disease in a patient with psychiatric and gastrointestinal symptoms. It underscores the importance of considering Wilson’s disease…

The Laboratory and Clinical Perspectives of Magnesium Imbalance

Jan 28, 2026
This review explains how magnesium imbalance affects neuromuscular and cardiac function and why lab results can mislead. It highlights pre-analytical errors, limits of serum magnesium, and strong…

Magnesium Matters: A Comprehensive Review of Its Vital Role in Health and Diseases

Jan 28, 2026
This review explains how magnesium supports energy, vascular function, immunity, glucose control, bone strength, and muscle health, and how low intake or poor absorption can raise risks for…

Arsenic binding to human metallothionein-3

Sep 11, 2025
This study investigates how arsenic(III) binds to human metallothionein-3, revealing detailed binding kinetics and the role of MT3 in arsenic detoxification. These findings have implications for…

Human milk metals and metalloids shape infant microbiota

Feb 3, 2026
This study examines the relationship between the metal content of human milk and the infant gut microbiota, highlighting metal-induced microbial shifts and their potential impact on infant health and…

A Comparative Study on the Paradoxical Relationship Between Heavy Metal Exposure and Kidney Function

Nov 28, 2025
This study compared heavy metal exposure and kidney function in Korea, revealing expected nephrotoxicity in the general population but paradoxically preserved eGFR in chronically exposed vulnerable…

Magnesium: The overlooked electrolyte in blood cancers?

Jan 31, 2026
This review explains why magnesium deficiency is common and overlooked in blood cancers. It links magnesium to immune control of EBV, inflammation, and DNA repair pathways, and it highlights XMEN…

Arsenic Exposure Perturbs the Gut Microbiome and Its Metabolic Profile in Mice: An Integrated Metagenomics and Metabolomics Analysis

Sep 13, 2025
Arsenic exposure perturbs the gut microbiome in mice and rewires fecal, urinary, and plasma metabolites, including sharp shifts in indole and bile acid pathways, alongside loss of several Firmicutes…

Long-Term Exposure to Low-Level Arsenic in Drinking Water and Diabetes Incidence: A Prospective Study of the Diet, Cancer and Health Cohort

Sep 12, 2025
This study explores the link between long-term low-level arsenic exposure and diabetes incidence in Denmark. The results suggest a modest association, highlighting the potential health risks of…

Biomarkers of Exposure: A Case Study with Inorganic Arsenic

Sep 15, 2025
The study examines biomarkers of inorganic arsenic exposure in humans, focusing on the metabolism and toxicological effects of arsenic. Key findings include the importance of urinary arsenic…

Bacterial Heavy Metal Resistance Systems: Mechanisms, Genes, and Clinical Implications

Jul 8, 2025
This review examines bacterial resistance systems to toxic metals, detailing efflux pumps, ATPases, and metallothioneins. It explores their mechanisms, gene regulation, and clinical or environmental…

Magnesium modulates phospholipid metabolism to promote bacterial phenotypic resistance to antibiotics

Jan 30, 2026
Magnesium influences bacterial phenotypic resistance by modulating fatty acid and phospholipid metabolism in Vibrio species, leading to reduced antibiotic uptake and increased resistance to drugs…

The magnesium transporter A is activated by cardiolipin and is highly sensitive to free magnesium in vitro

Jan 28, 2026
What was studied? This experimental study investigated how the bacterial magnesium transporter A (MgtA) functions at the biochemical level and how membrane lipids and free magnesium concentrations…

Gallium as novel Antimicrobial Agents: Innovations in Combating Drug-Resistant Pathogens

Nov 29, 2025
This review highlights gallium’s role as an iron mimic disrupting bacterial iron metabolism, effective against multidrug-resistant pathogens. Innovations in gallium delivery, including…

Role of Iron in Bacterial Pathogenesis: Clinical Takeaways from an Editorial

Aug 22, 2025
What was reviewed? This editorial synthesizes evidence on the role of iron in bacterial pathogenesis, emphasizing how iron scarcity and host nutritional immunity shape virulence, metabolic strategy,…

The interplay between copper metabolism and microbes: In perspective of host copper-dependent ATPases ATP7A/B

Sep 2, 2025
This review highlights the complex relationship between copper metabolism and microbial infections. It focuses on the role of copper transporters ATP7A/B in regulating copper homeostasis and how…

Non-classical roles of bacterial siderophores in pathogenesis.

Sep 4, 2025
This review shows non-classical siderophore roles in copper and zinc handling, oxidative stress control, and signaling, and maps gene–host markers that predict pathogen fitness across urine, gut, and…

Histatins: Salivary peptides with copper(II)- and zinc(II)-binding motifs

Sep 2, 2025
This study examines the copper-binding properties of Hist-5, a salivary peptide, and its role in combating Candida albicans infections. The findings highlight the critical role of copper ions in…

Lipid metabolism in ferroptosis: mechanistic insights and therapeutic potential

Jan 18, 2026
This review explains how lipid metabolism drives ferroptosis by shaping oxidation-prone membrane phospholipids and controlling iron-dependent lipid peroxidation. It highlights ACSL4 and LPCAT3…

UPEC Transition Metal Control in Virulence: Siderophores, Metallophores, and Clinical Implications

Aug 22, 2025
This review integrates host nutritional immunity with UPEC transition metal control, detailing siderophore and metallophore functions, copper “nutritional passivation,” and interspecies antagonism,…

An Essential Factor for High Mg2+ Tolerance of Staphylococcus aureus

Jan 28, 2026
This study identifies MpfA (SA0657) as a key magnesium protection factor in Staphylococcus aureus. Disabling MpfA makes the bacterium highly sensitive to Mg2+ and pinpoints a conserved CBS-domain…

Effects of Copper Addition on Copper Resistance, Antibiotic Resistance Genes, and intl1 during Swine Manure Composting

Sep 5, 2025
This study explores the effects of copper exposure on copper and antibiotic resistance genes during swine manure composting, revealing changes in microbial community composition and gene persistence,…

Distribution of Arsenic Resistance Genes in Prokaryotes

Sep 10, 2025
This review outlines the diversity, evolution, and distribution of arsenic resistance genes in prokaryotes, emphasizing their central role in the environmental microbiome, biogeochemical cycling, and…

Effect of Dietary Copper on Intestinal Microbiota and Antimicrobial Resistance Profiles of Escherichia coli in Weaned Piglets

Sep 2, 2025
Dietary copper effect on intestinal microbiota in weaned piglets increased E. coli abundance and raised ciprofloxacin and chloramphenicol resistance, while shifting key metabolic pathways without…

The Impact of Mercury Selection and Conjugative Genetic Elements on Community Structure and Resistance Gene Transfer

Jan 25, 2026
Mercury pollution reshaped a soil microbiome by lowering alpha diversity and increasing between-community divergence. A focal Pseudomonas strain survived mercury stress by acquiring mercury…

Introducing the ArsR-Regulated Arsenic Stimulon

Sep 10, 2025
This study explored the complex regulatory roles of ArsR proteins in Agrobacterium tumefaciens 5A, showing they influence a broad range of cellular functions, including arsenic resistance,…

Expanded Diversity and Phylogeny of mer Genes Broadens Mercury Resistance Paradigms and Reveals an Origin for MerA Among Thermophilic Archaea

Jan 24, 2026
What was studied? This original research study used large-scale bioinformatics to map where mercury detoxification genes occur across prokaryotes and to infer how those genes evolved. The authors…

Effects of cadmium exposure on intestinal microflora of Cipangopaludina cathayensis

Sep 28, 2025
The study examines how cadmium exposure alters the microbiota in rats, causing microbial translocation and metabolic shifts. The findings highlight potential biomarkers for assessing cadmium toxicity.

The interplay between antimicrobial resistance, heavy metal pollution, and the role of microplastics

Jan 22, 2026
This review explains how heavy metals and microplastics work together to drive antimicrobial resistance by enriching biofilms, speeding gene transfer, and co-selecting metal and antibiotic resistance…

Association between infants’ serum levels of 26 metals and gut microbiota: a hospital-based cross-sectional study in China

Feb 3, 2026
This study explores the impact of metal exposure on infant gut microbiota, identifying key metals like arsenic, copper, and manganese that alter microbial diversity and specific taxa, with…

Association of placental manganese levels, maternal gut microbiota, and preeclampsia: a tripartite perspective

Feb 3, 2026
This study links placental manganese levels, maternal gut microbiota, and preeclampsia risk, highlighting specific bacterial genera and metabolic pathways involved. It suggests that manganese may…

Genomic and pathogenicity islands of Listeria monocytogenes—overview of selected aspects

Feb 5, 2026
This study explores the persistence of Listeria monocytogenes biofilms in food industries, stressing the need for stronger hygiene protocols to prevent contamination. It highlights genetic factors…

Ferroptosis in ischemic stroke: mechanisms, pathological implications, and therapeutic strategies

Jan 18, 2026
This review explains how ferroptosis, driven by iron dysregulation and lipid peroxidation, exacerbates neuronal injury in ischemic stroke. It evaluates therapeutic strategies like ferrostatin-1,…

How Toxic and Essential Metals Disrupt Gut Microbiota: A Comprehensive Review

Jul 22, 2025
This review maps the bidirectional interactions between toxic and essential metals and the gut microbiota, detailing microbial shifts and host impacts. It highlights specific microbial taxa disrupted…

A critical appraisal of ferroptosis in Alzheimer’s and Parkinson’s disease

Jan 19, 2026
This review links ferroptosis to Alzheimer’s and Parkinson’s disease by connecting iron imbalance, mitochondrial stress, and lipid peroxidation to neuronal loss. It highlights LOX-driven oxidized…

Short-chain fatty acids regulate erastin-induced cardiomyocyte ferroptosis and ferroptosis-related genes

Jan 19, 2026
This study shows that gut microbiota–derived short-chain fatty acids can reduce erastin-induced lipid peroxidation and modulate iron and ATF3 signaling in cardiomyocytes. The findings link microbial…

The influence of gastrointestinal pH on speciation of copper in simulated digestive juice

Sep 2, 2025
The study explores how gastrointestinal pH affects copper solubility and speciation during digestion. It reveals the role of food components in modulating copper bioavailability and highlights the…

Unravelling the mechanisms of antibiotic and heavy metal resistance co-selection in environmental bacteria

Feb 3, 2026
This review explores how environmental bacteria acquire co-resistance to heavy metals and antibiotics, revealing complex genetic interactions and co-selection mechanisms.

Toxic and essential metals: metabolic interactions with the gut microbiota and health implications

Jan 7, 2026
This study explores the essential role of metal ions in human health, detailing their involvement in enzyme catalysis and the impacts of imbalances on diseases. It also highlights potential clinical…

Environmental cadmium exposure alters the internal microbiota and metabolome of Sprague–Dawley rats

Sep 22, 2025
The study investigates how cadmium exposure alters gut and blood microbiomes in rats, linking these changes to metabolic disruptions and systemic inflammation.

The biology of ferroptosis in kidney disease

Jan 18, 2026
This review explains how ferroptosis drives kidney injury through iron-dependent lipid peroxidation when GPX4- and FSP1-based defenses fail. It highlights proximal tubule vulnerability, links…

The Effect of the Combination of Probiotics and Heavy Metals From Various Aspects in Humans: A Systematic Review of Clinical Trial Studies

Sep 10, 2025
This systematic review links probiotics and heavy metals to clinical outcomes, showing faster diarrhea recovery with zinc, fewer H. pylori therapy side effects, improved iron absorption with…

Role of Calprotectin in Withholding Zinc and Copper from Candida albicans

Sep 3, 2025
What was studied? This original study tested the Role of calprotectin in withholding zinc and copper from Candida albicans and defined when this host protein blocks metal nutrition to shape fungal…

Role of Copper Efflux in Pneumococcal Pathogenesis and Resistance to Macrophage-Mediated Immune Clearance

Sep 5, 2025
The study highlights the crucial role of the copA copper efflux system in the virulence of Streptococcus pneumoniae by protecting it from macrophage-mediated copper toxicity, a key immune defense.

Acquisition of Mn(II) in Addition to Fe(II) Is Required for Full Virulence of Salmonella enterica Serovar Typhimurium

Feb 2, 2026
This study identifies the essential roles of manganese and iron transporters (mntH, sitABCD, and feoB) in Salmonella enterica Typhimurium virulence. These transporters are required for bacterial…

The Effects of Cadmium Toxicity

Sep 24, 2025
This study explores how cadmium disrupts the immune function of macrophages by inhibiting the NF-κB signaling pathway, impairing the response to LPS, and potentially contributing to immune…

Chelation in Metal Intoxication

Aug 29, 2025
This review discusses advancements in chelation therapy for treating metal toxicity, focusing on chelating agents, combination therapies, and antioxidants. Key findings highlight the effectiveness of…

Current Biomedical Use of Copper Chelation Therapy

Sep 6, 2025
Current biomedical use of copper chelation therapy spans Wilson’s disease, cancer, lung fibrosis, diabetes, and neurodegeneration, with strongest support in Wilson’s disease and emerging roles in…

The Connection between Czc and Cad Systems Involved in Cadmium Resistance in Pseudomonas putida

Sep 26, 2025
This study explored how the CzcRS3 two-component system regulates cadmium resistance in P. putida by controlling efflux pump gene expression. The findings emphasize the role of CadR in regulating…

Effects of Cadmium Exposure on Gut Villi in Danio rerio

Sep 28, 2025
This study shows that cadmium exposure disrupts gut function in zebrafish, affecting villi morphology, goblet cell mucus production, and glycoprotein distribution. These changes may impair gut…

CtpB Facilitates Mycobacterium tuberculosis Growth in Copper-Limited Niches

Sep 3, 2025
CtpB tailors Mycobacterium tuberculosis growth to copper-limited niches, boosts fitness in adipocytes, and raises copper stress risk during phagosomal surges, yielding a clear gene–niche signature…

Consequences of Disturbing Manganese Homeostasis

Feb 2, 2026
This review examines the essential role of manganese in human health, highlighting its involvement in enzyme activation and neurotransmitter function. It underscores the dangers of Mn dysregulation,…

Siderophore Biosynthesis Inhibitors: A Novel Strategy Against Microbial Virulence and Resistance

Aug 22, 2025
This review outlines current strategies targeting siderophore biosynthesis as a therapeutic approach to microbial infections, emphasizing enzyme-specific inhibitors, nanoparticle delivery, and…

The Role of Heavy Metals in the Biology of Female Cancers

Aug 9, 2025
This review explores how heavy metals, including cadmium, lead, and mercury, contribute to the development of female cancers by mimicking estrogen, inducing oxidative stress, and causing DNA damage.…

Role of Nickel in Microbial Pathogenesis

Nov 27, 2025
Nickel-dependent enzymes like urease and hydrogenase are essential for pathogen virulence. This review outlines the mechanisms by which pathogens acquire and utilize nickel and explores implications…

An efflux transporter PbrA and a phosphatase PbrB cooperate in a lead-resistance mechanism in bacteria

Aug 27, 2025
The study highlights the cooperation between the PbrA efflux pump and PbrB phosphatase in the detoxification of lead, uncovering a novel mechanism for lead resistance in Cupriavidus metallidurans.…

New insights into the metabolism of organomercury compounds

Jan 23, 2026
This study shows that mercury cysteine conjugates act like amino acids and directly affect sulfur metabolism enzymes. Human GTK can use and inhibit these conjugates, while cystathionine γ-lyase is…

Magnesium treatment increases gut microbiome synthesizing vitamin D and inhibiting colorectal cancer: results from a double-blind precision-based randomized placebo-controlled trial

Jan 31, 2026
This trial shows magnesium supplementation changes colorectal-adjacent microbes in a TRPM7 genotype-dependent way, especially in rectal swabs. In people with typical TRPM7 function, magnesium…

Methylmercury’s chemistry: From the environment to the mammalian brain

Jan 25, 2026
This review explains how methylmercury forms in the environment, enters the body, and reaches the brain through fast “exchange” chemistry with sulfur and selenium groups. It highlights microbial…

The MgtR regulatory peptide negatively controls expression of the MgtA Mg2+ transporter in Salmonella enterica serovar Typhimurium

Jan 28, 2026
This study shows that the Salmonella peptide MgtR directly limits the MgtA magnesium transporter during Mg2+ starvation. Deleting mgtR raises MgtA protein levels and makes MgtA appear earlier, which…

The gut microbiota attenuate neuroinflammation in manganese exposure by inhibiting cerebral NLRP3 inflammasome

Feb 3, 2026
This study shows that manganese exposure triggers neuroinflammation in rats through the NLRP3 inflammasome, but fecal microbiota transplantation can alleviate these effects, suggesting…

Essential metals in health and disease

Jan 7, 2026
This review explores the biological roles of essential metals in human health, focusing on their contributions to enzymatic functions and redox reactions. It also highlights how dysregulation of…

Bacterial manganese sensing and homeostasis

Feb 3, 2026
This review summarizes bacterial Mn sensing and homeostasis mechanisms, highlighting key regulators like MntR and the yybP-ykoY riboswitch. It discusses newly identified Mn exporters and their roles…

Sulfhydryl groups as targets of mercury toxicity

Jan 23, 2026
This review explains that mercury toxicity largely comes from binding thiol groups in cysteine, glutathione, and proteins. That binding disrupts enzymes, antioxidant defenses, and signaling, driving…

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Jan 18, 2026
What was studied? This study defined and experimentally mapped a distinct form of regulated cell death that the authors named ferroptosis. They used the RAS-selective small molecule erastin to…

Regulation of Ferroptotic Cancer Cell Death by GPX4

Jan 18, 2026
What was studied? This was an experimental mechanistic study that tested whether GPX4 is a central regulator of ferroptosis and whether chemically inducing GPX4 failure can selectively kill cancer…

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

Jan 18, 2026
This review explains ferroptosis, an iron-driven, lipid peroxidation cell-death pathway linked to metabolism and redox balance. It highlights key control points such as system xc−, glutathione, GPX4,…

Selenium: Tracing Another Essential Element of Ferroptotic Cell Death

Jan 18, 2026
What was reviewed? This review explored the role of selenium in ferroptosis, focusing on its essential involvement through glutathione peroxidase 4 (GPX4), a key selenoenzyme that protects against…

Nutrient Metal Sequestration by Calprotectin Inhibits Bacterial Superoxide Defense, Enhancing Neutrophil Killing of Staphylococcus aureus

Feb 2, 2026
This study highlights calprotectin’s role in sequestering manganese and zinc to disrupt bacterial superoxide defenses, making S. aureus more vulnerable to neutrophil-mediated killing, providing…

Copper in microbial pathogenesis: Meddling with the metal

Sep 2, 2025
This review explores copper’s role in microbial pathogenesis, highlighting its use by hosts as an antimicrobial weapon and the resistance mechanisms developed by pathogens. It discusses…

Commensal iron acquisition and nutritional immunity during Salmonella infection

Aug 22, 2025
XusB in Bacteroides thetaiotaomicron binds enterobactin in OMVs, sustains commensal fitness, and creates a lipocalin 2 resistant iron pool that Salmonella can recapture, redefining…

Measuring magnesium – Physiological, clinical and analytical perspectives

Jan 31, 2026
This review explains why magnesium testing often misses true deficiency, especially in critical illness. It compares blood and urine methods, highlights drug-related magnesium loss, and shows how…

Fecal microbiome transplantation attenuates manganese-induced neurotoxicity through regulation of the apelin signaling pathway by inhibition of autophagy in mouse brain

Feb 3, 2026
This study shows that fecal microbiome transplantation (FMT) can attenuate manganese-induced neurotoxicity by regulating the apelin signaling pathway and autophagy in the brain, offering new…

Effects of cadmium and copper mixtures on antibiotic resistance genes in rhizosphere soil

Sep 28, 2025
The study explores how cadmium and copper contamination in rhizosphere soil affects the distribution of antibiotic resistance genes. It shows that these metals contribute to the spread of resistance…

Probiotics in addressing heavy metal toxicities in fish farming: Current progress and perspective

Sep 6, 2025
This study shows that probiotics can mitigate the effects of heavy metal toxicity in farmed fish. By binding metals and reducing oxidative stress, probiotics improve fish health and safety for…

Urinary heavy metals and overall survival of advanced high-grade serous ovarian cancer: A nested case-control study in China

Aug 9, 2025
The study examines the association between urinary concentrations of heavy metals (arsenic, cadmium, mercury, lead) and survival in patients with advanced high-grade serous ovarian cancer. High…

Co-effect of cadmium and iron oxide nanoparticles on plasmid-mediated conjugative transfer of antibiotic resistance genes

Sep 28, 2025
This study examines how the combination of cadmium and iron oxide nanoparticles enhances the conjugative transfer of antibiotic resistance genes in microbial communities. It emphasizes the risk of…

Urinary metals and metal mixtures and timing of natural menopause in midlife women

Jul 9, 2025
The study links higher urinary arsenic and lead concentrations to earlier menopause, suggesting that exposure to these metals accelerates ovarian aging. Women with higher environmental risk scores…

Metal(loid)-gut microbiota interactions and microbiota-related protective strategies: A review

Jan 7, 2026
This review examines how metal(loid) exposure affects gut microbiota composition and function. It also evaluates microbiota-related strategies for metal(loid) detoxification.

Gut as a target for cadmium toxicity

Sep 28, 2025
The review examines how cadmium exposure affects gut microbiota, leading to dysbiosis, increased gut permeability, and systemic inflammation. It also explores the potential of probiotics to mitigate…

Exposure to heavy metals and hormone levels in midlife women

Jul 9, 2025
This study links urinary heavy metal exposure (arsenic, cadmium, mercury, lead) to altered sex hormone levels in midlife women, with stronger effects during the perimenopausal transition. It suggests…

Nickel exposure induces gut microbiome disorder and serum uric acid elevation

Nov 28, 2025
Nickel exposure induces gut microbiome disorder and serum uric acid elevation by disrupting purine-degrading microbes, increasing inflammatory taxa, impairing intestinal metabolism, and elevating…

Diffusion and enrichment of high-risk antibiotic resistance genes (ARGs)

Feb 3, 2026
This study explores how heavy metals in an ecological restoration area of a manganese mining site promote the diffusion of high-risk antibiotic resistance genes and pathogens through a transmission…

The effect of pharmacologically altered gastric pH on cadmium absorption from the diet and its accumulation in murine tissues

Sep 24, 2025
This study explores how altering gastric pH with omeprazole and cimetidine affects cadmium absorption from the diet and its accumulation in murine tissues, showing limited impact on tissue cadmium…

What is the best strategy for moving microbiome-based therapies for functional gastrointestinal disorders into the clinic?

Sep 28, 2025
This review discusses the strategies for translating microbiome-based therapies into clinical practice for FGIDs, particularly IBS. It highlights the need for a systems approach integrating…

Metallochaperones: A critical regulator of metal homeostasis and beyond

Jan 7, 2026
This study investigates metallochaperones in plants, focusing on their role in metal homeostasis, detoxification, and stress responses. These proteins are essential for managing toxic metals like…

Arsenic disturbs the gut microbiome of individuals in a disadvantaged community in Nepal

Sep 8, 2025
In Nepal, arsenic disturbs the gut microbiome, driving sulfate-reducers and depleting commensals; urine arsenic best explains dysbiosis patterns with clear taxa-level signals useful for…

Combined resistant dextrin and low-dose Mg oxide administration increases short-chain fatty acid and lactic acid production by gut microbiota

Jan 30, 2026
This study shows that combining resistant dextrin with low-dose magnesium oxide increases SCFA and lactic acid production by gut microbiota, improving gut health.

Inflammatory immunity and bacteriological perspectives: A new direction for copper treatment of sepsis

Sep 2, 2025
Copper treatment of sepsis links host copper delivery, microbial copper genes, and cell death pathways. The review highlights biomarker value and careful therapeutic targeting to aid control of…

The essential role of magnesium in immunity and gut health

Jan 30, 2026
Magnesium restriction in mice caused hypomagnesemia, increased inflammation, and altered the gut microbiome. These changes impacted immune function and highlighted the importance of magnesium in…

Zinc and multi-mineral supplementation should mitigate the pathogenic impact of cadmium exposure

Sep 28, 2025
The study emphasizes the potential benefits of zinc and multi-mineral supplementation in reducing cadmium toxicity. It links cadmium exposure to various health issues and suggests supplementation as…

The Promise of Copper Ionophores as Antimicrobials

Sep 6, 2025
The promise of copper ionophores as antimicrobials rests on raising intracellular copper to disable core enzymes, restore antibiotic activity, and boost host killing, with clear microbial markers to…

Cadmium monitoring in saliva and urine as indicator of smoking addiction

Sep 28, 2025
This study highlights the use of cadmium levels in saliva and urine as indicators of smoking addiction. It shows that cadmium concentrations correlate with tobacco use, offering a non-invasive method…

Environmentally relevant concentrations of mercury facilitate the horizontal transfer of plasmid-mediated antibiotic resistance genes

Jan 22, 2026
This study shows that low, environmentally relevant mercury levels can boost plasmid transfer of antibiotic resistance genes between E. coli by driving oxidative stress, membrane damage, and…

Efflux pumps activation caused by mercury contamination prompts antibiotic resistance and pathogen’s virulence under ambient and elevated CO2 concentration

Jan 25, 2026
Mercury-contaminated paddy soil increased plant and human pathogen signals under both ambient and elevated CO₂. Metagenomics showed strong activation of efflux pumps, especially the RND family,…

Modulation of methylmercury uptake by methionine: Prevention of mitochondrial dysfunction in rat liver slices by a mimicry mechanism

Jan 23, 2026
This study shows that methylmercury delivered as a cysteine complex increases liver and mitochondrial mercury uptake and worsens mitochondrial stress. Methionine pre-treatment lowers mercury uptake,…

Arsenic induces structural and compositional colonic microbiome change and promotes host nitrogen and amino acid metabolism

Sep 15, 2025
The study explored the impact of arsenic exposure on the gut microbiome and host metabolism. The results demonstrated significant changes in microbial composition, which were linked to alterations in…

Manganese-induced sex-specific gut microbiome perturbations in C57BL/6 mice

Feb 3, 2026
This study shows how manganese exposure alters the gut microbiome and metabolic functions in a sex-specific manner in C57BL/6 mice. It highlights changes in neurotransmitter pathways and microbial…

Arsenic exposure is associated with alterations to multiple red blood cell parameters among adults in rural Bangladesh

Sep 15, 2025
The study explored the impact of arsenic exposure on red blood cell parameters in rural Bangladesh, identifying sex-specific effects and changes in MCV and MCH, which may contribute to anemia or…

Targeting ACSLs to modulate ferroptosis and cancer immunity

Jan 18, 2026
This review explains how ACSL enzymes reshape tumor fatty-acid use and control ferroptosis and cancer immunity. It contrasts ACSL4-driven polyunsaturated lipid remodeling that promotes ferroptosis…

How pathogens feel and overcome magnesium limitation when in host tissues

Jan 28, 2026
This review explains how hosts restrict pathogens by triggering magnesium limitation signals during infection. It shows that bacteria respond to what they feel inside their cytoplasm and highlights…

Beyond ferrostatin-1: a comprehensive review of ferroptosis inhibitors

Jan 18, 2026
This review explains why stopping membrane lipid peroxidation is the most reliable way to block ferroptosis. It compares endogenous defenses with synthetic inhibitors and shows that optimized…

Gut as the target tissue of mercury and the extraintestinal effects

Jan 22, 2026
This review explains how inorganic and methylmercury disrupt gut microbes, metabolites, tight junctions, and immune signals, making the gut a key target tissue that can drive liver and brain toxicity…

THE ROLE OF GUT MICROBIOTA IN FETAL METHYLMERCURY EXPOSURE: INSIGHTS FROM A PILOT STUDY

Jan 25, 2026
This pilot study in late pregnancy linked maternal gut microbiota to mercury biomarkers and tested whether microbes directly change stool methylmercury. Stool methylmercury did not predict fetal…

Cadmium induces iron deficiency anemia through the suppression of iron transport in the duodenum

Jan 7, 2026
This study examines how cadmium exposure suppresses iron transport in the duodenum, leading to iron deficiency anemia. The research reveals the molecular mechanisms behind this disruption and its…

Extended sub-chronic exposure to heavy metal mixture induced multidrug resistance against chemotherapy agents in ovarian cancer cells

Aug 9, 2025
This study investigates how sub-chronic exposure to lead, cadmium, and cobalt induces multidrug resistance in ovarian cancer cells, highlighting the role of drug efflux transporters and reduced…

Effect of a controlled food-chain mediated exposure to cadmium and arsenic on oxidative enzymes in the tissues of rats

Sep 19, 2025
This study reveals how cadmium and arsenic exposure via the food chain disrupts oxidative enzyme activity in rats, leading to significant health risks, particularly in the liver and kidneys.

Speciation analysis and fractionation of manganese: A review

Feb 2, 2026
What was reviewed? This review provides an in-depth analysis of the speciation and fractionation of manganese (Mn) across various environmental and biological matrices, including water, soil, plants,…

Simultaneous antibiotic removal and mitigation of resistance induction by manganese bio-oxidation process

Feb 3, 2026
This study shows that manganese bio-oxidation, facilitated by Pseudomonas aeruginosa strain MQ2, can effectively degrade antibiotics and reduce antibiotic resistance gene propagation by alleviating…

Impact of oxidative stress induced by heavy metals on ovarian function

Jul 31, 2025
This review highlights the impact of heavy metal-induced oxidative stress on ovarian function, contributing to premature ovarian insufficiency. It discusses the mechanisms by which metals like…

Pseudomonas aeruginosa Magnesium Transporter MgtE Inhibits Type III Secretion System Gene Expression by Stimulating rsmYZ Transcription

Jan 28, 2026
This study shows that the magnesium transporter MgtE suppresses Pseudomonas aeruginosa type III secretion by blocking ExsA translation. MgtE activates the GacAS system, increases rsmY and rsmZ, and…

Staphylococcus aureus HrtA-heme-toxicity : ATPase function and heme-stress virulence reprogramming in S. aureus

Aug 22, 2025
HrtA is the ATPase of HrtAB that protects S. aureus from heme toxicity. Catalytic residues are essential in vitro and in vivo. Heme-stressed hrtA mutants undergo stringent-like reprogramming with a…

CadC, the transcriptional regulatory protein of the cadmium resistance system of Staphylococcus aureus plasmid pI258

Sep 25, 2025
This study identifies CadC as a key transcriptional regulator of the cadmium resistance operon in S. aureus plasmid pI258, revealing its role in controlling cadA expression in response to metal ions…

Cloning and Functional Analysis of the pbr Lead Resistance Determinant of Ralstonia metallidurans CH34

Aug 28, 2025
The study of the Ralstonia metallidurans pbr operon reveals mechanisms of lead resistance, highlighting Pb(II) uptake, efflux, and sequestration, and offering potential applications in bioremediation…

Cuprous Oxidase Activity of CueO from Escherichia coli.

Sep 3, 2025
The cuprous oxidase activity of CueO converts toxic Cu(I) to Cu(II) in E. coli, partners with CopA and CusCFBA, and marks copper-tolerant Enterobacterales that can persist in acidic, inflamed gut…

Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis

Jan 18, 2026
This study demonstrates that GPX4 is essential for motor neuron survival, with its ablation in mice leading to rapid motor neuron degeneration and paralysis via ferroptosis. Vitamin E supplementation…

Induction of Metallothionein I by Arsenic via Metal-activated Transcription Factor 1

Sep 11, 2025
The study reveals that MTF1 mediates the induction of Metallothionein I by arsenic, highlighting the importance of cysteine residues in the activation of MTF1 and its role in arsenic resistance.

Metal Preferences and Metallation

Jan 7, 2026
What was studied? The study investigates the metal preferences and metallation processes of enzymes, particularly focusing on the role of metal ions in metalloenzyme function. It explores how cells…

The Mismetallation of Enzymes during Oxidative Stress

Jan 7, 2026
This study explores the effects of oxidative stress on metallation in E. coli enzymes, focusing on the competition between iron, zinc, and manganese for enzyme binding sites, and the protective role…

Lysosome-related Organelles as Mediators of Metal Homeostasis

Jan 7, 2026
This review examines the role of lysosome-related organelles in regulating metal homeostasis, focusing on how these organelles store and transport metals like copper, zinc, and iron to maintain…

Mycobacterium tuberculosis and Copper: A Newly Appreciated Defense against an Old Foe?

Sep 3, 2025
Mycobacterium tuberculosis and copper shows copper rises at infection sites, while bacterial systems (MctB, CsoR–CtpV, RicR–MymT/MmcO) defend against toxicity; these markers inform clinical risk and…

The Role of Copper and Zinc Toxicity in Innate Immune Defense against Bacterial Pathogens

Sep 2, 2025
Copper and zinc toxicity in innate immunity drives early control of bacterial pathogens and shapes mucosal niches. The review links host metal routing and microbial export genes to killing,…

Combined DNase and Proteinase Treatment Interferes with Composition and Structural Integrity of Multispecies Oral Biofilms

Aug 29, 2025
The study investigates the effects of DNase I and proteinase K on the structure and composition of multispecies oral biofilms, finding that these enzymes disrupt biofilm integrity and shift microbial…

Investigative algorithms for disorders affecting plasma manganese concentration: a narrative review

Feb 3, 2026
This study addresses diagnostic challenges for manganese imbalances, providing algorithms for identifying hypermanganesemia and hypomanganesemia, and offering solutions to improve clinical diagnosis,…

Functional characterization of a cadmium resistance operon in Staphylococcus aureus ATCC12600: CadC does not function as a repressor

Sep 25, 2025
The study identifies and characterizes the cadmium resistance operon in S. aureus ATCC12600. It reveals that the cadC gene is crucial for cadmium efflux and resistance but does not function as a…

Widespread fungal–bacterial competition for magnesium lowers bacterial susceptibility to polymyxin antibiotics

Jan 29, 2026
Fungal competition for magnesium between Candida albicans and Pseudomonas aeruginosa significantly lowers bacterial fitness but enhances resistance to polymyxin antibiotics. This highlights the role…

The Escherichia coli Small Protein MntS and Exporter MntP Optimize the Intracellular Concentration of Manganese

Feb 3, 2026
This study examines the roles of MntS and MntP in regulating manganese levels in E. coli, highlighting their importance in preventing manganese toxicity and supporting enzyme activation. The findings…

The Staphylococcus aureus ABC-Type Manganese Transporter MntABC Is Critical for Reinitiation of Bacterial Replication Following Exposure to Phagocytic Oxidative Burst

Feb 3, 2026
This study identifies the MntABC manganese transporter as crucial for S. aureus survival after phagocytosis. It helps bacteria recover from oxidative stress by facilitating DNA repair through the…

Protective Effects of Lactobacillus plantarum CCFM8246 against Copper Toxicity in Mice

Sep 6, 2025
Lactobacillus plantarum CCFM8246 shows protective effects against copper toxicity in mice by promoting copper excretion, alleviating oxidative stress, and improving liver function and cognitive…

Structural analysis of the manganese transport regulator MntR from Bacillus halodurans in apo and manganese bound forms

Feb 3, 2026
This study uncovers the structural basis of manganese binding in the MntR regulator from Bacillus halodurans, revealing its role in bacterial manganese homeostasis. Understanding this process could…

Association of low-level heavy metal exposure with risk of chronic kidney disease and long-term mortality

Nov 28, 2025
This study links low-level heavy metal exposure to increased CKD risk and higher cadmium-associated mortality, with synergistic toxicity when both metals are elevated.

The battle for iron between bacterial pathogens and hosts: clinical microbiome implications

Aug 22, 2025
This review maps the battle for iron between bacterial pathogens and hosts, detailing nutritional immunity, bacterial siderophores and heme uptake, siderocalin defense, stealth siderophores, and…

Copper at the Front Line of the Host-Pathogen Battle

Sep 2, 2025
This review explores the critical role of copper in microbial pathogenesis, focusing on how the host uses it as an antimicrobial weapon and how pathogens resist Cu toxicity. It suggests potential…

The Two-Component System ArlRS and Alterations in Metabolism Enable Staphylococcus aureus to Resist Calprotectin-Induced Manganese Starvation

Feb 3, 2026
This study reveals that the ArlRS two-component system in S. aureus enables resistance to host-imposed manganese starvation by modulating metabolism, particularly by promoting amino acid utilization.…

Effects of chronic exposure to arsenic on the fecal carriage of antibiotic-resistant Escherichia coli among people in rural Bangladesh

Sep 12, 2025
This study evaluates the relationship between arsenic exposure and antibiotic-resistant E. coli carriage in rural Bangladesh, revealing significant associations between arsenic contamination and…

The exploitation of nutrient metals by bacteria for survival and infection in the gut

Jan 7, 2026
This study explores how trace metals impact gut microbiota composition and pathogen competition, emphasizing nutritional immunity and the potential for probiotic interventions to enhance pathogen…

Lead: Natural Occurrence, Toxicity to Organisms and Bioremediation by Lead-degrading Bacteria: A Comprehensive Review

Aug 27, 2025
This review maps mechanisms and taxa underlying lead bioremediation by bacteria, linking microbial toolkits (EPS, phosphatases, sulfate reducers, PIB-ATPases, metallothioneins) to field performance…

Health Effects of Chronic Arsenic Exposure

Sep 12, 2025
This study highlights the health effects of chronic arsenic exposure through drinking water, linking it to cancers, cardiovascular diseases, and diabetes. It emphasizes the need for monitoring…

Chronic arsenic exposure affects stromal cells and signaling in the small intestine in a sex-specific manner

Sep 15, 2025
This study explores the sex-specific effects of chronic arsenic exposure on stromal cells and signaling in the small intestine, highlighting how arsenic disrupts trophocytes and telocytes, which…

Cadmium Uptake Kinetics in Rat Hepatocytes: Correction for Albumin Binding

Sep 24, 2025
This study investigates how albumin influences cadmium uptake in primary rat hepatocytes, revealing its protective role in reducing toxicity. The findings suggest albumin’s involvement in…

The Effects of an Environmentally Relevant Level of Arsenic on the Gut Microbiome and Its Functional Metagenome

Sep 13, 2025
At 100 ppb, arsenic reshaped mouse gut communities, lowered SCFA gene capacity, increased LPS and stress pathways, and enriched multidrug and conjugation genes while shifting taxa toward Akkermansia…

A landscape of metallophore synthesis and uptake potential of the genus Staphylococcus

Feb 3, 2026
This study maps the metallophore synthesis and uptake potential across the Staphylococcus genus, revealing species-specific production and utilization of metallophores. These findings provide…

The Metallophore Staphylopine Enables Staphylococcus aureus To Compete with the Host for Zinc and Overcome Nutritional Immunity

Feb 3, 2026
This study reveals that S. aureus uses the Cnt-StP system to acquire zinc during infection, enabling it to compete with the host’s immune defenses. This zinc acquisition pathway is critical for…

Host subversion of bacterial metallophore usage drives copper intoxication

Sep 3, 2025
Host subversion of bacterial metallophore usage shows that zinc starvation makes S. aureus import copper via staphylopine, triggering copper stress and reducing fitness in vivo; these loci and host…

Magnesium Sensing Regulates Intestinal Colonization of Enterohemorrhagic Escherichia coli O157:H7

Jan 28, 2026
This study shows that low gut magnesium activates a virulence pathway in EHEC O157:H7 that boosts LEE gene expression and intestinal attachment. A magnesium-rich diet raised colon magnesium and…

Manganese Detoxification by MntE Is Critical for Resistance to Oxidative Stress and Virulence of Staphylococcus aureus

Feb 2, 2026
This study highlights the role of MntE in Mn detoxification and its crucial impact on S. aureus’s resistance to oxidative stress and virulence. Disrupting MntE leads to Mn accumulation, reduced…

Nickel exposure reduces enterobactin production in Escherichia coli.

Sep 4, 2025
Nickel exposure reduces enterobactin production in Escherichia coli, extends lag phase, triggers iron-starvation signals, and lowers extracellular catechols, defining gene and metal markers to track…

Heavy Metals Toxicity: Mechanism, Health Effects, and Therapeutic Interventions

Jan 7, 2026
This review addresses the health effects, toxicity mechanisms, and therapeutic interventions related to heavy metals, highlighting the importance of further research and improved treatment strategies.

Evaluation of serum heavy metal levels on primary ovarian insufficiency

Jul 31, 2025
This study explores the potential link between serum heavy metal levels and premature ovarian insufficiency. The higher levels of metals like lead and mercury in women with POI suggest environmental…

Zinc sequestration by human calprotectin facilitates manganese binding to the bacterial solute-binding proteins PsaA and MntC

Feb 3, 2026
This study reveals how the human immune protein calprotectin (CP) sequesters zinc, facilitating manganese binding to bacterial solute-binding proteins. This interaction prevents zinc toxicity and…

Wide Spectrum Potent Antimicrobial Efficacy of Wound Dressings Impregnated with Cuprous Oxide Microparticles

Sep 5, 2025
Wound dressings impregnated with cuprous oxide cut bioburden fast, block bacterial passage, and act against common wound microbes with durable activity, offering a practical tool to reshape the wound…

Microbial Metallophores in the Productivity of Agroecosystems

Sep 26, 2025
Microbial metallophores are vital in sustainable agriculture, enhancing nutrient availability, promoting plant growth, and mitigating heavy metal toxicity. The study highlights their potential in…

Diversity of Mercury-Tolerant Microorganisms

Jan 23, 2026
This review explains how mercury-tolerant bacteria, fungi, and microalgae resist and transform mercury. It highlights detox genes such as the mer system, biofilm binding, and redox-driven methylation…

The Dysbiosis of Gut Microbiota Caused by Low-Dose Cadmium Aggravate the Injury of Mice Liver through Increasing Intestinal Permeability

Sep 28, 2025
This study reveals how low-dose cadmium exposure disrupts gut microbiota, increasing intestinal permeability and liver injury in mice. The findings emphasize the role of microbiota in modulating…

Bacillus subtilis MntR coordinates the transcriptional regulation of manganese uptake and efflux systems

Feb 2, 2026
This study explores how the MntR metalloregulator in Bacillus subtilis coordinates Mn(II) uptake and efflux systems to maintain Mn homeostasis and prevent toxicity, offering insights into bacterial…

Moving metals: how microbes deliver metal cofactors to metalloproteins

Jan 7, 2026
This study explores the role of metallochaperones in bacteria, focusing on how they deliver essential metal ions to metalloproteins and maintain metal homeostasis under metal stress. These mechanisms…

A Review on Coordination Properties of Thiol-Containing Chelating Agents Towards Mercury, Cadmium, and Lead

Jan 25, 2026
This review explains how thiol-based chelators bind mercury, cadmium, and lead and how that chemistry guides clinical treatment. It compares common agents such as DMSA and DMPS, outlines safety…

Deferoxamine B: A Natural, Excellent and Versatile Metal Chelator

Aug 28, 2025
A comprehensive review of Deferoxamine B metal chelator links siderophore chemistry, microbial uptake, and clinical chelation/imaging, highlighting speciation across metals—including Pb(II)—and…

Heavy Metals and Human Health: Possible Exposure Pathways and the Competition for Protein Binding Sites

Aug 27, 2025
This review discusses the toxicological impact of heavy metals like arsenic, cadmium, and mercury on human health, particularly their interaction with proteins and enzymes, leading to various…

Cadmium Toxicity and Health Effects—A Brief Summary

Sep 28, 2025
The review examines the sources, accumulation, and health effects of cadmium, emphasizing its long-term toxicity, particularly its role in lung, kidney, bone, and neurological diseases. It…

Iron Supplementation and Microbiome in Preterm Infants: Risks of Dysbiosis and Pathogen Enrichment

Aug 22, 2025
High-dose enteral iron supplementation in VLBW infants was associated with reduced microbial diversity, Proteus enrichment, and increased microbial potential for ferroptosis and epithelial invasion,…

The siderophore yersiniabactin binds copper to protect pathogens during infection

Sep 4, 2025
Yersiniabactin binds copper in vivo, protects UPEC from copper stress, and blocks catecholate-driven Cu(II)→Cu(I) toxicity, yielding a clear urinary microbiome signature with direct clinical use.

Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae

Sep 18, 2025
The study uncovers how cadmium disrupts transition metal homeostasis in Streptococcus pneumoniae, affecting manganese and zinc uptake and contributing to oxidative stress.

Interplay between enterobactin myeloperoxidase and lipocalin 2 in the inflamed gut

Aug 22, 2025
Aferric enterobactin disables myeloperoxidase, granting E. coli a survival edge in colitis, while lipocalin 2 restores enzyme function and counters colonization.

Antimicrobial Properties of Magnesium Open Opportunities to Develop Healthier Food

Jan 28, 2026
This mini-review explains how higher-dose magnesium can reduce bacterial adhesion and weaken biofilm formation. It highlights why biofilms resist cleaning and heat, and it summarizes evidence that…

Beneficial Effects of a Low-Nickel Diet on Relapsing IBS-Like and Extraintestinal Symptoms of Celiac Patients during a Proper Gluten-Free Diet: Nickel Allergic Contact Mucositis in Suspected Non-Responsive Celiac Disease

Nov 27, 2025
A study of celiac patients revealed that persistent symptoms during gluten-free eating may stem from nickel allergic contact mucositis. A low-nickel diet significantly improved gastrointestinal and…

Effect of Dietary Magnesium Content on Intestinal Microbiota of Rats

Jan 30, 2026
This study explores how dietary magnesium levels affect the gut microbiota of rats. It shows that low magnesium increases beneficial microbes, while high magnesium promotes potentially harmful…

Magnesium: Biochemistry, Nutrition, Detection, and Social Impact of Diseases Linked to Its Deficiency

Jan 28, 2026
This review explains how magnesium supports energy, vascular tone, glucose handling, bone strength, and brain excitability, and why low intake or poor absorption can raise chronic disease risk. It…

Dietary Magnesium Alleviates Experimental Murine Colitis through Modulation of Gut Microbiota

Jan 30, 2026
This study explores how dietary magnesium supplementation can alleviate murine colitis by modulating the gut microbiota, improving microbiota richness, and reducing inflammation.

Magnesium Orotate and the Microbiome–Gut–Brain Axis Modulation: New Approaches in Psychological Comorbidities of Gastrointestinal Functional Disorders

Jan 31, 2026
This review links magnesium, especially magnesium orotate, to gut–brain axis modulation in functional GI disorders with anxiety or depression. It summarizes evidence that magnesium status can shift…

Dietary Strategies for the Treatment of Cadmium and Lead Toxicity

Sep 28, 2025
The study discusses dietary strategies to counteract the toxicity of cadmium and lead exposure, emphasizing the role of essential metals, vitamins, probiotics, and edible plants. These strategies…

An arsenic metallochaperone for an arsenic detoxification pump

Sep 10, 2025
The study explores how ArsD, a metallochaperone, enhances ArsA’s ability to expel arsenic from cells, improving arsenic detoxification. This interaction increases arsenic resistance in E. coli, with…

Copper resistance is essential for virulence of Mycobacterium tuberculosis

Sep 3, 2025
Copper resistance is essential for virulence of Mycobacterium tuberculosis; MctB prevents copper build-up, and loss of MctB cripples survival in copper-rich granulomas, defining actionable microbial…

Cadmium hijacks the high zinc response by binding and activating the HIZR-1 nuclear receptor

Sep 26, 2025
This study shows that cadmium acts as a zinc mimetic by binding to and activating the HIZR-1 nuclear receptor, leading to the activation of high zinc homeostasis genes in C. elegans. The research…

Mercury(II) binds to both of chymotrypsin’s histidines, causing inhibition followed by irreversible denaturation/aggregation

Jan 25, 2026
This study shows mercury(II) can bind histidines to inhibit chymotrypsin and trigger irreversible denaturation and aggregation. Imidazole blocks aggregation, aggregation rises above pH 6.5, and…

Neurotoxic Effects and Biomarkers of Lead Exposure: A Review

Aug 27, 2025
The review examines the neurotoxic effects of lead exposure, focusing on mechanisms such as ion mimicry, mitochondrial dysfunction, and neuroinflammation. It emphasizes the long-term impact of lead…

The buffer capacity and buffer systems of human whole saliva measured without loss of CO2

Feb 3, 2026
This study investigates the buffer capacity and systems of human whole saliva, revealing the key role of bicarbonate, saliva flow rate, and pH in maintaining oral health. It provides insights into…

Impacts of Mercury Exposure Levels and Sources on the Demethylation of Methylmercury Through Human Gut Microbiota

Jan 25, 2026
This study shows human gut microbiota can demethylate methylmercury and that detox rates vary by exposure level and food source. Higher Desulfovibrio and methanogen signals aligned with faster…

Copper: Toxicological relevance and mechanisms.

Sep 2, 2025
This study highlights how Cu imbalance leads to oxidative stress and cellular toxicity, contributing to liver and neurological diseases. It emphasizes the need for tight Cu regulation and offers…

Assessing the Role of the Gut Microbiome in Methylmercury Demethylation and Elimination in Humans and Gnotobiotic Mice

Jan 25, 2026
This study shows the gut microbiome helps clear dietary methylmercury by demethylating it in the intestine. People differed widely in elimination rates, which tracked with stool demethylation…

Heavy metals: toxicity and human health effects

Aug 28, 2025
A mechanistic review links heavy metals and human health to dysbiosis via protein-binding competition, redox injury, epithelial leak, and LPS-driven inflammation, outlining organ toxicity and…

Regulatory effects of transition metals supplementation/deficiency on the gut microbiota

Feb 3, 2026
This review examines how iron, copper, zinc, and manganese affect gut microbiota composition and function, highlighting their regulatory role in health and disease. It discusses both the effects of…

Staphylococcus aureus Metal Acquisition and Nutritional Immunity: Virulence Insights

Aug 22, 2025
This review outlines how Staphylococcus aureus overcomes host nutritional immunity by acquiring iron, manganese, and zinc, underscoring the critical role of metal transport systems in virulence and…

Parkinson-like wild-type superoxide dismutase 1 pathology induces nigral dopamine neuron degeneration in a novel murine model

Jan 7, 2026
This review examines the role of altered wild-type SOD1 in Parkinson’s disease, highlighting its involvement in dopamine neuron degeneration and presenting a novel mouse model for studying…

Copper homeostasis in Enterococcus hirae

Sep 3, 2025
Copper homeostasis in Enterococcus hirae maps a four-gene circuit—CopA, CopB, CopY, CopZ—and a reductase that set copper uptake and export, yielding clear genomic markers to predict copper tolerance…

Trace elements in human physiology and pathology. Copper

Sep 3, 2025
The review links copper’s enzyme roles and tight homeostasis to clinical states that shift metal supply at mucosa, offering host and microbial markers to track copper-shaped microbiome risk.

The ArsD As(III) metallochaperone

Sep 10, 2025
This study investigates the structural and biochemical role of ArsD, a metallochaperone in E. coli, in enhancing arsenic detoxification by transferring As(III) to the ArsA ATPase, providing new…

The many “faces” of copper in medicine and treatment

Sep 2, 2025
This review explores copper’s essential roles in human health and its involvement in diseases like Wilson’s disease, Alzheimer’s, and cancer. It highlights copper’s dual role in disease progression…

Metallochaperones: Bind and Deliver

Jan 7, 2026
This review examines the role of metallochaperones in copper and nickel ion transport, highlighting their significance in metal ion homeostasis and implications for treating diseases like…

The Dietary Fiber Pectin: Health Benefits and Potential for the Treatment of Allergies by Modulation of Gut Microbiota

Jan 25, 2026
This review explains how dietary pectin may shift gut microbiota and SCFA production to shape allergy risk, while also noting reports of pectin-related sensitization and anaphylaxis. It highlights…

The Role of Selenium in Arsenic and Cadmium Toxicity: an Updated Review of Scientific Literature

Sep 15, 2025
This review explores the protective effects of selenium against arsenic and cadmium toxicity, emphasizing its role in reducing oxidative stress, inflammation, and cellular damage. The findings…

Total arsenic and speciation analysis of saliva and urine samples from individuals living in a chronic arsenicosis area in China

Sep 15, 2025
The study assessed arsenic exposure in Shanyin County residents through saliva and urine samples. It confirmed that saliva is a potential biomarker for total arsenic exposure, although less effective…

Lead as a Risk Factor for Osteoporosis in Post-menopausal Women

Aug 26, 2025
The review highlights the connection between lead exposure and osteoporosis risk in post-menopausal women, showing how lead release during bone turnover contributes to health complications.…

Heavy metal association with chronic kidney disease of unknown cause in central India: results from a case-control study

Nov 28, 2025
The study demonstrates that arsenic exposure is independently associated with CKDu in central India, with CKDu and CKD patients showing heavier burdens of cadmium, lead, and chromium than healthy…

Long-term exposure to low-level arsenic in drinking water is associated with cause-specific mortality and hospitalization in the Mt. Amiata area (Tuscany, Italy)

Sep 12, 2025
Long-term exposure to low-level arsenic in drinking water in Mt. Amiata, Italy, was linked to increased mortality and hospitalization risks, especially for cardiovascular diseases and cancer. Even…

Ferroptosis: principles and significance in health and disease

Jan 18, 2026
What was reviewed? This paper reviewed ferroptosis as a regulated, non-apoptotic form of cell death driven by iron-dependent lipid peroxidation, then mapped the main molecular “pressure points” that…

The Role of Chelation in the Treatment of Arsenic and Mercury Poisoning

Sep 15, 2025
This review explores the role of chelation therapy in treating arsenic and mercury poisoning, focusing on the efficacy of BAL, DMPS, and DMSA in acute cases and the challenges posed by chronic…

The Human Gut Microbiome’s Influence on Arsenic Toxicity

Sep 10, 2025
The human gut microbiome and arsenic toxicity are tightly linked: microbes change arsenic speciation and dose, while arsenic reshapes gut ecology, altering risk. Clinicians should integrate…

Evaluation of mercury exposure level, clinical diagnosis and treatment for mercury intoxication

Jan 25, 2026
This review explains how mercury form and exposure route change diagnosis and treatment. It compares blood, urine, and hair biomarkers, discusses why symptoms do not always match measured levels, and…

Is Urinary Cadmium a Biomarker of Long-term Exposure in Humans? A Review

Sep 28, 2025
The review shows that urinary cadmium biomarker long-term exposure provides a stable signal of cumulative dose. Smoking, age, sex, iron status, and kidney function shape values. Proper dilution…

A narrative review on the role of magnesium in immune regulation, inflammation, infectious diseases, and cancer

Jan 31, 2026
This review explains how magnesium supports immune signaling and controls inflammation. It links magnesium deficiency to higher cytokine activity, oxidative stress, infection risk, and cancer…

Public and occupational health risks related to lead exposure updated according to present-day blood lead levels

Aug 26, 2025
A clinician-focused review updates present-day lead exposure risks and microbiome implications, contrasting older population metrics with SPHERL’s prospective data and outlining how exposure tiers,…

Fine control of metal concentrations is necessary for cells to discern zinc from cobalt

Sep 4, 2025
This study highlights how bacterial sensors for zinc and cobalt operate under tightly regulated metal conditions. It reveals how improper sensing during metal shock can compromise bacterial function,…

The gut microbiome is required for full protection against acute arsenic toxicity in mouse models

Sep 10, 2025
This study demonstrates that both a functional host As3mt enzyme and a stable, diverse gut microbiome—especially the presence of Faecalibacterium prausnitzii—are required for full protection against…

Exposure to environmental pollutants selects for xenobiotic-degrading functions in the human gut microbiome

Sep 28, 2025
This study highlights the significant impact of environmental pollutants on the gut microbiome, selecting for microbial functions that degrade xenobiotics and potentially promoting antibiotic…

Microbial regulation of ferroptosis in cancer

Jan 18, 2026
This review explains how a gut bacterial tryptophan metabolite, IDA, can promote colorectal cancer by blocking ferroptosis through an AHR–ALDH1A3–FSP1–CoQ10 pathway. It reframes microbial metabolites…

Bacterial siderophores in community and host interactions

Sep 26, 2025
The study explores the multifaceted role of bacterial siderophores in microbial community dynamics and host interactions. It highlights their impact on bacterial competition, survival, and virulence,…

Nutritional Immunity and Metallomic Signatures: Metal Competition at the Host–Pathogen Interface

Aug 1, 2025
This review details how nutritional immunity shapes host–pathogen interactions through metal sequestration and intoxication, highlights key microbial metal acquisition systems, and discusses their…

Sex-specific associations of infants’ gut microbiome with arsenic exposure in a US population

Sep 12, 2025
The study explores the relationship between arsenic exposure and the infant gut microbiome, revealing sex-specific associations and highlighting how formula-fed male infants are particularly…

Augmented antibiotic resistance associated with cadmium induced alterations in Salmonella enterica serovar Typhi

Sep 22, 2025
The study demonstrates how cadmium exposure enhances antibiotic resistance in Salmonella enterica serovar Typhi by altering bacterial growth, biofilm formation, and antibiotic susceptibility. The…

Nickel chelation therapy as an approach to combat multi-drug resistant enteric pathogens

Nov 27, 2025
This study evaluates nickel chelation therapy using DMG against multidrug-resistant Salmonella and Klebsiella. DMG impaired virulence by inhibiting Ni-dependent enzymes, reduced bacterial load in…

Inhibition of red blood cell development by arsenic-induced disruption of GATA-1

Sep 11, 2025
The study examines how arsenic exposure disrupts erythropoiesis by inhibiting GATA-1 function, leading to anemia. It highlights the role of zinc finger motifs in GATA-1 and provides insights into…

Bioavailability of arsenic, cadmium, lead and mercury as measured by intestinal permeability

Sep 24, 2025
The study explored how gut microbes and chelating agents influence the bioavailability of arsenic, cadmium, lead, and mercury by assessing their intestinal permeability using a Caco-2 cell model. It…

The association between low-concentration heavy metal exposure and chronic kidney disease risk through α-klotho

Nov 28, 2025
This study analyzed how low-level heavy metal exposures influence CKD risk and identified α-klotho as a mechanistic mediator, highlighting cadmium’s nephrotoxicity and complex mixture effects.

Arsenic toxicity: Sources, pathophysiology and mechanism

Sep 11, 2025
This review examines arsenic toxicity, its pathways of exposure, and its harmful effects on human health, focusing on oxidative stress, genotoxicity, and epigenetic changes. It highlights the link…

Elevated Lead, Nickel, and Bismuth Levels in the Peritoneal Fluid of a Peritoneal Endometriosis Patient without Toxic Habits or Occupational Exposure following a Vegetarian Diet

Nov 27, 2025
This case report describes markedly elevated lead, nickel, and bismuth in the peritoneal fluid of a young woman with endometriosis, highlighting dietary and environmental exposure considerations and…

The Mechanisms of Cadmium Toxicity in Living Organisms

Sep 26, 2025
This study examines the effects of cadmium exposure on the microbiome, showing how it alters gut and blood microbiota, impacts metabolites, and links to inflammatory responses. The research reveals…

Toxicity of Glutathione-Binding Metals: A Review of Targets and Mechanisms

Jan 24, 2026
This review explains how mercury, cadmium, arsenic, and lead disrupt glutathione and cysteine-based defenses. It emphasizes catalytic mercury-driven glutathione oxidation and metal-conjugate…

Gut Microbiome Phenotypes Driven by Host Genetics Affect Arsenic Metabolism

Sep 15, 2025
The study demonstrates how IL-10 gene knockout mice show significant changes in their gut microbiome and arsenic metabolism. These alterations contribute to higher levels of toxic arsenic…

Arsenic levels in the hair of people exposed to arsenic and awareness of its risk factors

Sep 13, 2025
In rural China, drinking water often exceeded standards, and hair arsenic was higher in exposed residents. Age, male sex, and wheat-based diet increased levels, making hair arsenic a useful long-term…

Stool as a novel biomarker for arsenic exposure through diet: a case-control study in a West Bengal population

Sep 15, 2025
What was studied? This study focused on evaluating arsenic exposure through diet by assessing stool samples in populations from West Bengal, India. Given that arsenic exposure via drinking water is…

Influence of Sulfate Reduction on Arsenic Migration and Transformation in Groundwater Environment

Sep 11, 2025
This study explores the impact of sulfate-reducing bacteria on arsenic migration and transformation in groundwater. It highlights how sulfate reduction enhances arsenic release and mobilization,…

Influence of toxic metal exposure on the gut microbiota (Review)

Sep 5, 2025
This study investigates how copper supplementation affects gut microbiota and E. coli resistance in weaned piglets. It reveals that copper alters microbial composition and promotes antibiotic…

The relationship between serum levels of uric acid and prognosis of infection in critically ill patients

Nov 28, 2025
This study evaluated how serum uric acid levels relate to infection outcomes in ICU patients and found that uric acid reflects renal and metabolic stress rather than prognosis.

Current opinion on the regulation of small intestinal magnesium absorption

Jan 28, 2026
This review explains that the small intestine absorbs magnesium through regulated transcellular and paracellular pathways. Hormones, luminal pH sensing, and proton pump inhibitors can suppress…

The Role of Metal Ions in Enzyme Catalysis and Human Health

Jan 7, 2026
What was studied? This study investigates the role of metal ions in enzyme catalysis and their implications for human health. It specifically looks at the biochemical roles of essential metal ions,…

Bacterial Iron Detoxification Mechanisms: Insights into Iron Homeostasis and Oxidative Stress Mitigation

Mar 18, 2025
This review explores bacterial iron homeostasis, focusing on detoxification pathways, oxidative stress mitigation, and iron-storage mechanisms. It highlights regulatory proteins like Fur and DtxR and…

Critical Review on Zeolite Clinoptilolite Safety and Medical Applications in vivo

Mar 18, 2025
What was reviewed? The review focused on the safety and medical applications of clinoptilolite, a naturally occurring zeolite, for in vivo use. The analysis encompassed the physical and chemical…

Does Exposure of Lead and Cadmium Affect the Endometriosis?

Mar 18, 2025
The study links lead and cadmium exposure to increased endometriosis risk, emphasizing lead’s role at low blood levels and synergistic effects with cadmium. It advocates for strict monitoring…

GS2 Gallium Complex: A Novel Inhibitor of MMP-14 for Anti-Metastatic Cancer Therapy

Mar 18, 2025
GS2, a gallium complex, inhibits tumor invasion by targeting MMP-14, with implications for anti-metastatic cancer therapy.

Gut Microbiota as a Mediator of Essential and Toxic Effects of Zinc in the Intestines and Other Tissues

Aug 11, 2025
This review illustrates zinc’s dose- and species-dependent impact on gut microbiota, linking both deficiency and excess to dysbiosis and systemic inflammation. Physiological Zn enhances barrier…

Heavy Metals and Pesticides Toxicity in Agricultural Soil and Plants: Ecological Risks and Human Health Implications

Mar 18, 2025
This review explores the toxicity of heavy metals and pesticides in agricultural ecosystems, detailing their ecological and health impacts. It highlights pathways, bioaccumulation, and synergistic…

Metalloestrogens exposure and risk of gestational diabetes mellitus: Evidence emerging from the systematic review and meta-analysis

Mar 18, 2025
What Was Reviewed? The systematic review and meta-analysis examined the relationship between exposure to metalloestrogens—specifically arsenic (As), antimony (Sb), chromium (Cr), cadmium (Cd), copper…

Metalloestrogens: an emerging class of inorganic xenoestrogens with potential to add to the oestrogenic burden of the human breast

Mar 18, 2025
This review identifies metalloestrogens as a critical factor in hormone disruption and breast cancer risk.

Metals at the Host–Fungal Pathogen Battleground

May 24, 2025
Fungal pathogens rely on metal acquisition for virulence. This review reveals how host tissues manipulate iron, copper, zinc, and manganese to starve or intoxicate fungi and how pathogens adapt, with…

Nickel Allergic Contact Mucositis in Suspected Non-Responsive Celiac Disease

Mar 18, 2025
The study found that 100% of the CD patients who completed the study tested positive for allergic contact mucositis to Nickel.

Nickel Allergy as a Risk Factor for Endometriosis

Mar 18, 2025
This study identifies nickel allergy as an independent risk factor for endometriosis, highlighting shared immune dysregulation and estrogenic pathways. Using a population-based cohort, researchers…

Nickel Allergy is Found in a Majority of Women with Chronic Fatigue Syndrome and Muscle Pain—and may be Triggered by Cigarette Smoke and Dietary Nickel Intake

Mar 18, 2025
Nickel allergy, smoking, and dietary nickel intake may worsen chronic fatigue and muscle pain. Managing exposure can improve symptoms.

Nickel Sensitivity in Patients With Irritable Bowel Syndrome

Mar 18, 2025
This study suggests that nickel sensitivity may play a significant role in the etiology of IBS, warranting further exploration and potentially influencing future diagnostic and therapeutic strategies…

Plants that Hyperaccumulate Heavy Metals

May 23, 2025
This chapter reviews hyperaccumulator plants, especially in the Brassicaceae family, and their mechanisms of metal uptake. It highlights implications for human health, including how high-metal diets…

Potential Role of Copper in Diabetes and Diabetic Kidney Disease

Mar 18, 2025
This review explores copper’s role in diabetes and diabetic kidney disease, emphasizing its impact on oxidative stress, glycemic control, and renal function. Findings highlight the potential of…

Presence of metalloestrogens in ectopic endometrial tissue

Mar 18, 2025
What was studied? This study investigated the presence of metalloestrogens in ectopic endometrial tissue from women with endometriosis. Metalloestrogens, heavy metals that can mimic estrogen and may…

Presence of metalloestrogens in ectopic endometrial tissue

Mar 18, 2025
This study quantified metalloestrogens—cadmium, nickel, and lead—in ectopic endometrial tissue, suggesting their role in endometriosis persistence.

Relaxed fibronectin: a potential novel target for imaging endometriotic lesions

Mar 18, 2025
The radiotracer [111In]In-FnBPA5 accumulated in the mouse uterus, with uptake varying according to the estrous cycle, suggesting an increased abundance of relaxed fibronectin during…

Role of Cholestyramine in Refractory Hyperthyroidism: A Case Report and Literature Review

Mar 18, 2025
The study investigates the role of cholestyramine for refractory iodine-induced hyperthyroidism, showing rapid FT4 reduction in 12 days.

The Association between Zinc and Copper Circulating Levels and Cardiometabolic Risk Factors in Adults: A Study of Qatar Biobank Data

Mar 18, 2025
This study evaluated the associations of zinc, copper, and Zn/Cu ratio with cardiometabolic risk factors in Qatari adults, revealing copper’s protective role and Zn/Cu ratio’s adverse implications…

The copper chelator ammonium tetrathiomolybdate inhibits the progression of experimental endometriosis in TNFR1-deficient mice

Mar 18, 2025
Ammonium tetrathiomolybdate (TM) inhibits endometriosis progression in TNFR1-deficient mice by reducing copper and estradiol levels, lesion growth, angiogenesis, and oxidative stress.

The effect of a low-nickel diet and nickel sensitization ongastroesophageal reflux disease: A pilot study

May 19, 2025
A low-nickel diet significantly reduced GERD symptoms in 95% of participants, regardless of patch test status. The results suggest dietary nickel may contribute to GERD pathophysiology independently…

The Influence of Lactoferrin in Plasma and Peritoneal Fluid on Iron Metabolism in Women with Endometriosis

May 24, 2025
This study demonstrates that peritoneal fluid-to-plasma ferritin and lactoferrin ratios distinguish endometriosis stage and severity. Iron overload and shifting iron-binding protein profiles reveal a…

The influence of nickel on intestinal microbiota disturbances

Mar 18, 2025
Excess nickel disrupts gut microbiota, promoting dysbiosis and contributing to conditions like obesity and systemic nickel allergy syndrome (SNAS). Probiotics and nickel-restricted diets show promise…

Trace Elements and Endometriosis: Insights into Oxidative Stress and Novel Therapies

Mar 18, 2025
This review explores the role of trace elements and oxidative stress in endometriosis, highlighting their potential as therapeutic targets. It underscores the need for further research into the trace…

Microbes (354)

Akkermansia muciniphila in infectious disease: A new target for this next-generation probiotic?

Feb 8, 2026
This review shows that Akkermansia muciniphila protects against bacterial and viral infections by strengthening gut barriers and regulating systemic immunity. Evidence supports its role as a…

The non-pathogenic Escherichia coli strain Nissle 1917 – features of a versatile probiotic

Nov 5, 2025
E. coli Nissle 1917 is a non-pathogenic probiotic strain that inhibits pathogenic bacteria, reduces inflammation, and strengthens intestinal barrier function, with proven clinical efficacy in…

Gut microbiota modulation: a narrative review on a novel strategy for prevention and alleviation of ovarian aging

Nov 15, 2025
This review explores how gut microbiota modulation influences ovarian aging and presents potential therapies like fecal microbiota transplantation and probiotics to prevent or alleviate ovarian…

Vaginal microbiome of women with premature ovarian insufficiency: a descriptive cross-sectional study

Jul 31, 2025
The study reveals that women with premature ovarian insufficiency on systemic hormone therapy maintain a Lactobacillus-dominated vaginal microbiome, similar to estrogenized women, though some show…

Mechanisms of antibiotic resistance in enterococci

Feb 16, 2026
Enterococcus develops antibiotic resistance through genetic adaptation, enabling microbiome dominance and infection persistence. Resistance mechanisms allow Enterococcus to survive antibiotic…

Adhesive threads of extraintestinal pathogenic Escherichia coli

Nov 16, 2025
This review explains how adhesive threads of extraintestinal pathogenic Escherichia coli shape gut colonization, tissue tropism and invasive disease and shows how detailed adhesin profiles can inform…

Insights from 100 Years of Research with Probiotic E. Coli

Nov 6, 2025
Probiotic-e-coli-nissle-1917 shows benefit in ulcerative colitis, infant diarrhea, and innate immune priming, with transient engraftment and microcin-based pathogen suppression, but no effect in…

The bacterial genotoxin colibactin promotes colon tumor growth by modifying the tumor microenvironment

Jan 15, 2026
This addendum explains how colibactin-producing E. coli can speed colon tumor growth by inducing senescence and a growth-factor secretory program. The pathway runs through c-Myc, miR-20a-5p, SENP1,…

Triggering Akkermansia with dietary polyphenols: A new weapon to combat the metabolic syndrome?

Feb 8, 2026
This review shows that dietary polyphenols selectively increase Akkermansia muciniphila, improving gut barrier function and metabolic outcomes through microbiome-mediated mechanisms rather than…

Listeriolysin S: A bacteriocin from epidemic Listeria monocytogenes strains that targets the gut microbiota

Feb 5, 2026
This study reveals how Listeria monocytogenes uses listeriolysin S (LLS) as a bacteriocin to alter the gut microbiota, aiding in colonization and infection, with implications for therapeutic…

Immuno-modulatory effect of probiotic E. coli Nissle 1917 in polarized human colonic cells against Campylobacter jejuni infection

Nov 18, 2025
This study shows that the immuno modulatory effect of Escherichia coli Nissle 1917 primes polarized colonic cells, reduces Campylobacter jejuni adhesion and survival, and rebalances NF kappa B, MAPK…

The role of key gut microbial metabolites in the development and treatment of cancer

Nov 15, 2025
This review explores the dual role of gut microbial metabolites in cancer, focusing on their anticancer and pro-carcinogenic effects. It emphasizes the potential of SCFAs, bacteriocins, and dietary…

The influence of the gut microbiome on ovarian aging

Aug 1, 2025
This review examines the relationship between gut microbiota and ovarian aging, highlighting microbial dysbiosis as a key factor in ovarian function decline. It explores microbiota-based therapies…

ZntA maintains zinc and cadmium homeostasis and promotes oxidative stress resistance and virulence in Vibrio parahaemolyticus

Sep 26, 2025
This study investigates the role of ZntA in zinc and cadmium homeostasis, oxidative stress resistance, and virulence in Vibrio parahaemolyticus. ZntA protects against metal toxicity and promotes…

Benefits and concerns of probiotics: an overview of the potential genotoxicity of the colibactin-producing Escherichia coli Nissle 1917 strain

Nov 8, 2025
Escherichia coli Nissle 1917, a probiotic strain, offers significant health benefits, but its genotoxic potential due to colibactin production raises safety concerns, particularly in relation to…

Adhesin RadD: the secret weapon of Fusobacterium nucleatum

Feb 12, 2026
This review discusses how Fusobacterium nucleatum adhesin RadD binds to CD147, promoting colorectal cancer proliferation. Targeting RadD may provide new therapeutic strategies for CRC treatment.

Akkermansia muciniphila modulates intestinal mucus composition to counteract high-fat diet-induced obesity in mice

Feb 8, 2026
This study shows that live Akkermansia muciniphila protects against diet-induced obesity by selectively remodeling intestinal mucus glycan composition and barrier gene expression, rather than…

Mucin-degrading gut bacteria: context-dependent roles in intestinal homeostasis and disease

Feb 8, 2026
This review explains how mucin-degrading gut bacteria regulate barrier integrity, immunity, and disease risk in a context-dependent manner. It highlights why microbes such as Akkermansia muciniphila…

Investigating the roles of Listeria monocytogenes peroxidases in growth and virulence

Feb 5, 2026
This study explores the role of peroxidase enzymes in Listeria monocytogenes pathogenesis, revealing how the bacteria survive oxidative stress and how targeting specific enzymes could offer new…

Escherichia coli Nissle 1917 Inhibits Clostridium perfringens Growth and Modulates Inflammation

Nov 5, 2025
This study evaluates the inhibitory effects of Escherichia coli Nissle 1917 (EcN) on Clostridium perfringens type A, focusing on growth inhibition, toxin production, biofilm formation, and…

Fecal microbiota transplantation and next-generation therapies: A review on targeting dysbiosis in metabolic disorders and beyond

Aug 19, 2025
The review examines the therapeutic potential of FMT and next-generation microbiome therapies in treating metabolic disorders. It highlights the promising role of FMT in restoring microbial balance…

Model systems for the study of Enterococcal colonization and infection

Feb 16, 2026
This review shows that Enterococcus expands during microbiome disruption, forms polymicrobial biofilms, and activates virulence factors that promote colonization, immune evasion, and systemic…

Staphylococcus aureus Virulence Review: Toxins, Immune Evasion, and Therapeutic Targets

Jul 8, 2025
This review outlines how S. aureus leverages diverse virulence factors—α-toxin, leukocidins, biofilms, and immune evasion mechanisms—regulated by systems like Agr to persist and cause disease. It…

Pathogenicity and virulence of Clostridium perfringens

Feb 14, 2026
This review explains how Clostridium perfringens uses toxin production, plasmid gene transfer, and microbiome colonization to cause intestinal and systemic disease. Virulence regulation, sporulation,…

Akkermansia muciniphila: A promising probiotic against inflammation and metabolic disorders

Feb 8, 2026
This review summarizes evidence that Akkermansia muciniphila reduces inflammation and improves metabolic health by strengthening the gut barrier and regulating immune signaling. Findings support its…

Mechanistic insights into staphylopine-mediated metal acquisition

Feb 3, 2026
This study reveals how S. aureus uses staphylopine (StP) to acquire transition metals, with CntA playing a central role in metal recognition and transport. The findings highlight new potential…

Significance and Characteristics of Listeria monocytogenes in Poultry Products

Feb 5, 2026
This study explores Listeria monocytogenes contamination in poultry products, highlighting serotype distribution, antimicrobial resistance, and molecular subtyping methods used to track outbreaks and…

The Link between Ankylosing Spondylitis, Crohn’s Disease, Klebsiella, and Starch Consumption

Dec 8, 2025
This article investigates the relationship between ankylosing spondylitis, Crohn’s disease, Klebsiella pneumoniae, and starch consumption, suggesting that high starch intake may trigger the growth of…

Disulfiram and Copper Ions Kill Mycobacterium tuberculosis in a Synergistic Manner

Sep 6, 2025
This study shows that disulfiram, in combination with copper ions, significantly enhances the bactericidal effects against M. tuberculosis, especially against drug-resistant strains. The…

Regulation of VanA- and VanB-Type Glycopeptide Resistance in Enterococci

Feb 16, 2026
What was reviewed? This review examined how Enterococcus faecalis and Enterococcus faecium regulate VanA- and VanB-type glycopeptide resistance, which enables survival during vancomycin and related…

The Gut Microbiome in Aging and Ovarian Cancer

Aug 8, 2025
This review examines how the aging gut microbiome affects ovarian cancer progression. It highlights microbial dysbiosis as a common feature in both aging and cancer, with implications for novel…

Genotoxic Escherichia coli Strains Encoding Colibactin, Cytolethal Distending Toxin, and Cytotoxic Necrotizing Factor in Laboratory Rats

Jan 15, 2026
This study found that many SPF laboratory rats carry phylogroup B2 E. coli with genotoxins, especially the pks colibactin island, and that vendor source strongly affects prevalence. These strains…

Impact of occupational exposure on human microbiota

Jan 25, 2026
This review explains how workplace microbes, chemicals, metals, and air pollution can change the adult human microbiome. It highlights links to colonization, gut permeability, and immune effects, and…

Specific Histidine Residues Confer Histatin Peptides with Copper-Dependent Activity against Candida albicans

Sep 2, 2025
Copper-dependent activity against Candida albicans rises when histatin peptides bind copper via a proximal bis-His site, lowering EC50 and improving killing in vitro; copper chelation reverses this…

Chronic arsenic exposure perturbs gut microbiota and bile acid homeostasis in mice

Sep 15, 2025
This study explores the effects of chronic arsenic exposure on the gut microbiota and bile acid metabolism in mice, revealing significant changes in microbial composition and bile acid homeostasis,…

F1C Fimbriae Play an Important Role in Biofilm Formation and Intestinal Colonization by the Escherichia coli Commensal Strain Nissle 1917

Nov 16, 2025
This study shows how F1C fimbriae in Escherichia coli Nissle 1917 drive biofilm formation, epithelial adhesion, and intestinal persistence, defining a functional microbiome signature for stable…

Bioremediation and Tolerance of Humans to Heavy Metals through Microbial Processes: a Potential Role for Probiotics?

Jan 7, 2026
What was reviewed? This review focuses on the role of probiotics, specifically lactobacilli, in bioremediation and the detoxification of heavy metals. The paper reviews how microbial processes,…

Dietary copper-fructose interactions alter gut microbial activity in male rats

Sep 2, 2025
Dietary copper-fructose interactions in rats depleted Akkermansia, shifted Firmicutes families, weakened tight junctions and goblet cells, and raised liver injury signals, defining a…

Transition metals and virulence in bacteria

Dec 8, 2025
What was reviewed? This review article examines how transition metals shape bacterial virulence through three interconnected processes: acquisition, limitation, and intoxication. It emphasizes the…

Role of Fungi in Tumorigenesis: Promises and Challenges

Aug 19, 2025
This review explores the role of fungi in cancer progression, highlighting their impact on tumor development and immune responses. It emphasizes the potential for mycobiome-based cancer diagnostics…

M. canis Antifungal Resistance: Enzymatic Correlates and Drug Efficacy

Jul 27, 2025
This study identified catalase and hemolysin as key virulence factors linked to antifungal resistance in Microsporum canis strains from symptomatic hosts. Voriconazole, terbinafine, and posaconazole…

Ciclopirox Antifungal and Anti-Inflammatory Review: Dermatology to Oncology

Jul 28, 2025
Ciclopirox and its salt form exhibit broad-spectrum antifungal, antibacterial, and anti-inflammatory activity via iron chelation and enzyme inhibition. With low resistance potential, they outperform…

Effects of Hydrogen Sulfide on the Microbiome: From Toxicity to Therapy

Sep 24, 2025
The review examines the complex role of hydrogen sulfide in modulating the gut microbiome, highlighting its potential as a therapeutic agent to stabilize microbiota biofilms and reduce inflammation…

Avoiding death by autophagy: interactions of Listeria monocytogenes with the macrophage autophagy system

Feb 5, 2026
This review explains how Listeria monocytogenes triggers and then evades macrophage autophagy, including SLAP formation that supports slow intracellular persistence.

Metallophores Drive Staphylococcus aureus Virulence and Pathogenicity

Jul 8, 2025
Metallophores in S. aureus enable metal acquisition and virulence; disrupting these systems may offer novel antimicrobial strategies.

The Key Element Role of Metallophores in the Pathogenicity and Virulence of Staphylococcus aureus: A Review

Jun 15, 2025
Metallophores in S. aureus are critical for pathogenicity, enabling metal acquisition under nutritional immunity. This review highlights their biosynthesis, regulation, and role in virulence,…

Zinc in Human Health and Infectious Diseases

Sep 6, 2025
This review maps zinc in human health and infectious diseases, linking host zinc control to pathogen survival, clinical trial signals, and simple gene and protein markers that explain microbiome…

Probiotics as Anti-Tumor Agents: Insights from Female Tumor Cell Culture Studies

Aug 7, 2025
Probiotics were shown to significantly reduce cancer cell proliferation, promote apoptosis, and inhibit migration in breast and ovarian cancer cells, suggesting their potential as adjunctive cancer…

The Effect of Microbiome-Derived Metabolites in Inflammation-Related Cancer Prevention and Treatment

Nov 15, 2025
This review explores the role of microbiome-derived metabolites in inflammation-related cancer prevention and treatment, highlighting their dual effects in modulating inflammation and immune…

Spatial Heterogeneity of Intratumoral Microbiota: A New Frontier in Cancer Immunotherapy Resistance

Aug 19, 2025
This review investigates the spatial heterogeneity of intratumoral microbiota and its impact on cancer immunotherapy resistance. It highlights how microbial distribution within tumors influences…

Heavy Metal–Gut Microbiota Interactions: Probiotics Modulation and Biosensors Detection

Sep 22, 2025
This review highlights how heavy metals alter the gut microbiota and discusses the potential of probiotics to mitigate these effects. It also emphasizes the role of advanced biosensors in detecting…

A new role of glutathione peroxidase 4 during human erythroblast enucleation

Jan 18, 2026
This study identifies GPX4 as essential for human erythroblast enucleation, independent of ferroptosis. The results show that lipid raft clustering and myosin phosphorylation, which are necessary for…

Gut Microbiota as Potential Biomarker and/or Therapeutic Target to Improve the Management of Cancer

Jan 15, 2026
This review explains how gut microbiota can guide cancer screening and treatment, focusing on colibactin-producing E. coli in colorectal cancer. It links pks-positive E. coli to DNA damage,…

Towards Understanding Tumour Colonisation by Probiotic Bacterium E. coli Nissle 1917

Nov 8, 2025
Escherichia coli Nissle 1917 (EcN) shows promise as a tumour-targeting probiotic bacterium for cancer treatment and detection. This review investigates its tumour-homing abilities and outlines future…

Probiotics Mechanism of Action on Immune Cells and Beneficial Effects on Human Health

Aug 19, 2025
This review examines the immunomodulatory effects of probiotics, detailing how they enhance immune functions through interactions with immune cells in the gut. Probiotics help regulate cytokine…

IDSA 2014 Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections

Feb 14, 2026
This guideline explains how microbiome-derived pathogens cause skin and soft tissue infections and highlights key microbial signatures linked to severe disease.

The Enterococcus: a Model of Adaptability to Its Environment

Feb 16, 2026
What was reviewed? This review examined how Enterococcus faecalis and Enterococcus faecium adapt to the gut microbiome, hospital environments, and host tissues through genetic plasticity,…

Listeria monocytogenes Internalin and E-cadherin: From Bench to Bedside

Feb 5, 2026
This study investigates the role of Listeria monocytogenes internalin A in the interaction with human E-cadherin, essential for invasion across host barriers, including the placenta, highlighting its…

Role of Probiotics in the Management of Helicobacter pylori

Sep 12, 2025
This review examines the use of probiotics in managing H. pylori infection, emphasizing their role in enhancing eradication rates, reducing side effects, and restoring gastric microbiota balance. The…

Magnesium Matters: A Comprehensive Review of Its Vital Role in Health and Diseases

Jan 28, 2026
This review explains how magnesium supports energy, vascular function, immunity, glucose control, bone strength, and muscle health, and how low intake or poor absorption can raise risks for…

Diagnostic Procedures for Inflammatory Bowel Disease: Laboratory, Endoscopy, Pathology, Imaging, and Beyond

Dec 6, 2025
The study examines the role of microbiome in IBD, highlighting its potential in diagnosing, predicting disease progression, and personalizing treatments.

Emergence of penicillin resistance among Fusobacterium nucleatum populations of commensal oral flora during early childhood

Feb 12, 2026
This study reveals a significant increase in penicillin-resistant Fusobacterium nucleatum in children due to beta-lactamase production, highlighting the role of antimicrobial exposure in the rise of…

Arsenic Exposure Perturbs the Gut Microbiome and Its Metabolic Profile in Mice: An Integrated Metagenomics and Metabolomics Analysis

Sep 13, 2025
Arsenic exposure perturbs the gut microbiome in mice and rewires fecal, urinary, and plasma metabolites, including sharp shifts in indole and bile acid pathways, alongside loss of several Firmicutes…

Bacterial Heavy Metal Resistance Systems: Mechanisms, Genes, and Clinical Implications

Jul 8, 2025
This review examines bacterial resistance systems to toxic metals, detailing efflux pumps, ATPases, and metallothioneins. It explores their mechanisms, gene regulation, and clinical or environmental…

Escherichia coli Nissle 1917 protects gnotobiotic pigs against human rotavirus by modulating plasmacytoid dendritic and natural killer cell responses

Nov 7, 2025
Escherichia coli Nissle 1917 (EcN) significantly enhances protection against human rotavirus in gnotobiotic pigs by modulating plasmacytoid dendritic cells and NK cell responses, suggesting its…

Magnesium modulates phospholipid metabolism to promote bacterial phenotypic resistance to antibiotics

Jan 30, 2026
Magnesium influences bacterial phenotypic resistance by modulating fatty acid and phospholipid metabolism in Vibrio species, leading to reduced antibiotic uptake and increased resistance to drugs…

Comparative Genome Analysis of Fusobacterium nucleatum

Feb 13, 2026
This study identifies Fusobacterium nucleatum W1481 as a potential new subspecies, with unique genomic islands and antibiotic resistance mechanisms, highlighting its role in periodontal disease and…

Gallium as novel Antimicrobial Agents: Innovations in Combating Drug-Resistant Pathogens

Nov 29, 2025
This review highlights gallium’s role as an iron mimic disrupting bacterial iron metabolism, effective against multidrug-resistant pathogens. Innovations in gallium delivery, including…

Shared and distinct mechanisms of iron acquisition by bacterial and fungal pathogens of humans

Feb 5, 2026
This study on Listeria monocytogenes reveals its mechanisms for acquiring iron from host proteins and external siderophores. Understanding these strategies aids in developing new treatments for…

How Listeria monocytogenes organizes its surface for virulence

Feb 5, 2026
This study explores how Listeria monocytogenes organizes its surface proteins, specifically InlA and InlH, to adapt to different host environments and promote virulence, shedding light on the dynamic…

Siderophore-Microcins in Escherichia coli: Determinants of Digestive Colonization, the First Step Toward Virulence

Nov 15, 2025
his review shows how siderophore microcins in Escherichia coli support competitive gut colonization, connect the fecal reservoir with urinary tract infection, and define functional microbiome…

Zinc and Microsporum canis: Targeting ZafA to Disrupt Fungal Virulence

Jul 27, 2025
Zinc deficiency significantly impairs Microsporum canis growth and virulence. The ZafA gene regulates zinc uptake and pathogenesis, and its deletion disrupts zinc transporters, conidiation, and host…

Fusobacterium nucleatum and colorectal cancer: From phenomenon to mechanism

Feb 13, 2026
This review explores the role of Fusobacterium nucleatum in colorectal cancer, its impact on tumor progression, metastasis, immune modulation, and chemoresistance, and proposes potential strategies…

The interplay between copper metabolism and microbes: In perspective of host copper-dependent ATPases ATP7A/B

Sep 2, 2025
This review highlights the complex relationship between copper metabolism and microbial infections. It focuses on the role of copper transporters ATP7A/B in regulating copper homeostasis and how…

The intratumoral microbiota: A new horizon in cancer immunology

Aug 18, 2025
This review explores the role of intratumoral microbiota in cancer progression and immunity. It discusses how microbiota influence tumor behavior and therapy outcomes, suggesting potential…

The ovarian cancer-associated microbiome contributes to the tumor’s inflammatory microenvironment

Aug 8, 2025
This review explores the ovarian cancer-associated microbiome’s role in shaping the inflammatory microenvironment of tumors. It discusses how microbial dysbiosis and its metabolites contribute…

Non-classical roles of bacterial siderophores in pathogenesis.

Sep 4, 2025
This review shows non-classical siderophore roles in copper and zinc handling, oxidative stress control, and signaling, and maps gene–host markers that predict pathogen fitness across urine, gut, and…

Gut microbiota dysbiosis in inflammatory bowel disease: Interaction with intestinal barriers and microbiota-targeted treatment options

Dec 13, 2025
This review discusses the role of gut microbiota dysbiosis in IBD, its interaction with intestinal barriers, and the potential of microbiota-targeted therapies like antibiotics, probiotics, and FMT…

Histatins: Salivary peptides with copper(II)- and zinc(II)-binding motifs

Sep 2, 2025
This study examines the copper-binding properties of Hist-5, a salivary peptide, and its role in combating Candida albicans infections. The findings highlight the critical role of copper ions in…

Revisiting the steps of Salmonella gut infection with a focus on antagonistic interbacterial interactions

Nov 15, 2025
This review shows how Salmonella reshapes the gut environment and engages in Salmonella gut infection antagonistic interbacterial interactions with commensals, and it explains how bacteriocins and…

Response of Akkermansia muciniphila to Bioactive Compounds: Effects on Its Abundance and Activity

Feb 8, 2026
What was reviewed? This systematic review evaluated how bioactive compounds, including dietary fibers, polyphenols, antioxidants, human milk oligosaccharides, and selected pharmaceuticals, influence…

Streptococcus pneumoniae’s Virulence and Host Immunity: Aging, Diagnostics, and Prevention

Jan 29, 2026
The study investigates Streptococcus pneumoniae’s virulence, immune evasion strategies, and how aging impacts susceptibility to infections. It explores diagnostic and vaccine strategies for…

Akkermansia muciniphila and Gut Immune System: A Good Friendship That Attenuates Inflammatory Bowel Disease, Obesity, and Diabetes

Feb 7, 2026
This review examines how Akkermansia muciniphila shapes gut immune signaling to reduce inflammation, obesity, and diabetes risk. Evidence shows that its abundance and derived proteins strengthen the…

Bacteria-based immunotherapy for cancer: A systematic review of preclinical studies

Aug 19, 2025
This review explores bacteria-based immunotherapy for cancer, highlighting how bacteria and their components modulate immune responses to enhance tumor targeting and therapy outcomes. It also…

Dermatophyte Virulence and Host Immunity: Key Mechanisms and Clinical Implications

Jul 27, 2025
This review outlines the pathogenic strategies of dermatophytes and host antifungal responses, with a focus on keratinolytic enzymes, PRRs, Th17 immunity, and CARD9-related immune dysfunction,…

Intratumoral microbiota: Implications for cancer onset, progression, and therapy

Aug 18, 2025
This review explores the role of intratumoral microbiota in cancer onset and progression, emphasizing their potential therapeutic applications in improving cancer treatment outcomes and offering new…

Fusobacterium-associated molecular and immunological alterations in colorectal cancer: Insights from a Norwegian cohort

Feb 13, 2026
This study reveals that Fusobacterium animalis is linked to increased immune gene expression and microsatellite instability in CRC. It suggests Fusobacterium’s role in tumor progression, offering…

Effects of Copper Addition on Copper Resistance, Antibiotic Resistance Genes, and intl1 during Swine Manure Composting

Sep 5, 2025
This study explores the effects of copper exposure on copper and antibiotic resistance genes during swine manure composting, revealing changes in microbial community composition and gene persistence,…

Distribution of Arsenic Resistance Genes in Prokaryotes

Sep 10, 2025
This review outlines the diversity, evolution, and distribution of arsenic resistance genes in prokaryotes, emphasizing their central role in the environmental microbiome, biogeochemical cycling, and…

Staphylococcus aureus Plasmids: Reservoirs of Antibiotic Resistance and Virulence Genes

Jul 8, 2025
This study sequenced and analyzed plasmids from poultry-associated Staphylococcus aureus, uncovering diverse resistance and virulence genes, novel mobilizable plasmids, and highlighting poultry as a…

Effect of Dietary Copper on Intestinal Microbiota and Antimicrobial Resistance Profiles of Escherichia coli in Weaned Piglets

Sep 2, 2025
Dietary copper effect on intestinal microbiota in weaned piglets increased E. coli abundance and raised ciprofloxacin and chloramphenicol resistance, while shifting key metabolic pathways without…

Oral Supplementation of Lead-Intolerant Intestinal Microbes Protects Against Lead (Pb) Toxicity in Mice

Aug 29, 2025
This review discusses the detrimental effects of lead (Pb) exposure on gut microbiota, metabolism, and homeostasis, highlighting its role in metabolic and systemic disorders. It suggests…

Innovative Strategies Toward the Disassembly of the EPS Matrix in Bacterial Biofilms

Aug 29, 2025
This study investigates EPS-rich biofilm dynamics, showing how biofilm dispersal via DNase and EPS-glycosidases influences microbial community structure and resilience. It highlights the role of…

How do intestinal probiotics restore the intestinal barrier?

Sep 12, 2025
The study examines how intestinal probiotics restore the intestinal barrier by regulating tight junctions, immune responses, and gut microbiota, offering insights into their therapeutic potential for…

Intra-species diversity of Clostridium perfringens: A diverse genetic repertoire reveals its pathogenic potential

Feb 14, 2026
This genomic study of 372 Clostridium perfringens strains revealed extreme genetic diversity, widespread toxin genes, and high antimicrobial resistance. Microbiome-associated virulence factors enable…

Effects of cadmium exposure on intestinal microflora of Cipangopaludina cathayensis

Sep 28, 2025
The study examines how cadmium exposure alters the microbiota in rats, causing microbial translocation and metabolic shifts. The findings highlight potential biomarkers for assessing cadmium toxicity.

Escherichia coli Nissle 1917 inhibits biofilm formation and mitigates virulence in Pseudomonas aeruginosa

Nov 15, 2025
E. coli Nissle 1917 demonstrates significant antibiofilm activity against P. aeruginosa, inhibiting biofilm formation and dispersing mature biofilms. Its CFS also downregulates key virulence factors…

Excessive consumption of mucin by over-colonized Akkermansia muciniphila promotes intestinal barrier damage during malignant intestinal environment

Feb 8, 2026
This study shows that excessive Akkermansia muciniphila colonization damages the intestinal mucus barrier and tight junctions in colorectal cancer models, worsening inflammation and disease…

Akkermansia muciniphila: new insights into resistance to gastrointestinal stress, adhesion, and protein interaction with human mucins through optimised in vitro trials and bioinformatics tools

Feb 8, 2026
This study shows that Akkermansia muciniphila survives gastrointestinal stress through aggregation, adheres preferentially to mucus-secreting intestinal cells, and interacts with human mucins via…

The synthesis of the novel Escherichia coli toxin—colibactin and its mechanisms of tumorigenesis of colorectal cancer

Jan 15, 2026
This mini-review explains how pks-positive E. coli make colibactin and how it drives colorectal cancer through DNA crosslinks, double-strand breaks, and mutational signatures such as SBS and ID-pks.…

The microbial landscape of tumors: A deep dive into intratumoral microbiota

Aug 19, 2025
This review examines the role of intratumoral microbiota in cancer progression, immune modulation, and therapy resistance. It highlights microbial species involved in tumor growth and discusses the…

First genomic analysis of a Clostridium perfringens strain carrying both the cpe and netB genes and the proposal of an amended toxin-based typing scheme

Feb 14, 2026
This genomic study identified a Clostridium perfringens strain carrying both enterotoxin and NetB toxin genes, revealing microbiome-driven virulence evolution through plasmid transfer. The findings…

Gut microbiota: Emerging biomarkers and potential therapeutics for premature ovarian failure

Aug 2, 2025
This paper explores how gut microbiota dysbiosis contributes to premature ovarian failure (POF) and highlights potential therapeutic interventions targeting GM for better management of POF.

Relationships Between Oral Microecosystem and Respiratory Diseases

Jan 5, 2026
This review explains how the oral microecosystem serves as a major source of lung microbes and a regulator of respiratory infection, inflammation, and disease severity.

Effects of a high-prebiotic diet versus probiotic supplements versus synbiotics on adult mental health: The “Gut Feelings” randomised controlled trial

Dec 28, 2025
This study evaluates the impact of prebiotics, probiotics, and synbiotics on mental health. It found that a high-prebiotic diet improved mood, anxiety, and stress, while probiotics and synbiotics…

The impact of intermittent fasting on gut microbiota: a systematic review of human studies

Jul 14, 2025
Intermittent fasting (IF) may positively influence gut microbiota by improving richness and diversity. However, findings are inconsistent across studies, requiring more research for clearer clinical…

How Toxic and Essential Metals Disrupt Gut Microbiota: A Comprehensive Review

Jul 22, 2025
This review maps the bidirectional interactions between toxic and essential metals and the gut microbiota, detailing microbial shifts and host impacts. It highlights specific microbial taxa disrupted…

The microbiome-product colibactin hits unique cellular targets mediating host–microbe interaction

Jan 15, 2026
This review explains how colibactin damages host DNA and also triggers bacterial SOS responses and prophage induction, reshaping gut communities and virulence. It connects barrier loss and…

Toxic and essential metals: metabolic interactions with the gut microbiota and health implications

Jan 7, 2026
This study explores the essential role of metal ions in human health, detailing their involvement in enzyme catalysis and the impacts of imbalances on diseases. It also highlights potential clinical…

Environmental cadmium exposure alters the internal microbiota and metabolome of Sprague–Dawley rats

Sep 22, 2025
The study investigates how cadmium exposure alters gut and blood microbiomes in rats, linking these changes to metabolic disruptions and systemic inflammation.

Heavy Metal Resistance Determinants of the Foodborne Pathogen Listeria monocytogenes

Feb 5, 2026
This review explores the mechanisms of heavy metal resistance in Listeria monocytogenes, focusing on arsenic and cadmium resistance genes and their potential role in persistence and virulence in food…

The Genetic Determinants of Listeria monocytogenes Resistance to Bacteriocins Produced by Lactic Acid Bacteria

Feb 5, 2026
This review discusses the genetic mechanisms behind Listeria monocytogenes resistance to LAB-produced bacteriocins, emphasizing receptor modifications and cross-resistance, and suggests strategies to…

Colibactin leads to a bacteria-specific mutation pattern and self-inflicted DNA damage

Jan 15, 2026
This study shows colibactin harms bacteria, triggers DNA damage defenses, and leaves a bacteria-specific mutation signature. Colibactin kills neighboring E. coli under contact-rich conditions,…

Cancer pharmacomicrobiomics: Targeting microbiota to optimise cancer therapy outcomes

Aug 19, 2025
The review discusses the impact of gut microbiota on cancer therapy outcomes, focusing on chemotherapy and immunotherapy. It highlights how microbiota influences drug effectiveness and immune…

The Effect of the Combination of Probiotics and Heavy Metals From Various Aspects in Humans: A Systematic Review of Clinical Trial Studies

Sep 10, 2025
This systematic review links probiotics and heavy metals to clinical outcomes, showing faster diarrhea recovery with zinc, fewer H. pylori therapy side effects, improved iron absorption with…

Relative Contributions of Ebp Pili and the Collagen Adhesin Ace to Host Extracellular Matrix Protein Adherence and Experimental Urinary Tract Infection by Enterococcus faecalis OG1RF

Feb 16, 2026
Enterococcus faecalis pili and adhesins enable microbiome persistence, collagen adherence, biofilm formation, and urinary tract infection. Loss of these factors reduces microbiome colonization and…

Klebsiella pneumoniae l-Fucose Metabolism Promotes Gastrointestinal Colonization and Modulates Its Virulence Determinants

Nov 18, 2025
This study shows that Klebsiella pneumoniae L fucose metabolism enhances gut colonization, strengthens biofilm and adherence traits, and increases virulence signalling, identifying a functional…

MntABC and MntH Enable Staphylococcus aureus to Overcome Host Nutritional Immunity and Manganese Starvation

Jul 9, 2025
This study shows that Staphylococcus aureus uses MntABC and MntH transporters to overcome host-imposed manganese starvation via calprotectin, preserving SOD activity and enabling systemic infection.

Identification of Multiple Iron Uptake Mechanisms in Enterococcus faecalis and Their Relationship to Virulence

Feb 17, 2026
Enterococcus faecalis utilizes five distinct iron uptake systems, including novel transporters, to maintain iron homeostasis and support virulence. Heme acquisition also plays a critical role in its…

Breaking down barriers: is intestinal mucus degradation by Akkermansia muciniphila beneficial or harmful?

Feb 8, 2026
This review explores when mucus degradation by Akkermansia muciniphila supports gut health and when it harms barrier integrity. Evidence shows its effects depend on host context, microbial balance,…

Fusobacterium nucleatum Outer Membrane Proteins Fap2 and RadD Induce Cell Death in Human Lymphocytes

Feb 13, 2026
What was studied? This study explored the role of Fusobacterium nucleatum’s outer membrane proteins, Fap2 and RadD, in inducing cell death in human lymphocytes. It focused on how these proteins,…

Role of Calprotectin in Withholding Zinc and Copper from Candida albicans

Sep 3, 2025
What was studied? This original study tested the Role of calprotectin in withholding zinc and copper from Candida albicans and defined when this host protein blocks metal nutrition to shape fungal…

Listeria monocytogenes Flagella Are Used for Motility, Not as Adhesins, To Increase Host Cell Invasion

Feb 5, 2026
This study examines the role of flagella in Listeria monocytogenes invasion, concluding that motility, not adhesion, is crucial for host cell invasion and early colonization.

Role of F1C Fimbriae, Flagella, and Secreted Bacterial Components in the Inhibitory Effect of Probiotic Escherichia coli Nissle 1917 on Atypical Enteropathogenic E. coli Infection

Nov 16, 2025
This study shows how Escherichia coli Nissle 1917 inhibitory mechanisms act through adhesion and suppression of EPEC virulence, defining a strong microbiome signature of pathogen interference.

Role of Copper Efflux in Pneumococcal Pathogenesis and Resistance to Macrophage-Mediated Immune Clearance

Sep 5, 2025
The study highlights the crucial role of the copA copper efflux system in the virulence of Streptococcus pneumoniae by protecting it from macrophage-mediated copper toxicity, a key immune defense.

Two Zinc Uptake Systems Contribute to the Full Virulence of Listeria monocytogenes during Growth In Vitro and In Vivo

Feb 5, 2026
This study examines how Listeria monocytogenes uses two zinc uptake systems (ZurAM and ZinABC) to survive within the host, highlighting their importance for growth and virulence during infection.

Effect of zinc and calcium ions on the production of alpha-toxin and proteases by Clostridium perfringens

Feb 14, 2026
This study shows that zinc stabilizes Clostridium perfringens alpha-toxin and protects it from protease degradation, while calcium promotes protease production that destroys toxin. These microbiome…

Metalloprotease Gene Family in Microsporum canis Identified as Potential Virulence Factors

Jul 27, 2025
This study identified a metalloprotease gene family in Microsporum canis and confirmed in vivo expression of MEP2 and MEP3 during infection. MEP3, a keratinolytic enzyme, was expressed recombinantly…

A Comprehensive Review of Progress in Preventing Urinary Infections Associated with the Use of Urinary Catheters: A Dual Analysis of Publications and Patents.

Nov 8, 2025
This review analyzes the advancements in preventing urinary catheter-related infections (CAUTIs) through scientific publications and patents, highlighting innovations like antimicrobial-coated…

Investigation of Antimicrobial Resistance Genes in Listeria monocytogenes from 2010 through to 2021

Feb 5, 2026
This study analyzes antimicrobial resistance in Listeria monocytogenes isolates from 2010 to 2021, finding no significant increase in resistance and highlighting key AMR genes.

Candida albicans Shields Porphyromonas gingivalis and Suppresses Host Immunity in Mixed-Species Periodontal Biofilms

Nov 29, 2025
C. albicans protects P. gingivalis from immune detection by enhancing gingipain activity, suppressing cytokine signaling, and promoting chronic bacterial persistence. Mixed biofilms weaken macrophage…

The Intestinal Microbiota: Impacts of Antibiotics Therapy, Colonization Resistance, and Diseases

Jan 5, 2026
This review explains how antibiotics disrupt gut microbiota, weaken colonization resistance, and increase infection and disease risk through metabolic and immune mechanisms.

The Connection between Czc and Cad Systems Involved in Cadmium Resistance in Pseudomonas putida

Sep 26, 2025
This study explored how the CzcRS3 two-component system regulates cadmium resistance in P. putida by controlling efflux pump gene expression. The findings emphasize the role of CadR in regulating…

CtpB Facilitates Mycobacterium tuberculosis Growth in Copper-Limited Niches

Sep 3, 2025
CtpB tailors Mycobacterium tuberculosis growth to copper-limited niches, boosts fitness in adipocytes, and raises copper stress risk during phagosomal surges, yielding a clear gene–niche signature…

Antibacterial MccM as the Major Microcin in Escherichia coli Nissle 1917 against Pathogenic Enterobacteria

Nov 16, 2025
This study shows that Escherichia coli Nissle 1917 microcin MccM is the key factor driving EcN’s inhibition of Salmonella, improving pathogen suppression, reducing cell invasion, and lowering…

From the Friend to the Foe—Enterococcus faecalis Diverse Impact on the Human Immune System

Feb 15, 2026
Enterococcus faecalis regulates immune tolerance and microbiome stability but becomes pathogenic during dysbiosis. It increases IgA production, modulates inflammatory signaling, and strengthens gut…

Virulence Factors of Microsporum canis: Enzymes, Genes, and Clinical Implication

Jul 27, 2025
This review details the enzymatic and genetic virulence arsenal of Microsporum canis, highlighting understudied factors like biofilms and dipeptidylpeptidases. Greater insight into these mechanisms…

Siderophore Biosynthesis Inhibitors: A Novel Strategy Against Microbial Virulence and Resistance

Aug 22, 2025
This review outlines current strategies targeting siderophore biosynthesis as a therapeutic approach to microbial infections, emphasizing enzyme-specific inhibitors, nanoparticle delivery, and…

Clostridium perfringens-Induced Necrotic Diseases: An Overview

Feb 14, 2026
This review explains how Clostridium perfringens causes necrotic disease through microbiome disruption, toxin production, and immune suppression. Microbiome imbalance increases pathogen abundance,…

The combined actions of the copper-responsive repressor CsoR and copper-metallochaperone CopZ modulate CopA-mediated copper efflux in the intracellular pathogen Listeria monocytogenes

Feb 5, 2026
This study explores copper resistance in Listeria monocytogenes, identifying how the csoR-copA-copZ operon, regulated by CsoR and CopZ, contributes to copper tolerance.

Gene regulation by the VirS/VirR system in Clostridium perfringens

Feb 14, 2026
This review explains how the VirS/VirR regulatory system controls toxin production and virulence in Clostridium perfringens. Microbiome signals activate toxin genes, enabling the bacterium to…

New insights into Clostridium perfringens epsilon toxin activation and action on the brain during enterotoxemia

Feb 14, 2026
This review explains how Clostridium perfringens epsilon toxin activates in the gut microbiome and causes brain injury, vascular damage, and systemic disease.

Expansion of the Clostridium perfringens toxin-based typing scheme

Feb 15, 2026
This review expands the Clostridium perfringens toxinotyping scheme to include toxinotypes F and G, linking enterotoxin and NetB production to specific microbiome-driven diseases. It highlights…

Functional analysis of an feoB mutant in Clostridium perfringens strain 13

Feb 14, 2026
This study shows that FeoB iron transport controls Clostridium perfringens growth, toxin production, and microbiome survival. Iron acquisition regulates virulence, metabolism, and infection risk,…

The molecular mechanisms of listeriolysin O-induced lipid membrane damage

Feb 5, 2026
This study reveals how Listeria monocytogenes uses listeriolysin O (LLO) to disrupt host cell membranes, aiding in bacterial survival and spread. It highlights the potential for LLO-targeted…

The MgtR regulatory peptide negatively controls expression of the MgtA Mg2+ transporter in Salmonella enterica serovar Typhimurium

Jan 28, 2026
This study shows that the Salmonella peptide MgtR directly limits the MgtA magnesium transporter during Mg2+ starvation. Deleting mgtR raises MgtA protein levels and makes MgtA appear earlier, which…

Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy

Feb 12, 2026
This study explores how Fusobacterium nucleatum contributes to chemoresistance in colorectal cancer by activating the autophagy pathway through the downregulation of specific microRNAs, offering…

De-coding the complex role of microbial metabolites in cancer

Nov 15, 2025
This review explores the complex role of microbial metabolites in cancer, focusing on their impact on tumor initiation, progression, metastasis, and therapy response. It highlights how microbial…

Copper in microbial pathogenesis: Meddling with the metal

Sep 2, 2025
This review explores copper’s role in microbial pathogenesis, highlighting its use by hosts as an antimicrobial weapon and the resistance mechanisms developed by pathogens. It discusses…

Probiotic Bacteria Reduce Salmonella Typhimurium Intestinal Colonization by Competing for Iron

Nov 8, 2025
Probiotic Escherichia coli Nissle 1917 iron competition reduced Salmonella in inflamed murine gut by using lipocalin-2–resistant siderophores and by dampening mucosal inflammation, showing a…

Defensive mutualism rescues NADPH oxidase inactivation in gut infection

Jan 6, 2026
In mice lacking epithelial NOX activity, the gut microbiome adapts by enriching H2O2-producing lactobacilli. This community suppresses Citrobacter rodentium virulence by downregulating LEE genes…

Fap2 Mediates Fusobacterium nucleatum Colorectal Adenocarcinoma Enrichment by Binding to Tumor-Expressed Gal-GalNAc

Feb 12, 2026
This study identifies the role of Fusobacterium nucleatum Fap2 in mediating bacterial enrichment in colorectal cancer by binding to tumor-expressed Gal-GalNAc. Targeting this interaction could reduce…

Commensal iron acquisition and nutritional immunity during Salmonella infection

Aug 22, 2025
XusB in Bacteroides thetaiotaomicron binds enterobactin in OMVs, sustains commensal fitness, and creates a lipocalin 2 resistant iron pool that Salmonella can recapture, redefining…

Necrotizing skin and soft-tissue infections in the intensive care unit

Feb 15, 2026
This review showed that toxin-producing Clostridium perfringens drives necrotizing infections by disrupting microbiome balance, destroying tissue, and promoting rapid pathogen expansion and disease…

The impact of iron on Listeria monocytogenes; inside and outside the host

Feb 5, 2026
This study explores the critical role of iron acquisition systems in Listeria monocytogenes pathogenesis, focusing on Fur-regulated iron transporters and their impact on bacterial survival and…

The rise and evolving role of Fusobacterium nucleatum subspecies

Feb 13, 2026
This study explores how Fusobacterium nucleatum promotes chemoresistance in colorectal cancer by activating autophagy and altering microRNA expression, highlighting potential therapeutic avenues.

Probiotics in addressing heavy metal toxicities in fish farming: Current progress and perspective

Sep 6, 2025
This study shows that probiotics can mitigate the effects of heavy metal toxicity in farmed fish. By binding metals and reducing oxidative stress, probiotics improve fish health and safety for…

Metal(loid)-gut microbiota interactions and microbiota-related protective strategies: A review

Jan 7, 2026
This review examines how metal(loid) exposure affects gut microbiota composition and function. It also evaluates microbiota-related strategies for metal(loid) detoxification.

Nickel exposure induces gut microbiome disorder and serum uric acid elevation

Nov 28, 2025
Nickel exposure induces gut microbiome disorder and serum uric acid elevation by disrupting purine-degrading microbes, increasing inflammatory taxa, impairing intestinal metabolism, and elevating…

What is the best strategy for moving microbiome-based therapies for functional gastrointestinal disorders into the clinic?

Sep 28, 2025
This review discusses the strategies for translating microbiome-based therapies into clinical practice for FGIDs, particularly IBS. It highlights the need for a systems approach integrating…

Arsenic disturbs the gut microbiome of individuals in a disadvantaged community in Nepal

Sep 8, 2025
In Nepal, arsenic disturbs the gut microbiome, driving sulfate-reducers and depleting commensals; urine arsenic best explains dysbiosis patterns with clear taxa-level signals useful for…

Unveiling the intratumoral microbiota within cancer landscapes

Aug 19, 2025
The review highlights the role of intratumoral microbiota in cancer initiation, progression, and therapy. It discusses the dual effects of these microbiota on immune responses, emphasizing their…

Intratumor microbiota and colorectal cancer: Comprehensive and lucid review

Aug 19, 2025
This review examines the role of intratumoral microbiota in colorectal cancer. It highlights how specific microbes influence tumor progression, immune responses, and therapy resistance, suggesting…

Microbiota-targeted interventions for mental health

Mar 19, 2025
This review explores microbiota-targeted interventions for mental health, including probiotics, prebiotics, synbiotics, FMT, and diet. While promising, large-scale trials are needed to refine…

The role of gut microbiota and metabolites in cancer chemotherapy

Aug 19, 2025
This review emphasizes how gut microbiota influences cancer chemotherapy efficacy and toxicity. It discusses microbial species, metabolites, and strategies to optimize chemotherapy response,…

A new member of the flavodoxin superfamily from Fusobacterium nucleatum that functions in heme trafficking and reduction of anaerobilin

Feb 13, 2026
This study uncovers the dual role of HmuF and FldH in Fusobacterium nucleatum’s anaerobic heme degradation, highlighting their functions in heme trafficking and reduction of anaerobilin, with…

Strategies to promote abundance of Akkermansia muciniphila, an emerging probiotics in the gut, evidence from dietary intervention studies

Feb 8, 2026
This review summarizes evidence that diet, prebiotics, and drugs such as metformin can increase Akkermansia muciniphila, a mucus-associated bacterium linked to improved metabolic health and reduced…

Vancomycin-resistant Enterococcus faecium: A current perspective on resilience, adaptation, and the urgent need for novel strategies

Feb 17, 2026
Enterococcus faecium (VREfm) has become a major healthcare threat due to its ability to acquire resistance and adapt to both clinical and environmental conditions. This review calls for new…

Inflammatory immunity and bacteriological perspectives: A new direction for copper treatment of sepsis

Sep 2, 2025
Copper treatment of sepsis links host copper delivery, microbial copper genes, and cell death pathways. The review highlights biomarker value and careful therapeutic targeting to aid control of…

Phenotypic and genotypic antimicrobial resistance of Listeria monocytogenes: an observational study in France

Feb 5, 2026
This study analyzes antimicrobial resistance in Listeria monocytogenes isolates from clinical and food environments in France, highlighting the low prevalence of acquired resistance and the continued…

Akkermansia muciniphila extracellular vesicles: Function and theranostic potential in disease

Feb 8, 2026
This review highlights Akkermansia-derived extracellular vesicles as powerful regulators of gut barrier function, immune balance, metabolism, and cancer response, positioning them as promising…

The Promise of Copper Ionophores as Antimicrobials

Sep 6, 2025
The promise of copper ionophores as antimicrobials rests on raising intracellular copper to disable core enzymes, restore antibiotic activity, and boost host killing, with clear microbial markers to…

Microsporum canis Whole Genome Sequencing Reveals Zoonotic Links

Nov 15, 2025
Genome sequencing of feline and canine Microsporum canis reveals close genetic identity to an invasive human strain and dissects secreted CAZymes that drive keratin degradation and potential zoonosis.

Antibiotic resistance plasmids and mobile genetic elements of Clostridium perfringens

Feb 14, 2026
This review explains how mobile plasmids drive antibiotic resistance and toxin spread in Clostridium perfringens, identifying key microbiome mechanisms behind treatment resistance and pathogenicity.

Clostridium perfringens type A–E toxin plasmids

Feb 15, 2026
This review showed that toxin plasmids control virulence in Clostridium perfringens by enabling toxin gene transfer between microbiome strains, allowing commensal bacteria to become pathogenic and…

Efflux pumps activation caused by mercury contamination prompts antibiotic resistance and pathogen’s virulence under ambient and elevated CO2 concentration

Jan 25, 2026
Mercury-contaminated paddy soil increased plant and human pathogen signals under both ambient and elevated CO₂. Metagenomics showed strong activation of efflux pumps, especially the RND family,…

Architecture of a PKS-NRPS hybrid megaenzyme involved in the biosynthesis of the genotoxin colibactin

Jan 15, 2026
What was studied? This study used structural biology to define how ClbK, a PKS–NRPS hybrid “megaenzyme” encoded by the pks biosynthetic gene cluster in colibactin-producing Enterobacteriaceae, is…

Arsenic induces structural and compositional colonic microbiome change and promotes host nitrogen and amino acid metabolism

Sep 15, 2025
The study explored the impact of arsenic exposure on the gut microbiome and host metabolism. The results demonstrated significant changes in microbial composition, which were linked to alterations in…

Gut microbial metabolism in ferroptosis and colorectal cancer

Jan 19, 2026
This review explains how gut microbes influence ferroptosis in colorectal cancer through vitamins, bile acids, SCFAs, and tryptophan metabolites. It highlights microbe-linked metabolites that either…

Emerging strategies for engineering E. coli Nissle 1917-based therapeutics

Nov 9, 2025
Engineering Escherichia coli Nissle 1917 therapeutics enables targeted antimicrobial, mucosal, metabolic, and anticancer actions but requires parallel engineering for biosafety and colibactin control.

THE ROLE OF GUT MICROBIOTA IN FETAL METHYLMERCURY EXPOSURE: INSIGHTS FROM A PILOT STUDY

Jan 25, 2026
This pilot study in late pregnancy linked maternal gut microbiota to mercury biomarkers and tested whether microbes directly change stool methylmercury. Stool methylmercury did not predict fetal…

Effect of a controlled food-chain mediated exposure to cadmium and arsenic on oxidative enzymes in the tissues of rats

Sep 19, 2025
This study reveals how cadmium and arsenic exposure via the food chain disrupts oxidative enzyme activity in rats, leading to significant health risks, particularly in the liver and kidneys.

Bacteriophage P100 for control of Listeria monocytogenes in foods: Genome sequence, bioinformatic analyses, oral toxicity study, and application

Feb 5, 2026
This study demonstrates that bacteriophage P100 is a safe and effective biocontrol agent for reducing Listeria monocytogenes in soft cheeses, offering a promising alternative to traditional…

Functional Identification of Conjugation and Replication Regions of the Tetracycline Resistance Plasmid pCW3 from Clostridium perfringens

Feb 14, 2026
This study shows how the pCW3 plasmid enables transfer of tetracycline resistance and toxin genes in Clostridium perfringens, identifying key microbiome mechanisms driving resistance and virulence…

Clostridium perfringens Spore Germination: Characterization of Germinants and Their Receptors

Feb 15, 2026
This study showed that Clostridium perfringens spore germination depends on specific germinant receptors, especially GerK, which detect nutrients like potassium and amino acids. GerK controls…

Staphylococcus aureus HrtA-heme-toxicity : ATPase function and heme-stress virulence reprogramming in S. aureus

Aug 22, 2025
HrtA is the ATPase of HrtAB that protects S. aureus from heme toxicity. Catalytic residues are essential in vitro and in vivo. Heme-stressed hrtA mutants undergo stringent-like reprogramming with a…

The Fsr Quorum-Sensing System of Enterococcus faecalisModulates Surface Display of the Collagen-Binding MSCRAMM Ace through Regulation of gelE

Feb 17, 2026
What was studied? This study examined the Fsr quorum-sensing system in Enterococcus faecalis and its role in regulating the surface display of the collagen-binding protein Ace, a key virulence…

CadC, the transcriptional regulatory protein of the cadmium resistance system of Staphylococcus aureus plasmid pI258

Sep 25, 2025
This study identifies CadC as a key transcriptional regulator of the cadmium resistance operon in S. aureus plasmid pI258, revealing its role in controlling cadA expression in response to metal ions…

Cuprous Oxidase Activity of CueO from Escherichia coli.

Sep 3, 2025
The cuprous oxidase activity of CueO converts toxic Cu(I) to Cu(II) in E. coli, partners with CopA and CusCFBA, and marks copper-tolerant Enterobacterales that can persist in acidic, inflamed gut…

Mycobacterium tuberculosis and Copper: A Newly Appreciated Defense against an Old Foe?

Sep 3, 2025
Mycobacterium tuberculosis and copper shows copper rises at infection sites, while bacterial systems (MctB, CsoR–CtpV, RicR–MymT/MmcO) defend against toxicity; these markers inform clinical risk and…

The Role of Copper and Zinc Toxicity in Innate Immune Defense against Bacterial Pathogens

Sep 2, 2025
Copper and zinc toxicity in innate immunity drives early control of bacterial pathogens and shapes mucosal niches. The review links host metal routing and microbial export genes to killing,…

Enterococcus VanB Resistance Enables Microbiome Persistence and Infection

Feb 16, 2026
VanB Enterococcus strains show inducible vancomycin resistance, enabling microbiome persistence and infection risk. Diagnostic methods reliably detect resistant strains, but low-level resistance may…

Combined DNase and Proteinase Treatment Interferes with Composition and Structural Integrity of Multispecies Oral Biofilms

Aug 29, 2025
The study investigates the effects of DNase I and proteinase K on the structure and composition of multispecies oral biofilms, finding that these enzymes disrupt biofilm integrity and shift microbial…

Mechanisms of Colonization Resistance Against Clostridioides difficile

Jan 3, 2026
This review explains how gut microbes prevent Clostridioides difficile infection through bile acid metabolism, short-chain fatty acids, nutrient competition, and direct antagonism, highlighting…

Zinc-Induced Siderophore Production in Penicillium and Rhizosphere Fungi

Jul 28, 2025
Zinc ions enhanced siderophore production in fungi from Panax ginseng rhizosphere, with optimal levels at 150 µg/ml. Penicillium commune JJHO produced ferrichrome-type siderophores, suggesting zinc…

Functional characterization of a cadmium resistance operon in Staphylococcus aureus ATCC12600: CadC does not function as a repressor

Sep 25, 2025
The study identifies and characterizes the cadmium resistance operon in S. aureus ATCC12600. It reveals that the cadC gene is crucial for cadmium efflux and resistance but does not function as a…

Microsporum canis Antifungal Susceptibility and Therapy: A Review

Jul 27, 2025
This review evaluates antifungal susceptibility and therapeutic options for Microsporum canis, highlighting methodological variability in testing and identifying terbinafine and itraconazole as the…

Genetic Clustering and Virulence Insights in Microsporum canis: Clinical Isolates from US Cats

Jul 27, 2025
This US-based study reveals that M. canis genotype correlates with disease severity in cats, identifies three genetic clusters, and confirms the dominance of the MAT1-1 mating type. Conserved…

How Oxygen Shapes Lactate Metabolism in Staphylococcus aureus: Insights from In Vivo NMR

Jul 8, 2025
The study demonstrates that Staphylococcus aureus adapts its glucose and lactate metabolism to oxygen levels, efficiently catabolizing lactate to acetate under aerobic conditions. This…

Protective Effects of Lactobacillus plantarum CCFM8246 against Copper Toxicity in Mice

Sep 6, 2025
Lactobacillus plantarum CCFM8246 shows protective effects against copper toxicity in mice by promoting copper excretion, alleviating oxidative stress, and improving liver function and cognitive…

HapX in Arthroderma benhamiae: Iron Regulation Without Virulence Loss

Jul 28, 2025
HapX regulates iron metabolism in A. benhamiae by controlling siderophore production and repressing iron-dependent genes, yet is dispensable for keratin-based virulence, suggesting compensatory iron…

The Pore-Forming Toxin Listeriolysin O Mediates a Novel Entry Pathway of L. monocytogenes into Human Hepatocytes

Feb 5, 2026
This study uncovers how Listeria monocytogenes uses listeriolysin O (LLO) to induce host cell entry via membrane perforation, a novel pathogen strategy for invasion.

Copper at the Front Line of the Host-Pathogen Battle

Sep 2, 2025
This review explores the critical role of copper in microbial pathogenesis, focusing on how the host uses it as an antimicrobial weapon and how pathogens resist Cu toxicity. It suggests potential…

Manganese acquisition is essential for virulence of Enterococcus faecalis

Feb 17, 2026
What was studied? This study examined the role of manganese (Mn) acquisition in the virulence of Enterococcus faecalis. Researchers identified and characterized the key manganese transport systems in…

Nickel-Dependent Urease Enables Staphylococcus aureus Persistence in Acidic Environments

Nov 27, 2025
Urease enables S. aureus to survive acid stress and persist in murine kidneys. Its expression is regulated by CcpA and Agr, and its activity is essential for long-term infection, highlighting a…

Deciphering the interplay between the genotoxic and probiotic activities of Escherichia coli Nissle 1917

Nov 7, 2025
This study uncovers the dual role of Escherichia coli Nissle 1917, where its beneficial antibacterial activity is linked to the ClbP protein, while its genotoxic effects are dependent on colibactin.…

Effects of chronic exposure to arsenic on the fecal carriage of antibiotic-resistant Escherichia coli among people in rural Bangladesh

Sep 12, 2025
This study evaluates the relationship between arsenic exposure and antibiotic-resistant E. coli carriage in rural Bangladesh, revealing significant associations between arsenic contamination and…

Fn-Dps, a novel virulence factor of Fusobacterium nucleatum, disrupts erythrocytes and promotes metastasis in colorectal cancer

Feb 13, 2026
This study reveals Fn-Dps, a virulence factor from Fusobacterium nucleatum, as a key player in colorectal cancer metastasis, immune evasion, and erythrocyte disruption, highlighting its potential as…

Intratumoral Microbiota: Insights from Anatomical, Molecular, and Clinical Perspectives

Aug 19, 2025
What was studied? This review article explores the role of intratumoral microbiota in cancer initiation, progression, and therapeutic responses. It highlights the complex interactions between…

Why does Listeria monocytogenes survive in food and food-production environments?

Feb 5, 2026
This review explores the survival mechanisms of Listeria monocytogenes in food production environments, focusing on stress resistance, biofilm formation, and its persistence despite sanitation…

A Meta-Analysis on the Association of Colibactin-Producing pks+ Escherichia coli with the Development of Colorectal Cancer

Jan 15, 2026
What was studied? This study performed a meta-analysis to clarify whether carrying colibactin-producing pks+ Escherichia coli associates with a higher risk of colorectal cancer (CRC), because prior…

Structural and Functional Analysis of the Pore-Forming Toxin NetB from Clostridium perfringens

Feb 14, 2026
This study defines how the NetB toxin from Clostridium perfringens forms membrane pores and drives enteric disease, linking toxin structure to microbiome-associated virulence and epithelial damage.

Host subversion of bacterial metallophore usage drives copper intoxication

Sep 3, 2025
Host subversion of bacterial metallophore usage shows that zinc starvation makes S. aureus import copper via staphylopine, triggering copper stress and reducing fitness in vivo; these loci and host…

Genetic Determinants of Hydrogen Sulfide Biosynthesis in Fusobacterium nucleatum Are Required for Bacterial Fitness, Antibiotic Sensitivity, and Virulence

Feb 12, 2026
This study identifies MegL as the major enzyme for H2S production in Fusobacterium nucleatum, crucial for bacterial fitness, antibiotic resistance, and virulence in preterm birth, offering potential…

The Colibactin Genotoxin Generates DNA Interstrand Cross-Links in Infected Cells

Jan 15, 2026
his study shows colibactin-producing bacteria directly create DNA interstrand cross-links in human cells, triggering ATR replication stress and Fanconi repair responses. Blocking colibactin…

Nickel exposure reduces enterobactin production in Escherichia coli.

Sep 4, 2025
Nickel exposure reduces enterobactin production in Escherichia coli, extends lag phase, triggers iron-starvation signals, and lowers extracellular catechols, defining gene and metal markers to track…

The role of the microscopic world: Exploring the role and potential of intratumoral microbiota in cancer immunotherapy

Aug 19, 2025
This review explores the complex role of intratumoral microbiota in cancer, emphasizing their influence on immune responses and the potential for microbiome-based therapies in cancer immunotherapy.…

A General Overview on the Hyperbaric Oxygen Therapy: Applications, Mechanisms and Translational Opportunities

Feb 15, 2026
What was reviewed? This review examined the biological mechanisms, clinical applications, and translational potential of hyperbaric oxygen therapy (HBOT), a treatment that delivers 100% oxygen under…

Ovarian Cancer and the Microbiome: Connecting the Dots for Early Diagnosis and Therapeutic Innovations—A Review

Aug 7, 2025
This review explores the role of the microbiome in ovarian cancer, emphasizing its potential for early diagnosis and treatment. The use of microbiome-based biomarkers and therapies like fecal and…

Gut Microbiota-Based Immunotherapy: Engineered Escherichia coli Nissle 1917 for Oral Delivery of Glypican-1 in Pancreatic Cancer

Nov 9, 2025
Oral delivery of a glypican-1–flagellin fusion by engineered EcN triggered systemic IgG and regulatory IL-10 in mice, confirming a safe probiotic cancer-vaccine chassis but indicating the need for…

Current understandings of colibactin regulation

Jan 15, 2026
This review explains how pks+ E. coli control colibactin production and why iron, oxygen, inflammation, diet, and drugs change DNA damage risk. It highlights ClbR regulation, inflammation-linked clb…

Candida albicans Enables Staphylococcus aureus “Hitchhiking” Across Mucosa

Nov 29, 2025
Candida albicans enables systemic Staphylococcus aureus infection via Als3p-mediated hyphal invasion. This “microbial hitchhiking” allows S. aureus to bypass epithelial barriers, with major…

Wide Spectrum Potent Antimicrobial Efficacy of Wound Dressings Impregnated with Cuprous Oxide Microparticles

Sep 5, 2025
Wound dressings impregnated with cuprous oxide cut bioburden fast, block bacterial passage, and act against common wound microbes with durable activity, offering a practical tool to reshape the wound…

Microbial Metallophores in the Productivity of Agroecosystems

Sep 26, 2025
Microbial metallophores are vital in sustainable agriculture, enhancing nutrient availability, promoting plant growth, and mitigating heavy metal toxicity. The study highlights their potential in…

Antimicrobial Resistance in Listeria Species

Feb 5, 2026
This review discusses the rising antimicrobial resistance in Listeria species, focusing on their resistance mechanisms to antibiotics, biocides, and heavy metals, and their implications for food…

Sporulation and Germination in Clostridial Pathogens

Feb 14, 2026
This review explains how Clostridium spores enable microbiome survival, toxin production, and infection through sporulation and germination.

Biology of Oral Streptococci

Jan 5, 2026
This review explains how oral streptococci shape biofilm formation, regulate microbial balance, and influence oral and systemic health through niche-specific adaptations.

Clostridium perfringens Sporulation and Sporulation-Associated Toxin Production

Feb 14, 2026
This review shows how Clostridium perfringens sporulation enables toxin production, microbiome persistence, and intestinal disease.

Surviving Between Hosts: Sporulation and Transmission

Feb 14, 2026
This review explains how Clostridium perfringens uses sporulation to survive microbiome stress, resist antibiotics, and transmit infection between hosts. Sporulation enables toxin production,…

Oral Microbiota and Tumor—A New Perspective of Tumor Pathogenesis

Aug 18, 2025
This review explores how the oral microbiota influences cancer pathogenesis, highlighting its role in immune modulation, inflammation, and tumor progression. It emphasizes the potential of oral…

Escherichia coli Nissle 1917 Antagonizes Candida albicans Growth and Protects Intestinal Cells from C. albicans-Mediated Damage

Nov 18, 2025
Escherichia coli Nissle 1917 inhibited Candida albicans growth, reduced virulence traits and protected intestinal cells, showing strong preventive potential through contact based and soluble…

Amebicidal Activity of Escherichia coli Nissle 1917 Against Entamoeba histolytica

Nov 18, 2025
This study shows that Escherichia coli Nissle exerts strong dose dependent amebicidal activity against Entamoeba histolytica through oxidative stress and structural damage, highlighting its…

Diversity of Mercury-Tolerant Microorganisms

Jan 23, 2026
This review explains how mercury-tolerant bacteria, fungi, and microalgae resist and transform mercury. It highlights detox genes such as the mer system, biofilm binding, and redox-driven methylation…

Akkermansia muciniphila in the Human Gastrointestinal Tract: When, Where, and How?

Feb 7, 2026
This review maps where Akkermansia muciniphila appears across the human gut and beyond, from early infancy to old age. Evidence links higher abundance with stronger mucus-barrier function and better…

The Dysbiosis of Gut Microbiota Caused by Low-Dose Cadmium Aggravate the Injury of Mice Liver through Increasing Intestinal Permeability

Sep 28, 2025
This study reveals how low-dose cadmium exposure disrupts gut microbiota, increasing intestinal permeability and liver injury in mice. The findings emphasize the role of microbiota in modulating…

Listeria monocytogenes Biofilms in the Food Industry: Is the Current Hygiene Program Sufficient to Combat the Persistence of the Pathogen?

Feb 5, 2026
The review examines the persistence of Listeria monocytogenes biofilms in the food industry and evaluates current cleaning methods, offering insights into innovative control strategies.

Gut Microbiota and Colonization Resistance against Bacterial Enteric Infection

Jan 5, 2026
This review explains how gut microbiota prevent bacterial enteric infections through metabolic competition, antimicrobial activity, barrier support, and ecosystem stability.

The biology and pathogenicity of Clostridium perfringens type F: a common human enteropathogen with a new(ish) name

Feb 14, 2026
This review explains how Clostridium perfringens type F causes gastrointestinal disease through microbiome colonization, sporulation, and enterotoxin production. The toxin disrupts intestinal…

Role of internalin proteins in the pathogenesis of Listeria monocytogenes

Feb 5, 2026
This review explores the role of internalin proteins in Listeria monocytogenes pathogenesis, focusing on their ability to facilitate bacterial invasion, spread, and crossing of key host barriers such…

The biofunction of Akkermansia muciniphila in intestinal-related diseases

Feb 7, 2026
What was reviewed? This review synthesized experimental, translational, and clinical evidence describing the biological functions of Akkermansia muciniphila in intestinal-related diseases. The…

Germinant Synergy Facilitates Clostridium difficile Spore Germination under Physiological Conditions

Jan 30, 2026
This study explores the conditions that regulate C. difficile spore germination in the GI tract, showing how pH, bile salts, calcium, and amino acids interact to trigger germination, and how this…

Microcins mediate competition among Enterobacteriaceae in the inflamed gut

Nov 7, 2025
The study explores how Escherichia coli Nissle 1917’s microcins mediate competition in the inflamed gut, showing potential for therapeutic use in enterobacterial infections and colitis management.

The siderophore yersiniabactin binds copper to protect pathogens during infection

Sep 4, 2025
Yersiniabactin binds copper in vivo, protects UPEC from copper stress, and blocks catecholate-driven Cu(II)→Cu(I) toxicity, yielding a clear urinary microbiome signature with direct clinical use.

Engineered probiotic Escherichia coli can eliminate and prevent Pseudomonas aeruginosa gut infection in animal models

Nov 9, 2025
What was studied? Engineered Escherichia coli Nissle 1917 Pseudomonas aeruginosa control was tested as a live targeted therapy for gut infection. The authors rebuilt the earlier “sense-and-kill”…

Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae

Sep 18, 2025
The study uncovers how cadmium disrupts transition metal homeostasis in Streptococcus pneumoniae, affecting manganese and zinc uptake and contributing to oxidative stress.

Interplay between enterobactin myeloperoxidase and lipocalin 2 in the inflamed gut

Aug 22, 2025
Aferric enterobactin disables myeloperoxidase, granting E. coli a survival edge in colitis, while lipocalin 2 restores enzyme function and counters colonization.

The skin microbiome

Jan 3, 2026
This review explains how the skin microbiome shapes barrier function, immune responses, and disease risk, highlighting key microbial associations that protect against infection and drive inflammatory…

Effect of Dietary Magnesium Content on Intestinal Microbiota of Rats

Jan 30, 2026
This study explores how dietary magnesium levels affect the gut microbiota of rats. It shows that low magnesium increases beneficial microbes, while high magnesium promotes potentially harmful…

Health Effects and Therapeutic Potential of the Gut Microbe Akkermansia muciniphila

Feb 7, 2026
This review synthesizes evidence showing Akkermansia muciniphila supports gut barrier integrity, immune balance, and metabolic health through mucin degradation, SCFA production, and bioactive…

Clostridium perfringens—Opportunistic Foodborne Pathogen, Its Diversity and Epidemiological Significance

Feb 14, 2026
This review explains how Clostridium perfringens functions as a gut microbiome commensal and toxin-producing pathogen. Toxin genes, plasmid virulence, antimicrobial resistance, and microbiome…

Intestinal bacterial biofilms modulate mucosal immune responses

Jan 5, 2026
This review explains how intestinal bacterial biofilms directly modulate mucosal immunity and drive inflammation through structured microbial–host interactions.

Complete genome sequence of Clostridium perfringens, an anaerobic flesh-eater

Feb 14, 2026
This genome sequencing study revealed how Clostridium perfringens survives in the gut microbiome and causes disease. Virulence genes, toxin regulation, and host-dependent metabolism enable tissue…

Targeting and crossing of the human maternofetal barrier by Listeria monocytogenes: Role of internalin interaction with trophoblast E-cadherin

Feb 5, 2026
This study identifies the InlA–E-cadherin interaction as crucial for Listeria monocytogenes invasion of the human placenta, providing insights into mechanisms of fetoplacental listeriosis.

An arsenic metallochaperone for an arsenic detoxification pump

Sep 10, 2025
The study explores how ArsD, a metallochaperone, enhances ArsA’s ability to expel arsenic from cells, improving arsenic detoxification. This interaction increases arsenic resistance in E. coli, with…

Copper resistance is essential for virulence of Mycobacterium tuberculosis

Sep 3, 2025
Copper resistance is essential for virulence of Mycobacterium tuberculosis; MctB prevents copper build-up, and loss of MctB cripples survival in copper-rich granulomas, defining actionable microbial…

The peptide pheromone-inducible conjugation system of Enterococcus faecalis plasmid pCF10

Feb 16, 2026
Enterococcus faecalis uses pheromone signaling to detect microbiome conditions, transfer antibiotic resistance genes, and activate virulence. This system promotes microbiome persistence, bacterial…

Listeria monocytogenes hijacks CD147 to ensure proper membrane protrusion formation and efficient bacterial dissemination

Feb 5, 2026
This study highlights the critical role of CD147 in facilitating Listeria monocytogenes membrane protrusion formation and cell-to-cell spreading, offering insights into potential therapeutic targets…

Fluconazole Downregulates Metallothionein in Microsporum canis and Increases Copper Toxicity

Jul 28, 2025
Fluconazole downregulates the metallothionein gene in Microsporum canis, enhancing copper cytotoxicity. This ergosterol-independent antifungal mechanism reveals a novel vulnerability in M. canis and…

Impacts of Mercury Exposure Levels and Sources on the Demethylation of Methylmercury Through Human Gut Microbiota

Jan 25, 2026
This study shows human gut microbiota can demethylate methylmercury and that detox rates vary by exposure level and food source. Higher Desulfovibrio and methanogen signals aligned with faster…

Assessing the Role of the Gut Microbiome in Methylmercury Demethylation and Elimination in Humans and Gnotobiotic Mice

Jan 25, 2026
This study shows the gut microbiome helps clear dietary methylmercury by demethylating it in the intestine. People differed widely in elimination rates, which tracked with stool demethylation…

Optimizing Magnesium Uptake in Lacticaseibacillus Rhamnosus To Advance Nutribiotic Strategies

Jan 30, 2026
This study shows that Lacticaseibacillus rhamnosus can internalize magnesium from its environment, making it a potential probiotic carrier for improving magnesium absorption in the gut. The findings…

A double-blind placebo-controlled trial to study therapeutic effects of probiotic Escherichia coli Nissle 1917 in subgroups of patients with irritable bowel syndrome

Nov 8, 2025
Escherichia coli Nissle 1917 improved IBS modestly overall but clearly in postinfectious or postantibiotic IBS, was as safe as placebo, and fits a dysbiosis-linked microbiome signature that needs…

The probiotic Escherichia coli strain Nissle 1917 (EcN) stops acute diarrhoea in infants and toddlers

Nov 8, 2025
Escherichia coli Nissle 1917 acute diarrhoea therapy in infants and toddlers shortened illness from 4.8 to 2.5 days, raised response to 94.5%, and was as safe as placebo.

Identification of Fusobacterium nucleatum in primary and secondary endodontic infections

Feb 12, 2026
This study explores the prevalence of Fusobacterium nucleatum in primary and secondary endodontic infections, highlighting its association with clinical symptoms like pain and swelling. PCR detection…

Identification of Fusobacterium nucleatum in primary and secondary endodontic infections and its association with clinical features by using two different methods

Feb 13, 2026
This study identifies Fusobacterium nucleatum as a significant pathogen in primary endodontic infections, strongly associated with clinical features like pain and swelling. The higher detection rate…

Copper homeostasis in Enterococcus hirae

Sep 3, 2025
Copper homeostasis in Enterococcus hirae maps a four-gene circuit—CopA, CopB, CopY, CopZ—and a reductase that set copper uptake and export, yielding clear genomic markers to predict copper tolerance…

The probiotic Escherichia coli strain Nissle 1917 interferes with invasion of human intestinal epithelial cells by different enteroinvasive bacterial pathogens

Nov 7, 2025
Escherichia coli Nissle 1917 (EcN) interferes with the invasion of human intestinal epithelial cells by various pathogens through a secreted component, not by microcins or physical contact,…

Pregnancy-associated listeriosis in England and Wales

Feb 5, 2026
This study examines pregnancy-associated listeriosis in England and Wales, exploring factors influencing pregnancy outcomes and infant survival, with a focus on maternal symptoms and timing of…

The ArsD As(III) metallochaperone

Sep 10, 2025
This study investigates the structural and biochemical role of ArsD, a metallochaperone in E. coli, in enhancing arsenic detoxification by transferring As(III) to the ArsA ATPase, providing new…

Synergistic Nanoparticle–Essential Oil Combinations Show Promising Antifungal Activity

Jul 27, 2025
Ag₀.₉₉Fe₁.₀₁O₃ nanoparticles, especially when combined with cinnamon, clove, or lemongrass essential oils, exhibited strong synergistic antifungal effects against multiple dermatophytes, offering a…

Fusobacterium nucleatum-derived extracellular vesicles carrying virulence factor DNA trigger AIM2 inflammasome activation to facilitate UC progression

Feb 13, 2026
This study shows that Fusobacterium nucleatum-derived extracellular vesicles activate the AIM2 inflammasome in intestinal epithelial cells, leading to pyroptosis and exacerbating ulcerative colitis.…

Functional Proteins of Akkermansia Muciniphila: Impacts on Host Health and Metabolism

Feb 8, 2026
This review explains how Akkermansia muciniphila proteins, not just the bacterium itself, regulate immunity, metabolism, gut barrier integrity, cancer response, and neuroinflammation, highlighting…

FadA antigen of Fusobacterium nucleatum: implications for ceRNA network in colorectal cancer and adenomatous polyps progression

Feb 13, 2026
What was studied? This study investigated the impact of Fusobacterium nucleatum’s FadA antigen on the competing endogenous RNA (ceRNA) network involving ANXA2 (Annexin A2) and its role in the…

Association between premature ovarian insufficiency and gut microbiota

Jul 31, 2025
The study reveals a distinct gut microbiome profile in women with premature ovarian insufficiency (POI), with altered bacterial populations linked to hormonal changes, suggesting a potential role of…

Berberine and Palmatine Show Superior Antifungal Activity Against Microsporum canis

Jul 28, 2025
This study found that berberine and palmatine hydrochloride synergistically inhibit M. canis by disrupting cell structure and modulating virulence-related genes. The combination outperformed…

Toxin-neutralizing antibodies protect against Clostridium perfringens-induced necrosis in an intestinal loop model for bovine necrohemorrhagic enteritis

Feb 14, 2026
This study shows that toxin-neutralizing antibodies protect against Clostridium perfringens intestinal damage by blocking alpha toxin and perfringolysin O. These toxins drive microbiome-associated…

Intratumoral microbiome: Implications for immune modulation and innovative therapeutic strategies in cancer

Aug 19, 2025
This review explores the dual role of the intratumoral microbiome in cancer, highlighting its impact on immune modulation and its potential as a target for innovative therapeutic strategies,…

Akkermansia muciniphila: a microbial guardian against oxidative stress–gut microbiota crosstalk and clinical prospects

Feb 8, 2026
This review positions Akkermansia muciniphila as a key regulator of oxidative stress through mucin metabolism, bioactive proteins, and gut–organ signaling. Its clinical impact spans metabolic,…

Characteristics of the vaginal microbiome in women with premature ovarian insufficiency

Jul 31, 2025
This study identifies significant differences in vaginal microbiota between women with premature ovarian insufficiency (POI) and healthy controls, suggesting that microbial shifts could contribute to…

The effects of dietary fat on gut microbial composition and function in a mouse model of ovarian cancer

Aug 7, 2025
This study investigates the effects of ketogenic and high-fat diets on gut microbial composition and ovarian cancer progression in mice. It shows that high-fat diets increase tumor growth and disrupt…

Fusobacterium nucleatum: a transboundary pathogen in host-microbiota networks

Feb 12, 2026
This review explores Fusobacterium nucleatum’s role as a transboundary pathogen in diseases like colorectal cancer and inflammatory bowel disease, highlighting its virulence factors, immune…

Gentamicin combination treatment is associated with lower mortality in patients with invasive listeriosis: a retrospective analysis

Feb 5, 2026
This study demonstrates that gentamicin combination therapy significantly reduces 90-day mortality in patients with invasive listeriosis, especially in those with neurolisteriosis.

The metabolites of gut microbiota: their role in ferroptosis in inflammatory bowel disease

Jan 19, 2026
This review explains how gut microbiota metabolites—SCFAs, bile acids, and tryptophan products—shape ferroptosis in intestinal epithelial cells and influence IBD severity, highlighting microbial…

Non-digestible oligosaccharides directly regulate host kinome to modulate host inflammatory responses without alterations in the gut microbiota

Dec 28, 2025
The study provides molecular mechanisms showing how prebiotics like inulin and scFOS directly regulate host immune signaling to modulate inflammation, independent of microbiota changes.

Antibiotic-associated changes in Akkermansia muciniphila alter its effects on host metabolic health

Feb 7, 2026
This study shows that antibiotics can select Akkermansia muciniphila variants that lose their ability to protect against obesity and metabolic dysfunction. The findings reveal a direct mechanistic…

Intestinal effect of the probiotic Escherichia coli strain Nissle 1917 and its OMV

Nov 14, 2025
This review explains intestinal effect of Escherichia coli Nissle 1917 and its vesicles on the gut barrier, dysbiosis and mucosal immunity, and it links these microbial actions to clinical outcomes…

The Human Gut Microbiome’s Influence on Arsenic Toxicity

Sep 10, 2025
The human gut microbiome and arsenic toxicity are tightly linked: microbes change arsenic speciation and dose, while arsenic reshapes gut ecology, altering risk. Clinicians should integrate…

Vaccination against Clostridium perfringens type C enteritis in pigs: a field study using an adapted vaccination scheme

Feb 15, 2026
This study showed that vaccination against Clostridium perfringens type C protects piglets by generating neutralizing antibodies against beta toxin, preventing microbiome-driven intestinal necrosis…

Prophylaxis of acute respiratory infections via improving the immune system in late preterm newborns with E. coli strain Nissle 1917: a controlled pilot trial

Nov 8, 2025
Escherichia coli Nissle 1917 reduces the incidence of acute respiratory infections in late preterm newborns during the first month of life, with no adverse effects, highlighting its potential as a…

Intratumoral microbiota: Roles in cancer initiation, development and therapeutic efficacy

Aug 18, 2025
This review explores how intratumoral microbiota influence cancer initiation, progression, and therapy. It highlights their roles in immune modulation, tumor growth, and therapeutic resistance,…

Intratumoural microbiota: a new frontier in cancer development and therapy

Aug 18, 2025
This review discusses how intratumoral microbiota influence cancer progression and therapy. It explores their roles in immune modulation, inflammation, and treatment resistance, and suggests…

Mucosal immune response in biology, disease prevention and treatment

Jan 3, 2026
This review explains how mucosal immunity relies on constant interaction with the microbiome, showing how commensal microbes shape immune tolerance, barrier integrity, and protection against…

Ferroptosis: a potential bridge linking gut microbiota and chronic kidney disease

Jan 19, 2026
This review connects gut microbiota dysbiosis to ferroptosis biology in chronic kidney disease, emphasizing how microbial metabolites and altered antioxidant defenses can amplify iron-driven lipid…

An update on the human and animal enteric pathogen Clostridium perfringens

Feb 14, 2026
This review explains how Clostridium perfringens shifts from a gut microbiome commensal to a toxin-producing pathogen. Genomic diversity, toxin genes, antibiotic resistance, and microbiome disruption…

The gut microbiome is required for full protection against acute arsenic toxicity in mouse models

Sep 10, 2025
This study demonstrates that both a functional host As3mt enzyme and a stable, diverse gut microbiome—especially the presence of Faecalibacterium prausnitzii—are required for full protection against…

Improvement of a synthetic live bacterial therapeutic for phenylketonuria with biosensor-enabled enzyme engineering

Nov 9, 2025
Engineered EcN for phenylketonuria was upgraded to SYNB1934 using biosensor-enabled PAL evolution, doubling gut phenylalanine conversion and keeping biocontainment, supporting development of an oral…

Siderophore-mediated zinc acquisition enhances enterobacterial colonization of the inflamed gut

Nov 6, 2025
E. coli Nissle uses yersiniabactin to bind zinc, overcome calprotectin, and colonize the inflamed gut, defining a metal-driven microbiome signature linked to Enterobacteriaceae dominance in colitis,…

Structural and mechanistic insights into the cleavage of clustered O-glycan patches-containing glycoproteins by mucinases of the human gut

Feb 8, 2026
This study shows how gut bacterial mucinases precisely cleave O-glycan-rich glycoproteins using specialized structural adaptations, enabling controlled mucus turnover while preserving barrier…

Immunopeptidomics-based design of mRNA vaccine formulations against Listeria monocytogenes

Feb 5, 2026
This study explores the virulence mechanisms of Listeria monocytogenes, focusing on its surface proteins and iron acquisition systems, shedding light on potential therapeutic interventions and food…

Engineering tumor-colonizing E. coli Nissle 1917 for detection and treatment of colorectal neoplasia

Nov 8, 2025
This study demonstrates that engineered E. coli Nissle 1917 can selectively colonize colorectal adenomas and reduce tumor burden in mice. The probiotic also shows promise for non-invasive detection…

Exposure to environmental pollutants selects for xenobiotic-degrading functions in the human gut microbiome

Sep 28, 2025
This study highlights the significant impact of environmental pollutants on the gut microbiome, selecting for microbial functions that degrade xenobiotics and potentially promoting antibiotic…

The lipooligosaccharide of the gut symbiont Akkermansia muciniphila exhibits a remarkable structure and TLR signaling capacity

Feb 8, 2026
This study shows that Akkermansia muciniphila produces a uniquely structured lipooligosaccharide that preferentially activates anti-inflammatory TLR2 signaling while limiting TLR4-driven endotoxin…

Akkermansia muciniphila MucT harnesses dietary polyphenols as xenosiderophores for enhanced iron uptake

Feb 8, 2026
This study shows that Akkermansia muciniphila uses dietary polyphenols as iron carriers, enabling growth under iron limitation and outcompeting pathogenic bacteria through advanced iron acquisition…

Tumour-resident oncolytic bacteria trigger potent anticancer effects through selective intratumoural thrombosis and necrosis

Aug 19, 2025
This study demonstrates the potent anticancer effects of a tumor-resident bacterial consortium in both immunocompetent and immunocompromised mice. The consortium induces tumor remission through…

Listeriosis

Feb 5, 2026
The paper reviews Listeria monocytogenes, its global prevalence, risk factors, and clinical management of listeriosis, with a focus on vulnerable populations.

Bacterial siderophores in community and host interactions

Sep 26, 2025
The study explores the multifaceted role of bacterial siderophores in microbial community dynamics and host interactions. It highlights their impact on bacterial competition, survival, and virulence,…

Enterococcus faecium: evolution, adaptation, pathogenesis and emerging therapeutics

Feb 17, 2026
Enterococcus faecium adapts through gene transfer and resistance mechanisms, making it a major cause of hospital infections. The study emphasizes the importance of genomic surveillance and the…

Akkermansia muciniphila: biology, microbial ecology, host interactions and therapeutic potential

Feb 7, 2026
This review explains how Akkermansia muciniphila supports gut barrier integrity, immune balance, and metabolic health. Evidence highlights its role as a key microbiome signal across obesity,…

Fusobacterium nucleatum: ecology, pathogenesis and clinical implications

Feb 12, 2026
This review discusses Fusobacterium nucleatum’s pivotal role in diseases like colorectal cancer and inflammatory bowel disease, emphasizing its pathogenic mechanisms, including immune evasion and…

A small molecule inhibitor prevents gut bacterial genotoxin production

Jan 15, 2026
This study shows a selective small molecule can block colibactin production by inhibiting the activating enzyme ClbP. The inhibitor stops colibactin-linked DNA damage signals and DNA adduct formation…

Crosstalk between skin microbiota and immune system in health and disease

Jan 5, 2026
This review explains how skin microbes shape immune tolerance, barrier defense, and inflammation in health and skin disease.

Probiotic Escherichia coli inhibits biofilm formation of pathogenic E. coli via extracellular activity of DegP

Nov 16, 2025
This study shows that DegP secretion drives probiotic Escherichia coli DegP biofilm inhibition by repressing pathogenic biofilms through a targeted extracellular mechanism that shapes microbial…

Sex-specific associations of infants’ gut microbiome with arsenic exposure in a US population

Sep 12, 2025
The study explores the relationship between arsenic exposure and the infant gut microbiome, revealing sex-specific associations and highlighting how formula-fed male infants are particularly…

Augmented antibiotic resistance associated with cadmium induced alterations in Salmonella enterica serovar Typhi

Sep 22, 2025
The study demonstrates how cadmium exposure enhances antibiotic resistance in Salmonella enterica serovar Typhi by altering bacterial growth, biofilm formation, and antibiotic susceptibility. The…

Characterization of antibiotic-resistance traits in Akkermansia muciniphila strains of human origin

Feb 7, 2026
This study shows that human-derived Akkermansia muciniphila strains carry limited, mostly nonfunctional antibiotic resistance traits. Phenotypic testing confirms low risk of transferable resistance,…

Antifungal Activity of Compound 2d Against Dermatophytes via Ergosterol Pathway Disruption

Jul 27, 2025
This study identified compound 2d as a potent antifungal agent against dermatophytes, demonstrating efficacy via ergosterol pathway suppression, cell wall disruption, and oxidative stress induction.…

An engineered E. coli Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans

Nov 9, 2025
Engineered Escherichia coli Nissle 1917 for hyperammonemia (SYNB1020) safely consumed gut ammonia, improved survival in mice, and showed dose-linked metabolic activity and clearance in healthy…

Passive immunization with anti-ActA and anti-listeriolysin O antibodies protects against Listeria monocytogenes infection in mice

Feb 5, 2026
This study examines the protective effect of passive immunization with anti-ActA and anti-LLO antibodies against Listeria monocytogenes infection, showing how these antibodies reduce bacterial load…

A case report of oral sulfamethoxazole in the treatment of posttransplant Listeria monocytogenes meningitis

Feb 5, 2026
This case report demonstrates the effectiveness of oral sulfamethoxazole in treating Listeria monocytogenes meningitis in a renal transplant patient, offering an alternative treatment approach for…

Colibactin: More Than a New Bacterial Toxin

Jan 15, 2026
This review explains how pks-positive bacteria produce colibactin, how it damages host DNA, and why it links to colorectal cancer and invasive infection severity. It also summarizes toxin-pathway…

Mechanisms of Action and Cell Death Associated with Clostridium perfringens Toxins

Feb 14, 2026
This review explains how Clostridium perfringens toxins disrupt microbiome-host interactions by damaging cell membranes, forming pores, and activating intracellular pathways that cause cell death,…

Structure, Function, and Biology of the Enterococcus faecalis Cytolysin

Feb 16, 2026
Cytolysin allows Enterococcus faecalis to disrupt the microbiome, kill competitors, evade immune defenses, and increase infection severity. This toxin promotes microbial imbalance, pathogen…

Clostridium perfringens Enterotoxin: Action, Genetics, and Translational Applications

Feb 14, 2026
This review explains how Clostridium perfringens enterotoxin causes gastrointestinal disease by binding claudins and forming pores in intestinal epithelial cells. Toxin production during sporulation…

Gut Microbiome Phenotypes Driven by Host Genetics Affect Arsenic Metabolism

Sep 15, 2025
The study demonstrates how IL-10 gene knockout mice show significant changes in their gut microbiome and arsenic metabolism. These alterations contribute to higher levels of toxic arsenic…

A Bacteriophage Cocktail Significantly Reduces Listeria monocytogenes without Deleterious Impact on the Commensal Gut Microbiota under Simulated Gastrointestinal Conditions

Feb 5, 2026
This study demonstrates that the FOP bacteriophage cocktail effectively reduces Listeria monocytogenes levels in the gastrointestinal tract, without disturbing the gut microbiota, offering a…

Role of Clostridium perfringens Necrotic Enteritis B-like Toxin in Disease Pathogenesis

Feb 14, 2026
This review explains how NetB toxin enables Clostridium perfringens to shift from a gut microbiome commensal to a toxin-producing pathogen. NetB disrupts intestinal epithelial barriers, promotes…

Zinc Oxide Nanoparticles Suppress Microsporum canis Growth and Virulence

Nov 15, 2025
Zinc oxide nanoparticles inhibited Microsporum canis growth in a concentration-dependent manner and significantly reduced SUB1 virulence-gene expression. MIC values of 250–500 ppm and fungicidal…

Influence of toxic metal exposure on the gut microbiota (Review)

Sep 5, 2025
This study investigates how copper supplementation affects gut microbiota and E. coli resistance in weaned piglets. It reveals that copper alters microbial composition and promotes antibiotic…

Role and mechanisms of action of Escherichia coli Nissle 1917 in the maintenance of remission in ulcerative colitis patients

Nov 7, 2025
Escherichia coli Nissle 1917 (EcN) is a safe and effective probiotic for maintaining remission in ulcerative colitis patients, with clinical trial evidence showing equivalence to mesalazine in…

NUTRITIONAL REQUIREMENTS OF CLOSTRIDIUM PERFRINGENS PB6K FOR ALPHA TOXIN PRODUCTION

Feb 14, 2026
This study shows that microbiome nutrients such as arginine, zinc, and vitamins regulate alpha-toxin production in Clostridium perfringens. Toxin production depends on specific nutrient conditions…

Antimicrobial, Probiotic, and Immunomodulatory Potential of Cannabis sativa Extract and Delivery Systems

Mar 18, 2025
What was studied? The study investigated the antimicrobial, probiotic, and immunobiological effects of the Henola Cannabis sativae extract and its combinations with specific carriers: polyvinyl…

Associations Between Endometriosis and Gut Microbiota

Mar 18, 2025
What was studied? The study examined the gut microbiota in women with endometriosis compared to healthy controls. It aimed to explore differences based on disease localization, symptoms, or treatment…

Comparison of Vaginal, Cervical and Gut Microbiota Between Women with Stage 3/4 Endometriosis and Healthy Controls

Mar 18, 2025
What was studied? The study focused on exploring the associations between the microbiota of the vaginal, cervical, and gut regions and stage 3–4 endometriosis in women. This research aimed to uncover…

Copper in microbial pathogenesis: meddling with the metal

Mar 18, 2025
What was studied? The study investigated the role of copper in microbial pathogenesis. Specifically, it examined how copper serves as both a necessary nutrient for microbial organisms and a microbial…

Correlation of fecal metabolomics and gut microbiota in mice with endometriosis

Mar 18, 2025
What was studied? The study investigated the interaction between fecal metabolomics and gut microbiota in mice with endometriosis (EMS), aiming to identify metabolic changes and microbiota diversity…

Effect of endometriosis on the fecal bacteriota composition of mice during the acute phase of lesion formation

Mar 18, 2025
What was studied? The study investigated whether the induction of endometriosis in mice affects the composition of their gut microbiota. It tested this by transplanting uterine tissue fragments into…

Effect of Oxygen on Glucose Metabolism: Utilization of Lactate in Staphylococcus Aureus as Revealed by In Vivo NMR Studies

Jun 13, 2025
This study shows that oxygen drives a shift in S. aureus metabolism from glucose fermentation to aerobic lactate oxidation. Lactate supports growth and energy production under oxygenated conditions,…

Endometriosis induces gut microbiota alterations in mice

Mar 18, 2025
What was studied? The research focused on investigating the impact of murine endometriosis on gut microbiota composition using high-throughput DNA sequencing to explore how the disease affects…

Gut microbiota imbalance and its correlations with hormone and inflammatory factors in patients with stage 3/4 endometriosis

Mar 18, 2025
What was studied? The study investigated the role of gut microbiota in endometriosis (EM), focusing on its differences between individuals with stage 3/4 EM and healthy controls and how these…

In vitro antibiofilm, antibacterial, antioxidant, and antitumor activities of the brown alga Padina pavonica biomass extract

Mar 18, 2025
What was studied? The study focused on evaluating the antibiofilm, antibacterial, antioxidant, and anticancer activities of the methanolic extract of the marine algae Padina pavonica L. Who was…

Lippia origanoides derivatives in vitro evaluation on polymicrobial biofilms: Streptococcus mutans, Lactobacillus rhamnosus and Candida albicans

Mar 18, 2025
What was studied? The study investigated the antimicrobial effects of essential oils derived from the Colombian plant Lippia origanoides, specifically focusing on two terpenes, thymol and carvacrol,…

Meta-analysis of gut microbiome studies identifies disease-specific and shared responses

Mar 18, 2025
What was studied?The meta-analysis focused on the human gut microbiome’s association with various diseases by analyzing 28 published case-control gut microbiome studies covering ten diseases. The…

Microbiome of the lower genital tract in Chinese women with endometriosis by 16s-rRNA sequencing technique: a pilot study

Mar 18, 2025
What was studied? The study investigated the relationship between the genital tract microbiota and endometriosis, particularly focusing on how microbiota diversity and specific bacteria like…

Microbiome Profile of Deep Endometriosis Patients: Comparison of Vaginal Fluid, Endometrium and Lesion

Mar 18, 2025
What was studied? The study focused on identifying and comparing the bacterial patterns present in the vaginal fluid, eutopic endometrium, and endometriotic lesions of patients with endometriosis to…

Microbiota composition and distribution along the female reproductive tract of women with endometriosis

Mar 18, 2025
What was studied? The study investigated the microbiota distribution across the entire female reproductive tract of endometriosis (EMS) patients and non-EMS women, aiming to identify EMS-specific…

Molecular detection of microbial colonization in cervical mucus of women with and without endometriosis

Mar 18, 2025
What was studied? The study investigated the microbiota in the cervical mucus of women with and without endometriosis using next-generation sequencing (NGS) technologies. It aimed to clarify whether…

Reproductive Microbiomes: Using the Microbiome as a Novel Diagnostic Tool for Endometriosis

Mar 18, 2025
What was studied? The study aimed to investigate how endometriosis affects the uterine and cervical bacterial communities. Utilizing next-generation amplicon sequencing of the bacterial 16S rRNA…

Role of Cholestyramine in Refractory Hyperthyroidism: A Case Report and Literature Review

Mar 18, 2025
The study investigates the role of cholestyramine for refractory iodine-induced hyperthyroidism, showing rapid FT4 reduction in 12 days.

Staphylococcus aureus: A Review of the Pathogenesis and Virulence Mechanisms

Jun 13, 2025
This review synthesizes key mechanisms of Staphylococcus aureus virulence, including colonization strategies, immune evasion, metabolic adaptability, and antimicrobial resistance. It highlights major…

The impact of photobiomodulation of major salivary glands on caries risk

Mar 18, 2025
What was studied? The study explored the impact of photobiomodulation therapy using different types of light on the major salivary glands and its subsequent effects on caries risk factors in…

The influence of nickel on intestinal microbiota disturbances

Mar 18, 2025
Excess nickel disrupts gut microbiota, promoting dysbiosis and contributing to conditions like obesity and systemic nickel allergy syndrome (SNAS). Probiotics and nickel-restricted diets show promise…

The Revaluation of Plant-Derived Terpenes to Fight Antibiotic-Resistant Infections

Mar 18, 2025
What was studied? The study focused on terpenes derived from plants as potential antimicrobial agents, particularly their effectiveness against antibiotic-resistant infections. This included an…

The Vaginal Microbiome as a Tool to Predict rASRM Stage of Disease in Endometriosis: a Pilot Study

Mar 18, 2025
What was studied? The study focused on characterizing the gut and vaginal microbiome profiles of women with endometriosis compared to controls without the disease, exploring the potential of these…

Urinary lead concentration and composition of the adult gut microbiota in a cross-sectional population-based sample

Mar 18, 2025
What was studied? The study examined the association between urinary lead concentrations and changes in the gut microbiota composition in a population-based sample of adults. The research explored…

Microbial Metallomics (4)

Microbiome Signatures (1)

Microbiome-Targeted Interventions (MBTIs) (3)

Microsporum canis (M. canis) (15)

M. canis Antifungal Resistance: Enzymatic Correlates and Drug Efficacy

Jul 27, 2025
This study identified catalase and hemolysin as key virulence factors linked to antifungal resistance in Microsporum canis strains from symptomatic hosts. Voriconazole, terbinafine, and posaconazole…

Ciclopirox Antifungal and Anti-Inflammatory Review: Dermatology to Oncology

Jul 28, 2025
Ciclopirox and its salt form exhibit broad-spectrum antifungal, antibacterial, and anti-inflammatory activity via iron chelation and enzyme inhibition. With low resistance potential, they outperform…

Microsporum canis Siderophores Identified as Ferrichrome and Ferricrocin

Nov 15, 2025
This study characterized the siderophores produced by Microsporum and Trichophyton species, revealing that M. canis secretes ferrichrome and ferricrocin under iron-limited conditions, indicating…

Zinc and Microsporum canis: Targeting ZafA to Disrupt Fungal Virulence

Jul 27, 2025
Zinc deficiency significantly impairs Microsporum canis growth and virulence. The ZafA gene regulates zinc uptake and pathogenesis, and its deletion disrupts zinc transporters, conidiation, and host…

Dermatophyte Virulence and Host Immunity: Key Mechanisms and Clinical Implications

Jul 27, 2025
This review outlines the pathogenic strategies of dermatophytes and host antifungal responses, with a focus on keratinolytic enzymes, PRRs, Th17 immunity, and CARD9-related immune dysfunction,…

Cold Atmospheric Plasma for Dermatophytes: In Vitro Efficacy Against T. rubrum and M. canis

Jul 28, 2025
Cold atmospheric plasma significantly inhibited T. rubrum and M. canis growth in vitro, matching the efficacy of ciclopirox olamine. Daily 10-minute CAP treatments proved most effective, acting…

Metalloprotease Gene Family in Microsporum canis Identified as Potential Virulence Factors

Jul 27, 2025
This study identified a metalloprotease gene family in Microsporum canis and confirmed in vivo expression of MEP2 and MEP3 during infection. MEP3, a keratinolytic enzyme, was expressed recombinantly…

Virulence Factors of Microsporum canis: Enzymes, Genes, and Clinical Implication

Jul 27, 2025
This review details the enzymatic and genetic virulence arsenal of Microsporum canis, highlighting understudied factors like biofilms and dipeptidylpeptidases. Greater insight into these mechanisms…

Microsporum canis Whole Genome Sequencing Reveals Zoonotic Links

Nov 15, 2025
Genome sequencing of feline and canine Microsporum canis reveals close genetic identity to an invasive human strain and dissects secreted CAZymes that drive keratin degradation and potential zoonosis.

Microsporum canis Antifungal Susceptibility and Therapy: A Review

Jul 27, 2025
This review evaluates antifungal susceptibility and therapeutic options for Microsporum canis, highlighting methodological variability in testing and identifying terbinafine and itraconazole as the…

Genetic Clustering and Virulence Insights in Microsporum canis: Clinical Isolates from US Cats

Jul 27, 2025
This US-based study reveals that M. canis genotype correlates with disease severity in cats, identifies three genetic clusters, and confirms the dominance of the MAT1-1 mating type. Conserved…

Bee Venom as a Novel Antifungal Agent Against Microsporum canis

Jul 27, 2025
Bee venom showed partial antifungal activity against resistant M. canis isolates, supporting its evaluation as a potential topical therapeutic. While not as potent as terbinafine, BV outperformed…

Synergistic Nanoparticle–Essential Oil Combinations Show Promising Antifungal Activity

Jul 27, 2025
Ag₀.₉₉Fe₁.₀₁O₃ nanoparticles, especially when combined with cinnamon, clove, or lemongrass essential oils, exhibited strong synergistic antifungal effects against multiple dermatophytes, offering a…

Berberine and Palmatine Show Superior Antifungal Activity Against Microsporum canis

Jul 28, 2025
This study found that berberine and palmatine hydrochloride synergistically inhibit M. canis by disrupting cell structure and modulating virulence-related genes. The combination outperformed…

Antifungal Activity of Compound 2d Against Dermatophytes via Ergosterol Pathway Disruption

Jul 27, 2025
This study identified compound 2d as a potent antifungal agent against dermatophytes, demonstrating efficacy via ergosterol pathway suppression, cell wall disruption, and oxidative stress induction.…

Multiple Sclerosis (MS) (1)

Nickel (5)

Nutritional Immunity (3)

Organophosphates (4)

Ovarian Cancer (31)

Dietary Intake and Ovarian Cancer Risk: A Systematic Review

Aug 7, 2025
This review examines the relationship between diet and ovarian cancer risk, finding that animal fats and dairy are linked to higher risk, while vegetables and bioactive compounds may offer protective…

Reducing Ovarian Cancer Mortality Through Early Detection: Approaches using Circulating Biomarkers

Aug 6, 2025
This review discusses liquid biopsy techniques for early ovarian cancer detection, focusing on circulating tumor cells, cell-free DNA, and extracellular vesicles. It highlights their potential to…

The microbiome and ovarian cancer: insights, implications, and therapeutic opportunities

Aug 8, 2025
This review explores how the microbiome influences ovarian cancer development, progression, and treatment response. It emphasizes microbial dysbiosis as a factor in carcinogenesis and offers insights…

The Gut Microbiome in Aging and Ovarian Cancer

Aug 8, 2025
This review examines how the aging gut microbiome affects ovarian cancer progression. It highlights microbial dysbiosis as a common feature in both aging and cancer, with implications for novel…

Correlation of Heavy Metal Content in the Blood of Patients with Ovarian Cancer by Place of Residence

Aug 8, 2025
This study explores how the concentration of heavy metals, particularly zinc and copper, in the blood of ovarian cancer patients correlates with their recurrence-free survival. It highlights the…

Cellular and molecular processes in ovarian cancer metastasis. A Review in the Theme: Cell and Molecular Processes in Cancer Metastasis

Aug 6, 2025
This review explores the molecular mechanisms of ovarian cancer metastasis, focusing on the role of stromal cells and the metastatic routes—passive dissemination and hematogenous spread—while…

The Role of Lead and Cadmium in Gynecological Malignancies

Aug 9, 2025
This study explores the role of lead and cadmium in gynecological malignancies, focusing on their ability to mimic estrogen and induce oxidative stress, contributing to cancer development. It…

Endometriosis and Ovarian Cancer: An Integrative Review (Endometriosis and Ovarian Cancer)

Aug 12, 2025
This review explores the link between endometriosis and ovarian cancer, focusing on genetic mutations like ARID1A, oxidative stress, and estrogen receptor loss, which contribute to the development of…

Probiotics as Anti-Tumor Agents: Insights from Female Tumor Cell Culture Studies

Aug 7, 2025
Probiotics were shown to significantly reduce cancer cell proliferation, promote apoptosis, and inhibit migration in breast and ovarian cancer cells, suggesting their potential as adjunctive cancer…

Revolutionizing ovarian cancer therapy by drug repositioning for accelerated and cost-effective treatments

Aug 12, 2025
What was studied? The study explores drug repositioning as a transformative strategy for ovarian cancer (OC) treatment, highlighting the potential of repurposing existing drugs for more effective,…

New hopes and promises in the treatment of ovarian cancer focusing on targeted treatment—A narrative review

Aug 12, 2025
This review explores the role of targeted therapies in ovarian cancer treatment, focusing on the potential of angiogenesis inhibitors, PARP inhibitors, and folate receptor alpha inhibitors. While…

The application of metabolomics in ovarian cancer management: A systematic review

Aug 10, 2025
his systematic review highlights the role of metabolomics in ovarian cancer management, identifying key metabolic alterations in lipids and amino acids that could improve diagnosis, prognosis, and…

Recycling the Purpose of Old Drugs to Treat Ovarian Cancer

Aug 12, 2025
The review explores the potential of repurposing non-oncological drugs for ovarian cancer treatment, highlighting their ability to improve chemotherapy effectiveness and reduce treatment costs, with…

Paradigm Shift: A Comprehensive Review of Ovarian Cancer Management in an Era of Advancements.

Aug 6, 2025
This review maps advances in ovarian cancer management, from surgery and chemotherapy to targeted and emerging therapies, and highlights a need to integrate microbiome insights.

Endometriosis-Associated Ovarian Cancer: From Molecular Pathologies to Clinical Relevance

Aug 12, 2025
This review explores the molecular pathogenesis of endometriosis-associated ovarian cancer, highlighting key genetic mutations, hormonal imbalances, and microRNA dysregulation that contribute to the…

Ovarian Cancer—Epidemiology, Classification, Pathogenesis, Treatment, and Estrogen Receptors’ Molecular Backgrounds

Aug 6, 2025
This review covers the epidemiology, genetics, and molecular mechanisms of ovarian cancer, focusing on the role of estrogen receptors and genetic mutations such as BRCA1/2. It emphasizes the…

Ovarian cancer in the world: Epidemiology and risk factors

Aug 6, 2025
This review analyzes the global epidemiology and risk factors of ovarian cancer, emphasizing the role of genetic predispositions, reproductive factors, and lifestyle choices. It highlights the…

Urinary heavy metals and overall survival of advanced high-grade serous ovarian cancer: A nested case-control study in China

Aug 9, 2025
The study examines the association between urinary concentrations of heavy metals (arsenic, cadmium, mercury, lead) and survival in patients with advanced high-grade serous ovarian cancer. High…

Nutritional interventions during treatment for ovarian cancer: A narrative review and recommendations for future research

Aug 11, 2025
This review discusses the role of nutritional interventions in improving the nutritional status and clinical outcomes of women with ovarian cancer during treatment. It highlights the importance of…

Metformin use and survival in people with ovarian cancer: A population-based cohort study from British Columbia, Canada

Aug 12, 2025
This study examines the association between metformin use and survival outcomes in ovarian cancer patients. A significant survival benefit was found in diabetic patients, suggesting metformin may…

Extended sub-chronic exposure to heavy metal mixture induced multidrug resistance against chemotherapy agents in ovarian cancer cells

Aug 9, 2025
This study investigates how sub-chronic exposure to lead, cadmium, and cobalt induces multidrug resistance in ovarian cancer cells, highlighting the role of drug efflux transporters and reduced…

Ovarian Cancer and the Microbiome: Connecting the Dots for Early Diagnosis and Therapeutic Innovations—A Review

Aug 7, 2025
This review explores the role of the microbiome in ovarian cancer, emphasizing its potential for early diagnosis and treatment. The use of microbiome-based biomarkers and therapies like fecal and…

Ovarian cancer: Diagnosis and treatment strategies (Review)

Aug 6, 2025
This review discusses ovarian cancer diagnosis, molecular characteristics, and treatment strategies, emphasizing the role of targeted therapies like PARP inhibitors and immunotherapy, with a focus on…

Potential Role of Vaginal Microbiota in Ovarian Cancer Carcinogenesis, Progression and Treatment

Aug 7, 2025
This review highlights the role of vaginal microbiota in ovarian cancer carcinogenesis, progression, and treatment. It discusses microbial dysbiosis and potential therapeutic interventions like…

The role of the microbiome in ovarian cancer: mechanistic insights into oncobiosis and to bacterial metabolite signaling

Aug 8, 2025
This review explores the role of the microbiome in ovarian cancer, focusing on microbial dysbiosis and bacterial metabolites that influence inflammation and carcinogenesis. It highlights the…

Causal association between 637 human metabolites and ovarian cancer: A mendelian randomization study

Aug 10, 2025
Mendelian randomization identified causal links between 9 metabolites and ovarian cancer risk. Some metabolites promote, others protect against OC. These findings suggest potential biomarkers for…

Exploring the causal role of multiple metabolites on ovarian cancer: a two sample Mendelian randomization study

Aug 10, 2025
A two-sample MR of 486 metabolites reports suggestive causal links across OC and histotypes, maps caffeine/arginine/TCA and alpha-linolenic pathways, and surfaces microbially influenced xenobiotics…

The effects of dietary fat on gut microbial composition and function in a mouse model of ovarian cancer

Aug 7, 2025
This study investigates the effects of ketogenic and high-fat diets on gut microbial composition and ovarian cancer progression in mice. It shows that high-fat diets increase tumor growth and disrupt…

Repurposing approved non-oncology drugs for cancer therapy: a comprehensive review of mechanisms, efficacy, and clinical prospects

Aug 12, 2025
This review explores the potential of repurposing non-oncological drugs for cancer therapy, highlighting their efficacy in preclinical studies and their mechanisms of action. It emphasizes the…

Profiling of metabolic dysregulation in ovarian cancer tissues and biofluids

Aug 10, 2025
This study profiles metabolic dysregulation in ovarian cancer, identifying key metabolites and pathways altered in OC tissues and biofluids. N1,N12-diacetylspermine emerges as a potential biomarker.

Diet and ovarian cancer risk: A case–control study in China

Aug 7, 2025
This case-control study highlights the significant role of diet in ovarian cancer risk, with high vegetable and fruit intake reducing risk, while animal fats and salted vegetables increase it. Fried…

Parkinson’s Disease (7)

A prebiotic dietary pilot intervention restores faecal metabolites and may be neuroprotective in Parkinson’s Disease

Dec 22, 2025
A 4-week prebiotic diet in PD patients increased faecal SCFAs, improved gut-brain metabolite profiles, and alleviated gastrointestinal symptoms, but core dysbiosis persisted. Results support…

Minocycline in Parkinson’s Disease: Preclinical Promise, Clinical Uncertainty

Dec 22, 2025
What was reviewed? This review article examined the therapeutic potential of minocycline, a second-generation tetracycline antibiotic, as a neuroprotective agent in Parkinson’s disease (PD). The…

Metallomic signatures of brain tissues distinguishes between cases of dementia with Lewy bodies, Alzheimer’s disease, and Parkinson’s disease dementia

Oct 20, 2025
Dementia with Lewy bodies (DLB) brains show widespread copper depletion and region-specific sodium, manganese, iron, and selenium alterations. While copper loss is common to AD and PDD, DLB presents…

Differences in the gut microbiome across typical ageing and in Parkinson’s disease

Dec 22, 2025
Cross-sectional metagenomic profiling shows that the gut microbiome in Parkinson’s disease differs from age-matched controls via selective loss of butyrate-producing taxa, especially…

Gut microbiome is not associated with mild cognitive impairment in Parkinson’s disease

Dec 22, 2025
What was studied? This study investigated whether the gut microbiome harbors a distinct microbial signature associated with mild cognitive impairment (MCI) in individuals with Parkinson’s disease…

Meta-analysis of shotgun sequencing of gut microbiota in Parkinson’s disease

Dec 4, 2025
This meta-analysis of shotgun gut microbiome datasets in Parkinson’s disease identified cross-country microbial and functional signatures, including reduced riboflavin and biotin biosynthesis,…

Microbial Metallomics Theory of Parkinson’s Disease: A Unified Framework

Dec 23, 2025
This review unifies Parkinson’s disease mechanisms under a single framework of heavy metal-induced ferroptosis, microbial virulence, and α-synuclein aggregation, emphasizing the central role of…

Pelvic Inflammatory Disease (PID) (23)

Evidence for the Use of Complementary and Alternative Medicine for Pelvic Inflammatory Disease: A Literature Review

Jun 20, 2025
This review investigates the potential of Complementary and Alternative Medicine (CAM) in managing Pelvic Inflammatory Disease (PID). Therapies like Chinese Herbal Medicine and acupuncture show…

Pelvic inflammatory disease: a family practice perspective

Jun 19, 2025
Family practice perspectives highlight challenges diagnosing PID, advocating enhanced clinical suspicion, multi-antibiotic treatment adherence, and regular screening for asymptomatic infections to…

Microbiology profile in women with pelvic inflammatory disease in relation to IUD use

Jun 19, 2025
This study identifies microbial differences in women with PID based on IUD use, highlighting a higher presence of anaerobic bacteria in IUD users and an increased risk of PID complications. These…

Epidermiological markers in pelvic inflammatory disease (PID) among the women of reproductive age group

Jun 19, 2025
This study identifies key socio-demographic factors associated with PID in women of reproductive age, highlighting the need for better education, healthcare access, and early intervention. It…

Pelvic inflammatory disease and infertility

Jun 27, 2025
This review details the polymicrobial pathogenesis of PID, its major microbial culprits—including both classical STIs and vaginal anaerobes—and underscores the high risk of infertility. Early…

Bacterial isolates associated with pelvic inflammatory disease among female patients attending some hospitals in abuja, Nigeria

Jun 19, 2025
This study identifies key bacterial pathogens associated with pelvic inflammatory disease (PID) in Abuja, Nigeria, highlighting the effectiveness of Cefotaxime in treatment. The research also…

Relationships between female infertility and female genital infections and pelvic inflammatory disease

Jun 27, 2025
A large-scale Taiwanese study found that upper and lower genital tract infections, but not comorbidities or bacterial vaginosis, independently increased infertility risk. PID and lower genital tract…

Association between dietary trace minerals and pelvic inflammatory disease: Data from the 2015–2018 National Health and Nutrition Examination Surveys

Jun 20, 2025
Higher dietary copper intake significantly lowers the risk of pelvic inflammatory disease in U.S. women, highlighting copper’s role in inflammation and reproductive health.

Association between dietary magnesium intake and pelvic inflammatory disease in US women: a cross-sectional study of NHANES

Jun 20, 2025
Higher dietary magnesium intake significantly reduces pelvic inflammatory disease risk in U.S. women, especially older adults, highlighting magnesium’s role in inflammation and reproductive health.

Integrated Metabolomics and Network Pharmacology Study on the Mechanism of Kangfuxiaoyan Suppository for Treating Chronic Pelvic Inflammatory Disease

Jun 20, 2025
Kangfuxiaoyan suppository effectively treats chronic pelvic inflammatory disease by regulating key inflammatory and metabolic pathways, significantly reducing inflammation. Integrated metabolomics…

Lactobacilli–lactoferrin interplay in Chlamydia trachomatis infection

Jun 24, 2025
The study found a potent inhibitory effect against Chlamydia trachomatis infection using Lactobacillus brevis combined with lactoferrin, notably reducing bacterial adhesion, invasion, and…

Perception prevalence of the relationship between PID and infertility amongst women of reproductive age: A Nigerian study

Jun 27, 2025
A Nigerian study found only 10% of reproductive-age women recognized the link between PID and infertility, despite high education levels. The findings emphasize the need for improved public health…

Bacterial vaginosis and its association with infertility, endometritis, and pelvic inflammatory disease

Jun 27, 2025
This review details the links between bacterial vaginosis, endometritis, pelvic inflammatory disease, and infertility, highlighting the role of vaginal and endometrial microbiota disruptions and…

A Metabolomics Study of the Volatile Oil from Prunella vulgaris L. On Pelvic Inflammatory Disease

Jun 20, 2025
This study shows volatile oil from Prunella vulgaris effectively reduces pelvic inflammation by correcting metabolic disruptions in a rat PID model, highlighting key inflammatory metabolites as…

Research Progress on the Interaction between Intestinal Flora and MicroRNA in Pelvic Inflammatory Diseases

Jun 20, 2025
This review highlights the crucial interactions between gut microbiota and microRNAs in pelvic inflammatory disease, revealing novel diagnostic markers and therapeutic targets.

Risk of Endometrial Cancer in Women With Pelvic Inflammatory Disease

Jun 20, 2025
Women with pelvic inflammatory disease have a higher risk of endometrial cancer, especially older and hypertensive women, highlighting the need for vigilant care.

Gynecologists and pelvic inflammatory disease: do we actually know what to do?

Jun 19, 2025
This study highlights significant gaps in gynecologists’ knowledge regarding Pelvic Inflammatory Disease (PID). Misdiagnosis, inadequate treatment duration, and poor adherence to guidelines…

Pelvic Inflammatory Disease Trends Among Emergency Department Visits in North Carolina, 2008 to 2017

Jun 19, 2025
This study identified a declining trend in emergency department diagnoses of PID among North Carolina women from 2008-2017. Persistent disparities emerged among young, low-income, and publicly…

The challenge of pelvic inflammatory disease

Jun 19, 2025
This review highlights PID’s diagnostic challenges, microbiological associations, and evidence-based treatment guidelines. It emphasizes routine screening for chlamydia to reduce disease incidence,…

Characteristics of Vaginal Microbiome in Women with Pelvic Inflammatory Disease in Korea

Jun 19, 2025
This study identifies key differences in the vaginal microbiome of women with PID, emphasizing a significant reduction in Lactobacillus and an increase in polymicrobial infections. The findings…

Microbiota and Pelvic Inflammatory Disease

Jun 19, 2025
This review highlights how vaginal microbiota imbalance, particularly bacterial vaginosis, significantly increases the risk of pelvic inflammatory disease. Advanced molecular methods have identified…

Pelvic inflammatory disease and the risk of ovarian cancer: a meta-analysis

Jun 19, 2025
This meta-analysis reveals a significant association between pelvic inflammatory disease (PID) and an increased risk of ovarian cancer. The link is particularly strong among Asian women, with…

Association of pelvic inflammatory disease (PID) with ovarian cancer: a nationwide population-based retrospective cohort study from Taiwan

Jun 19, 2025
This nationwide study from Taiwan demonstrates that women with a history of pelvic inflammatory disease (PID) are at a significantly higher risk of developing ovarian cancer. The study highlights the…

Polycystic ovary syndrome (PCOS) (9)

The Application of Complementary and Alternative Medicine in Polycystic Ovary Syndrome Infertility

Jul 3, 2025
This review summarizes clinical and mechanistic evidence for complementary and alternative medicine in PCOS infertility, highlighting TCM, acupuncture, nutrient supplementation, and lifestyle…

Female Fertility and Environmental Pollution

Jun 30, 2025
Environmental pollution—including heavy metals, air pollutants, and endocrine disruptors—negatively impacts female fertility through hormonal disruption, oxidative stress, and epigenetic changes. The…

Altered Follicular Fluid Metabolic Pattern Correlates with Female Infertility and Outcome Measures of In Vitro Fertilization

Jun 30, 2025
This study identified 27 follicular fluid metabolites differentiating infertile from fertile women, developed a predictive Biomarker Score, and demonstrated strong correlations with IVF outcomes,…

Metabolic risk factors and fertility disorders: A narrative review of the female perspective

Jun 30, 2025
This review explores how metabolic risk factors—obesity, the female athlete triad, and oxidative stress—contribute to female infertility, highlighting associations with PCOS, endometriosis, and…

Evaluation of the relationship between polycystic ovary syndrome and intestinal inflammation as measured by fecal calprotectin levels

Apr 27, 2025
PCOS is linked with higher gut inflammation, as shown by elevated fecal calprotectin. This may help guide diagnosis and treatment.

Evidence for statin therapy in polycystic ovary syndrome. 

Apr 26, 2025
This review highlights the potential benefits of statin therapy in women with polycystic ovary syndrome (PCOS), showing improvements in metabolic dysfunction, hyperandrogenism, and cardiovascular…

Metformin use in women with polycystic ovary syndrome

Apr 27, 2025
This review discusses the role of metformin in treating PCOS-related infertility. It highlights its effectiveness in improving ovulation, reducing insulin resistance, and managing hyperandrogenism.…

Role of Metformin in Polycystic Ovary Syndrome (PCOS)-Related Infertility

Apr 27, 2025
This review examines the role of metformin in treating PCOS-related infertility, highlighting its effectiveness in improving insulin sensitivity, reducing hyperandrogenism, and restoring ovulation.…

Usefulness of intermittent clomiphene citrate treatment for women with polycystic ovarian syndrome that is resistant to standard clomiphene citrate treatment

Apr 26, 2025
The study explored intermittent clomiphene citrate treatment (ICT) for women with PCOS who were resistant to standard CC treatment. ICT showed an 80.8% response rate, offering an effective and safer…

Postpartum Depression (PPD) (27)

Maternal Iron Deficiency Anemia Affects Postpartum Emotions and Cognition

Jun 14, 2025
The study explored the impact of iron deficiency anemia on postpartum cognitive and emotional health. Iron supplementation significantly improved depression, stress, and cognitive performance in…

Fecal Microbiota Changes in Patients With Postpartum Depressive Disorder

Jul 23, 2025
This study investigates the link between gut microbiota and postpartum depressive disorder (PPD), identifying specific microbiota changes that correlate with depressive symptoms and hormonal levels.…

919 Syrup Alleviates Postpartum Depression by Modulating the Structure and Metabolism of Gut Microbes and Affecting the Function of the Hippocampal GABA/Glutamate System

Jun 16, 2025
This study explores how 919 syrup, a Chinese herbal remedy, alleviates postpartum depression (PPD) by modulating the gut microbiome and hippocampal GABA metabolism, offering a novel treatment…

Gut microbiota: Linking nutrition and perinatal depression

Jun 16, 2025
This review investigates the relationship between gut microbiota and perinatal depression, highlighting how nutrition and probiotics may help regulate mood disorders during pregnancy and postpartum.

The role of gut microbiota and blood metabolites in postpartum depression: A Mendelian randomization analysis.

Jun 16, 2025
This study identifies gut microbiota and blood metabolites causally associated with postpartum depression, revealing potential biomarkers and therapeutic targets for PPD.

Treatment of postpartum depression: Clinical, psychological and pharmacological options

Jun 16, 2025
This review explores the clinical, psychological, and pharmacological treatment options for postpartum depression (PPD), focusing on antidepressants, therapy, and alternative treatments like omega-3s…

The Role ofNutrient Supplementation to Prevent Perinatal Depression. A Narrative Review

Jun 16, 2025
This systematic review explores the impact of diet and nutritional supplementation on perinatal depression (PPD), highlighting protective effects from healthy dietary patterns, omega-3s, and…

The effectiveness of iron supplementation for postpartum depression

Jun 14, 2025
What was reviewed? The review was a protocol for a systematic review and meta-analysis aimed at evaluating the effectiveness of iron supplementation in treating postpartum depression (PPD). The…

Dysmenorrhea increased the risk of postpartum depression in Chinese Han parturients

Jul 28, 2025
This study links dysmenorrhea to an increased risk of postpartum depression in Chinese women. It highlights the need for early PPD screening in women with a history of dysmenorrhea.

A Comprehensive Review on Postpartum Depression

Jun 13, 2025
This comprehensive review of postpartum depression (PPD) explores its pathophysiology, risk factors, and treatment options. It emphasizes the need for early diagnosis, multidisciplinary care, and…

Correlation of Serum Zinc Levels with Postpartum Depression-A Case- control Study in North Karnataka

Jun 14, 2025
This study demonstrates that low serum zinc levels correlate with increased severity of postpartum depression, suggesting the potential benefits of zinc supplementation in postpartum care.

Diagnosis of peripartum depression disorder: A state-of-the-art approach from the COST Action Riseup-PPD

Jun 13, 2025
This review emphasizes peripartum depression as distinct from general depression, featuring pronounced anxiety, psychomotor symptoms, and obsessive thoughts, urging expanded diagnostic criteria to…

Exposure to environmental chemicals and perinatal psychopathology

Jun 13, 2025
This review links prenatal chemical exposures to perinatal depression and anxiety through microbiome disruption and neuroinflammation. Environmental chemicals alter the gut-brain axis, emphasizing…

Factors Related to Seeking Help for Postpartum Depression: A Secondary Analysis of New York City PRAMS Data

Jun 13, 2025
This study identifies significant barriers preventing women from seeking help for postpartum depression, notably stigma and socio-cultural factors. Active help-seeking behaviors significantly…

Gestational iron supplementation reverses depressive-like behavior in post-partum Sprague Dawley rats: Evidence from behavioral and neurohistological studies

Jun 14, 2025
This study highlights the role of gestational iron supplementation in alleviating depressive-like behavior in postpartum rats, showing improvements in neuronal health and mood regulation. It suggests…

Joint effects of traffic-related air pollution and hypertensive disorders of pregnancy on maternal postpartum depressive and anxiety symptoms

Jun 13, 2025
This study demonstrates significant associations between prenatal traffic-related air pollution exposure and postpartum depressive and anxiety symptoms, highlighting increased vulnerability among…

Postpartum Depression and Role of Serum Trace Elements

Jun 13, 2025
This review explores how deficiencies or imbalances in zinc, magnesium, iron, and copper contribute to postpartum depression. It supports trace element supplementation as a nonpharmacologic treatment…

Postpartum Depression in The Arab Region: A Systematic Literature Review

Jun 13, 2025
This systematic review examines postpartum depression in Arab countries, revealing varying prevalence rates and highlighting socio-economic, marital, and health-related factors as major risk…

Risk Factors for Postpartum Depression: An Umbrella Review

Jun 13, 2025
This umbrella review synthesizes research on postpartum depression risk factors, highlighting prenatal depression and current abuse as the strongest predictors. It emphasizes the need for targeted…

Risk Factors of Postpartum Depression

Jun 13, 2025
This review analyzes the risk factors for postpartum depression (PPD), highlighting key predictors such as a history of depression, lack of support, gestational diabetes, and birth complications. It…

The association between anemia and postpartum depression: A systematic review and meta-analysis

Jun 14, 2025
What was reviewed? This study is a systematic review and meta-analysis that investigates the association between anemia (both postpartum anemia and anemia during pregnancy) and postpartum depression…

The Impact of Cultural Factors Upon Postpartum Depression: A Literature Review

Jun 13, 2025
This review examines how cultural factors influence postpartum depression, identifying both protective and harmful cultural practices. It emphasizes the need for culturally sensitive care and…

The magnitude of postpartum depression among mothers in Africa: a literaturereview

Jun 13, 2025
This review explores the prevalence of postpartum depression (PPD) among African mothers, highlighting significant variation across countries and the need for culturally validated diagnostic tools to…

The Possible Effects of Zinc Supplementation on Postpartum Depression and Anemia

Jun 14, 2025
Postpartum zinc supplementation shows promise in reducing postpartum depression risk and improving maternal zinc levels, though it may cause transient hematological changes when combined with iron.

The Rate and Risk Factors of Postpartum Depression in Vietnam From 2010 to 2020: A Literature Review

Jun 13, 2025
This review examines the prevalence and risk factors of postpartum depression in Vietnam, highlighting significant socio-economic, cultural, and personal contributors. It calls for early screening…

The role of gut microbiota in the pathogenesis and treatment of postpartum depression

Jun 13, 2025
This review highlights how gut microbiota disruptions contribute to postpartum depression via hormonal, inflammatory, and neurochemical pathways. It supports microbial modulation as a novel,…

Women’s experiences of psychological treatment and psychosocial interventions for postpartum depression: a qualitative systematic review and meta-synthesis

Jun 13, 2025
This review explores women’s experiences with psychological treatments for postpartum depression, emphasizing the importance of personalized care, supportive relationships, and social support…

Premenstrual Dysphoric Disorder (PMDD) (14)

Allopregnanolone in premenstrual dysphoric disorder (PMDD)

May 19, 2025
This review identifies impaired sensitivity of GABA-A receptors to the neurosteroid allopregnanolone as central to PMDD, linking receptor plasticity and stress dysregulation to mood symptoms, and…

Biological rhythms in premenstrual syndrome and premenstrual dysphoric disorder: a systematic review

May 19, 2025
Women with PMS/PMDD experience disrupted biological rhythms, notably lower melatonin, higher nighttime temperature, and poor sleep quality. These circadian disturbances contribute to symptom…

Characteristics of the gut microbiota in women with premenstrual symptoms: A cross-sectional study

May 19, 2025
This study identified specific gut microbiota alterations, including reduced butyrate- and GABA-producing bacteria, associated with premenstrual disorder severity, offering new insights into PMD…

Determinants of premenstrual dysphoric disorder and associated factors among regular undergraduate students at Hawassa University Southern, Ethiopia

May 19, 2025
Among Ethiopian female university students, PMDD affects nearly two-thirds and links strongly to severe menstrual pain, irregular cycles, low social support, and contraceptive use. Early…

Impact of nutritional diet therapy on premenstrual syndrome

May 22, 2025
This review highlights the role of diet and micronutrients in modulating PMS symptoms, showing potential benefits of calcium, magnesium, vitamin D, and B vitamins, while emphasizing the need for…

Premenstrual disorders and PMDD – a review

May 19, 2025
Premenstrual dysphoric disorder (PMDD) significantly impairs women’s lives due to abnormal sensitivity to hormonal fluctuations. Accurate diagnosis relies on prospective symptom tracking. Evidence…

Premenstrual Dysphoric Disorder and the Brain

May 19, 2025
What was reviewed? This paper reviewed the neurological basis of premenstrual dysphoric disorder (PMDD), emphasizing its recognition as a distinct mood disorder linked to menstrual cycle hormonal…

Premenstrual dysphoric disorder-an undervalued diagnosis? A cross-sectional study in Hungarian women

May 19, 2025
Hungarian women with probable PMDD experience high rates of anxio-depressive symptoms and reduced well-being. Retrospective screening suggests higher-than-expected prevalence, highlighting the need…

Premenstrual Dysphoric Disorder: Epidemiology and Treatment

May 19, 2025
This review delineates PMDD’s unique neurobiology, highlighting hormone sensitivity, GABAergic dysfunction, and stress interaction. SSRIs provide rapid symptom relief, with hormonal and behavioral…

Premenstrual dysphoric disorder: General overview, treatment strategies, and focus on sertraline for symptom-onset dosing

May 19, 2025
Symptom-onset dosing of sertraline effectively reduces PMDD symptoms, especially mood-related ones, with fewer side effects and limited drug exposure. This targeted approach offers a promising,…

Premenstrual Syndrome and Premenstrual Dysphoric Disorder as Centrally Based Disorders

May 20, 2025
PMS and PMDD stem from neuroendocrine and neurochemical imbalances, especially altered allopregnanolone and GABA activity. Hormonal and neuroactive therapies improve symptoms, while microbiome and…

Premenstrual syndrome, a common but underrated entity: review of the clinical literature

May 12, 2025
This review explores premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD), focusing on symptoms, prevalence, risk factors, and treatment options.

Prevalence and associated factors of premenstrual dysphoric disorder among high school students in Finote Selam town, northwest Ethiopia

May 19, 2025
Among Ethiopian high school girls, PMDD affects one-third, linked to irregular cycles, depression, prolonged menstruation, and stress. Early screening and mental health support are crucial to…

Tobacco consumption and premenstrual syndrome: A case-control study

May 14, 2025
This study highlights the significant link between tobacco consumption and the increased risk of premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD). Women who smoke are at higher…

Premenstrual Syndrome (PMS) (10)

A Systematic Review and Meta-Analysis of Premenstrual Syndrome with Special Emphasis on Herbal Medicine and Nutritional Supplements.

May 12, 2025
This systematic review and meta-analysis explores the effectiveness of herbal medicine and nutritional supplements in reducing PMS symptoms, highlighting significant reductions in physical, mood, and…

Characteristics of the Gut Microbiota in Japanese Patients with Premenstrual Syndrome

May 13, 2025
This study explores the gut microbiota in Japanese women with Premenstrual Syndrome (PMS), finding significant differences in microbial composition and highlighting the potential role of Collinsella…

Characteristics of the gut microbiota in women with premenstrual symptoms: A cross-sectional study

May 13, 2025
This study explores the association between gut microbiota composition and the severity of premenstrual symptoms, suggesting a potential role for microbiome-based therapies in managing PMS.

Epidemiology of Premenstrual Syndrome (PMS)-A Systematic Review and Meta-Analysis Study

May 12, 2025
This systematic review and meta-analysis estimate the global prevalence of PMS, revealing wide variations across countries and highlighting the need for standardized diagnostic approaches.

Impact of nutritional diet therapy on premenstrual syndrome

May 22, 2025
This review highlights the role of diet and micronutrients in modulating PMS symptoms, showing potential benefits of calcium, magnesium, vitamin D, and B vitamins, while emphasizing the need for…

Premenstrual Syndrome and Exercise: A Narrative Review

May 12, 2025
This narrative review explores how exercise can help manage the symptoms of Premenstrual Syndrome (PMS), focusing on the physiological and psychological benefits of regular physical activity.

Premenstrual Syndrome and Premenstrual Dysphoric Disorder as Centrally Based Disorders

May 20, 2025
PMS and PMDD stem from neuroendocrine and neurochemical imbalances, especially altered allopregnanolone and GABA activity. Hormonal and neuroactive therapies improve symptoms, while microbiome and…

Premenstrual syndrome, a common but underrated entity: review of the clinical literature

May 12, 2025
This review explores premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD), focusing on symptoms, prevalence, risk factors, and treatment options.

Premenstrual syndrome: New insights into etiology and review of treatment methods

May 12, 2025
This review examines the latest insights into the etiology and treatment of Premenstrual Syndrome (PMS) and Premenstrual Dysphoric Disorder (PMDD), focusing on hormonal and neurosteroid imbalances.

Tobacco consumption and premenstrual syndrome: A case-control study

May 14, 2025
This study highlights the significant link between tobacco consumption and the increased risk of premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD). Women who smoke are at higher…

Primary Dysmenorrhea (31)

Exercise for dysmenorrhoea

Jul 28, 2025
This Cochrane review confirms that structured exercise markedly reduces menstrual pain in primary dysmenorrhea but reveals no microbiome data, prompting a call for studies linking exercise…

Nifedipine for primary dysmenorrhoea

Jul 26, 2025
Nifedipine may provide significant pain relief for women with primary dysmenorrhoea, but evidence quality is low. Larger studies are needed to confirm its effectiveness and safety.

The role of probiotics in improving menstrual health in women with primary dysmenorrhoea

Jul 26, 2025
Three-month probiotic supplementation improved mental health and reduced NSAID reliance in women with primary dysmenorrhea, though it did not alter inflammatory cytokines or directly measure…

Acupuncture for Primary Dysmenorrhea: A Potential Mechanism from an Anti-Inflammatory Perspective

Jul 28, 2025
This review details how acupuncture and related therapies reduce inflammatory mediators, cytokines, chemokines, and leukocytes, to relieve primary dysmenorrhea, and underscores the need for…

Primary Dysmenorrhea in Relation to Oxidative Stress and Antioxidant Status: A Systematic Review of Case-Control Studies

Jul 26, 2025
This systematic review highlights elevated oxidative stress and potential antioxidant deficiencies in women with primary dysmenorrhea. While oxidative markers such as MDA and NO were significantly…

Diagnosis and Management of Primary Dysmenorrhea

Jul 25, 2025
Primary dysmenorrhea is a common, underdiagnosed condition that causes significant pain and affects women’s daily lives. The study highlights its pathophysiology, diagnostic approach, treatment…

To explore the mechanism of acupoint application in the treatment of primary dysmenorrhea by 16S rDNA sequencing and metabolomics

Jul 25, 2025
This study explores how graphene-based warm uterus acupoint paste (GWUAP) treats primary dysmenorrhea by regulating intestinal microbiota and metabolites, highlighting its potential as a non-drug…

Management of dysmenorrhea through yoga: A narrative review

Jul 28, 2025
Yoga, especially asanas, pranayama, and yoga nidra, significantly reduces menstrual pain and distress in women with dysmenorrhea. These practices improve pain tolerance and overall well-being,…

Significant Increase in Depression in Women With Primary Dysmenorrhea

Jul 25, 2025
This systematic review highlights the significant association between primary dysmenorrhea and depression, emphasizing the need for integrated care that addresses both physical and mental health in…

Effects of a Bovine Lactoferrin Formulation from Cow’s Milk on Menstrual Distress in Volunteers

Jul 28, 2025
FeLf improved psychological symptoms related to menstrual distress, particularly autonomic balance, in healthy women. However, no significant effects on menstrual pain or quality of life were…

The effects of vitamin D and calcium on primary dysmenorrhea: a systematic review

Jul 28, 2025
Vitamin D and calcium supplementation can significantly reduce primary dysmenorrhea symptoms and reliance on analgesics. The inverse relationship between serum vitamin D and calcium levels and…

Association between cigarette smoking and the risk of dysmenorrhea: A meta-analysis of observational studies

Jul 26, 2025
This meta-analysis demonstrates that cigarette smoking increases the risk of dysmenorrhea, with both current and former smokers showing a significantly higher likelihood of experiencing menstrual…

Insight into Dysmenorrhea Research from 1992 to 2022: A Bibliometric Analysis

Jul 25, 2025
A bibliometric analysis of dysmenorrhea research from 1992 to 2022 reveals increasing global interest in its pathogenesis, treatment, and functional connectivity. It emphasizes the role of…

Prevalence and Impact of Dysmenorrhea on Hispanic Female Adolescent

Jul 25, 2025
Primary dysmenorrhea is a common and impactful condition affecting young women. This review explores its pathophysiology, symptoms, and treatment options to improve diagnosis and management in…

Primary Dysmenorrhea: Pathophysiology, Diagnosis, and Treatment Updates

Jul 28, 2025
This review explores the pathophysiology, impact, and treatment of primary dysmenorrhea, emphasizing the role of prostaglandins and the significant effects on women’s quality of life. It highlights…

Vitamin Effects in Primary Dysmenorrhea

Jul 28, 2025
This review evaluates the potential therapeutic role of vitamins (D, E, B1, C, K) in reducing primary dysmenorrhea symptoms, proposing them as alternatives to NSAIDs, with promising results,…

Acupuncture with or without moxibustion for primary dysmenorrhea

Jul 28, 2025
This protocol outlines a systematic review and meta‐analysis plan to evaluate acupuncture, with or without moxibustion, for pain relief and safety in women with primary dysmenorrhea.

Metabolomics study on primary dysmenorrhea patients during the luteal regression stage

Jul 25, 2025
This metabolomics study identifies ten urinary biomarkers linked to primary dysmenorrhea, providing insights into the metabolic disruptions that contribute to PD and suggesting potential new…

Associations between dysmenorrhea symptom-based phenotypes and vaginal microbiome: A pilot study

Jul 25, 2025
This study links dysmenorrhea symptom phenotypes with distinct vaginal microbiome compositions, suggesting that microbiome imbalances contribute to more severe menstrual pain, which could be targeted…

Relationship between Diet, Menstrual Pain and other Menstrual Characteristics among Spanish Students

Jul 26, 2025
This study links specific elements of the Mediterranean diet, particularly fruit and olive oil intake, to menstrual pain and characteristics, highlighting potential roles for anti-inflammatory foods…

Effect of Vitamin D Supplementation on Primary Dysmenorrhea

Jul 28, 2025
A systematic review and meta-analysis showed that vitamin D supplementation effectively reduces primary dysmenorrhea pain, especially with doses over 50,000 IU weekly, with significant improvements…

Efficacy of Zinc Supplementation in the Management of Primary Dysmenorrhea

Jul 26, 2025
Zinc supplementation significantly reduces pain severity in women with primary dysmenorrhea, especially with longer durations of use, offering a safe and effective treatment option.

Impact of Probiotic Supplementation and High-Intensity Interval Training on Primary Dysmenorrhea

Jul 26, 2025
HIIT significantly improved pain and physical fitness in women with primary dysmenorrhea, while probiotics showed some benefits in alleviating premenstrual symptoms. However, probiotics alone did not…

The Efficacy of Zinc Administration in the Treatment of Primary Dysmenorrhea

Jul 28, 2025
This study demonstrates that zinc supplementation, when combined with mefenamic acid, significantly reduces primary dysmenorrhea pain and incidence, offering a more effective treatment strategy than…

Primary Dysmenorrhea: Assessment and Treatment

Jul 28, 2025
Primary dysmenorrhea is a prevalent condition that affects many women, particularly in their younger years. This review discusses its pathophysiology, impact on quality of life, and treatment…

Lactobacillus gasseri OLL2809 is effective especially on the menstrual pain and dysmenorrhea in endometriosis patients

Jul 28, 2025
Lactobacillus gasseri OLL2809 significantly reduced menstrual pain and dysmenorrhea in endometriosis patients, offering a potential non-hormonal alternative to traditional treatments. No adverse…

Dysmenorrhea pattern in adolescences informing adult endometriosis

Jul 28, 2025
The study links adolescent dysmenorrhea patterns with adult endometriosis development. It suggests that early intervention, guided by dysmenorrhea frequency and onset, can reduce the risk of EMs and…

Comparative effectiveness of exercise interventions for primary dysmenorrhea

Jul 28, 2025
This network meta‑analysis ranks six exercise modalities for primary dysmenorrhea, showing resistance and multi‑component training best reduce pain and symptoms, with clear dosage guidelines for…

The effectiveness of self-care and lifestyle interventions in primary dysmenorrhea: a systematic review and meta-analysis

Jul 28, 2025
Self-care interventions like exercise, heat, and acupressure significantly reduce menstrual pain in primary dysmenorrhea, with exercise showing the largest effect. These methods may be effective…

Depression, anxiety, stress, and dysmenorrhea: a protocol for a systematic review

Jul 28, 2025
This systematic review will investigate the relationship between dysmenorrhea and psychological distress, including depression, anxiety, and stress, aiming to provide insights into their…

Dysmenorrhea increased the risk of postpartum depression in Chinese Han parturients

Jul 28, 2025
This study links dysmenorrhea to an increased risk of postpartum depression in Chinese women. It highlights the need for early PPD screening in women with a history of dysmenorrhea.

Primary Ovarian Insufficiency (POI) (27)

Diagnosis of the menopause: NICE guidance and quality standards

Aug 24, 2025
NICE guidance recommends diagnosing menopause in women over 45 clinically, not with lab tests, while FSH measurement is reserved for suspected POI in women under 40, streamlining care and reducing…

Vaginal microbiome of women with premature ovarian insufficiency: a descriptive cross-sectional study

Jul 31, 2025
The study reveals that women with premature ovarian insufficiency on systemic hormone therapy maintain a Lactobacillus-dominated vaginal microbiome, similar to estrogenized women, though some show…

The influence of the gut microbiome on ovarian aging

Aug 1, 2025
This review examines the relationship between gut microbiota and ovarian aging, highlighting microbial dysbiosis as a key factor in ovarian function decline. It explores microbiota-based therapies…

The Role of Lifestyle and Dietary Factors in the Development of Premature Ovarian Insufficiency

Jul 30, 2025
The review examines how lifestyle factors like diet, exercise, and oxidative stress contribute to Premature Ovarian Insufficiency (POI) and explores potential interventions using antioxidants,…

Metabolic dysregulation in patients with premature ovarian insufficiency revealed by integrated transcriptomic, methylomic and metabolomic analyses

Aug 1, 2025
This study identifies metabolic disruptions in POI, including altered amino acid and lipid metabolism. Key metabolites such as acetoacetate and HDCA were found to be potential biomarkers, shedding…

Premature Ovarian Insufficiency: New Perspectives on Genetic Cause and Phenotypic Spectrum

Jul 30, 2025
This review provides a comprehensive look at the genetic and phenotypic aspects of Premature Ovarian Insufficiency (POI), emphasizing the roles of various genes and chromosomal abnormalities, and…

Premature ovarian insufficiency: an update on recent advances in understanding and management

Jul 30, 2025
This review explores the causes, clinical presentation, and management of Premature Ovarian Insufficiency (POI), highlighting the role of genetic, autoimmune, and environmental factors, and discusses…

Premature Ovarian Insufficiency: Past, Present, and Future

Jul 30, 2025
This review investigates the genetic and non-genetic causes of Premature Ovarian Insufficiency (POI), highlighting recent advances in understanding its mechanisms and exploring novel therapeutic…

Hormone Replacement Therapy Reverses Gut Microbiome and Serum Metabolome Alterations in Premature Ovarian Insufficiency

Aug 2, 2025
This study explored the role of hormone replacement therapy (HRT) in reversing gut microbiome and serum metabolome alterations in women with premature ovarian insufficiency (POI), identifying…

Non-targeted metabolomics revealed novel links between serum metabolites and primary ovarian insufficiency: A Mendelian randomization study

Aug 1, 2025
This study identifies 33 serum metabolites, including N-acetylalanine, linked to an increased risk of primary ovarian insufficiency (POI), offering new insights into the disease’s genetic and…

Primary ovarian insufficiency: Update on clinical and genetic findings

Jul 30, 2025
This review explores the genetic and clinical factors contributing to primary ovarian insufficiency (POI), highlighting key genes and the importance of early diagnosis, fertility preservation, and…

Recent advances in the nutritional therapy for premature ovarian insufficiency

Jul 31, 2025
The review explores the potential of dietary supplements, including probiotics and phytoestrogens, to manage premature ovarian insufficiency (POI) symptoms. It highlights the safety, bioavailability,…

Metabolome-wide Mendelian randomization assessing the causal relationship between blood metabolites and primary ovarian insufficiency

Aug 1, 2025
This study identifies 27 metabolites linked to primary ovarian insufficiency (POI), revealing novel metabolic pathways and offering insights into POI biomarkers and therapeutic targets.

Hormone replacement therapy in young women with primary ovarian insufficiency and early menopause

Aug 1, 2025
The review discusses the therapeutic use of hormone replacement therapy (HRT) for managing POI and early menopause, highlighting its benefits in preventing complications like osteoporosis,…

Impact of oxidative stress induced by heavy metals on ovarian function

Jul 31, 2025
This review highlights the impact of heavy metal-induced oxidative stress on ovarian function, contributing to premature ovarian insufficiency. It discusses the mechanisms by which metals like…

Metabolic Profile of Patients with Premature Ovarian Insufficiency

Jul 31, 2025
This study examines the metabolic profile of women with premature ovarian insufficiency, finding significant changes in lipid and glucose metabolism. The results underscore the importance of early…

Evaluation of serum heavy metal levels on primary ovarian insufficiency

Jul 31, 2025
This study explores the potential link between serum heavy metal levels and premature ovarian insufficiency. The higher levels of metals like lead and mercury in women with POI suggest environmental…

Primary ovarian insufficiency

Jul 30, 2025
Primary Ovarian Insufficiency affects young women with amenorrhea and elevated FSH levels. It involves follicle dysfunction or depletion and requires comprehensive diagnosis and management, including…

Changes in the vaginal microbiota associated with primary ovarian failure

Jul 30, 2025
This study identifies significant differences in vaginal microbiota between women with Primary Ovarian Failure (POF) and healthy controls, highlighting the role of Lactobacillus species in…

Association between premature ovarian insufficiency and gut microbiota

Jul 31, 2025
The study reveals a distinct gut microbiome profile in women with premature ovarian insufficiency (POI), with altered bacterial populations linked to hormonal changes, suggesting a potential role of…

Association of dietary preferences with primary ovarian insufficiency (POI)

Jul 31, 2025
This study identifies dietary habits that influence the risk of Primary Ovarian Insufficiency (POI), finding that high-fat dairy products increase risk while oily fish and pork offer protection,…

Characteristics of the vaginal microbiome in women with premature ovarian insufficiency

Jul 31, 2025
This study identifies significant differences in vaginal microbiota between women with premature ovarian insufficiency (POI) and healthy controls, suggesting that microbial shifts could contribute to…

Metabolic differences in women with premature ovarian insufficiency: a systematic review and meta-analysis

Jul 31, 2025
This study investigates the metabolic differences in women with premature ovarian insufficiency (POI), highlighting increased waist circumference, cholesterol, and glucose levels. It underscores the…

Plasma metabolomic characterization of premature ovarian insufficiency

Jul 31, 2025
This study identifies key metabolites altered in premature ovarian insufficiency (POI), including arachidonoyl amide and 18-HETE, which could serve as diagnostic biomarkers. The findings reveal…

Premature ovarian insufficiency: a review on the role of tobacco smoke, its clinical harm, and treatment

Jul 31, 2025
Tobacco smoke significantly impacts ovarian function, leading to premature ovarian insufficiency. The review outlines the harmful effects of various tobacco-related toxins, such as nicotine, cadmium,…

Model construction and drug therapy of primary ovarian insufficiency by ultrasound-guided injection

Aug 1, 2025
This study demonstrates the effectiveness of ultrasound-guided hUC-MSC exosome injection in restoring ovarian function and fertility in POI rat models, offering a new therapeutic approach for women…

Premature ovarian insufficiency: the context of long-term effects

Jul 30, 2025
Premature ovarian insufficiency (POI) leads to fertility issues, bone loss, cardiovascular risks, and cognitive decline. Early intervention, including hormone therapy and lifestyle changes, is vital…

Probiotics (9)

The non-pathogenic Escherichia coli strain Nissle 1917 – features of a versatile probiotic

Nov 5, 2025
E. coli Nissle 1917 is a non-pathogenic probiotic strain that inhibits pathogenic bacteria, reduces inflammation, and strengthens intestinal barrier function, with proven clinical efficacy in…

Insights from 100 Years of Research with Probiotic E. Coli

Nov 6, 2025
Probiotic-e-coli-nissle-1917 shows benefit in ulcerative colitis, infant diarrhea, and innate immune priming, with transient engraftment and microcin-based pathogen suppression, but no effect in…

Oral Administration of Probiotics Inhibits Absorption of the Heavy Metal Cadmium by Protecting the Intestinal Barrier

Sep 28, 2025
This study highlights the protective effects of Lactobacillus plantarum CCFM8610 probiotics against cadmium toxicity by preserving intestinal barrier function and reducing oxidative stress, offering…

Probiotics Mechanism of Action on Immune Cells and Beneficial Effects on Human Health

Aug 19, 2025
This review examines the immunomodulatory effects of probiotics, detailing how they enhance immune functions through interactions with immune cells in the gut. Probiotics help regulate cytokine…

Escherichia coli strain Nissle 1917—from bench to bedside and back

Nov 5, 2025
Escherichia coli Nissle 1917 (EcN), a probiotic with a rich history, is now being engineered for therapeutic uses beyond gastrointestinal health, including metabolic disease treatment and immune…

Microcins mediate competition among Enterobacteriaceae in the inflamed gut

Nov 7, 2025
The study explores how Escherichia coli Nissle 1917’s microcins mediate competition in the inflamed gut, showing potential for therapeutic use in enterobacterial infections and colitis management.

The probiotic Escherichia coli strain Nissle 1917 interferes with invasion of human intestinal epithelial cells by different enteroinvasive bacterial pathogens

Nov 7, 2025
Escherichia coli Nissle 1917 (EcN) interferes with the invasion of human intestinal epithelial cells by various pathogens through a secreted component, not by microcins or physical contact,…

Intestinal effect of the probiotic Escherichia coli strain Nissle 1917 and its OMV

Nov 14, 2025
This review explains intestinal effect of Escherichia coli Nissle 1917 and its vesicles on the gut barrier, dysbiosis and mucosal immunity, and it links these microbial actions to clinical outcomes…

Improvement of a synthetic live bacterial therapeutic for phenylketonuria with biosensor-enabled enzyme engineering

Nov 9, 2025
Engineered EcN for phenylketonuria was upgraded to SYNB1934 using biosensor-enabled PAL evolution, doubling gut phenylalanine conversion and keeping biocontainment, supporting development of an oral…

Research Fast-Track (RFT) Designation (1)

Resistance (Strength) Training (5)

Rheumatoid Arthritis (16)

An expansion of rare lineage intestinal microbes characterizes rheumatoid arthritis

May 24, 2025
Rheumatoid arthritis gut microbiome dysbiosis is marked by Collinsella expansion and Faecalibacterium loss, disrupting gut barrier function and promoting inflammation. These findings reveal potential…

Analyzing the impact of heavy metal exposure on osteoarthritis and rheumatoid arthritis: an approach based on interpretable machine learning

Mar 18, 2025
What Was Studied? This study examined the impact of heavy metal exposure on the prevalence and differentiation of osteoarthritis (OA) and rheumatoid arthritis (RA) using interpretable machine…

Association of Bitter Taste Receptor T2R38 Polymorphisms, Oral Microbiota, and Rheumatoid Arthritis

May 20, 2025
This study links T2R38 genotype to oral microbiota composition in rheumatoid arthritis, revealing microbial shifts modulated by taste receptor polymorphisms. Findings suggest buccal dysbiosis in RA…

Dysbiotic Subgingival Microbial Communities in Periodontally Healthy Patients With Rheumatoid Arthritis

May 24, 2025
Subgingival microbiota in rheumatoid arthritis patients shows citrulline-producing and pro-inflammatory species enrichment despite periodontal health. These findings highlight Cryptobacterium curtum…

Gut Microbial Composition and Function Are Altered in Patients with Early Rheumatoid Arthritis

May 24, 2025
This study explores the gut microbiome in early rheumatoid arthritis, revealing Prevotella enrichment and Collinsella depletion. These microbial shifts, seen before full disease onset, highlight the…

Metagenome-wide association study of gut microbiome revealed novel aetiology of rheumatoid arthritis in the Japanese population

May 23, 2025
This study used gut microbiome metagenomics in rheumatoid arthritis to identify Prevotella enrichment and redox gene loss in RA. Findings reveal microbiome-host genomic interactions and metabolic…

Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients

May 24, 2025
This review highlights how oral microbiota in rheumatoid arthritis patients shows pathogenic enrichment, increased cytokines, and worsened periodontal outcomes. These dysbiotic patterns, involving…

Oral Microbiota Identifies Patients in Early Onset Rheumatoid Arthritis

May 20, 2025
This study found that oral microbiota in early rheumatoid arthritis displays distinct bacterial enrichments and metabolic shifts. Key taxa, including Filifactor alocis and Porphyromonas endodontalis,…

Oral Microbiota Perturbations Are Linked to High Risk for Rheumatoid Arthritis

May 24, 2025
This study reveals oral microbiota dysbiosis in rheumatoid arthritis, with distinct shifts in high-risk individuals before clinical symptoms. Prevotella_6 and Rothia were enriched, while Neisseria…

Oral status in patients with early rheumatoid arthritis: a prospective, case-control study

May 24, 2025
This study shows that the oral microbiota in early rheumatoid arthritis includes enriched Tannerella forsythia and Streptococcus anginosus, correlating with increased periodontal attachment loss.…

Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis

May 24, 2025
Oral microbiota in new-onset rheumatoid arthritis shows unique enrichment of Prevotella, Leptotrichia, and Anaeroglobus, independent of periodontitis severity. These taxa may act as microbial…

Role of Some Heavy Metals in Rheumatoid Arthritis

Mar 18, 2025
This study explored the association between rheumatoid arthritis and heavy metal exposure, identifying a significant deficiency of copper in RA patients. No significant correlations were found for…

Self-Balance of Intestinal Flora in Spouses of Patients With Rheumatoid Arthritis

May 24, 2025
This study on intestinal microbiota in rheumatoid arthritis spouses reveals shared dysbiosis, with enrichment of Streptococcus and Blautia and depletion of Roseburia. These shifts implicate…

Subgingival Microbiome in Rheumatoid Arthritis Patients with Periodontitis

May 20, 2025
This study links the subgingival microbiome in rheumatoid arthritis to elevated ACPAs via enrichment of A. butyrica, P. simiae, and P. stomatis. These bacteria contribute to citrullination and may be…

Subgingival microbiome of rheumatoid arthritis patients in relation to their disease status and periodontal health

May 24, 2025
Subgingival microbiome in rheumatoid arthritis reveals microbial community shifts driven by disease activity, smoking, and treatment. Prednisolone use correlates with healthier profiles, while…

Variations in oral microbiome profiles in rheumatoid arthritis and osteoarthritis with potential biomarkers for arthritis screening

May 24, 2025
This study identifies oral microbiome biomarkers for arthritis screening, distinguishing RA from OA using salivary microbial profiles. It highlights Prevotella and Veillonella in RA and Rothia and…

STOPs (3)

Short-chain Fatty Acids (SCFAs) (5)

Staphylococcus aureus (S. Aureus) (5)

Ciclopirox Antifungal and Anti-Inflammatory Review: Dermatology to Oncology

Jul 28, 2025
Ciclopirox and its salt form exhibit broad-spectrum antifungal, antibacterial, and anti-inflammatory activity via iron chelation and enzyme inhibition. With low resistance potential, they outperform…

Staphylococcus aureus Plasmids: Reservoirs of Antibiotic Resistance and Virulence Genes

Jul 8, 2025
This study sequenced and analyzed plasmids from poultry-associated Staphylococcus aureus, uncovering diverse resistance and virulence genes, novel mobilizable plasmids, and highlighting poultry as a…

MntABC and MntH Enable Staphylococcus aureus to Overcome Host Nutritional Immunity and Manganese Starvation

Jul 9, 2025
This study shows that Staphylococcus aureus uses MntABC and MntH transporters to overcome host-imposed manganese starvation via calprotectin, preserving SOD activity and enabling systemic infection.

Staphylococcus aureus HrtA-heme-toxicity : ATPase function and heme-stress virulence reprogramming in S. aureus

Aug 22, 2025
HrtA is the ATPase of HrtAB that protects S. aureus from heme toxicity. Catalytic residues are essential in vitro and in vivo. Heme-stressed hrtA mutants undergo stringent-like reprogramming with a…

Candida albicans Enables Staphylococcus aureus “Hitchhiking” Across Mucosa

Nov 29, 2025
Candida albicans enables systemic Staphylococcus aureus infection via Als3p-mediated hyphal invasion. This “microbial hitchhiking” allows S. aureus to bypass epithelial barriers, with major…

Tinidazole (2)

Urease (2)

Vulvovaginal Candidiasis (VVC) (10)

Mycobiome Study Reveals Different Pathogens of Vulvovaginal Candidiasis Shape Characteristic Vaginal Bacteriome

Jul 23, 2025
What was studied? This study examined the interaction between the vaginal microbiota and mycobiota in patients with vulvovaginal candidiasis (VVC). The research focused on understanding the role of…

Biosorption of Heavy Metals by Candida albicans

Jun 6, 2025
The study showed Candida albicans can resist and efficiently biosorb heavy metals, especially chromium, from contaminated water and soil. Optimal removal depends on pH, temperature, biomass state,…

Current patient perspectives of vulvovaginal candidiasis: incidence, symptoms, management and post-treatment outcomes

Jun 6, 2025
This contemporary survey validates historical data on VVC/RVVC prevalence, identifying common symptoms, risk factors, and treatment outcomes. It highlights antibiotics as a major risk factor and…

Dual Mechanisms of Action: Anti-Candida and Anti-Inflammatory Potential of Lactobacillus Fermentation Broth in Treating Vulvovaginal Candidiasis

Jun 13, 2025
This study explored VAGINNE®, a Lactobacillus fermentation broth, showing strong anti-Candida and anti-inflammatory effects in mice with VVC. It enhanced microbiome health and reduced proinflammatory…

Management of recurrent vulvovaginal candidosis: Narrative review of the literature and European expert panel opinion

Jun 6, 2025
This review assesses management strategies for recurrent vulvovaginal candidiasis, highlighting the limitations of current antifungal treatments, rising resistance concerns, and potential novel…

Metal Nanoparticles to Combat Candida albicans Infections: An Update

Jun 6, 2025
This review examines metal nanoparticles as innovative antifungal agents against Candida albicans. It highlights their multi-target actions, synergistic potential with antifungal drugs, and drug…

Microbiota in vaginal health and pathogenesis of recurrent vulvovaginal infections: a critical review

Jun 6, 2025
This review clarifies the role of vaginal microbiota in health and recurrent infections, highlighting Lactobacillus complexity, pathogen interactions, and the need for personalized diagnostic and…

Vaginal microbiota: Potential targets for vulvovaginal candidiasis infection

Jun 6, 2025
This review discusses vaginal microbiota imbalance in vulvovaginal candidiasis and evaluates probiotics, postbiotics, synbiotics, and vaginal microbiota transplantation as novel treatments to improve…

Vulvovaginal Candidiasis: A Current Understanding and Burning Questions.

Jun 6, 2025
This review clarifies mechanisms behind vulvovaginal candidiasis, emphasizing candidalysin-driven inflammation, microbiome complexity, and the potential of inflammasome-targeted therapies. It…

Vulvovaginal Candidosis: Current Concepts, Challenges and Perspectives

May 29, 2025
This review consolidates current knowledge on vulvovaginal candidosis, highlighting Candida albicans virulence factors, diagnostic challenges, and the need for precise clinical differentiation…

Women’s Health (497)

Diagnosis of the menopause: NICE guidance and quality standards

Aug 24, 2025
NICE guidance recommends diagnosing menopause in women over 45 clinically, not with lab tests, while FSH measurement is reserved for suspected POI in women under 40, streamlining care and reducing…

Factors associated with age at menarche, menstrual knowledge, and hygiene practices among schoolgirls in Sharjah, UAE

Aug 14, 2025
This study explores the factors influencing age at menarche, menstrual knowledge, and hygiene practices among schoolgirls in Sharjah, UAE. It highlights how socioeconomic factors, education, and…

Gut microbiota modulation: a narrative review on a novel strategy for prevention and alleviation of ovarian aging

Nov 15, 2025
This review explores how gut microbiota modulation influences ovarian aging and presents potential therapies like fecal microbiota transplantation and probiotics to prevent or alleviate ovarian…

Long-term postmenopausal hormone therapy and endometrial cancer

Aug 21, 2025
Long-term use of estrogen and estrogen-progestin therapies significantly increases the risk of endometrial cancer, particularly for women with lower BMI. The risk is dose-dependent, with…

Dietary Intake and Ovarian Cancer Risk: A Systematic Review

Aug 7, 2025
This review examines the relationship between diet and ovarian cancer risk, finding that animal fats and dairy are linked to higher risk, while vegetables and bioactive compounds may offer protective…

Maternal Iron Deficiency Anemia Affects Postpartum Emotions and Cognition

Jun 14, 2025
The study explored the impact of iron deficiency anemia on postpartum cognitive and emotional health. Iron supplementation significantly improved depression, stress, and cognitive performance in…

Evidence for the Use of Complementary and Alternative Medicine for Pelvic Inflammatory Disease: A Literature Review

Jun 20, 2025
This review investigates the potential of Complementary and Alternative Medicine (CAM) in managing Pelvic Inflammatory Disease (PID). Therapies like Chinese Herbal Medicine and acupuncture show…

Prevalence of hot flushes and night sweats around the world: a systematic review

Jul 19, 2025
This systematic review explores the global prevalence of hot flashes and night sweats, revealing significant cultural and regional variations. It emphasizes the need for personalized, region-specific…

Hormone therapy and the risk of stroke: Perspectives ten years after the Women’s Health Initiative trials

Aug 21, 2025
This review investigates the stroke risk associated with hormonal therapies in postmenopausal women, comparing oral and transdermal estrogen formulations and highlighting the need for individualized…

Vaginal microbiome of women with premature ovarian insufficiency: a descriptive cross-sectional study

Jul 31, 2025
The study reveals that women with premature ovarian insufficiency on systemic hormone therapy maintain a Lactobacillus-dominated vaginal microbiome, similar to estrogenized women, though some show…

Exercise for dysmenorrhoea

Jul 28, 2025
This Cochrane review confirms that structured exercise markedly reduces menstrual pain in primary dysmenorrhea but reveals no microbiome data, prompting a call for studies linking exercise…

Black cohosh (Cimicifuga spp.) for menopausal symptoms.

Jul 14, 2025
This review finds insufficient evidence that black cohosh effectively reduces menopausal symptoms. Hormone therapy outperforms black cohosh, which appears safe but needs further study for efficacy…

Hormone replacement therapy for women previously treated for endometrial cancer

Aug 21, 2025
This review highlights the lack of conclusive evidence on the safety of hormone replacement therapy (HRT) in women treated for early-stage endometrial cancer. While a small study found no significant…

Nifedipine for primary dysmenorrhoea

Jul 26, 2025
Nifedipine may provide significant pain relief for women with primary dysmenorrhoea, but evidence quality is low. Larger studies are needed to confirm its effectiveness and safety.

Drugs for the treatment of menopausal symptoms.

Jul 14, 2025
Estrogen therapy remains the most effective treatment for menopausal symptoms, with transdermal delivery preferred for safety. Non-hormonal options offer moderate relief; emerging therapies like…

Does Physical Exercise Lower Endometriosis Risk? Systematic Review Insights

Jul 22, 2025
This systematic review found insufficient evidence to confirm that physical exercise reduces endometriosis risk or symptoms, though some data suggest a potential protective effect. Well-designed…

The Effects of Toxic Heavy Metals Lead, Cadmium and Copper on the Epidemiology of Male and Female Infertility

Jun 30, 2025
This review synthesizes evidence linking lead, cadmium, and copper exposure to male and female infertility, detailing mechanisms of reproductive toxicity, epidemiological patterns, and the potential…

Ospemifene for the treatment of menopausal vaginal dryness, a symptom of the genitourinary syndrome of menopause

Aug 22, 2025
Ospemifene is an effective and safe treatment for menopausal vaginal dryness and dyspareunia, particularly in women with contraindications for estrogen therapy. It improves vaginal health without…

The role of probiotics in improving menstrual health in women with primary dysmenorrhoea

Jul 26, 2025
Three-month probiotic supplementation improved mental health and reduced NSAID reliance in women with primary dysmenorrhea, though it did not alter inflammatory cytokines or directly measure…

Hormone therapy for first-line management of menopausal symptoms: Practical recommendations

Aug 20, 2025
This review sets a simple plan for menopausal hormone therapy first-line management, favors transdermal routes when risk exists, and backs local therapy for genitourinary symptoms with clear links to…

Elevated levels of whole blood nickel in a group of Sri Lankan women with endometriosis: a case control study

Nov 27, 2025
This study examined blood nickel and endometriosis, revealing significantly higher nickel levels in affected Sri Lankan women, supporting a potential metalloestrogenic role.

Compositional and functional features of the female premenopausal and postmenopausal gut microbiota

Jul 7, 2025
Menopause is linked to reduced gut microbiome diversity, loss of beneficial Firmicutes and Roseburia, and increased risk-associated taxa and metabolic pathways. These changes may contribute to higher…

Acupuncture for Primary Dysmenorrhea: A Potential Mechanism from an Anti-Inflammatory Perspective

Jul 28, 2025
This review details how acupuncture and related therapies reduce inflammatory mediators, cytokines, chemokines, and leukocytes, to relieve primary dysmenorrhea, and underscores the need for…

Reducing Ovarian Cancer Mortality Through Early Detection: Approaches using Circulating Biomarkers

Aug 6, 2025
This review discusses liquid biopsy techniques for early ovarian cancer detection, focusing on circulating tumor cells, cell-free DNA, and extracellular vesicles. It highlights their potential to…

POI: Premature Ovarian Insufficiency/Pregnancy or Infertility?

Jun 27, 2025
This case report describes a young woman with premature ovarian insufficiency who, despite infertility and diagnostic confirmation of POI, experienced spontaneous conception. The case underscores the…

The influence of the gut microbiome on ovarian aging

Aug 1, 2025
This review examines the relationship between gut microbiota and ovarian aging, highlighting microbial dysbiosis as a key factor in ovarian function decline. It explores microbiota-based therapies…

A systematic review of randomised clinical trials – The safety of vaginal hormones and selective estrogen receptor modulators for the treatment of genitourinary menopausal symptoms in breast cancer survivors

Aug 21, 2025
This review assesses the safety of vaginal hormones and SERMs in treating genitourinary menopausal symptoms in breast cancer survivors. It finds no significant rise in serum estrogen levels or an…

The gut microbiota in menopause: Is there a role for prebiotic and probiotic solutions?

Jul 14, 2025
Menopause alters gut microbiota composition and estrogen metabolism, contributing to symptoms and disease risks. Prebiotic and probiotic interventions show promise for symptom relief and metabolic…

Pelvic inflammatory disease: a family practice perspective

Jun 19, 2025
Family practice perspectives highlight challenges diagnosing PID, advocating enhanced clinical suspicion, multi-antibiotic treatment adherence, and regular screening for asymptomatic infections to…

Comparison of Gabapentin with Estrogen for treatment of hot flashes in post-menopausal women

Aug 22, 2025
This study demonstrates that gabapentin 300 mg/day is as effective as estrogen 0.625 mg/day for reducing hot flashes in post-menopausal women. It provides a viable non-hormonal alternative with fewer…

The microbiome and ovarian cancer: insights, implications, and therapeutic opportunities

Aug 8, 2025
This review explores how the microbiome influences ovarian cancer development, progression, and treatment response. It emphasizes microbial dysbiosis as a factor in carcinogenesis and offers insights…

Complementary and Alternative Medicine for Menopause

Jul 14, 2025
Mind-body therapies like hypnosis effectively reduce menopausal hot flashes; natural products and whole-system CAM approaches show mixed evidence. More high-quality research is needed.

Contraceptive potential of Hibiscus rosa-sinensis (Linn.)

Jul 27, 2025
Hibiscus rosa-sinensis shows potent antifertility effects through antiovulatory, antiimplantation, and antispermatogenic mechanisms in animal studies, supporting its development as a safe, natural…

Microbiology profile in women with pelvic inflammatory disease in relation to IUD use

Jun 19, 2025
This study identifies microbial differences in women with PID based on IUD use, highlighting a higher presence of anaerobic bacteria in IUD users and an increased risk of PID complications. These…

The Application of Complementary and Alternative Medicine in Polycystic Ovary Syndrome Infertility

Jul 3, 2025
This review summarizes clinical and mechanistic evidence for complementary and alternative medicine in PCOS infertility, highlighting TCM, acupuncture, nutrient supplementation, and lifestyle…

User Outcomes for an App-Delivered Hypnosis Intervention for Menopausal Hot Flashes: Retrospective Analysis.

Jul 21, 2025
The study assessed the effectiveness of the Evia app, a smartphone-based hypnotherapy intervention, in reducing hot flash frequency and severity in menopausal women.

Epidermiological markers in pelvic inflammatory disease (PID) among the women of reproductive age group

Jun 19, 2025
This study identifies key socio-demographic factors associated with PID in women of reproductive age, highlighting the need for better education, healthcare access, and early intervention. It…

The Gut Microbiome in Aging and Ovarian Cancer

Aug 8, 2025
This review examines how the aging gut microbiome affects ovarian cancer progression. It highlights microbial dysbiosis as a common feature in both aging and cancer, with implications for novel…

Correlation of Heavy Metal Content in the Blood of Patients with Ovarian Cancer by Place of Residence

Aug 8, 2025
This study explores how the concentration of heavy metals, particularly zinc and copper, in the blood of ovarian cancer patients correlates with their recurrence-free survival. It highlights the…

Life-course origins of the ages at menarche and menopause

Aug 14, 2025
A comprehensive review of evidence on the determinants and health implications of ages at menarche and menopause, highlighting their complex, independent origins and the influence of life-course…

Pelvic inflammatory disease and infertility

Jun 27, 2025
This review details the polymicrobial pathogenesis of PID, its major microbial culprits—including both classical STIs and vaginal anaerobes—and underscores the high risk of infertility. Early…

Potential biomarkers of infertility associated with microbiome imbalances

Jun 27, 2025
Microbiome dysbiosis and elevated miR-21-5p and miR-155-5p levels are strongly linked to unexplained infertility, suggesting their role as biomarkers. Correcting these microbiome imbalances could…

Bacterial isolates associated with pelvic inflammatory disease among female patients attending some hospitals in abuja, Nigeria

Jun 19, 2025
This study identifies key bacterial pathogens associated with pelvic inflammatory disease (PID) in Abuja, Nigeria, highlighting the effectiveness of Cefotaxime in treatment. The research also…

Cellular and molecular processes in ovarian cancer metastasis. A Review in the Theme: Cell and Molecular Processes in Cancer Metastasis

Aug 6, 2025
This review explores the molecular mechanisms of ovarian cancer metastasis, focusing on the role of stromal cells and the metastatic routes—passive dissemination and hematogenous spread—while…

Herbal contraceptives: Evaluation of antifertility potential of Hibiscus rosa-sinensis (Linn.)

Jul 15, 2025
Hibiscus rosa-sinensis exhibits significant antifertility effects in animal models through antiovulatory, antiimplantation, and spermatogenic disruption mechanisms, highlighting its potential as a…

Onset of natural menopause in African American women

Jul 7, 2025
This prospective study of 17,070 African American women found smoking most strongly predicts earlier menopause, while higher BMI and oral contraceptive use are protective. Perceived racism showed…

Potential for Phages in the Treatment of Bacterial Sexually Transmitted Infections

Jun 24, 2025
Bacteriophage therapy presents a promising alternative to antibiotics for bacterial sexually transmitted infections, particularly against antibiotic-resistant strains like N. gonorrhoeae, through…

Medical-Grade Honey as a Potential New Therapy for Bacterial Vaginosis

Jul 4, 2025
What was reviewed? This review article examines current evidence on the use of medical-grade honey (MGH) as a novel therapy for bacterial vaginosis (BV), a prevalent condition among women of…

The Role of Lead and Cadmium in Gynecological Malignancies

Aug 9, 2025
This study explores the role of lead and cadmium in gynecological malignancies, focusing on their ability to mimic estrogen and induce oxidative stress, contributing to cancer development. It…

The Role of Lifestyle and Dietary Factors in the Development of Premature Ovarian Insufficiency

Jul 30, 2025
The review examines how lifestyle factors like diet, exercise, and oxidative stress contribute to Premature Ovarian Insufficiency (POI) and explores potential interventions using antioxidants,…

Assessing the Impact of (Poly)phenol-Rich Foods on Cardiometabolic Risk in Postmenopausal Women

Jul 14, 2025
Dietary intake of (poly)phenol-rich foods modestly improves cardiometabolic risk factors and reduces oxidative stress in postmenopausal women, with gut microbiome variability influencing outcomes.

Primary Dysmenorrhea in Relation to Oxidative Stress and Antioxidant Status: A Systematic Review of Case-Control Studies

Jul 26, 2025
This systematic review highlights elevated oxidative stress and potential antioxidant deficiencies in women with primary dysmenorrhea. While oxidative markers such as MDA and NO were significantly…

Endometriosis and Ovarian Cancer: An Integrative Review (Endometriosis and Ovarian Cancer)

Aug 12, 2025
This review explores the link between endometriosis and ovarian cancer, focusing on genetic mutations like ARID1A, oxidative stress, and estrogen receptor loss, which contribute to the development of…

Severe hot flashes are associated with chronic insomnia

Jul 19, 2025
This study links severe hot flashes to chronic insomnia in perimenopausal and postmenopausal women, suggesting that managing hot flashes could improve sleep quality and reduce the health risks…

Role of menopausal hormone therapy in the prevention of postmenopausal osteoporosis

Aug 20, 2025
The review shows that menopausal hormone therapy osteoporosis prevention lowers fractures when started near menopause, favors transdermal routes for safety, and maps RANKL–OPG and cytokine shifts…

Interaction of metals, menopause and COVID-19: A review of the literature

Jul 9, 2025
This review details how environmental metal exposures influence menopause onset, symptoms, and COVID-19 outcomes, emphasizing the potential for trace mineral supplementation and the need for…

Targeting Oxidative Stress Involved in Endometriosis and Its Pain

Dec 21, 2025
This review links oxidative stress, ferroptosis, immune activation, pain, and emerging gut microbiome changes to endometriosis progression and severity.

Probiotics as Anti-Tumor Agents: Insights from Female Tumor Cell Culture Studies

Aug 7, 2025
Probiotics were shown to significantly reduce cancer cell proliferation, promote apoptosis, and inhibit migration in breast and ovarian cancer cells, suggesting their potential as adjunctive cancer…

Metformin as a Potential Treatment Option for Endometriosis

Jun 24, 2025
Metformin shows potential in treating endometriosis through anti-inflammatory, anti-angiogenic, anti-proliferative effects, and modulation of the gut microbiome. It could be a safe, effective…

Interpretation of reproductive hormones before, during and after the pubertal transition—identifying health and disordered puberty

Aug 15, 2025
A comprehensive review of the hormonal regulation of puberty, diagnostic markers for distinguishing healthy from disordered puberty, and the implications for clinical practice, with emphasis on the…

Rethinking Menopausal Hormone Therapy: For Whom, What, When and How long?

Aug 21, 2025
This review offers updated guidance on the use of menopausal hormone therapy, highlighting its benefits when started early, particularly for women with low cardiovascular risk. It stresses the…

Diagnosis and Management of Primary Dysmenorrhea

Jul 25, 2025
Primary dysmenorrhea is a common, underdiagnosed condition that causes significant pain and affects women’s daily lives. The study highlights its pathophysiology, diagnostic approach, treatment…

Metabolic dysregulation in patients with premature ovarian insufficiency revealed by integrated transcriptomic, methylomic and metabolomic analyses

Aug 1, 2025
This study identifies metabolic disruptions in POI, including altered amino acid and lipid metabolism. Key metabolites such as acetoacetate and HDCA were found to be potential biomarkers, shedding…

The Female Reproductive Tract Microbiome and Cancerogenesis: A Review Story of Bacteria, Hormones, and Disease

Aug 7, 2025
This review highlights the significant role of the female reproductive tract microbiome in the development of gynecological cancers, focusing on microbial dysbiosis, estrogen regulation, and…

Menopausal Changes in the Microbiome—A Review Focused on the Genitourinary Microbiome

Jul 7, 2025
Menopause alters the gut, vaginal, and urinary microbiomes, decreasing Lactobacillus and increasing microbial diversity. These changes contribute to GSM, rUTI, and urinary symptoms. Hormone therapy…

Socioeconomic and Lifestyle Factors Affecting Age at Natural Menopause: Global Systematic Review

Jul 7, 2025
What was reviewed? This systematic review and meta-analysis synthesized data from 46 community-based studies across 24 countries, assessing the influence of socioeconomic position (SEP) and lifestyle…

Influence of tobacco smoking and alcohol drinking on dysmenorrhoea

Jul 26, 2025
This study identifies a strong association between concurrent tobacco smoking and alcohol drinking and increased dysmenorrhea risk. It emphasizes the need for lifestyle modifications, such as smoking…

Relationships between female infertility and female genital infections and pelvic inflammatory disease

Jun 27, 2025
A large-scale Taiwanese study found that upper and lower genital tract infections, but not comorbidities or bacterial vaginosis, independently increased infertility risk. PID and lower genital tract…

Premature Ovarian Insufficiency: New Perspectives on Genetic Cause and Phenotypic Spectrum

Jul 30, 2025
This review provides a comprehensive look at the genetic and phenotypic aspects of Premature Ovarian Insufficiency (POI), emphasizing the roles of various genes and chromosomal abnormalities, and…

Premature ovarian insufficiency: an update on recent advances in understanding and management

Jul 30, 2025
This review explores the causes, clinical presentation, and management of Premature Ovarian Insufficiency (POI), highlighting the role of genetic, autoimmune, and environmental factors, and discusses…

Premature Ovarian Insufficiency: Past, Present, and Future

Jul 30, 2025
This review investigates the genetic and non-genetic causes of Premature Ovarian Insufficiency (POI), highlighting recent advances in understanding its mechanisms and exploring novel therapeutic…

Fecal Microbiota Changes in Patients With Postpartum Depressive Disorder

Jul 23, 2025
This study investigates the link between gut microbiota and postpartum depressive disorder (PPD), identifying specific microbiota changes that correlate with depressive symptoms and hormonal levels.…

919 Syrup Alleviates Postpartum Depression by Modulating the Structure and Metabolism of Gut Microbes and Affecting the Function of the Hippocampal GABA/Glutamate System

Jun 16, 2025
This study explores how 919 syrup, a Chinese herbal remedy, alleviates postpartum depression (PPD) by modulating the gut microbiome and hippocampal GABA metabolism, offering a novel treatment…

Alterations of Vaginal Microbiota in Women With Infertility and Chlamydia trachomatis Infection

Jun 27, 2025
This study identified vaginal microbiota dysbiosis, marked by Lactobacillus iners dominance, in infertile women infected with Chlamydia trachomatis. Post-antibiotic recovery suggested microbiome…

Gut microbiota: Linking nutrition and perinatal depression

Jun 16, 2025
This review investigates the relationship between gut microbiota and perinatal depression, highlighting how nutrition and probiotics may help regulate mood disorders during pregnancy and postpartum.

The role of gut microbiota and blood metabolites in postpartum depression: A Mendelian randomization analysis.

Jun 16, 2025
This study identifies gut microbiota and blood metabolites causally associated with postpartum depression, revealing potential biomarkers and therapeutic targets for PPD.

The ovarian cancer-associated microbiome contributes to the tumor’s inflammatory microenvironment

Aug 8, 2025
This review explores the ovarian cancer-associated microbiome’s role in shaping the inflammatory microenvironment of tumors. It discusses how microbial dysbiosis and its metabolites contribute…

Risks, Benefits, and Treatment Modalities of Menopausal Hormone Therapy: Current Concepts

Aug 21, 2025
The study emphasizes the risks and benefits of menopausal hormone therapy in managing vasomotor symptoms, osteoporosis, and cardiovascular health. It highlights the importance of timing, formulation,…

Hormone Replacement Therapy Reverses Gut Microbiome and Serum Metabolome Alterations in Premature Ovarian Insufficiency

Aug 2, 2025
This study explored the role of hormone replacement therapy (HRT) in reversing gut microbiome and serum metabolome alterations in women with premature ovarian insufficiency (POI), identifying…

Endometriosis-associated infertility: From pathophysiology to tailored treatment

Jun 27, 2025
This review synthesizes evidence on the multifactorial mechanisms underlying endometriosis-associated infertility, emphasizing inflammatory, hormonal, anatomical, and molecular drivers. It highlights…

Non-targeted metabolomics revealed novel links between serum metabolites and primary ovarian insufficiency: A Mendelian randomization study

Aug 1, 2025
This study identifies 33 serum metabolites, including N-acetylalanine, linked to an increased risk of primary ovarian insufficiency (POI), offering new insights into the disease’s genetic and…

To explore the mechanism of acupoint application in the treatment of primary dysmenorrhea by 16S rDNA sequencing and metabolomics

Jul 25, 2025
This study explores how graphene-based warm uterus acupoint paste (GWUAP) treats primary dysmenorrhea by regulating intestinal microbiota and metabolites, highlighting its potential as a non-drug…

Primary ovarian insufficiency: Update on clinical and genetic findings

Jul 30, 2025
This review explores the genetic and clinical factors contributing to primary ovarian insufficiency (POI), highlighting key genes and the importance of early diagnosis, fertility preservation, and…

Metformin, the Rise of a New Medical Therapy for Endometriosis? A Systematic Review of the Literature

Jun 24, 2025
Metformin emerges as a promising non-hormonal therapy for endometriosis, showing potent anti-inflammatory, anti-angiogenic, and fertility-enhancing effects, with significant symptom relief in limited…

Role of Vaginal Microbiota Dysbiosis in Gynecological Diseases and the Potential Interventions

Jul 3, 2025
This review reveals how vaginal microbiota dysbiosis underpins diverse gynecological diseases, highlights characteristic microbial signatures, and evaluates interventions—especially probiotics and…

Recent advances in the nutritional therapy for premature ovarian insufficiency

Jul 31, 2025
The review explores the potential of dietary supplements, including probiotics and phytoestrogens, to manage premature ovarian insufficiency (POI) symptoms. It highlights the safety, bioavailability,…

Gut microbiota: Emerging biomarkers and potential therapeutics for premature ovarian failure

Aug 2, 2025
This paper explores how gut microbiota dysbiosis contributes to premature ovarian failure (POF) and highlights potential therapeutic interventions targeting GM for better management of POF.

Female infertility and diet, is there a role for a personalized nutritional approach in assisted reproductive technologies? 

Jul 4, 2025
This review highlights how dietary patterns, micronutrients, genetics, and the microbiome interact to influence female infertility and ART outcomes, supporting the role of personalized nutrition and…

Association between dietary trace minerals and pelvic inflammatory disease: Data from the 2015–2018 National Health and Nutrition Examination Surveys

Jun 20, 2025
Higher dietary copper intake significantly lowers the risk of pelvic inflammatory disease in U.S. women, highlighting copper’s role in inflammation and reproductive health.

Diet-driven microbiome changes and physical activity in cancer patients

Aug 7, 2025
This review underscores the importance of diet and physical activity in modulating the gut microbiome of cancer patients. Diets like fiber-rich and Mediterranean diets show promise in improving…

Association between dietary magnesium intake and pelvic inflammatory disease in US women: a cross-sectional study of NHANES

Jun 20, 2025
Higher dietary magnesium intake significantly reduces pelvic inflammatory disease risk in U.S. women, especially older adults, highlighting magnesium’s role in inflammation and reproductive health.

Management of dysmenorrhea through yoga: A narrative review

Jul 28, 2025
Yoga, especially asanas, pranayama, and yoga nidra, significantly reduces menstrual pain and distress in women with dysmenorrhea. These practices improve pain tolerance and overall well-being,…

Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause

Jul 14, 2025
This review details the estrogenic activity, neuroprotective effects, and clinical relevance of medicinal plants for menopausal women, highlighting their potential to prevent cognitive decline and…

Integrated Metabolomics and Network Pharmacology Study on the Mechanism of Kangfuxiaoyan Suppository for Treating Chronic Pelvic Inflammatory Disease

Jun 20, 2025
Kangfuxiaoyan suppository effectively treats chronic pelvic inflammatory disease by regulating key inflammatory and metabolic pathways, significantly reducing inflammation. Integrated metabolomics…

New hopes and promises in the treatment of ovarian cancer focusing on targeted treatment—A narrative review

Aug 12, 2025
This review explores the role of targeted therapies in ovarian cancer treatment, focusing on the potential of angiogenesis inhibitors, PARP inhibitors, and folate receptor alpha inhibitors. While…

Significant Increase in Depression in Women With Primary Dysmenorrhea

Jul 25, 2025
This systematic review highlights the significant association between primary dysmenorrhea and depression, emphasizing the need for integrated care that addresses both physical and mental health in…

Association between heavy metals exposure and infertility among American women aged 20-44 years: A cross-sectional analysis from 2013 to 2018 NHANES data

Jun 30, 2025
This cross-sectional study in American women found that higher urinary arsenic—and, to a lesser extent, cadmium—were associated with increased infertility risk, with lead exposure linked to…

Lactobacilli–lactoferrin interplay in Chlamydia trachomatis infection

Jun 24, 2025
The study found a potent inhibitory effect against Chlamydia trachomatis infection using Lactobacillus brevis combined with lactoferrin, notably reducing bacterial adhesion, invasion, and…

What’s in a name: are menopausal “hot flashes” a symptom of menopause or a manifestation of neurovascular dysregulation?

Jul 19, 2025
The article redefines menopausal hot flashes as signs of underlying neurovascular dysregulation, linking them to chronic conditions like cardiovascular disease and cognitive decline. It advocates for…

What’s in a name: are menopausal ‘hot flashes’ a symptom of menopause or a manifestation of neurovascular dysregulation?

Jul 7, 2025
This review challenges the labeling of hot flashes as mere menopausal symptoms, proposing they signal underlying neurovascular dysregulation linked to chronic disease risk, and calls for new clinical…

Ospemifene, a novel selective estrogen receptor modulator for treating dyspareunia associated with postmenopausal vulvar and vaginal atrophy

Aug 22, 2025
Ospemifene (60 mg/day) significantly reduces dyspareunia and improves vaginal health in postmenopausal women with vulvar and vaginal atrophy. It offers a non-estrogenic treatment option, especially…

Premenopausal Bone Health: Osteoporosis in Premenopausal Women

Jul 8, 2025
This review outlines the evaluation and management of osteoporosis in premenopausal women, emphasizing secondary causes, appropriate BMD interpretation, and tailored treatment—highlighting the…

Microbiota and Human Reproduction: The Case of Female Infertility

Jun 26, 2025
This review summarizes the essential role of balanced reproductive microbiota, particularly Lactobacillus dominance, in fertility and IVF success, linking microbial dysbiosis to infertility and…

The Effect of Salvia Officinalis on Hot Flashes in Postmenopausal Women

Jul 21, 2025
This systematic review and meta-analysis found that Salvia officinalis significantly reduces the frequency of hot flashes in postmenopausal women, making it a promising non-hormonal alternative.

Inflammatory Markers in Dysmenorrhea and Therapeutic Options

Jul 25, 2025
This review discusses inflammatory markers and therapeutic options in primary dysmenorrhea, focusing on prostaglandins, cytokines, and vasopressin, and evaluates treatments like NSAIDs, acupuncture,…

Female Infertility Associated with Blood Lead and Cadmium Levels

Jun 30, 2025
What was studied? This original research article investigated the association between blood levels of lead and cadmium (two common environmental heavy metals) and self-reported infertility among…

Female Fertility and Environmental Pollution

Jun 30, 2025
Environmental pollution—including heavy metals, air pollutants, and endocrine disruptors—negatively impacts female fertility through hormonal disruption, oxidative stress, and epigenetic changes. The…

The application of metabolomics in ovarian cancer management: A systematic review

Aug 10, 2025
his systematic review highlights the role of metabolomics in ovarian cancer management, identifying key metabolic alterations in lipids and amino acids that could improve diagnosis, prognosis, and…

The microbiome and gynecologic cancer: Cellular mechanisms and clinical applications.

Aug 7, 2025
This review examines the role of the microbiome in gynecologic cancer development and treatment, emphasizing its potential for early diagnosis and therapeutic modulation. The microbiome’s influence…

Perception prevalence of the relationship between PID and infertility amongst women of reproductive age: A Nigerian study

Jun 27, 2025
A Nigerian study found only 10% of reproductive-age women recognized the link between PID and infertility, despite high education levels. The findings emphasize the need for improved public health…

Effects of a Bovine Lactoferrin Formulation from Cow’s Milk on Menstrual Distress in Volunteers

Jul 28, 2025
FeLf improved psychological symptoms related to menstrual distress, particularly autonomic balance, in healthy women. However, no significant effects on menstrual pain or quality of life were…

Altered Follicular Fluid Metabolic Pattern Correlates with Female Infertility and Outcome Measures of In Vitro Fertilization

Jun 30, 2025
This study identified 27 follicular fluid metabolites differentiating infertile from fertile women, developed a predictive Biomarker Score, and demonstrated strong correlations with IVF outcomes,…

The Role of Genital Tract Microbiome in Fertility: A Systematic Review

Jun 26, 2025
This review underscores the importance of genital tract microbiome composition in fertility, particularly Lactobacillus crispatus dominance, which is linked to better fertility outcomes. Dysbiosis…

Paradigm Shift: A Comprehensive Review of Ovarian Cancer Management in an Era of Advancements.

Aug 6, 2025
This review maps advances in ovarian cancer management, from surgery and chemotherapy to targeted and emerging therapies, and highlights a need to integrate microbiome insights.

Endometriosis-Associated Ovarian Cancer: From Molecular Pathologies to Clinical Relevance

Aug 12, 2025
This review explores the molecular pathogenesis of endometriosis-associated ovarian cancer, highlighting key genetic mutations, hormonal imbalances, and microRNA dysregulation that contribute to the…

Protective Mechanisms of Vaginal Lactobacilli against Sexually Transmitted Viral Infections

Jan 5, 2026
This review explains how vaginal lactobacilli protect against viral sexually transmitted infections by strengthening epithelial barriers, reducing inflammation, and directly inactivating viruses.

Ovarian Cancer—Epidemiology, Classification, Pathogenesis, Treatment, and Estrogen Receptors’ Molecular Backgrounds

Aug 6, 2025
This review covers the epidemiology, genetics, and molecular mechanisms of ovarian cancer, focusing on the role of estrogen receptors and genetic mutations such as BRCA1/2. It emphasizes the…

The Role of Heavy Metals in the Biology of Female Cancers

Aug 9, 2025
This review explores how heavy metals, including cadmium, lead, and mercury, contribute to the development of female cancers by mimicking estrogen, inducing oxidative stress, and causing DNA damage.…

Ovarian cancer in the world: Epidemiology and risk factors

Aug 6, 2025
This review analyzes the global epidemiology and risk factors of ovarian cancer, emphasizing the role of genetic predispositions, reproductive factors, and lifestyle choices. It highlights the…

Spotlight on the gut microbiome in menopause: current insights

Jul 7, 2025
Menopause reduces gut microbiome diversity and shifts composition toward a male-like profile, likely due to declining estrogen and progesterone. These changes may impact postmenopausal health and…

Vasomotor Symptoms During Menopause: A Practical Guide on Current Treatments and Future Perspectives

Aug 21, 2025
The review defines menopause vasomotor symptoms treatment and microbiome relevance, favors timely hormone therapy and transdermal routes, details effective nonhormone options, and highlights…

Treatment of postpartum depression: Clinical, psychological and pharmacological options

Jun 16, 2025
This review explores the clinical, psychological, and pharmacological treatment options for postpartum depression (PPD), focusing on antidepressants, therapy, and alternative treatments like omega-3s…

The effect of dietary intake on hot flashes in menopausal women

Jul 21, 2025
This study examines how dietary intake affects hot flash frequency in postmenopausal women. It finds that stable blood glucose levels, achieved through regular meals, reduce hot flash occurrences,…

Bacterial vaginosis and its association with infertility, endometritis, and pelvic inflammatory disease

Jun 27, 2025
This review details the links between bacterial vaginosis, endometritis, pelvic inflammatory disease, and infertility, highlighting the role of vaginal and endometrial microbiota disruptions and…

Estrogens and breast cancer

Aug 21, 2025
This study examines estrogen’s dual role in breast cancer, focusing on its effects on estrogen receptor-positive cancers and how different therapies, such as SERMs and aromatase inhibitors, mitigate…

Cervicovaginal microbiome and natural history of Chlamydia trachomatis in adolescents and young women

Jul 23, 2025
A longitudinal study in predominantly Black and Hispanic young women found that a molecular BV subtype (CST-IV-A) and a network of specific bacteria increase risk for Chlamydia trachomatis infection…

Metabolome-wide Mendelian randomization assessing the causal relationship between blood metabolites and primary ovarian insufficiency

Aug 1, 2025
This study identifies 27 metabolites linked to primary ovarian insufficiency (POI), revealing novel metabolic pathways and offering insights into POI biomarkers and therapeutic targets.

A dietary intervention for postmenopausal hot flashes: A potential role of gut microbiome

Jul 14, 2025
A plant-based diet with soy reduces hot flashes in postmenopausal women, potentially by modulating gut bacteria linked to inflammation and estrogen metabolism.

A Metabolomics Study of the Volatile Oil from Prunella vulgaris L. On Pelvic Inflammatory Disease

Jun 20, 2025
This study shows volatile oil from Prunella vulgaris effectively reduces pelvic inflammation by correcting metabolic disruptions in a rat PID model, highlighting key inflammatory metabolites as…

Effect of Lactobacillus rhamnosus HN001 in Pregnancy on Postpartum Symptoms of Depression and Anxiety: A Randomised Double-blind Placebo-controlled Trial

Jun 16, 2025
This study demonstrates that Lactobacillus rhamnosus HN001 reduces symptoms of postpartum depression and anxiety, providing a potential non-pharmaceutical treatment for new mothers.

Urinary heavy metals and overall survival of advanced high-grade serous ovarian cancer: A nested case-control study in China

Aug 9, 2025
The study examines the association between urinary concentrations of heavy metals (arsenic, cadmium, mercury, lead) and survival in patients with advanced high-grade serous ovarian cancer. High…

Urinary metals and metal mixtures and timing of natural menopause in midlife women

Jul 9, 2025
The study links higher urinary arsenic and lead concentrations to earlier menopause, suggesting that exposure to these metals accelerates ovarian aging. Women with higher environmental risk scores…

Exposure to heavy metals and hormone levels in midlife women

Jul 9, 2025
This study links urinary heavy metal exposure (arsenic, cadmium, mercury, lead) to altered sex hormone levels in midlife women, with stronger effects during the perimenopausal transition. It suggests…

Urinary phthalate metabolite concentrations and hot flashes in women from an urban convenience sample of midlife women

Jul 19, 2025
The study links urinary phthalate metabolite levels with increased risk and frequency of hot flashes in midlife women, suggesting environmental exposure as a contributing factor. Associations varied…

Association between co-exposure to phenols and phthalates mixture and infertility risk in women

Jul 1, 2025
This study explores the relationship between co-exposure to phenols and phthalates and infertility risk in women of reproductive age, highlighting significant associations with BPA and DEHP…

Metformin in the Treatment of Infertility in PCOS: An Alternative Perspective

Jul 4, 2025
This editorial reviews evidence on metformin for PCOS-related infertility, highlighting its benefits for ovulation induction, especially in women with longer fertility timelines, and advocating for…

Menopausal hormone therapy and menopausal symptoms

Aug 21, 2025
This review emphasizes the benefits and risks of MHT in managing menopause symptoms, including the prevention of long-term conditions. It advocates for individualized treatment plans, especially…

Hormone replacement therapy in young women with primary ovarian insufficiency and early menopause

Aug 1, 2025
The review discusses the therapeutic use of hormone replacement therapy (HRT) for managing POI and early menopause, highlighting its benefits in preventing complications like osteoporosis,…

Optimizing menopausal hormone therapy: For treatment and prevention, menstrual regulation, and reduction of possible risks

Aug 20, 2025
This review links menopausal hormone therapy and vaginal microbiome care to safer symptom relief, bleeding control, and prevention. It favors transdermal estradiol and physiologic progestogens, and…

Menopausal hot flashes: mechanisms, endocrinology, treatment.

Jul 7, 2025
This review elucidates the neuroendocrine and thermoregulatory mechanisms of menopausal hot flashes, evaluating objective measurement and treatment strategies, with a focus on central sympathetic…

Menopausal hot flashes: mechanisms, endocrinology, treatment

Jul 19, 2025
The review explores the physiological mechanisms behind menopausal hot flashes, including thermoregulatory changes, sympathetic nervous activation, and estrogen depletion. It also examines treatments…

Menopause-Induced Metabolic Shifts: Implications for Cardiovascular and Metabolic Risk

Jul 9, 2025
What was studied? The study examined the metabolic changes that occur during menopause, focusing on how menopause modulates circulating metabolites in midlife women. Researchers specifically analyzed…

Dietary advanced glycation end-products and postmenopausal hot flashes

Jul 21, 2025
This study shows that reducing dietary advanced glycation end-products (AGEs) through a plant-based diet significantly reduces hot flashes in postmenopausal women, offering a non-hormonal alternative…

Nutritional interventions during treatment for ovarian cancer: A narrative review and recommendations for future research

Aug 11, 2025
This review discusses the role of nutritional interventions in improving the nutritional status and clinical outcomes of women with ovarian cancer during treatment. It highlights the importance of…

Research Progress on the Interaction between Intestinal Flora and MicroRNA in Pelvic Inflammatory Diseases

Jun 20, 2025
This review highlights the crucial interactions between gut microbiota and microRNAs in pelvic inflammatory disease, revealing novel diagnostic markers and therapeutic targets.

Endometriosis and Infertility: A review of the pathogenesis and treatment of endometriosis-associated infertility

Jun 27, 2025
This review details the multifactorial pathogenesis of endometriosis-associated infertility, emphasizing molecular, genetic, and inflammatory mechanisms, and evaluates current and emerging…

Genome-wide association analysis of pain severity in dysmenorrhea identifies association at chromosome 1p13.2, near the nerve growth factor locus

Jul 28, 2025
A GWAS study identifies a significant genetic association at the NGF gene locus on chromosome 1p13.2, which may explain variations in dysmenorrhea pain severity, suggesting potential new therapeutic…

Pause menopause with Rhodiola rosea, a natural selective estrogen receptor modulator

Jul 14, 2025
Rhodiola rosea shows promise as a natural selective estrogen receptor modulator, offering neuroprotective, cardiovascular, and bone health benefits for menopausal women with fewer risks than…

Metabolic risk factors and fertility disorders: A narrative review of the female perspective

Jun 30, 2025
This review explores how metabolic risk factors—obesity, the female athlete triad, and oxidative stress—contribute to female infertility, highlighting associations with PCOS, endometriosis, and…

Phthalate metabolite levels and menopausal hot flashes in midlife women

Jul 19, 2025
This study links higher levels of phthalate metabolites, particularly from personal care products, to an increased risk and severity of hot flashes in midlife women, suggesting that phthalate…

Estrogen and Thrombosis: A Bench to Bedside Review

Aug 21, 2025
This study explores estrogen’s effects on thrombosis risk in hormonal contraceptives and HRT, highlighting mechanisms of action, the role of different estrogen doses, and the importance of…

Extended sub-chronic exposure to heavy metal mixture induced multidrug resistance against chemotherapy agents in ovarian cancer cells

Aug 9, 2025
This study investigates how sub-chronic exposure to lead, cadmium, and cobalt induces multidrug resistance in ovarian cancer cells, highlighting the role of drug efflux transporters and reduced…

Impact of oxidative stress induced by heavy metals on ovarian function

Jul 31, 2025
This review highlights the impact of heavy metal-induced oxidative stress on ovarian function, contributing to premature ovarian insufficiency. It discusses the mechanisms by which metals like…

The Gut Microbiome Is Altered in Postmenopausal Women With Osteoporosis and Osteopenia.

Jul 7, 2025
This study identifies distinct gut microbiome and functional gene signatures associated with osteoporosis and osteopenia in postmenopausal women, highlighting key microbial taxa and metabolic…

Associations of the fecal microbiome with urinary estrogens and estrogen metabolites in postmenopausal women

Jul 7, 2025
Greater fecal microbiome diversity in postmenopausal women correlates with urinary estrogen metabolite profiles linked to lower breast cancer risk. Specific taxa, notably Clostridiales, are…

Treatment of Symptoms of the Menopause: An Endocrine Society Clinical Practice Guideline

Aug 21, 2025
This guideline on menopausal symptom treatment prioritizes early initiation of hormone therapy, safe routes like transdermal estradiol, and vaginal care for genitourinary symptoms. It promotes a…

Characterizing the gut microbiota in females with infertility and preliminary results of a water-soluble dietary fiber intervention study.

Jun 27, 2025
This study shows gut microbiota differences between fertile and infertile women, highlighting improved fertility outcomes with dietary fiber (PHGG) supplementation that enhances beneficial gut…

Properties of Infertility Microbiome in a Review Article

Jun 21, 2025
This review explores the impact of microbiome imbalances on infertility, with insights into microbial diagnostics and potential treatments to improve fertility outcomes.

Metabolic Profile of Patients with Premature Ovarian Insufficiency

Jul 31, 2025
This study examines the metabolic profile of women with premature ovarian insufficiency, finding significant changes in lipid and glucose metabolism. The results underscore the importance of early…

The effect of herbal tea capsule on menopause hot flashes

Jul 21, 2025
This study demonstrates that herbal tea capsules significantly reduce the frequency, duration, and severity of hot flashes in postmenopausal women, offering a promising natural alternative to hormone…

Comparative Effect of Nigella Sativa+ Black Pepper and Letrozole + Tamoxifen on Female Infertility in Women with Polycystic Ovarian Syndrome: A Randomized Clinical Trial

Jul 4, 2025
A randomized clinical trial found Nigella sativa plus black pepper significantly improved pregnancy rates and reproductive parameters versus letrozole plus tamoxifen in infertile women with PCOS,…

Intermittent Fasting and Weight Management at Menopause

Jul 14, 2025
Intermittent fasting improves weight, insulin sensitivity, and cardiovascular health in postmenopausal women, offering a promising non-pharmacological strategy for managing metabolic disorders.

Menopausal Hot Flashes: A Concise Review

Jul 19, 2025
This review synthesizes current evidence on menopausal hot flashes, focusing on neuroendocrine mechanisms, genetic factors, and a stepwise, personalized treatment approach, emphasizing new targets…

The effects of vitamin D and calcium on primary dysmenorrhea: a systematic review

Jul 28, 2025
Vitamin D and calcium supplementation can significantly reduce primary dysmenorrhea symptoms and reliance on analgesics. The inverse relationship between serum vitamin D and calcium levels and…

The 2020 Menopausal Hormone Therapy Guidelines

Aug 20, 2025
The guideline links menopausal hormone therapy guidelines and vaginal microbiome care to safer symptom control, better GSM outcomes, and lower UTI risk through local estrogen, with timing and route…

Menopausal Hot Flashes: A Review of Physiology and Biosociocultural Perspective on Methods of Assessment

Jul 19, 2025
What was reviewed? The article presents a detailed review of menopausal hot flashes, examining both the physiological and biosociocultural factors that contribute to this common menopausal symptom.…

High Prevalence of Nickel Allergy in an Overweight Female Population: A Microbial Metallomics Commentary

Nov 27, 2025
This study links nickel allergy to overweight status in women and shows that a low-nickel diet reduces BMI and waist size while suggesting immunologic and microbiome-related mechanisms.

A cross-sectional pilot study of birth mode and vaginal microbiota in reproductive-age women Original paper

Jul 23, 2025
This study suggests that birth mode may influence the vaginal microbiota, with C-section delivery potentially linked to a less protective microbiome and higher odds of Molecular-BV in adulthood.

Association between cigarette smoking and the risk of dysmenorrhea: A meta-analysis of observational studies

Jul 26, 2025
This meta-analysis demonstrates that cigarette smoking increases the risk of dysmenorrhea, with both current and former smokers showing a significantly higher likelihood of experiencing menstrual…

Menopausal hormone therapy increases the risk of gallstones: Health Insurance Database in South Korea (HISK)-based cohort study

Aug 21, 2025
This study shows that menopausal hormone therapy increases the risk of gallstones, especially with topical estrogen and tibolone. However, no increased risk for gallbladder cancer was found. These…

Physical Activity and Exercise Improve Quality of Life in Endometriosis: A Systematic Review

Jul 7, 2025
This review found that physical activity and exercise significantly improved pain, emotional well-being, and perceived control in women with endometriosis, supporting their use as safe and effective…

The Role ofNutrient Supplementation to Prevent Perinatal Depression. A Narrative Review

Jun 16, 2025
This systematic review explores the impact of diet and nutritional supplementation on perinatal depression (PPD), highlighting protective effects from healthy dietary patterns, omega-3s, and…

Insight into Dysmenorrhea Research from 1992 to 2022: A Bibliometric Analysis

Jul 25, 2025
A bibliometric analysis of dysmenorrhea research from 1992 to 2022 reveals increasing global interest in its pathogenesis, treatment, and functional connectivity. It emphasizes the role of…

Prevalence and Impact of Dysmenorrhea on Hispanic Female Adolescent

Jul 25, 2025
Primary dysmenorrhea is a common and impactful condition affecting young women. This review explores its pathophysiology, symptoms, and treatment options to improve diagnosis and management in…

Primary Dysmenorrhea: Pathophysiology, Diagnosis, and Treatment Updates

Jul 28, 2025
This review explores the pathophysiology, impact, and treatment of primary dysmenorrhea, emphasizing the role of prostaglandins and the significant effects on women’s quality of life. It highlights…

Vitamin Effects in Primary Dysmenorrhea

Jul 28, 2025
This review evaluates the potential therapeutic role of vitamins (D, E, B1, C, K) in reducing primary dysmenorrhea symptoms, proposing them as alternatives to NSAIDs, with promising results,…

Aerobic Exercise and Gut Health: New Research Shows Reduced Zonulin and Inflammation

Mar 14, 2026
Eight weeks of aerobic exercise in overweight/obese women improved body composition, lipid profiles, inflammation, and significantly reduced intestinal permeability markers zonulin and LBP. Benefits…

Risk of Endometrial Cancer in Women With Pelvic Inflammatory Disease

Jun 20, 2025
Women with pelvic inflammatory disease have a higher risk of endometrial cancer, especially older and hypertensive women, highlighting the need for vigilant care.

Acupuncture with or without moxibustion for primary dysmenorrhea

Jul 28, 2025
This protocol outlines a systematic review and meta‐analysis plan to evaluate acupuncture, with or without moxibustion, for pain relief and safety in women with primary dysmenorrhea.

The effectiveness of iron supplementation for postpartum depression

Jun 14, 2025
What was reviewed? The review was a protocol for a systematic review and meta-analysis aimed at evaluating the effectiveness of iron supplementation in treating postpartum depression (PPD). The…

Gynecologists and pelvic inflammatory disease: do we actually know what to do?

Jun 19, 2025
This study highlights significant gaps in gynecologists’ knowledge regarding Pelvic Inflammatory Disease (PID). Misdiagnosis, inadequate treatment duration, and poor adherence to guidelines…

High Physical Activity Level May Reduce Menopausal Symptoms

Aug 22, 2025
This study reveals that higher levels of physical activity, especially during leisure time, are linked to reduced severity of menopausal symptoms, particularly urogenital and somato-vegetative…

Ovarian Cancer and the Microbiome: Connecting the Dots for Early Diagnosis and Therapeutic Innovations—A Review

Aug 7, 2025
This review explores the role of the microbiome in ovarian cancer, emphasizing its potential for early diagnosis and treatment. The use of microbiome-based biomarkers and therapies like fecal and…

Evaluation of serum heavy metal levels on primary ovarian insufficiency

Jul 31, 2025
This study explores the potential link between serum heavy metal levels and premature ovarian insufficiency. The higher levels of metals like lead and mercury in women with POI suggest environmental…

The Vaginal Microbiome in Health and Disease—What Role Do Common Intimate Hygiene Practices Play?

Jan 5, 2026
This review explains how the vaginal microbiome regulates immune balance, protects against infection, and influences reproductive and gynecologic health.

Possible Therapeutic Mechanisms and Future Perspectives of Vaginal Microbiota Transplantation

Jun 24, 2025
Vaginal microbiota transplantation (VMT) successfully treats bacterial vaginosis by restoring Lactobacillus dominance, lowering vaginal pH, and inhibiting pathogens through nutritional competition,…

Metabolomics study on primary dysmenorrhea patients during the luteal regression stage

Jul 25, 2025
This metabolomics study identifies ten urinary biomarkers linked to primary dysmenorrhea, providing insights into the metabolic disruptions that contribute to PD and suggesting potential new…

Protective Roles of Honey in Reproductive Health: A Review

Jul 4, 2025
Honey exerts protective effects in reproductive health by modulating oxidative stress, supporting hormonal balance, and selectively inhibiting pathogens while preserving beneficial microbiota, making…

Daily Vaginal Microbiota Fluctuations Associated with Natural Hormonal Cycle, Contraceptives, Diet, and Exercise

Jul 15, 2025
Vaginal microbiota composition in young women varies daily with hormonal cycles, contraceptive use, diet, and exercise, affecting Lactobacillus dominance and community stability linked to…

Menopause Alters Gut Microbiome and Increases Cardiometabolic Risk in Hispanic Women

Jul 7, 2025
Menopause in Hispanic/Latina women is linked to distinctive gut microbiome and estrobolome alterations, resembling those in men, and these microbial changes are associated with increased…

Characterization of the Vaginal Microbiome in Women with Infertility and Its Potential Correlation with Hormone Stimulation during In Vitro Fertilization Surgery

Jun 27, 2025
This study shows women with secondary infertility have persistently altered, less diverse vaginal microbiomes unresponsive to IVF hormone stimulation. Increased Atopobium and decreased Lactobacillus…

A metabolic view on menopause and ageing

Jul 9, 2025
This study reveals significant metabolic changes in postmenopausal women, including a pro-atherogenic lipid profile and increased amino acids linked to cardiovascular and metabolic risk, emphasizing…

Primary ovarian insufficiency

Jul 30, 2025
Primary Ovarian Insufficiency affects young women with amenorrhea and elevated FSH levels. It involves follicle dysfunction or depletion and requires comprehensive diagnosis and management, including…

Post-Coital Antifertility Activity of Hibiscus rosa-sinensis Linn. roots

Jul 15, 2025
The ethanolic root extract of Hibiscus rosa-sinensis shows potent, reversible post-coital antifertility effects in rats via estrogenic mechanisms, supporting its potential as a safe herbal…

Female Fertility and the Nutritional Approach: The Most Essential Aspects

Jul 5, 2025
A narrative review examining how dietary patterns, nutrients, and gut microbiota impact female fertility, highlighting the Mediterranean diet’s benefits, the risks of Western diets, key…

Associations between dysmenorrhea symptom-based phenotypes and vaginal microbiome: A pilot study

Jul 25, 2025
This study links dysmenorrhea symptom phenotypes with distinct vaginal microbiome compositions, suggesting that microbiome imbalances contribute to more severe menstrual pain, which could be targeted…

Menopause-Associated Lipid Metabolic Disorders and Foods Beneficial for Postmenopausal Women

Jul 9, 2025
This review synthesizes evidence on menopause-related lipid metabolic disorders, emphasizing estrogen deficiency, dietary interventions, and the role of probiotics and microbiome modulation in…

Low-Nickel Diet in Endometriosis: Symptom Relief and Nickel Mucositis Evidence

Oct 14, 2025
Nickel allergic contact mucositis was identified in over 90% of endometriosis patients with IBS-like symptoms. A low-nickel diet significantly reduced gastrointestinal, extra-intestinal, and…

Relationship between Diet, Menstrual Pain and other Menstrual Characteristics among Spanish Students

Jul 26, 2025
This study links specific elements of the Mediterranean diet, particularly fruit and olive oil intake, to menstrual pain and characteristics, highlighting potential roles for anti-inflammatory foods…

Effect of Vitamin D Supplementation on Primary Dysmenorrhea

Jul 28, 2025
A systematic review and meta-analysis showed that vitamin D supplementation effectively reduces primary dysmenorrhea pain, especially with doses over 50,000 IU weekly, with significant improvements…

The Importance of Nutrition in Menopause and Perimenopause—A Review

Aug 22, 2025
This review underscores the importance of nutrition in managing menopausal symptoms and preventing chronic diseases. It highlights key nutrients such as calcium, vitamin D, and protein and promotes a…

Menopause hot flashes and molecular mechanisms modulated by food-derived nutrients

Jul 21, 2025
This review discusses how food-derived nutrients modulate molecular mechanisms related to hot flashes in menopause, identifying dietary compounds that may offer effective, natural alternatives to…

The Role of the Mediterranean Diet in Assisted Reproduction: A Literature Review

Jul 4, 2025
This review summarizes evidence linking Mediterranean Diet adherence to improved ART outcomes, highlighting modest benefits for clinical pregnancy and live birth rates. Methodological heterogeneity…

Efficacy of Zinc Supplementation in the Management of Primary Dysmenorrhea

Jul 26, 2025
Zinc supplementation significantly reduces pain severity in women with primary dysmenorrhea, especially with longer durations of use, offering a safe and effective treatment option.

Butyrate as a Potential Modulator in Gynecological Disease Progression

Aug 2, 2025
This review explores butyrate’s role as a modulator in gynecological diseases, including PCOS, endometriosis, and cancer, highlighting its potential as a therapeutic agent through immune modulation,…

Impact of Probiotic Supplementation and High-Intensity Interval Training on Primary Dysmenorrhea

Jul 26, 2025
HIIT significantly improved pain and physical fitness in women with primary dysmenorrhea, while probiotics showed some benefits in alleviating premenstrual symptoms. However, probiotics alone did not…

Differential Composition of Vaginal Microbiome Is Associated With Successful Intrauterine Insemination in Couples With Idiopathic Infertility

Jun 26, 2025
This study links the vaginal microbiome, particularly Lactobacillus crispatus dominance, to successful IUI outcomes in idiopathic infertility. Dysbiosis, with an increase in Bifidobacterium, was…

Ovarian cancer: Diagnosis and treatment strategies (Review)

Aug 6, 2025
This review discusses ovarian cancer diagnosis, molecular characteristics, and treatment strategies, emphasizing the role of targeted therapies like PARP inhibitors and immunotherapy, with a focus on…

Pelvic Inflammatory Disease Trends Among Emergency Department Visits in North Carolina, 2008 to 2017

Jun 19, 2025
This study identified a declining trend in emergency department diagnoses of PID among North Carolina women from 2008-2017. Persistent disparities emerged among young, low-income, and publicly…

The Efficacy of Zinc Administration in the Treatment of Primary Dysmenorrhea

Jul 28, 2025
This study demonstrates that zinc supplementation, when combined with mefenamic acid, significantly reduces primary dysmenorrhea pain and incidence, offering a more effective treatment strategy than…

The challenge of pelvic inflammatory disease

Jun 19, 2025
This review highlights PID’s diagnostic challenges, microbiological associations, and evidence-based treatment guidelines. It emphasizes routine screening for chlamydia to reduce disease incidence,…

Actaea racemosa L. Is More Effective in Combination with Rhodiola rosea L. for Relief of Menopausal Symptoms

Jul 14, 2025
Combining Rhodiola rosea and Actaea racemosa extracts significantly improves menopausal symptoms and quality of life, outperforming black cohosh alone with good safety.

Potential Role of Vaginal Microbiota in Ovarian Cancer Carcinogenesis, Progression and Treatment

Aug 7, 2025
This review highlights the role of vaginal microbiota in ovarian cancer carcinogenesis, progression, and treatment. It discusses microbial dysbiosis and potential therapeutic interventions like…

Characteristics of Vaginal Microbiome in Women with Pelvic Inflammatory Disease in Korea

Jun 19, 2025
This study identifies key differences in the vaginal microbiome of women with PID, emphasizing a significant reduction in Lactobacillus and an increase in polymicrobial infections. The findings…

Physiology of pubertal development in females

Aug 15, 2025
This review elucidates the hormonal and physiological mechanisms underpinning female puberty, detailing HPG and HPA axis activation, pubertal milestones, and regulatory factors, and discusses…

Do SSRIs and SNRIs reduce the frequency and/or severity of hot flashes in menopausal women

Aug 22, 2025
This review confirms that SSRIs and SNRIs, particularly paroxetine and venlafaxine, are effective for managing hot flashes in menopausal women. These therapies provide an alternative to hormone…

Effects of dietary quercetin on female fertility in mice: implication of transglutaminase 2

Jul 4, 2025
What was studied? This original research investigated the long-term effects of dietary quercetin supplementation on female fertility and ovarian physiology in mice, with a specific focus on the role…

Hormonal therapies and venous thrombosis: Considerations for prevention and management

Aug 21, 2025
This review explores the thrombosis risks of hormonal therapies, comparing various estrogen formulations and progestins. It emphasizes the need for personalized treatment based on thrombophilic risk…

Microbiota and Pelvic Inflammatory Disease

Jun 19, 2025
This review highlights how vaginal microbiota imbalance, particularly bacterial vaginosis, significantly increases the risk of pelvic inflammatory disease. Advanced molecular methods have identified…

Primary Dysmenorrhea: Assessment and Treatment

Jul 28, 2025
Primary dysmenorrhea is a prevalent condition that affects many women, particularly in their younger years. This review discusses its pathophysiology, impact on quality of life, and treatment…

Systemic and local effects of vaginal dehydroepiandrosterone (DHEA): NCCTG N10C1 (Alliance)

Aug 22, 2025
What was studied? This study examined the systemic and local effects of vaginal dehydroepiandrosterone (DHEA) in postmenopausal women, particularly those with a history of breast or gynecologic…

Neurokinin 3 receptor antagonism as a novel treatment for menopausal hot flushes

Jul 21, 2025
This study demonstrates that MLE4901, an NK3R antagonist, significantly reduces hot flash frequency, severity, and interference in menopausal women, offering a non-hormonal treatment alternative.

The role of the microbiome in ovarian cancer: mechanistic insights into oncobiosis and to bacterial metabolite signaling

Aug 8, 2025
This review explores the role of the microbiome in ovarian cancer, focusing on microbial dysbiosis and bacterial metabolites that influence inflammation and carcinogenesis. It highlights the…

Gut microbiome associations with breast cancer risk factors and tumor characteristics: a pilot study

Jul 23, 2025
This pilot study links gut microbiome diversity with breast cancer risk factors and tumor characteristics, particularly in HER2+ tumors and those with early menarche. It suggests microbial…

Pelvic inflammatory disease and the risk of ovarian cancer: a meta-analysis

Jun 19, 2025
This meta-analysis reveals a significant association between pelvic inflammatory disease (PID) and an increased risk of ovarian cancer. The link is particularly strong among Asian women, with…

Lactobacillus gasseri OLL2809 is effective especially on the menstrual pain and dysmenorrhea in endometriosis patients

Jul 28, 2025
Lactobacillus gasseri OLL2809 significantly reduced menstrual pain and dysmenorrhea in endometriosis patients, offering a potential non-hormonal alternative to traditional treatments. No adverse…

SSRIs for hot flashes: a systematic review and meta-analysis of randomized trials.

Jul 21, 2025
This meta-analysis reveals that SSRIs are effective in reducing hot flashes in menopausal women, with escitalopram showing the highest efficacy. These results support SSRIs as a non-hormonal…

Causal association between 637 human metabolites and ovarian cancer: A mendelian randomization study

Aug 10, 2025
Mendelian randomization identified causal links between 9 metabolites and ovarian cancer risk. Some metabolites promote, others protect against OC. These findings suggest potential biomarkers for…

Changes in the vaginal microbiota associated with primary ovarian failure

Jul 30, 2025
This study identifies significant differences in vaginal microbiota between women with Primary Ovarian Failure (POF) and healthy controls, highlighting the role of Lactobacillus species in…

Insights into estrogen impact in oral health & microbiome in COVID-19

Jul 23, 2025
This study examined the impact of estrogen on oral health and microbiome composition in COVID-19 patients, showing that postmenopausal women and men experience poorer oral health, which correlates…

Association between premature ovarian insufficiency and gut microbiota

Jul 31, 2025
The study reveals a distinct gut microbiome profile in women with premature ovarian insufficiency (POI), with altered bacterial populations linked to hormonal changes, suggesting a potential role of…

Relationship between risk factors for infertility in women and lead, cadmium, and arsenic blood levels: a cross-sectional study from Taiwan

Jun 30, 2025
Infertile women in Taiwan showed higher blood lead and arsenic levels than pregnant women, mainly linked to frequent Chinese herbal medicine use. Physical activity may help lower lead accumulation,…

Dysmenorrhea pattern in adolescences informing adult endometriosis

Jul 28, 2025
The study links adolescent dysmenorrhea patterns with adult endometriosis development. It suggests that early intervention, guided by dysmenorrhea frequency and onset, can reduce the risk of EMs and…

Major dietary patterns in relation to menstrual pain: a nested case control study

Jul 26, 2025
This study links a snack‐heavy dietary pattern to a significantly higher risk of moderate to severe dysmenorrhea among young women, highlighting the importance of dietary counseling in menstrual pain…

Association of pelvic inflammatory disease (PID) with ovarian cancer: a nationwide population-based retrospective cohort study from Taiwan

Jun 19, 2025
This nationwide study from Taiwan demonstrates that women with a history of pelvic inflammatory disease (PID) are at a significantly higher risk of developing ovarian cancer. The study highlights the…

The relationship between menopausal syndrome and gut microbes

Jul 7, 2025
This study found that menopausal syndrome is linked to gut microbiota dysbiosis, with reduced Bifidobacterium animalis and altered metabolic pathways, suggesting microbiome-targeted interventions may…

Study on gut microbiota and metabolomics in postmenopausal women

Jul 7, 2025
This study reveals how FSH-driven changes in perimenopausal women associate with distinct gut microbiota and metabolomic profiles, linking specific bacteria and metabolic pathways to symptoms like…

Comparative effectiveness of exercise interventions for primary dysmenorrhea

Jul 28, 2025
This network meta‑analysis ranks six exercise modalities for primary dysmenorrhea, showing resistance and multi‑component training best reduce pain and symptoms, with clear dosage guidelines for…

Diet quality, body weight, and postmenopausal hot flashes: a secondary analysis of a randomized clinical trial

Jul 21, 2025
This study suggests that a low-fat vegan diet, particularly one supplemented with soybeans, significantly reduces hot flashes in postmenopausal women, with improvements linked to higher plant-based…

Association of dietary preferences with primary ovarian insufficiency (POI)

Jul 31, 2025
This study identifies dietary habits that influence the risk of Primary Ovarian Insufficiency (POI), finding that high-fat dairy products increase risk while oily fish and pork offer protection,…

The effectiveness of self-care and lifestyle interventions in primary dysmenorrhea: a systematic review and meta-analysis

Jul 28, 2025
Self-care interventions like exercise, heat, and acupressure significantly reduce menstrual pain in primary dysmenorrhea, with exercise showing the largest effect. These methods may be effective…

Health disorders in menopausal women: microbiome alterations, associated problems, and possible treatments

Jul 14, 2025
Menopause disrupts multiple microbiomes, elevating risks for infections, metabolic and cardiovascular diseases, and osteoporosis. Targeted interventions including probiotics, diet, and hormone…

Putting menarche and girls into the global population health agenda

Aug 14, 2025
This commentary reviews the global neglect of menstrual health education at menarche, highlighting psychosocial and health consequences for girls. It advocates for standardized, early education and…

How does chronic endometritis influence pregnancy outcomes in endometriosis associated infertility? A retrospective cohort study

Jun 26, 2025
This study shows chronic endometritis significantly increases pregnancy complications in women with endometriosis-associated infertility. Placenta previa, gestational hypertension, and cesarean…

Characteristics of the vaginal microbiome in women with premature ovarian insufficiency

Jul 31, 2025
This study identifies significant differences in vaginal microbiota between women with premature ovarian insufficiency (POI) and healthy controls, suggesting that microbial shifts could contribute to…

Metabolic differences in women with premature ovarian insufficiency: a systematic review and meta-analysis

Jul 31, 2025
This study investigates the metabolic differences in women with premature ovarian insufficiency (POI), highlighting increased waist circumference, cholesterol, and glucose levels. It underscores the…

Plasma metabolomic characterization of premature ovarian insufficiency

Jul 31, 2025
This study identifies key metabolites altered in premature ovarian insufficiency (POI), including arachidonoyl amide and 18-HETE, which could serve as diagnostic biomarkers. The findings reveal…

Premature ovarian insufficiency: a review on the role of tobacco smoke, its clinical harm, and treatment

Jul 31, 2025
Tobacco smoke significantly impacts ovarian function, leading to premature ovarian insufficiency. The review outlines the harmful effects of various tobacco-related toxins, such as nicotine, cadmium,…

Exploring the causal role of multiple metabolites on ovarian cancer: a two sample Mendelian randomization study

Aug 10, 2025
A two-sample MR of 486 metabolites reports suggestive causal links across OC and histotypes, maps caffeine/arginine/TCA and alpha-linolenic pathways, and surfaces microbially influenced xenobiotics…

The effects of dietary fat on gut microbial composition and function in a mouse model of ovarian cancer

Aug 7, 2025
This study investigates the effects of ketogenic and high-fat diets on gut microbial composition and ovarian cancer progression in mice. It shows that high-fat diets increase tumor growth and disrupt…

Gut microbiota signatures and fecal metabolites in postmenopausal women with osteoporosis

Jul 7, 2025
This study demonstrates significant alterations in gut bacteria, fungi, and metabolites in postmenopausal women with osteoporosis, revealing microbial and metabolic signatures closely linked to bone…

Model construction and drug therapy of primary ovarian insufficiency by ultrasound-guided injection

Aug 1, 2025
This study demonstrates the effectiveness of ultrasound-guided hUC-MSC exosome injection in restoring ovarian function and fertility in POI rat models, offering a new therapeutic approach for women…

Depression, anxiety, stress, and dysmenorrhea: a protocol for a systematic review

Jul 28, 2025
This systematic review will investigate the relationship between dysmenorrhea and psychological distress, including depression, anxiety, and stress, aiming to provide insights into their…

Ketogenic Diet as a Possible Non-pharmacological Therapy in Main Endocrine Diseases of the Female Reproductive System

Jul 14, 2025
Ketogenic diets effectively improve metabolic, hormonal, and inflammatory profiles in female endocrine disorders, aiding PCOS, menopause, and hormone-related cancers by promoting weight loss and…

Fusobacterium Infection: A New Pathogenic Insight into Endometriosis and Microbiome-Targeted Therapy Potential

Nov 15, 2025
Fusobacterium infection significantly contributes to endometriosis pathogenesis, activating fibroblast inflammation and lesion formation. Antibiotics like metronidazole show promise.

Endometrial microbiota composition is associated with reproductive outcome in infertile patients

Jun 26, 2025
This study links endometrial microbiota composition to reproductive success in ART, showing that Lactobacillus dominance is associated with better outcomes, while dysbiosis with pathogens like…

Exploring the female genital tract mycobiome in young South African women using metaproteomics

Jul 23, 2025
This study characterized the fungal communities in the female genital tract of young South African women and identified how fungal composition relates to bacterial vaginosis and other clinical…

The Effects of Environmental Contaminant Exposure on Reproductive Aging and the Menopause Transition

Jul 19, 2025
This study explores how exposure to environmental contaminants like PFAS, BPA, and phthalates accelerates reproductive aging and leads to early menopause, with significant health risks.

Premature ovarian insufficiency: the context of long-term effects

Jul 30, 2025
Premature ovarian insufficiency (POI) leads to fertility issues, bone loss, cardiovascular risks, and cognitive decline. Early intervention, including hormone therapy and lifestyle changes, is vital…

Human genital tracts microbiota: dysbiosis crucial for infertility

Jun 26, 2025
This review connects genital microbiota dysbiosis to infertility, highlighting the role of Lactobacillus dominance in female fertility and microbial imbalances in seminal fluid affecting male…

Connecting microbiome and menopause for healthy ageing

Jul 7, 2025
This review details how menopause-driven hormonal changes alter the vaginal and gut microbiome, emphasizing the clinical implications for symptoms and therapies, and advocating for more inclusive,…

Dysmenorrhea increased the risk of postpartum depression in Chinese Han parturients

Jul 28, 2025
This study links dysmenorrhea to an increased risk of postpartum depression in Chinese women. It highlights the need for early PPD screening in women with a history of dysmenorrhea.

A cross-sectional analysis about bacterial vaginosis, high-risk human papillomavirus infection, and cervical intraepithelial neoplasia in Chinese women

Jul 23, 2025
This study examined how bacterial vaginosis and HR-HPV infection influence vaginal microbiota diversity and cervical dysplasia in Chinese women, identifying Lactobacillus iners as a key microbial…

A two-sample mendelian randomization analysis investigates associations between gut microbiota and infertility

Jun 26, 2025
This study demonstrates a causal link between specific gut microbiota and infertility risks, identifying protective and harmful bacterial taxa in both men and women. It highlights the…

Profiling of metabolic dysregulation in ovarian cancer tissues and biofluids

Aug 10, 2025
This study profiles metabolic dysregulation in ovarian cancer, identifying key metabolites and pathways altered in OC tissues and biofluids. N1,N12-diacetylspermine emerges as a potential biomarker.

Probiotics and the envisaged role in treating human infertility

Jul 3, 2025
This review details how probiotics modulate the human microbiome to support fertility, addressing mechanisms, clinical evidence, and implications for male and female reproductive health, with…

Reproductive tract microbiome and therapeutics of infertility

Jul 3, 2025
This review details how the reproductive tract microbiome impacts infertility and reproductive outcomes, highlighting the roles of specific microbial taxa, dysbiosis in disease, and potential…

Menopausal shift on women’s health and microbial niches

Jul 7, 2025
Menopause drives profound shifts in the oral, gut, and vaginal microbiome, decreasing protective species and increasing disease risk. Understanding these hormone-microbe interactions is crucial for…

Diet and ovarian cancer risk: A case–control study in China

Aug 7, 2025
This case-control study highlights the significant role of diet in ovarian cancer risk, with high vegetable and fruit intake reducing risk, while animal fats and salted vegetables increase it. Fried…

Effects of vaginal microbiota on in vitro fertilization outcomes in women with different infertility causes

Jul 23, 2025
This study explores the impact of vaginal microbiota on IVF outcomes in women with infertility. It highlights how specific bacteria like Lactobacillus iners and Pseudomonas spp. can predict IVF…

Mycobiome Study Reveals Different Pathogens of Vulvovaginal Candidiasis Shape Characteristic Vaginal Bacteriome

Jul 23, 2025
What was studied? This study examined the interaction between the vaginal microbiota and mycobiota in patients with vulvovaginal candidiasis (VVC). The research focused on understanding the role of…

Elevated Lead, Nickel, and Bismuth Levels in the Peritoneal Fluid of a Peritoneal Endometriosis Patient without Toxic Habits or Occupational Exposure following a Vegetarian Diet

Nov 27, 2025
This case report describes markedly elevated lead, nickel, and bismuth in the peritoneal fluid of a young woman with endometriosis, highlighting dietary and environmental exposure considerations and…

Causal Effects of Gut Microbiota on Female Reproductive Tract Inflammation and Infertility: A Mendelian Randomization Study

Jun 26, 2025
The study confirmed causal links between specific gut microbiota and female reproductive tract inflammation and infertility. Notably, Lachnospiraceae and Ruminococcus increased inflammation risks,…

Heavy Metals in Obese and Non-Obese Polycystic Ovary Syndrome Patients: A Review

Dec 4, 2025
This study shows women with PCOS have elevated blood lead and cadmium and reduced magnesium, calcium, and manganese—disrupting hormone levels through oxidative stress and possibly altering gut…

Variations in the age of onset of menarche among inhabitants of rural and urban areas in Delta State, South-South Nigeria

Aug 15, 2025
This study identifies significant differences in age of menarche between rural and urban Nigerian girls, highlighting the influence of socioeconomic status and residence. Findings have implications…

Menopause modulates the circulating metabolome: Evidence from a prospective cohort study

Jul 9, 2025
Menopause is linked to significant metabolic shifts, including a proatherogenic lipid profile and altered amino acid levels, which may increase cardiovascular and metabolic disease risks in women.…

1H NMR- based metabolomics approaches as non-invasive tools for diagnosis of endometriosis

Jun 6, 2025
This study demonstrates the potential of ¹H-NMR metabolomics to diagnose endometriosis non-invasively by identifying metabolic biomarkers and disrupted pathways. Quadratic Discriminant Analysis…

A comprehensive analysis of breast cancer microbiota and host gene expression

Mar 18, 2025
The study analyzed breast tumor and adjacent tissues, linking microbiota composition to cancer pathways. Key findings implicate specific microbes in breast cancer progression.

A Comprehensive Review on Postpartum Depression

Jun 13, 2025
This comprehensive review of postpartum depression (PPD) explores its pathophysiology, risk factors, and treatment options. It emphasizes the need for early diagnosis, multidisciplinary care, and…

A metabonomics approach as a means for identification of potentialbiomarkers for early diagnosis of endometriosis

Mar 18, 2025
This study used 1H-NMR metabonomics to identify serum biomarkers for early endometriosis diagnosis. Elevated lactate, alanine, and reduced glucose levels highlight metabolic disruptions, offering a…

A More Diverse Cervical Microbiome Associates with Better Clinical Outcomes in Patients with Endometriosis: A Pilot Study

Mar 18, 2025
This study links cervical microbiome diversity with endometriosis severity. Findings reveal microbial imbalances, particularly in advanced stages, correlate with pain, infertility, and inflammatory…

A New Approach to Polycystic Ovary Syndrome: The Gut Microbiota

Apr 27, 2025
This review examines the link between PCOS and gut microbiota dysbiosis, highlighting how dietary and microbial interventions may improve clinical outcomes. The study underscores the potential of…

A Systematic Review and Meta-Analysis of Premenstrual Syndrome with Special Emphasis on Herbal Medicine and Nutritional Supplements.

May 12, 2025
This systematic review and meta-analysis explores the effectiveness of herbal medicine and nutritional supplements in reducing PMS symptoms, highlighting significant reductions in physical, mood, and…

Adherence to the Mediterranean Diet, Dietary Patterns and Body Composition in Women with Polycystic Ovary Syndrome (PCOS)

Apr 27, 2025
Women with PCOS had lower Mediterranean diet adherence and worse metabolic, inflammatory, and hormonal profiles. Poor MD adherence correlated with higher testosterone, CRP, and HOMA-IR, suggesting a…

Adverse Events Due to Suspected Nickel Hypersensitivity in Patients with Essure Micro-Inserts

Mar 18, 2025
The study reviewed adverse events linked to nickel hypersensitivity in Essure implants, noting rare reactions and the role of the menstrual cycle in modulating hypersensitivity.

Allopregnanolone in premenstrual dysphoric disorder (PMDD)

May 19, 2025
This review identifies impaired sensitivity of GABA-A receptors to the neurosteroid allopregnanolone as central to PMDD, linking receptor plasticity and stress dysregulation to mood symptoms, and…

Alteration in gut mycobiota of patients with polycystic ovary syndrome

Apr 27, 2025
This study reveals that women with PCOS have altered gut fungal communities, marked by enriched Saccharomyces and depleted Aspergillus. These shifts may contribute to inflammation, metabolic stress,…

Alterations of bacteriome, mycobiome and metabolome characteristics in PCOS patients with normal/overweight individuals

Apr 27, 2025
The study explores how alterations in gut bacteria, fungi, and serum metabolites are linked to polycystic ovary syndrome (PCOS), revealing potential diagnostic markers and the role of…

Altered Composition of Microbiota in Women with Ovarian Endometrioma: Microbiome Analyses of Extracellular Vesicles in the Peritoneal Fluid

May 26, 2025
This study identifies microbiota alterations in ovarian endometrioma, showing distinct microbial shifts in peritoneal fluid extracellular vesicles. Enrichment of Pseudomonas and Acinetobacter,…

Anti-Endometriotic Effects of Pueraria Flower Extract: A Novel Therapeutic Approach

Apr 1, 2025
Pueraria flower extract (PFE) inhibits endometriotic cell adhesion, migration, and MMP expression, reducing lesions in a mouse model, offering potential for non-hormonal therapies.

Antibiotic therapy with metronidazole reduces endometriosis disease progression in mice: a potential role for gut microbiota

Mar 18, 2025
What was studied? The research investigated the impact of antibiotic treatment on the progression of endometriosis, specifically examining how altering the gut microbiota with antibiotics affects the…

Antibiotic therapy with metronidazole reduces endometriosis disease progression in mice: a potential role for gut microbiota

May 19, 2025
This study shows that antibiotic therapy with metronidazole reduces endometriotic lesion growth and inflammation in mice by targeting the gut microbiota, particularly Bacteroidetes. Findings suggest…

Antioxidant status in relation to heavy metals induced oxidative stress in patients with polycystic ovarian syndrome (PCOS)

Apr 27, 2025
This study links elevated arsenic, cadmium, lead, and mercury levels to oxidative stress and low antioxidant defenses in PCOS patients, highlighting heavy metal toxicity as a key contributor to…

Are Heavy Metal Exposure and Trace Element Levels Related to Metabolic and Endocrine Problems in Polycystic Ovary Syndrome?

Apr 27, 2025
This study found that women with PCOS had elevated cadmium, antimony, lead, and mercury levels, alongside reduced zinc and copper. These imbalances correlated with insulin resistance, oxidative…

Association Between Dietary Patterns and Bacterial Vaginosis

Apr 3, 2025
A diet high in processed foods and sugar increases bacterial vaginosis (BV) risk, while a plant-based diet lowers it. This study highlights the importance of dietary choices in vaginal health,…

Association between dietary patterns and premenstrual disorders: A cross-sectional analysis of 1382 college students in China

May 22, 2025
This study found that adherence to the Traditional South China Diet, rich in rice and animal proteins, is linked to reduced premenstrual disorders. Dietary patterns may influence PMD symptoms,…

Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case–control studies

Mar 18, 2025
Endometriosis significantly increases the risk of clear-cell, low-grade serous, and endometrioid ovarian cancers. This study highlights the need for subtype-specific ovarian cancer surveillance and…

Association between Gut Microbiota and Breast Cancer: Diet as a Potential Modulating Factor

Mar 18, 2025
This study links reduced gut microbial diversity and specific taxa (e.g., Acidaminococcus, Hungatella) to breast cancer, influenced by diet. Findings suggest microbiome-targeted interventions and…

Association Between Heavy Metal Exposure and Bacterial Vaginosis

Apr 3, 2025
This cross-sectional study identified a strong link between elevated serum lead and cadmium levels and increased risk of bacterial vaginosis. It suggests that heavy metal exposure may disrupt vaginal…

Association between Polycystic Ovary Syndrome and Gut Microbiota

Apr 27, 2025
This study demonstrates that gut dysbiosis in PCOS is not just correlative but causative. FMT and Lactobacillus transplantation restored hormonal balance and ovarian morphology in PCOS rats,…

Association Between Smoking and Premenstrual Syndrome: A Meta-Analysis

May 14, 2025
This meta-analysis identifies a significant association between smoking and increased risk of PMS and PMDD. Women who smoke are more likely to experience these disorders, with stronger effects in…

Association of the Cervical Microbiota With Pregnancy Outcome in a Subfertile Population Undergoing In Vitro Fertilization: A Case-Control Study

Mar 18, 2025
What Was Studied? The study focused on the association between the composition of cervical microbiota and pregnancy outcomes in a subfertile population undergoing in vitro fertilization (IVF).…

Association of Trace Elements with Polycystic Ovary Syndrome in Women—A Case-Control Study

Apr 27, 2025
This case–control study links high copper and low molybdenum levels to metabolic, hormonal, and inflammatory changes in PCOS. Dietary habits influenced these levels, suggesting potential for targeted…

Associations Between Endometriosis and Gut Microbiota

Mar 18, 2025
What was studied? The study examined the gut microbiota in women with endometriosis compared to healthy controls. It aimed to explore differences based on disease localization, symptoms, or treatment…

Associations Between Endometriosis and Gut Microbiota

May 17, 2025
This study examines the association between endometriosis and gut microbiota, highlighting significant differences in microbial diversity and composition. Women with endometriosis showed altered gut…

Bacterial Vaginosis – A Brief Synopsis of the Literature

Apr 3, 2025
This review explores bacterial vaginosis, emphasizing its recurrence, microbial associations, and treatment challenges. It highlights the need for microbiome-based therapies, standardized diagnostic…

Bacterial vaginosis and biofilms: Therapeutic challenges and innovations

Apr 3, 2025
This review links BV recurrence to resilient biofilms formed by Gardnerella vaginalis. Probiotics and biofilm disruptors (e.g., Astodrimer gel) improve outcomes by restoring Lactobacillus dominance.…

Bacterial Vaginosis and Chlamydia in Tubal Infertility

Apr 3, 2025
Study links BV and past chlamydial infection to tubal infertility, with 87.5% of BV-positive women having tubal damage. Both infections were often asymptomatic. IVF pregnancy rates were unaffected,…

Bacterial Vaginosis and its Association with Infertility, Endometritis, and Pelvic Inflammatory Disease

Apr 3, 2025
BV disrupts Lactobacillus dominance, increasing infertility risk via inflammation, PID, and endometritis. L. crispatus probiotics reduce BV recurrence; CE treatment boosts IVF success. Early…

Bacterial Vaginosis Is Associated with Variation in Dietary Indices

Apr 28, 2025
A high glycemic load diet increases bacterial vaginosis (BV) risk, while nutrient-rich diets lower it. This study highlights the link between diet quality and vaginal microbiome balance, providing…

Biological rhythms in premenstrual syndrome and premenstrual dysphoric disorder: a systematic review

May 19, 2025
Women with PMS/PMDD experience disrupted biological rhythms, notably lower melatonin, higher nighttime temperature, and poor sleep quality. These circadian disturbances contribute to symptom…

Biosorption of Heavy Metals by Candida albicans

Jun 6, 2025
The study showed Candida albicans can resist and efficiently biosorb heavy metals, especially chromium, from contaminated water and soil. Optimal removal depends on pH, temperature, biomass state,…

Boric acid vaginal suppositories: a brief review

May 1, 2025
This review discusses the effectiveness of boric acid vaginal suppositories in treating azole-resistant vaginitis, including its benefits and limitations.

Breast cancer but not the menopausal status is associated with small changes of the gut microbiota

Aug 11, 2025
This study shows that breast cancer, rather than menopausal status, drives subtle gut microbiota changes. Dysbiosis in BC patients included reduced Blautia obeum and Bifidobacterium. Functional…

Breast cancer in postmenopausal women is associated with an altered gut metagenome

Mar 18, 2025
The study revealed altered gut microbiota in postmenopausal breast cancer patients, with enriched inflammation-associated species and depleted butyrate producers. Functional gene changes suggest…

Breast cancer patients from the Midwest region of the United States have reduced levels of short-chain fatty acid-producing gut bacteria

Mar 18, 2025
This study identifies gut dysbiosis in breast cancer patients, highlighting reduced SCFA-producing bacteria and altered microbial pathways. Findings suggest microbiome-targeted interventions could…

Causal effects of gut microbiome on endometriosis: a two-sample Mendelian randomization study

Aug 11, 2025
What was studied? This study investigated the causal relationship between gut microbiome composition and endometriosis using a two-sample Mendelian randomization (MR) approach. The researchers aimed…

Causal relationships between gut microbiota and polycystic ovarian syndrome

Apr 27, 2025
This Mendelian randomization study identifies a bidirectional causal link between specific gut microbes and PCOS. Bacilli and Burkholderiales increase PCOS risk, while Blautia and Cyanobacteria show…

Characteristics of gut microbiota in patients with asthenozoospermia: a Chinese pilot study

Mar 18, 2025
What was studied? The study investigated the characteristics of gut microbiota in patients with asthenozoospermia (AS), a common cause of male infertility characterized by reduced sperm motility. It…

Characteristics of the Gut Microbiota in Japanese Patients with Premenstrual Syndrome

May 13, 2025
This study explores the gut microbiota in Japanese women with Premenstrual Syndrome (PMS), finding significant differences in microbial composition and highlighting the potential role of Collinsella…

Characteristics of the gut microbiota in women with premenstrual symptoms: A cross-sectional study

May 13, 2025
This study explores the association between gut microbiota composition and the severity of premenstrual symptoms, suggesting a potential role for microbiome-based therapies in managing PMS.

Characteristics of the gut microbiota in women with premenstrual symptoms: A cross-sectional study

May 19, 2025
This study identified specific gut microbiota alterations, including reduced butyrate- and GABA-producing bacteria, associated with premenstrual disorder severity, offering new insights into PMD…

Characterization of the gut microbiota in polycystic ovary syndrome with dyslipidemia

Apr 27, 2025
This study explores the gut microbiota in women with PCOS and dyslipidemia, revealing significant microbial imbalances associated with lipid metabolism and hormonal dysregulation, offering potential…

Characterization of Vaginal Microbiota in Women With Recurrent Spontaneous Abortion That Can Be Modified by Drug Treatment

Apr 3, 2025
This study explores the link between vaginal microbiota and recurrent spontaneous abortion (RSA), showing that drug treatment, including metformin combined with aspirin, can alter microbiota…

Circulating bile acid profile characteristics in PCOS patients and the role of bile acids in predicting the pathogenesis of PCOS

Apr 27, 2025
This study identified significant bile acid profile changes in PCOS patients and highlighted CDCA and LCA as promising biomarkers, especially when combined with testosterone. The results suggest a…

Clinicians’ use of Intravaginal Boric Acid Maintenance Therapy for Recurrent Vulvovaginal Candidiasis and Bacterial Vaginosis

Apr 3, 2025
This study evaluates the use of intravaginal boric acid for recurrent vulvovaginal candidiasis and bacterial vaginosis, highlighting its long-term tolerability, high patient satisfaction, and rare…

Coincidence of uterine malformations and endometriosis: a clinically relevant problem?

Mar 18, 2025
What was studied?The retrospective study explored the prevalence of endometriosis in patients with uterine malformations. It specifically investigated the relationship between different types of…

Combatting antibiotic resistance in Gardnerella vaginalis: A comparative in silico investigation for drug target identification

Apr 3, 2025
This study identifies phospho-2-dehydro-3-deoxyheptonate aldolase as a drug target in Gardnerella vaginalis and highlights five FDA-approved compounds as potential treatments for bacterial vaginosis.

Combination therapy of curcumin and fecal microbiota transplant: Potential treatment of polycystic ovarian syndrome

Apr 27, 2025
This review proposes a combination of fecal microbiota transplantation (FMT) and curcumin as a potential treatment for Polycystic Ovary Syndrome (PCOS). The hypothesis suggests these therapies could…

Comorbid Premenstrual Dysphoric Disorder in Women with Bipolar Disorder: Management Challenges

May 20, 2025
Management of comorbid PMDD and bipolar disorder requires mood stabilization first, cautious use of antidepressants, hormonal therapy, and adjunctive psychotherapy. Evidence is limited, highlighting…

Comparison of Vaginal, Cervical and Gut Microbiota Between Women with Stage 3/4 Endometriosis and Healthy Controls

Mar 18, 2025
What was studied? The study focused on exploring the associations between the microbiota of the vaginal, cervical, and gut regions and stage 3–4 endometriosis in women. This research aimed to uncover…

Composition and Functional Potential of the Human Mammary Microbiota Prior to and Following Breast Tumor Diagnosis

Mar 18, 2025
This study explores the mammary microbiota’s composition and function before and after breast cancer diagnosis, revealing dysbiosis and metabolic shifts as early markers.

Comprehensive profiles and diagnostic value of menopausal-specific gut microbiota in premenopausal breast cancer

Aug 11, 2025
What was studied? This study investigated the gut microbiota profiles, diagnostic value, and functional pathways specific to premenopausal breast cancer patients. It aimed to identify unique gut…

Correlation of calprotectin serum levels with degrees of endometriosis: A cross-sectional study

May 24, 2025
This study found no significant correlation between serum calprotectin levels and the severity of endometriosis. Despite its known role as an inflammatory biomarker, calprotectin did not…

Correlation of fecal metabolomics and gut microbiota in mice with endometriosis

Mar 18, 2025
What was studied? The study investigated the interaction between fecal metabolomics and gut microbiota in mice with endometriosis (EMS), aiming to identify metabolic changes and microbiota diversity…

Correlation of fecal metabolomics and gut microbiota in mice with endometriosis

May 19, 2025
This study identifies gut microbiota and metabolomic shifts in endometriosis, with altered bile acid biosynthesis and ALA metabolism. Elevated CDCA and UDCA levels, coupled with microbial changes,…

Correlation of Serum Zinc Levels with Postpartum Depression-A Case- control Study in North Karnataka

Jun 14, 2025
This study demonstrates that low serum zinc levels correlate with increased severity of postpartum depression, suggesting the potential benefits of zinc supplementation in postpartum care.

Critical Review on Zeolite Clinoptilolite Safety and Medical Applications in vivo

Mar 18, 2025
What was reviewed? The review focused on the safety and medical applications of clinoptilolite, a naturally occurring zeolite, for in vivo use. The analysis encompassed the physical and chemical…

Current patient perspectives of vulvovaginal candidiasis: incidence, symptoms, management and post-treatment outcomes

Jun 6, 2025
This contemporary survey validates historical data on VVC/RVVC prevalence, identifying common symptoms, risk factors, and treatment outcomes. It highlights antibiotics as a major risk factor and…

Current Treatment of Bacterial Vaginosis—Limitations and Need for Innovation

Apr 3, 2025
This review reveals high BV recurrence rates after metronidazole or clindamycin treatment due to microbial biofilms and potential sexual transmission. While both antibiotics show similar short-term…

Determinants of premenstrual dysphoric disorder and associated factors among regular undergraduate students at Hawassa University Southern, Ethiopia

May 19, 2025
Among Ethiopian female university students, PMDD affects nearly two-thirds and links strongly to severe menstrual pain, irregular cycles, low social support, and contraceptive use. Early…

Diagnosis of peripartum depression disorder: A state-of-the-art approach from the COST Action Riseup-PPD

Jun 13, 2025
This review emphasizes peripartum depression as distinct from general depression, featuring pronounced anxiety, psychomotor symptoms, and obsessive thoughts, urging expanded diagnostic criteria to…

Dietary Intake of Selected Nutrients Affects Bacterial Vaginosis in Women

Apr 3, 2025
Higher dietary fat intake increases the risk of bacterial vaginosis (BV), while folate, vitamin E, and calcium may lower severe BV risk. This study suggests dietary interventions could play a role in…

Dietary Patterns and Bacterial Vaginosis: is there any association?

Apr 3, 2025
A nutrient-rich diet lowers bacterial vaginosis (BV) risk, while processed foods increase it. This study highlights the importance of dietary choices in vaginal microbiome balance, offering insights…

Dioxin-like PCB 126 increases intestinal inflammation and disrupts gut microbiota and metabolic homeostasis.

Mar 18, 2025
What was studied? The research focused on examining the effects of PCB 126, a dioxin-like pollutant, on gut health and microbiota as well as metabolic homeostasis in a mouse model predisposed to…

Dioxin-like PCBs and Endometriosis

Mar 18, 2025
What was studied? The study focused on the potential impact of environmental exposure to dioxin-like polychlorinated biphenyls (PCBs) on the development of endometriosis. It specifically reviewed the…

Does Exposure of Lead and Cadmium Affect the Endometriosis?

Mar 18, 2025
The study links lead and cadmium exposure to increased endometriosis risk, emphasizing lead’s role at low blood levels and synergistic effects with cadmium. It advocates for strict monitoring…

Dual Mechanisms of Action: Anti-Candida and Anti-Inflammatory Potential of Lactobacillus Fermentation Broth in Treating Vulvovaginal Candidiasis

Jun 13, 2025
This study explored VAGINNE®, a Lactobacillus fermentation broth, showing strong anti-Candida and anti-inflammatory effects in mice with VVC. It enhanced microbiome health and reduced proinflammatory…

Dysbiosis of Gut Microbiota (DOGMA) – A novel theory for the development of Polycystic Ovarian Syndrome

Apr 27, 2025
This review introduces the DOGMA theory linking gut dysbiosis and leaky gut to insulin resistance, inflammation, and hyperandrogenism in PCOS. It outlines a compelling rationale for…

Dysbiosis of Gut Microbiota Associated with Clinical Parameters in Polycystic Ovary Syndrome

Apr 27, 2025
This study reveals significant dysbiosis of gut microbiota in women with PCOS, particularly in obese individuals. The altered microbial composition correlates with metabolic and hormonal imbalances,…

Dysbiosis of the Saliva Microbiome in Patients With Polycystic Ovary Syndrome

Apr 27, 2025
This study reveals disrupted diurnal rhythms and significant dysbiosis in the salivary microbiota of PCOS patients, notably elevated Fusobacterium and reduced Actinobacteria. These oral microbial…

Effect of endometriosis on the fecal bacteriota composition of mice during the acute phase of lesion formation

Mar 18, 2025
What was studied? The study investigated whether the induction of endometriosis in mice affects the composition of their gut microbiota. It tested this by transplanting uterine tissue fragments into…

Effect of endometriosis on the fecal bacteriota composition of mice during the acute phase of lesion formation

May 19, 2025
This study found that endometriosis does not induce significant changes in the fecal bacteriota composition during the acute phase of lesion formation. Findings suggest that gut microbial shifts in…

Efficacy and Safety of Different Drugs for the Treatment of Bacterial Vaginosis

Apr 3, 2025
This meta-analysis compared BV treatments, identifying ornidazole as the most effective oral drug and sucrose/probiotics as top non-antibiotic options. Restoring Lactobacillus dominance is key, with…

Efficacy of Vitamin C Vaginal Tablets in Preventing Recurrence of Bacterial Vaginosis: A Randomized Controlled Trial

Apr 3, 2025
This study demonstrates that 250 mg vitamin C vaginal tablets reduce the recurrence of bacterial vaginosis, offering an effective and safe prophylactic treatment.

Elevated Lactoferrin and Anti-Lactoferrin Antibodies in Endometriosis: Autoimmune and Microbiome Insights

Mar 18, 2025
This study confirms elevated lactoferrin and anti-lactoferrin antibody levels in endometriosis, suggesting autoimmune involvement. Anti-lactoferrin drops post-surgery, hinting at a biomarker role,…

Endometrial whole metabolome profile at the receptive phase: influence of Mediterranean Diet and infertility

Mar 18, 2025
What was studied?The study focused on analyzing the receptive-phase endometrial metabolome profiles among women with infertility and examining their associations with adherence to the Mediterranean…

Endometriosis and adenomyosis: shared pathophysiology

Mar 18, 2025
What was studied? The study focused on the pathophysiology, genetic variants, and epigenetic abnormalities underlying endometriosis and adenomyosis. It emphasized the mechanisms through which these…

Endometriosis induces gut microbiota alterations in mice

Mar 18, 2025
What was studied? The research focused on investigating the impact of murine endometriosis on gut microbiota composition using high-throughput DNA sequencing to explore how the disease affects…

Endometriosis induces gut microbiota alterations in mice

May 19, 2025
This study demonstrates that endometriosis induces gut microbiota alterations in a murine model, particularly increasing the Firmicutes/Bacteroidetes ratio and enriching Bifidobacterium and…

Endometriosis of the lung: A case report and brief review of the literature

Mar 18, 2025
What was studied? The study focused on pulmonary endometriosis, a rare condition characterized by the presence of endometrial tissue in the lungs. It analyzed a series of historical and recent cases,…

Epidemiology of Premenstrual Syndrome (PMS)-A Systematic Review and Meta-Analysis Study

May 12, 2025
This systematic review and meta-analysis estimate the global prevalence of PMS, revealing wide variations across countries and highlighting the need for standardized diagnostic approaches.

Epigenetics of endometriosis

Mar 18, 2025
What was studied?The review focused on the role of epigenetic changes in endometriosis, exploring how these modifications influence the disease’s etiopathogenesis, diagnosis, and therapeutic…

Evaluation of the relationship between polycystic ovary syndrome and intestinal inflammation as measured by fecal calprotectin levels

Apr 27, 2025
PCOS is linked with higher gut inflammation, as shown by elevated fecal calprotectin. This may help guide diagnosis and treatment.

Evidence for statin therapy in polycystic ovary syndrome. 

Apr 26, 2025
This review highlights the potential benefits of statin therapy in women with polycystic ovary syndrome (PCOS), showing improvements in metabolic dysfunction, hyperandrogenism, and cardiovascular…

Exploring the link between dietary zinc intake and endometriosis risk: insights from a cross-sectional analysis of American women

Mar 18, 2025
This study links higher dietary zinc intake with increased endometriosis risk among American women, highlighting zinc’s complex role in immune modulation and estrogen-related pathways. Findings…

Exposure to environmental chemicals and perinatal psychopathology

Jun 13, 2025
This review links prenatal chemical exposures to perinatal depression and anxiety through microbiome disruption and neuroinflammation. Environmental chemicals alter the gut-brain axis, emphasizing…

Factors Related to Seeking Help for Postpartum Depression: A Secondary Analysis of New York City PRAMS Data

Jun 13, 2025
This study identifies significant barriers preventing women from seeking help for postpartum depression, notably stigma and socio-cultural factors. Active help-seeking behaviors significantly…

Fecal Microbiota Transplantation: A Potential Tool for Treatment of Human Female Reproductive Tract Diseases

Apr 27, 2025
This study evaluates the therapeutic potential of fecal microbiota transplantation (FMT) for treating female reproductive tract diseases, including PCOS, by restoring microbiota balance.

Fruit and vegetable consumption and risk of endometriosis

Mar 18, 2025
What Was Studied This study explored the potential link between the consumption of fruits and vegetables and the risk of laparoscopically confirmed endometriosis. Using data collected from the…

Gestational iron supplementation reverses depressive-like behavior in post-partum Sprague Dawley rats: Evidence from behavioral and neurohistological studies

Jun 14, 2025
This study highlights the role of gestational iron supplementation in alleviating depressive-like behavior in postpartum rats, showing improvements in neuronal health and mood regulation. It suggests…

GS2 Gallium Complex: A Novel Inhibitor of MMP-14 for Anti-Metastatic Cancer Therapy

Mar 18, 2025
GS2, a gallium complex, inhibits tumor invasion by targeting MMP-14, with implications for anti-metastatic cancer therapy.

Gut and oral microbial compositional differences in women with breast cancer, women with ductal carcinoma in situ, and healthy women

Mar 18, 2025
This study reveals distinct gut microbiota profiles in breast cancer and DCIS patients, with reduced alpha diversity and functional shifts linked to inflammation. Major microbial associations,…

Gut and Vaginal Microbiomes in PCOS: Implications for Women’s Health

Apr 27, 2025
This review links dysbiosis of gut and vaginal microbiota to PCOS pathogenesis, highlighting reduced Lactobacillus, elevated Bacteroides, and hormonal imbalance. It supports microbiome-targeted…

Gut microbiome in PCOS associates to serum metabolomics

Apr 27, 2025
This study shows that gut microbiota dysbiosis in PCOS correlates with altered serum metabolites, including elevated LPCs and reduced citric acid. Roseburia and Prevotella_9 were linked to protective…

Gut microbiota alterations reveal potential gut–brain axis changes in polycystic ovary syndrome (PCOS)

Apr 27, 2025
This study shows reduced gut microbiota diversity and increased GABA-producing bacteria in PCOS, linking microbial shifts to elevated LH levels and supporting a gut–brain axis mechanism. The findings…

Gut microbiota imbalance and its correlations with hormone and inflammatory factors in patients with stage 3/4 endometriosis

Mar 18, 2025
What was studied? The study investigated the role of gut microbiota in endometriosis (EM), focusing on its differences between individuals with stage 3/4 EM and healthy controls and how these…

Gut microbiota imbalance and its correlations with hormone and inflammatory factors in patients with stage 3/4 endometriosis

May 17, 2025
This study explores the gut microbiota imbalance and its correlations with hormone and inflammatory factors in stage 3/4 endometriosis. Key findings reveal distinct microbial shifts linked to…

Heavy Metals and Essential Elements in Association with Oxidative Stress in Women with Polycystic Ovary Syndrome

Apr 27, 2025
This systematic review links heavy metal exposure and trace element deficiencies to oxidative stress, inflammation, and hormonal imbalance in PCOS, with implications for metabolic dysfunction and gut…

High-Fiber Diet or Combined With Acarbose Alleviates Heterogeneous Phenotypes of Polycystic Ovary Syndrome by Regulating Gut Microbiota

Apr 27, 2025
A high-fiber diet combined with acarbose improved hormonal, metabolic, and inflammatory markers in women with PCOS by remodeling the gut microbiota. Key microbial shifts included increases in…

I Am the 1 in 10—What Should I Eat? A Research Review of Nutrition in Endometriosis

Mar 18, 2025
This review explores how dietary modifications impact endometriosis progression. Antioxidants, omega-3s, and anti-inflammatory diets show promise in symptom relief and hormonal regulation.…

Identification of distinct stool metabolites in women with endometriosis for non-invasive diagnosis and potential for microbiota-based therapies

Mar 18, 2025
This study identifies stool-based biomarkers for endometriosis diagnosis and highlights the therapeutic potential of 4-hydroxyindole, a microbiota-derived metabolite, in reducing inflammation and…

Identification of polycystic ovary syndrome potential drug targets based on pathobiological similarity in the protein-protein interaction network

Apr 27, 2025
This study identifies potential drug targets for PCOS, focusing on genes involved in insulin resistance and hormone signaling pathways. Findings could help develop more targeted treatments.

Identifying Bacterial Vaginosis-Associated Bacteria

Apr 3, 2025
This study identifies bacterial vaginosis-associated species, improving BV diagnostics and treatment strategies through metagenomic sequencing.

Impact of nutritional diet therapy on premenstrual syndrome

May 22, 2025
This review highlights the role of diet and micronutrients in modulating PMS symptoms, showing potential benefits of calcium, magnesium, vitamin D, and B vitamins, while emphasizing the need for…

Improved cure of bacterial vaginosis with single dose of tinidazole (2g), Lactobacillus rhamnosus GR-1, and Lactobacillus reuteri RC-14

Apr 29, 2025
This study shows that oral probiotics significantly boost cure rates of bacterial vaginosis when used with tinidazole, restoring a healthy vaginal microbiome.

Increased circulating conjugated primary bile acids are associated with hyperandrogenism in women with polycystic ovary syndrome

Apr 27, 2025
This study links elevated conjugated primary bile acids to hyperandrogenism in PCOS, suggesting bile acid metabolism plays a direct role in endocrine dysfunction and opens new therapeutic…

Influence of heavy metal exposure on gut microbiota: Recent advances

Mar 18, 2025
What was studied? The study investigated the impact of heavy metal exposure on the composition and function of gut microbiota. Specifically, it looked at how heavy metals such as arsenic, cadmium,…

Insulin Resistance and the Polycystic Ovary Syndrome Revisited: An Update on Mechanisms and Implications

Apr 27, 2025
This review explores insulin resistance as a primary driver of PCOS, detailing molecular signaling defects and their clinical consequences. It provides critical insight into how hyperinsulinemia…

Intestinal microbiota influences clinical outcome and side effects of early breast cancer treatment

Mar 18, 2025
Gut microbiota influences early breast cancer prognosis and treatment side effects, with specific commensals correlating to outcomes. Chemotherapy alters microbiota, favoring beneficial species and…

Investigation of In Vitro Efficacy of Boric Acid on Pseudomonas aeruginosa Strains Isolated from Diabetic Foot Infections

May 1, 2025
What was studied? This study investigated the in vitro efficacy of boric acid as an antiseptic agent against Pseudomonas aeruginosa strains isolated from diabetic foot infections. The research aimed…

Iron Overload and Endometriosis: Mechanisms, Implications, and Therapeutic Targets

Mar 18, 2025
Iron overload in endometriosis contributes to oxidative stress, inflammation, and tissue damage, driving lesion persistence and subfertility. Ferroptosis resistance and dysregulated iron metabolism…

Joint effects of traffic-related air pollution and hypertensive disorders of pregnancy on maternal postpartum depressive and anxiety symptoms

Jun 13, 2025
This study demonstrates significant associations between prenatal traffic-related air pollution exposure and postpartum depressive and anxiety symptoms, highlighting increased vulnerability among…

Ketogenic diet improves fertility in patients with polycystic ovary syndrome: A brief report

Apr 27, 2025
A ketogenic diet restored menstrual cycles and improved pregnancy rates in obese women with PCOS, even without metformin or ovulation induction. Findings suggest KD enhances fertility through…

Lactobacillus crispatus inhibits growth of Gardnerella vaginalis and Neisseria gonorrhoeae on a porcine vaginal mucosa model.

Apr 3, 2025
The study shows that Lactobacillus crispatus inhibits the growth of Gardnerella vaginalis and Neisseria gonorrhoeae by lowering pH and producing lactic acid, offering insights into…

Levels of Trace Elements in Erythrocytes as Endocrine Disruptors in Obese and Nonobese Women with Polycystic Ovary Syndrome

Apr 27, 2025
This study identified elevated erythrocyte nickel in obese women with PCOS and revealed trace element–hormone correlations linked to reproductive dysfunction. These findings point to…

Long-term use of gonadotropin-releasing hormone analogs and hormone replacement therapy in the management of endometriosis: a randomized trial with a 6-year follow-up

Mar 18, 2025
Who was studied? The study included forty-nine symptomatic women diagnosed with endometriosis via laparoscopy, who volunteered to participate in the randomized trial. These women were undergoing…

Low intakes of dietary fiber and magnesium are associated with insulin resistance and hyperandrogenism in polycystic ovary syndrome

Apr 27, 2025
This study reveals that low fiber and magnesium intake—not overeating or inactivity—contribute significantly to insulin resistance and hyperandrogenism in PCOS, with strong implications for…

Lower Fiber Consumption in Women with Polycystic Ovary Syndrome

Apr 27, 2025
This meta-analysis confirms that women with PCOS consume significantly less dietary fiber than controls, independent of calorie intake. Reduced fiber may worsen PCOS via gut dysbiosis and diminished…

Management of recurrent vulvovaginal candidosis: Narrative review of the literature and European expert panel opinion

Jun 6, 2025
This review assesses management strategies for recurrent vulvovaginal candidiasis, highlighting the limitations of current antifungal treatments, rising resistance concerns, and potential novel…

Mediterranean Diet Combined With a Low-Carbohydrate Dietary Pattern in the Treatment of Overweight Polycystic Ovary Syndrome Patients

Apr 27, 2025
A Mediterranean/low-carb diet significantly improved insulin resistance, androgen levels, and weight in overweight PCOS patients. The findings suggest microbiome-mediated metabolic benefits and…

Meta-analysis of gut microbiome studies identifies disease-specific and shared responses

Mar 18, 2025
What was studied?The meta-analysis focused on the human gut microbiome’s association with various diseases by analyzing 28 published case-control gut microbiome studies covering ten diseases. The…

Metabolomics reveals perturbations in endometrium and serum of minimal and mild endometriosis

Mar 18, 2025
This study highlights metabolic alterations in endometrial tissue and serum of minimal and mild endometriosis patients, identifying amino acid biomarkers with diagnostic potential. A combined serum…

Metal Nanoparticles to Combat Candida albicans Infections: An Update

Jun 6, 2025
This review examines metal nanoparticles as innovative antifungal agents against Candida albicans. It highlights their multi-target actions, synergistic potential with antifungal drugs, and drug…

Metalloestrogens: an emerging class of inorganic xenoestrogens with potential to add to the oestrogenic burden of the human breast

Mar 18, 2025
This review identifies metalloestrogens as a critical factor in hormone disruption and breast cancer risk.

Metformin use in women with polycystic ovary syndrome

Apr 27, 2025
This review discusses the role of metformin in treating PCOS-related infertility. It highlights its effectiveness in improving ovulation, reducing insulin resistance, and managing hyperandrogenism.…

Microbial Dysbiosis Is Associated with Human Breast Cancer

Mar 18, 2025
Microbial dysbiosis, marked by reduced bacterial load and altered species composition, is linked to breast cancer progression. Enrichment of Methylobacterium radiotolerans in tumors and depletion of…

Microbiome of the lower genital tract in Chinese women with endometriosis by 16s-rRNA sequencing technique: a pilot study

Mar 18, 2025
What was studied? The study investigated the relationship between the genital tract microbiota and endometriosis, particularly focusing on how microbiota diversity and specific bacteria like…

Microbiome of the lower genital tract in Chinese women with endometriosis by 16s-rRNA sequencing technique: a pilot study

May 19, 2025
This study identifies microbiome shifts in the lower genital tract of Chinese women with endometriosis, marked by Atopobium enrichment and changes in ribosome biogenesis and immune modulation.…

Microbiome Profile of Deep Endometriosis Patients: Comparison of Vaginal Fluid, Endometrium and Lesion

Mar 18, 2025
What was studied? The study focused on identifying and comparing the bacterial patterns present in the vaginal fluid, eutopic endometrium, and endometriotic lesions of patients with endometriosis to…

Microbiome Profile of Deep Endometriosis Patients: Comparison of Vaginal Fluid, Endometrium and Lesion

May 19, 2025
This study reveals a distinct microbiome profile in deep endometriosis, with unique bacterial communities in lesion sites, suggesting a role in inflammation and disease progression. Potentially…

Microbiota composition and distribution along the female reproductive tract of women with endometriosis

Mar 18, 2025
What was studied? The study investigated the microbiota distribution across the entire female reproductive tract of endometriosis (EMS) patients and non-EMS women, aiming to identify EMS-specific…

Microbiota composition and distribution along the female reproductive tract of women with endometriosis

Aug 11, 2025
This study maps the microbiota composition along the reproductive tract in endometriosis patients, revealing microbial dysbiosis, reduced Lactobacillus, and increased Pseudomonas and Sphingobium in…

Microbiota in vaginal health and pathogenesis of recurrent vulvovaginal infections: a critical review

Jun 6, 2025
This review clarifies the role of vaginal microbiota in health and recurrent infections, highlighting Lactobacillus complexity, pathogen interactions, and the need for personalized diagnostic and…

Molecular detection of intrauterine microbial colonization in women with endometriosis

May 19, 2025
This study reveals that intrauterine microbial colonization is prevalent in women with endometriosis, particularly with Streptococcaceae, Staphylococcaceae, and Enterobacteriaceae. Findings suggest…

Molecular detection of microbial colonization in cervical mucus of women with and without endometriosis

Mar 18, 2025
What was studied? The study investigated the microbiota in the cervical mucus of women with and without endometriosis using next-generation sequencing (NGS) technologies. It aimed to clarify whether…

Molecular detection of microbial colonization in cervical mucus of women with and without endometriosis

Aug 11, 2025
This study identifies intrauterine microbial colonization in endometriosis, with enriched Streptococcaceae, Staphylococcaceae, and Enterobacteriaceae. GnRHa therapy exacerbated microbial imbalances,…

Müllerian duct anomalies coincident with endometriosis: a review

Mar 18, 2025
What was studied?The study reviewed the relationship between Müllerian duct anomalies (MDAs) and endometriosis, focusing on their coexistence and the underlying pathophysiological theories that might…

New Insights into Photobiomodulation of the Vaginal Microbiome—A Critical Review

Mar 18, 2025
What was studied? The study reviewed the potential effects of photobiomodulation (PBM) on the vaginal microbiome, particularly exploring theoretical and emerging research on how PBM may influence…

Oral, Vaginal, and Stool Microbial Signatures in Patients With Endometriosis as Potential Diagnostic Non-Invasive Biomarkers: A Prospective Cohort Study

Aug 11, 2025
This study explores oral, vaginal, and stool microbial signatures in patients with endometriosis, highlighting their potential as non-invasive diagnostic biomarkers. Findings suggest distinct…

Persistent Organic Pollutants and Endometriosis

Mar 18, 2025
This study links persistent organic pollutants to metabolic alterations in deep endometriosis, identifying trans-nonachlor and 2-hydroxybutyrate as key markers.

Plants as source of new therapies for endometriosis: a review of preclinical and clinical studies

Mar 18, 2025
This review highlights the potential of plant-derived therapies for endometriosis. Key findings include anti-inflammatory, anti-proliferative, and anti-angiogenic effects of herbal extracts and…

Polycystic Ovary Syndrome: Etiology, Current Management, and Future Therapeutics

Apr 27, 2025
This review links PCOS to gut microbiota dysbiosis, showing how LPS leakage, SCFA deficiency, and altered bile acids contribute to insulin resistance and hyperandrogenism. Microbiome-based therapies,…

Polycystic ovary syndrome: pathophysiology and therapeutic opportunities

Apr 27, 2025
This review presents PCOS as a multisystem disorder driven by gut dysbiosis, neuroendocrine disruption, and adipose androgen synthesis. Targeting B. vulgatus, IL-22, and AKR1C3 may offer novel…

Possible Therapeutic Mechanisms and Future Perspectives of Vaginal Microbiota Transplantation

Mar 18, 2025
What was studied? The study explored the therapeutic mechanisms and future perspectives of Vaginal Microbiota Transplantation (VMT). It focused on transferring healthy vaginal microbiota from a donor…

Postpartum Depression and Role of Serum Trace Elements

Jun 13, 2025
This review explores how deficiencies or imbalances in zinc, magnesium, iron, and copper contribute to postpartum depression. It supports trace element supplementation as a nonpharmacologic treatment…

Postpartum Depression in The Arab Region: A Systematic Literature Review

Jun 13, 2025
This systematic review examines postpartum depression in Arab countries, revealing varying prevalence rates and highlighting socio-economic, marital, and health-related factors as major risk…

Premenstrual disorders and PMDD – a review

May 19, 2025
Premenstrual dysphoric disorder (PMDD) significantly impairs women’s lives due to abnormal sensitivity to hormonal fluctuations. Accurate diagnosis relies on prospective symptom tracking. Evidence…

Premenstrual Dysphoric Disorder and the Brain

May 19, 2025
What was reviewed? This paper reviewed the neurological basis of premenstrual dysphoric disorder (PMDD), emphasizing its recognition as a distinct mood disorder linked to menstrual cycle hormonal…

Premenstrual dysphoric disorder-an undervalued diagnosis? A cross-sectional study in Hungarian women

May 19, 2025
Hungarian women with probable PMDD experience high rates of anxio-depressive symptoms and reduced well-being. Retrospective screening suggests higher-than-expected prevalence, highlighting the need…

Premenstrual Dysphoric Disorder: Epidemiology and Treatment

May 19, 2025
This review delineates PMDD’s unique neurobiology, highlighting hormone sensitivity, GABAergic dysfunction, and stress interaction. SSRIs provide rapid symptom relief, with hormonal and behavioral…

Premenstrual dysphoric disorder: General overview, treatment strategies, and focus on sertraline for symptom-onset dosing

May 19, 2025
Symptom-onset dosing of sertraline effectively reduces PMDD symptoms, especially mood-related ones, with fewer side effects and limited drug exposure. This targeted approach offers a promising,…

Premenstrual Syndrome and Exercise: A Narrative Review

May 12, 2025
This narrative review explores how exercise can help manage the symptoms of Premenstrual Syndrome (PMS), focusing on the physiological and psychological benefits of regular physical activity.

Premenstrual Syndrome and Premenstrual Dysphoric Disorder as Centrally Based Disorders

May 20, 2025
PMS and PMDD stem from neuroendocrine and neurochemical imbalances, especially altered allopregnanolone and GABA activity. Hormonal and neuroactive therapies improve symptoms, while microbiome and…

Premenstrual syndrome, a common but underrated entity: review of the clinical literature

May 12, 2025
This review explores premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD), focusing on symptoms, prevalence, risk factors, and treatment options.

Premenstrual syndrome: New insights into etiology and review of treatment methods

May 12, 2025
This review examines the latest insights into the etiology and treatment of Premenstrual Syndrome (PMS) and Premenstrual Dysphoric Disorder (PMDD), focusing on hormonal and neurosteroid imbalances.

Presence of metalloestrogens in ectopic endometrial tissue

Mar 18, 2025
What was studied? This study investigated the presence of metalloestrogens in ectopic endometrial tissue from women with endometriosis. Metalloestrogens, heavy metals that can mimic estrogen and may…

Presence of metalloestrogens in ectopic endometrial tissue

Mar 18, 2025
This study quantified metalloestrogens—cadmium, nickel, and lead—in ectopic endometrial tissue, suggesting their role in endometriosis persistence.

Prevalence and associated factors of premenstrual dysphoric disorder among high school students in Finote Selam town, northwest Ethiopia

May 19, 2025
Among Ethiopian high school girls, PMDD affects one-third, linked to irregular cycles, depression, prolonged menstruation, and stress. Early screening and mental health support are crucial to…

Probiotics and Polycystic Ovary Syndrome: A Perspective for Management in Adolescents with Obesity

Apr 27, 2025
This review highlights how probiotic and synbiotic supplementation improves insulin resistance, inflammation, and androgen levels in obese adolescents with PCOS. Microbiome modulation offers a…

Profile of Bile Acid Metabolomics in the Follicular Fluid of PCOS Patients

Apr 27, 2025
This study reveals elevated primary and conjugated bile acids in follicular fluid of PCOS patients, suggesting a novel ovarian micro-environmental role in ovulation dysfunction and potential links to…

Promising Drug Candidates for the Treatment of Polycystic Ovary Syndrome (PCOS) as Alternatives to the Classical Medication Metformin

Apr 27, 2025
The study evaluates the efficacy of Irosustat, STX140, and compound 1G as alternative treatments for PCOS, showing improvements in metabolic and hormonal profiles, with promising results on oxidative…

Recurrent Bacterial Vaginosis Following Metronidazole Treatment is Associated with Microbiota Richness at Diagnosis

Apr 3, 2025
This study links high pre-treatment vaginal microbiota diversity to BV recurrence after metronidazole. Women with sustained clearance had lower richness. Lactobacillus iners improved immune markers…

Relaxed fibronectin: a potential novel target for imaging endometriotic lesions

Mar 18, 2025
The radiotracer [111In]In-FnBPA5 accumulated in the mouse uterus, with uptake varying according to the estrous cycle, suggesting an increased abundance of relaxed fibronectin during…

Reproductive Microbiomes: Using the Microbiome as a Novel Diagnostic Tool for Endometriosis

Mar 18, 2025
What was studied? The study aimed to investigate how endometriosis affects the uterine and cervical bacterial communities. Utilizing next-generation amplicon sequencing of the bacterial 16S rRNA…

Repurposing new drug candidates and identifying crucial molecules underlying PCOS Pathogenesis Based On Bioinformatics Analysis

Apr 27, 2025
What was studied? This study investigated the potential of repurposing FDA-approved drugs to treat Polycystic Ovary Syndrome (PCOS). Using bioinformatics tools, the authors analyzed protein-protein…

Risk Factors for Postpartum Depression: An Umbrella Review

Jun 13, 2025
This umbrella review synthesizes research on postpartum depression risk factors, highlighting prenatal depression and current abuse as the strongest predictors. It emphasizes the need for targeted…

Risk Factors of Postpartum Depression

Jun 13, 2025
This review analyzes the risk factors for postpartum depression (PPD), highlighting key predictors such as a history of depression, lack of support, gestational diabetes, and birth complications. It…

Role of gut microbiota in the development of insulin resistance and the mechanism underlying polycystic ovary syndrome (PCOS)

Apr 27, 2025
This review connects gut microbiota dysbiosis to insulin resistance and hyperandrogenism in PCOS, identifying reduced SCFA producers and increased LPS-producing microbes as key signatures. It…

Role of Metformin in Polycystic Ovary Syndrome (PCOS)-Related Infertility

Apr 27, 2025
This review examines the role of metformin in treating PCOS-related infertility, highlighting its effectiveness in improving insulin sensitivity, reducing hyperandrogenism, and restoring ovulation.…

Secnidazole for the Treatment of Bacterial Vaginosis

Apr 3, 2025
This systematic review analyzed six trials evaluating secnidazole for bacterial vaginosis treatment. Secnidazole at 2 g significantly improved clinical and microbiologic cure rates, showing…

Serum copper assessment in patients with polycystic ovary syndrome and tubal infertility

Apr 27, 2025
This 5-year study found significantly higher serum copper levels in women with PCOS, correlating with triglycerides and BMI but not IVF outcomes. Copper may reflect metabolic dysfunction and…

Serum Copper Level and Polycystic Ovarian Syndrome: A Meta-Analysis

Apr 27, 2025
This meta-analysis confirms that serum copper levels are significantly elevated in women with PCOS. Copper may drive hormonal imbalance and oxidative stress, and could influence gut microbiota,…

Serum micro- and macroelements levels in women with polycystic ovary syndrome associated with pelvic inflammatory disease

Apr 27, 2025
What was studied? This clinical study investigated the serum levels of essential macro- and microelements, specifically magnesium, copper, manganese, nickel, zinc, chromium, selenium, and vanadium,…

Serum trace elements and heavy metals in polycystic ovary syndrome

Apr 27, 2025
This study revealed elevated serum copper and zinc, and reduced manganese and lead, in women with PCOS, suggesting trace element dysregulation may fuel oxidative stress and hormonal imbalance. These…

Somatic stem cells and their dysfunction in endometriosis

Mar 18, 2025
What was studied?The study focused on the role of somatic stem cells (SSCs), including endometrial stem cells (EnSCs) and bone marrow-derived mesenchymal stem cells (MSCs), in the pathogenesis of…

Systems pharmacology to investigate the interaction of berberine and other drugs in treating polycystic ovary syndrome

Apr 27, 2025
This study explores the use of berberine in combination with other drugs for treating PCOS, highlighting its effects on insulin resistance, androgen excess, and metabolic dysfunction.

The association between anemia and postpartum depression: A systematic review and meta-analysis

Jun 14, 2025
What was reviewed? This study is a systematic review and meta-analysis that investigates the association between anemia (both postpartum anemia and anemia during pregnancy) and postpartum depression…

The bidirectional relationship between endometriosis and microbiome

Mar 18, 2025
This review highlights the bidirectional relationship between endometriosis and the microbiome, showcasing dysbiosis as a key factor in inflammation and estrogen metabolism. Emerging…

The Comorbidity of Endometriosis and Systemic Lupus Erythematosus: A Systematic Review

Mar 18, 2025
This review explores the significant comorbidity between systemic lupus erythematosus (SLE) and endometriosis, emphasizing shared pathological pathways.

The Comparative Effects of Myo-Inositol and Metformin Therapy on the Clinical and Biochemical Parameters of Women of Normal Weight Suffering from Polycystic Ovary Syndrome

Apr 27, 2025
This study compared the effects of myo-inositol and metformin on insulin resistance, menstrual cycle regularity, and hyperandrogenism in women with PCOS. Both therapies were effective, with fewer…

The copper chelator ammonium tetrathiomolybdate inhibits the progression of experimental endometriosis in TNFR1-deficient mice

Mar 18, 2025
Ammonium tetrathiomolybdate (TM) inhibits endometriosis progression in TNFR1-deficient mice by reducing copper and estradiol levels, lesion growth, angiogenesis, and oxidative stress.

The effect of resistant dextrin as a prebiotic on metabolic parameters and androgen level in women with polycystic ovarian syndrome

Apr 27, 2025
This study demonstrates that resistant dextrin supplementation can improve metabolic and endocrine parameters in women with PCOS, offering a promising alternative to traditional therapies.

The effects of a low-carbohydrate, ketogenic diet on the polycystic ovary syndrome

Apr 27, 2025
A 24-week ketogenic diet significantly reduced insulin resistance, free testosterone, and LH/FSH ratio in women with PCOS, improving fertility markers. The dietary intervention may influence gut…

The effects of probiotics, prebiotics, and synbiotics on polycystic ovarian syndrome

Apr 27, 2025
What was reviewed? This overview synthesized evidence from eight systematic reviews and meta-analyses investigating the effects of probiotics, prebiotics, and synbiotics on the management of…

The effects of synbiotic supplementation on hormonal status, biomarkers of inflammation and oxidative stress in subjects with polycystic ovary syndrome

Apr 27, 2025
This randomized trial evaluates the effects of synbiotic supplementation on hormonal, inflammatory, and metabolic parameters in women with PCOS. It shows significant improvements in androgen levels,…

The Endobiota Study: Comparison of Vaginal, Cervical and Gut Microbiota Between Women with Stage 3/4 Endometriosis and Healthy Controls

May 19, 2025
This study reveals distinct microbiome shifts in the vaginal, cervical, and gut microbiota of women with stage 3/4 endometriosis. The absence of Atopobium and elevated Gardnerella in reproductive…

The Female Vaginal Microbiome in Health and Bacterial Vaginosis

Mar 18, 2025
This review in Frontiers in Cellular and Infection Microbiology examines the vaginal microbiome’s role in health and disease, particularly bacterial vaginosis (BV). It highlights the shift from…

The Gut Microbiome in Polycystic Ovary Syndrome and Its Association with Metabolic Traits

Apr 27, 2025
This study links the gut microbiome in PCOS to metabolic traits, identifying microbial shifts tied to insulin resistance and prediabetes. Specific taxa like Ruminococcaceae UCG-002 and Dorea…

The gut microbiota and endometriosis: From pathogenesis to diagnosis and treatment

Mar 18, 2025
What was reviewed? The study reviewed the relationship between the gut microbiota and endometriosis, focusing on how the gut microbiota may influence the pathogenesis, diagnosis, and potential…

The Human Microbiome during Bacterial Vaginosis

Apr 3, 2025
This review explores bacterial vaginosis, focusing on microbial imbalances, immune responses, and diagnostic challenges. It highlights the need for microbiome-based treatments and improved…

The Impact of Cultural Factors Upon Postpartum Depression: A Literature Review

Jun 13, 2025
This review examines how cultural factors influence postpartum depression, identifying both protective and harmful cultural practices. It emphasizes the need for culturally sensitive care and…

The impact of endometriosis on dietary choices and activities of everyday life: a cross-sectional study

Mar 18, 2025
This review highlights how gluten-free, Mediterranean, and anti-inflammatory diets improve pain perception in endometriosis by reducing inflammation and modulating the gut microbiome. Probiotics and…

The Implication of Mechanistic Approaches and the Role of the Microbiome in Polycystic Ovary Syndrome (PCOS)

Apr 27, 2025
This review connects gut and vaginal microbiome dysbiosis with PCOS-related inflammation, metabolic imbalance, and hormone disruption, highlighting bile acids and SCFAs as key mediators and…

The Influence of Lactoferrin in Plasma and Peritoneal Fluid on Iron Metabolism in Women with Endometriosis

May 24, 2025
This study demonstrates that peritoneal fluid-to-plasma ferritin and lactoferrin ratios distinguish endometriosis stage and severity. Iron overload and shifting iron-binding protein profiles reveal a…

The interplay between microbiota, metabolites, immunity during BV

Apr 3, 2025
This review explains how microbial shifts, metabolite production, and immune responses interact in bacterial vaginosis. It highlights the roles of Gardnerella, Atopobium, and other anaerobes in…

The magnitude of postpartum depression among mothers in Africa: a literaturereview

Jun 13, 2025
This review explores the prevalence of postpartum depression (PPD) among African mothers, highlighting significant variation across countries and the need for culturally validated diagnostic tools to…

The oral microbiome and breast cancer and non-malignant breast disease, and its relationship with the fecal microbiome in the Ghana Breast Health Study

Mar 18, 2025
The study linked reduced oral microbiome diversity and altered microbial profiles to breast cancer and non-malignant breast disease, highlighting strong correlations between oral and fecal…

The Possible Effects of Zinc Supplementation on Postpartum Depression and Anemia

Jun 14, 2025
Postpartum zinc supplementation shows promise in reducing postpartum depression risk and improving maternal zinc levels, though it may cause transient hematological changes when combined with iron.

The Rate and Risk Factors of Postpartum Depression in Vietnam From 2010 to 2020: A Literature Review

Jun 13, 2025
This review examines the prevalence and risk factors of postpartum depression in Vietnam, highlighting significant socio-economic, cultural, and personal contributors. It calls for early screening…

The right bug in the right place: opportunities for bacterial vaginosis treatment

Apr 3, 2025
This review explores the role of vaginal microbiota in bacterial vaginosis and highlights emerging microbiome-informed treatments. It emphasizes microbial signatures of BV, the limitations of…

The role of gut and genital microbiota and the estrobolome in endometriosis, infertility and chronic pelvic pain

Mar 18, 2025
This review highlights the gut and genital microbiome’s roles in estrogen-driven conditions like endometriosis, infertility, and CPP, emphasizing dysbiosis’ impact on inflammation and…

The role of gut microbiota in the pathogenesis and treatment of postpartum depression

Jun 13, 2025
This review highlights how gut microbiota disruptions contribute to postpartum depression via hormonal, inflammatory, and neurochemical pathways. It supports microbial modulation as a novel,…

The role of the vaginal microbiome in distinguishing female chronic pelvic pain caused by endometriosis/adenomyosis

May 17, 2025
This study examines the role of the vaginal microbiome in distinguishing chronic pelvic pain caused by endometriosis and adenomyosis. Findings highlight specific microbial signatures associated with…

The Vaginal Microbiome as a Tool to Predict rASRM Stage of Disease in Endometriosis: a Pilot Study

Mar 18, 2025
This study reveals Anaerococcus as a predictive marker for endometriosis severity and highlights Lactobacillus crispatus’s lactic acid-mediated modulatory role, offering promise for non-invasive…

The Vaginal Microbiome as a Tool to Predict rASRM Stage of Disease in Endometriosis: a Pilot Study

Mar 18, 2025
What was studied? The study focused on characterizing the gut and vaginal microbiome profiles of women with endometriosis compared to controls without the disease, exploring the potential of these…

The Vaginal Microbiome as a Tool to Predict rASRM Stage of Disease in Endometriosis: a Pilot Study

May 19, 2025
This study identifies the vaginal microbiome as a predictor of endometriosis severity, highlighting microbial shifts that correlate with rASRM staging. Anaerococcus emerged as a key biomarker for…

Tobacco consumption and premenstrual syndrome: A case-control study

May 14, 2025
This study highlights the significant link between tobacco consumption and the increased risk of premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD). Women who smoke are at higher…

Trace Elements and Endometriosis: Insights into Oxidative Stress and Novel Therapies

Mar 18, 2025
This review explores the role of trace elements and oxidative stress in endometriosis, highlighting their potential as therapeutic targets. It underscores the need for further research into the trace…

Transvaginal Photobiomodulation for the Treatment of Chronic Pelvic Pain: A Pilot Study

Mar 18, 2025
The study in question focused on the use of transvaginal photobiomodulation (TV-PBM) as a treatment for chronic pelvic pain (CPP) in women. Here are the details based on the key aspects of the study:…

Unveiling Resistance and Virulence Mechanisms under Darwinian Positive Selection for Novel Drug Discovery for Gardnerella vaginalis

Apr 3, 2025
The study analyzed the genetic evolution of Gardnerella vaginalis, focusing on its resistance and virulence under Darwinian positive selection. It identifies new drug targets and emphasizes the…

Usefulness of intermittent clomiphene citrate treatment for women with polycystic ovarian syndrome that is resistant to standard clomiphene citrate treatment

Apr 26, 2025
The study explored intermittent clomiphene citrate treatment (ICT) for women with PCOS who were resistant to standard CC treatment. ICT showed an 80.8% response rate, offering an effective and safer…

Vaginal microbiota: Potential targets for vulvovaginal candidiasis infection

Jun 6, 2025
This review discusses vaginal microbiota imbalance in vulvovaginal candidiasis and evaluates probiotics, postbiotics, synbiotics, and vaginal microbiota transplantation as novel treatments to improve…

Vitamin D and probiotic co-supplementation affects mental health, hormonal, inflammatory and oxidative stress parameters in women with polycystic ovary syndrome

Apr 27, 2025
What was studied? This randomized, double-blinded, placebo-controlled clinical trial investigated the effects of co-supplementation with vitamin D and probiotics on mental health, hormonal profiles,…

Vulvovaginal Candidiasis: A Current Understanding and Burning Questions.

Jun 6, 2025
This review clarifies mechanisms behind vulvovaginal candidiasis, emphasizing candidalysin-driven inflammation, microbiome complexity, and the potential of inflammasome-targeted therapies. It…

Vulvovaginal Candidosis: Current Concepts, Challenges and Perspectives

May 29, 2025
This review consolidates current knowledge on vulvovaginal candidosis, highlighting Candida albicans virulence factors, diagnostic challenges, and the need for precise clinical differentiation…

Women’s experiences of psychological treatment and psychosocial interventions for postpartum depression: a qualitative systematic review and meta-synthesis

Jun 13, 2025
This review explores women’s experiences with psychological treatments for postpartum depression, emphasizing the importance of personalized care, supportive relationships, and social support…

Zinc (2)