Divine Aleru, Microbiome Signatures Research Coordinator

This review explains how antibiotics disrupt gut microbiota, weaken colonization resistance, and increase infection and disease risk through metabolic and immune mechanisms.

This review explains how gut microbiota prevent bacterial enteric infections through metabolic competition, antimicrobial activity, barrier support, and ecosystem stability.

This review explains how antibiotic disruption of gut microbiota removes colonization resistance, enabling Clostridium difficile infection through metabolic, immune, and ecological mechanisms.

This paper reviewed the emerging role of commensal bacteria in protecting the host against respiratory pathogens, with a strong focus on immune-mediated and direct microbial mechanisms operating along the gut–lung axis. The authors synthesized experimental, translational, and limited human clinical evidence to explain how resident microbiota in the gut, oral cavity, nasal […]

This review explains how the microbiome trains and regulates the immune system, showing how disrupted immune–microbial balance contributes to inflammatory, autoimmune, metabolic, and cancer-related diseases.

This review explains how antimicrobial peptides protect against infection, regulate immunity, and interact with the microbiome, highlighting their promise and limits as clinical therapeutics.

This review explains how moisturizers and emollients restore skin barrier function, reduce inflammation, and limit microbial overgrowth in atopic dermatitis.

This review explains how mucosal immunity relies on constant interaction with the microbiome, showing how commensal microbes shape immune tolerance, barrier integrity, and protection against infection and inflammatory disease.

This review explains how the skin microbiome shapes barrier function, immune responses, and disease risk, highlighting key microbial associations that protect against infection and drive inflammatory skin disorders when disrupted.

This review explains how gut microbes prevent Clostridioides difficile infection through bile acid metabolism, short-chain fatty acids, nutrient competition, and direct antagonism, highlighting microbial functions that protect the gut after antibiotic disruption.

Prebiotics are non-digestible fibers that selectively promote the growth of beneficial gut bacteria, offering a range of health benefits from improved digestion and immune function to enhanced metabolic health. Prebiotics are an essential part of a healthy diet that supports both gut and overall well-being.

This review analyzes the effects of probiotics, prebiotics, and synbiotics on human health, focusing on their impact on the gut-brain axis and various health conditions.

A review exploring the relationship between fiber intake and mental health reveals promising results but highlights the need for further well-designed studies to establish conclusive therapeutic guidelines.

This review analyzes the role of fiber intake in managing depression and anxiety, focusing on prebiotic-rich foods. It finds moderate benefits, especially in anxiety reduction, but calls for further research to confirm these effects in clinical settings.

This study aimed to investigate the effects of inulin supplementation on cognitive flexibility, body composition, and gut microbiota in a mouse model fed a high-fat (HF) diet. Specifically, the study evaluated how inulin modulates cognitive performance and its potential impact on the gut microbiota composition. Who was studied? Male CD1 mice were […]

This paper updates the definitions of prebiotics and prebiotic effects, proposing changes that reflect scientific advancements in microbiome research and regulatory needs.

The study provides molecular mechanisms showing how prebiotics like inulin and scFOS directly regulate host immune signaling to modulate inflammation, independent of microbiota changes.

The research focused on short-chain fatty acids (SCFAs), particularly acetate, propionate, and butyrate, and their roles in gastrointestinal and metabolic health. The study examined how SCFAs are produced via microbial fermentation in the gastrointestinal tract and explored their absorption mechanisms, their beneficial effects on gut health, and their therapeutic applications in treating […]

This review explores butyrate’s role in colorectal cancer prevention, showing its potential to modulate epithelial cell behavior and reduce tumor formation. However, the need for optimized delivery methods and further research is emphasized to confirm its efficacy in human CRC prevention.

This paper reviews the potential effects of prebiotics, probiotics, and synbiotics in managing diabetes mellitus (DM), focusing on their ability to restore intestinal barrier function, modulate the immune response, and improve metabolic parameters. It synthesizes findings from various preclinical and clinical studies to assess the effectiveness of these dietary interventions in addressing […]

This review explores the effects of probiotics, prebiotics, and synbiotics on the gut-brain axis, suggesting their potential to enhance cognitive function, emotional regulation, and reduce neuroinflammation, offering promising therapeutic options for neurodegenerative and neuropsychiatric conditions.

This review explores how prebiotics and probiotics modulate the gut microbiome to enhance bone health, improve calcium absorption, and reduce bone loss, suggesting these could be valuable adjuncts to traditional treatments for bone diseases.

This review discusses how prebiotics, such as GOS and inulin, influence gut microbiota and improve depression symptoms through mechanisms like neurotransmitter synthesis and inflammation regulation. The findings are promising but call for more rigorous clinical trials.

This study evaluates the impact of prebiotics, probiotics, and synbiotics on mental health. It found that a high-prebiotic diet improved mood, anxiety, and stress, while probiotics and synbiotics showed minimal effects, highlighting the potential of dietary interventions in mental health management.