Divine Aleru, Microbiome Signatures Research Coordinator

This review discusses the potential of probiotics and prebiotics in modulating the gut-brain axis, focusing on their effects on mental disorders like depression and anxiety.

This review highlights the beneficial role of probiotics in managing metabolic diseases like obesity, type 2 diabetes, and hypertension. It explores how probiotics improve gut health, regulate metabolic processes, and reduce inflammation, offering a promising and sustainable approach to treating these conditions.

The review explores the role of prebiotics and probiotics in gut health, highlighting their impact on immunity, metabolic health, and disease prevention. It emphasizes the potential benefits of functional foods enriched with these components, offering a promising avenue for managing chronic health conditions.

This clinical trial demonstrates that prebiotic and probiotic supplementation, in addition to a weight-loss diet, can improve body composition, metabolic parameters, and psychological health in obese individuals, with notable improvements in insulin resistance and muscle strength.

This review explores recent advancements in prebiotic research, highlighting their impact on gut health, immune function, metabolism, and mental well-being. It discusses emerging prebiotics, the development of synbiotics, and innovations in delivery systems like microencapsulation, suggesting a promising future for personalized prebiotic-based therapies.

This review explores the health benefits of prebiotic dietary fibers, highlighting their ability to modulate gut microbiota, enhance immune function, and improve digestive health through fermentation. It examines the regulatory challenges and outlines the promising potential of various prebiotics like FOS, inulin, and GOS in clinical applications.

This review evaluates the therapeutic potential of probiotics, prebiotics, and postbiotics in managing gut-related diseases. It explores their mechanisms, effectiveness in clinical trials, and their future role in personalized medicine to improve gut health and treat conditions such as IBS, obesity, and neuropsychiatric disorders.

This review updates the definition of prebiotics, expanding their scope beyond the gut to include other body sites and highlighting their selective impact on microbiota to confer health benefits.

This review revisits the concept of prebiotics, defining the criteria for classification and highlighting the importance of gut microbiota composition in determining the prebiotic effect. It introduces the prebiotic index as a more accurate measure and underscores the need for further research to optimize prebiotics for health benefits.

Glutathione, the body’s most important intracellular antioxidant, plays a far-reaching role in the immune system that goes beyond simply neutralizing oxidative stress. As a crucial player in nutritional immunity, glutathione helps regulate nutrient competition between the host and pathogens, ensuring that pathogens are deprived of essential nutrients, like cysteine, that are critical for their survival. Through its involvement in redox signaling, cytokine production, and immune cell activation, glutathione contributes to immune resilience, particularly under nutrient-limited conditions.

This review explores the potential of glutathione supplementation in improving antibiotic efficacy and immune responses in HIV-M.tb co-infection, particularly in CNS cases.

This study examines how glutathione influences T cell function in HIV and tuberculosis co-infection. It reveals that restoring GSH levels enhances cytokine production and controls M. tb growth, suggesting therapeutic potential for GSH-based interventions in HIV-infected individuals.

This review examines the crucial role of glutathione in sepsis, emphasizing its function in managing oxidative stress, modulating immune responses, and preventing organ dysfunction. It suggests that glutathione-targeted therapies could offer new opportunities for improving patient outcomes in sepsis.

This review examines how glutathione (GSH) and other thiols regulate bacterial virulence and pathogenesis. It discusses their role in modulating virulence factors, biofilm formation, and host immune interactions, suggesting that targeting GSH pathways could be a novel approach for treating bacterial infections.

This review investigates the role of reactive oxygen species in endometriosis, linking oxidative stress to infertility and pain. It suggests antioxidants as potential therapeutic strategies for disease management.

This review highlights the critical role of metabolic reprogramming in rheumatoid arthritis, where immune cells’ altered metabolism contributes to chronic inflammation and tissue damage, suggesting new therapeutic targets.

This review explores the role of glutathione in chronic illness development, highlighting its function in oxidative stress defense and mitochondrial health. It discusses the potential for GSH augmentation using NAC to improve outcomes in conditions such as metabolic syndrome, cardiovascular disease, and neurodegenerative disorders.

This review highlights glutathione’s key role in protecting plants from metal-induced oxidative stress, focusing on its functions in metal chelation, antioxidative defense, and signaling. GSH’s involvement in metal homeostasis and its regulation of cellular responses to metal stress suggest potential strategies for enhancing plant resilience and improving phytoremediation.

This study examined the protective effect of glutathione (GSH) against oxidative stress-induced cytotoxicity in RAW 264.7 macrophage cells, with a focus on its role in mitigating DNA damage, apoptosis, and mitochondrial dysfunction caused by hydrogen peroxide (H2O2). The researchers investigated how glutathione activates the Nrf2/HO-1 signaling pathway to protect cells from oxidative […]

This study explores the role of glutathione in Streptococcus suis’s resistance to oxidative stress and its contribution to virulence. Deletion of the gshAB and gshT genes significantly impairs oxidative stress tolerance, growth, and virulence, suggesting glutathione as a potential target for therapeutic intervention.

This review explores the critical roles of amino acids in regulating immune cell metabolism and function, emphasizing their potential for modulating immune responses in cancer, infections, and autoimmune diseases. Targeting amino acid metabolism could offer new therapeutic opportunities, but more research is needed to understand these complex mechanisms.

This review analyzes methods for boosting glutathione (GSH) levels, including supplementation, Nrf2 activation, cysteine prodrugs like NACET, and dietary approaches. While promising, further clinical research is needed to confirm their efficacy for treating oxidative stress-related diseases.

This review connects immune-stressing mechanisms, like glucose limitation, oxygen deprivation, and ROS production, to pathogen control during infection. It highlights how the immune system exploits metabolic stress to restrict pathogen growth, offering insights into new therapeutic strategies targeting immune metabolism.

This study shows that glutathione preserves regulatory T cell function by limiting serine metabolism, preventing mTOR overactivation, and maintaining FoxP3 expression.