Divine Aleru, Microbiome Signatures Research Coordinator

This study explores how altering gastric pH with omeprazole and cimetidine affects cadmium absorption from the diet and its accumulation in murine tissues, showing limited impact on tissue cadmium levels despite changes in gastric pH.

This review explores the toxic effects of cadmium exposure on multiple organ systems and its link to various diseases, including cancer and kidney dysfunction. It also discusses treatment options, including chelation therapy and nanoparticle-based interventions.

This study explores how cadmium disrupts the immune function of macrophages by inhibiting the NF-κB signaling pathway, impairing the response to LPS, and potentially contributing to immune dysfunction in diseases like COPD.

Cadmium exposure inhibits macrophage immune function through suppression of the NF-κB pathway, impairing the response to LPS. This may contribute to immune dysfunction and increased susceptibility to infections, especially in COPD patients.

The study demonstrates how cadmium exposure enhances antibiotic resistance in Salmonella enterica serovar Typhi by altering bacterial growth, biofilm formation, and antibiotic susceptibility. The findings highlight the environmental impact of cadmium in promoting resistance.

This review highlights how heavy metals alter the gut microbiota and discusses the potential of probiotics to mitigate these effects. It also emphasizes the role of advanced biosensors in detecting heavy metals in urine, supporting real-time monitoring of detoxification processes.

The study investigates how cadmium exposure alters gut and blood microbiomes in rats, linking these changes to metabolic disruptions and systemic inflammation.

This study reveals how cadmium and arsenic exposure via the food chain disrupts oxidative enzyme activity in rats, leading to significant health risks, particularly in the liver and kidneys.

The study uncovers how cadmium disrupts transition metal homeostasis in Streptococcus pneumoniae, affecting manganese and zinc uptake and contributing to oxidative stress.

Fecal microbiota transplantation (FMT) has demonstrated high success in treating recurrent Clostridium difficile infection, with potential benefits for other gastrointestinal disorders, including IBD, obesity, and metabolic syndrome. FMT restores microbial diversity,

This review explores the role of chelation therapy in treating arsenic and mercury poisoning, focusing on the efficacy of BAL, DMPS, and DMSA in acute cases and the challenges posed by chronic exposure. It discusses therapeutic benefits, limitations, and the need for further research.

This review explores the protective effects of selenium against arsenic and cadmium toxicity, emphasizing its role in reducing oxidative stress, inflammation, and cellular damage. The findings suggest selenium supplementation may help mitigate the harmful effects of these metals on human health.

This study explores the effects of chronic arsenic exposure on the gut microbiota and bile acid metabolism in mice, revealing significant changes in microbial composition and bile acid homeostasis, which may contribute to metabolic dysfunction and related diseases.

The study explored the impact of arsenic exposure on red blood cell parameters in rural Bangladesh, identifying sex-specific effects and changes in MCV and MCH, which may contribute to anemia or macrocytosis.

The study explored the impact of arsenic exposure on the gut microbiome and host metabolism. The results demonstrated significant changes in microbial composition, which were linked to alterations in metabolic pathways, particularly nitrogen metabolism, shedding light on arsenic’s role in disease promotion.

This study explores the sex-specific effects of chronic arsenic exposure on stromal cells and signaling in the small intestine, highlighting how arsenic disrupts trophocytes and telocytes, which regulate stem cell functions.

The study assessed arsenic exposure in Shanyin County residents through saliva and urine samples. It confirmed that saliva is a potential biomarker for total arsenic exposure, although less effective for understanding arsenic metabolism.

This study focused on evaluating arsenic exposure through diet by assessing stool samples in populations from West Bengal, India. Given that arsenic exposure via drinking water is well-documented, the researchers aimed to explore whether stool could serve as a reliable biomarker for arsenic exposure through the food chain, particularly in areas where […]

The study examines biomarkers of inorganic arsenic exposure in humans, focusing on the metabolism and toxicological effects of arsenic. Key findings include the importance of urinary arsenic measurements and the impact of genetic differences in arsenic metabolism.

The study demonstrates how IL-10 gene knockout mice show significant changes in their gut microbiome and arsenic metabolism. These alterations contribute to higher levels of toxic arsenic metabolites, highlighting the role of host genetics in shaping exposure outcomes.

Arsenic exposure perturbs the gut microbiome in mice and rewires fecal, urinary, and plasma metabolites, including sharp shifts in indole and bile acid pathways, alongside loss of several Firmicutes families and a rise in a Clostridiales group, before any histologic injury appears.

At 100 ppb, arsenic reshaped mouse gut communities, lowered SCFA gene capacity, increased LPS and stress pathways, and enriched multidrug and conjugation genes while shifting taxa toward Akkermansia and Bifidobacterium and away from SCFA-producing Firmicutes.

In rural China, drinking water often exceeded standards, and hair arsenic was higher in exposed residents. Age, male sex, and wheat-based diet increased levels, making hair arsenic a useful long-term marker for clinical screening and for stratifying microbiome studies.

This study highlights the health effects of chronic arsenic exposure through drinking water, linking it to cancers, cardiovascular diseases, and diabetes. It emphasizes the need for monitoring arsenic levels and improving public health interventions.