Divine Aleru, Microbiome Signatures Research Coordinator

This study assessed acute and chronic arsenic exposure in an Ethiopian population, finding significant health risks associated with contaminated groundwater and cigarette smoking. Biomarkers like urine and nail arsenic levels were key in understanding exposure.

Long-term exposure to low-level arsenic in drinking water in Mt. Amiata, Italy, was linked to increased mortality and hospitalization risks, especially for cardiovascular diseases and cancer. Even low-level exposure below the regulatory limit showed significant health implications.

This study explores the link between long-term low-level arsenic exposure and diabetes incidence in Denmark. The results suggest a modest association, highlighting the potential health risks of low-level arsenic exposure and the need for further research in this area.

This study evaluates the relationship between arsenic exposure and antibiotic-resistant E. coli carriage in rural Bangladesh, revealing significant associations between arsenic contamination and increased resistance to antibiotics, particularly in children.

The study explores the relationship between arsenic exposure and the infant gut microbiome, revealing sex-specific associations and highlighting how formula-fed male infants are particularly affected. The findings emphasize the importance of early-life environmental exposures on microbiome health and immune development.

This review examines the use of probiotics in managing H. pylori infection, emphasizing their role in enhancing eradication rates, reducing side effects, and restoring gastric microbiota balance. The findings highlight the potential of probiotics as adjuncts to conventional antibiotic therapy.

The study examines how intestinal probiotics restore the intestinal barrier by regulating tight junctions, immune responses, and gut microbiota, offering insights into their therapeutic potential for gut-related diseases.

The study examines how arsenic exposure disrupts erythropoiesis by inhibiting GATA-1 function, leading to anemia. It highlights the role of zinc finger motifs in GATA-1 and provides insights into arsenic-induced hematological disorders.

This review explores the potential for arsenate to replace phosphate in biochemical reactions, examining enzyme promiscuity, arsenate esters’ instability, and the implications for arsenic-based life forms. It also highlights the potential applications in bioremediation and astrobiology.

This review examines arsenic toxicity, its pathways of exposure, and its harmful effects on human health, focusing on oxidative stress, genotoxicity, and epigenetic changes. It highlights the link between arsenic exposure and diseases like cancer, cardiovascular disorders, and neurotoxicity.

This study explores the impact of sulfate-reducing bacteria on arsenic migration and transformation in groundwater. It highlights how sulfate reduction enhances arsenic release and mobilization, providing insights into potential bioremediation strategies for arsenic-contaminated aquifers.

The study reveals that MTF1 mediates the induction of Metallothionein I by arsenic, highlighting the importance of cysteine residues in the activation of MTF1 and its role in arsenic resistance.

This study investigates how arsenic(III) binds to human metallothionein-3, revealing detailed binding kinetics and the role of MT3 in arsenic detoxification. These findings have implications for understanding arsenic poisoning and potential therapeutic strategies.

This review examines how arsenic binds to proteins, disrupting their function and contributing to toxicity and resistance mechanisms. It highlights key proteins like thioredoxin and pyruvate dehydrogenase and discusses implications for arsenic-related diseases and bioremediation strategies.

The study explores how ArsD, a metallochaperone, enhances ArsA’s ability to expel arsenic from cells, improving arsenic detoxification. This interaction increases arsenic resistance in E. coli, with potential applications in bioremediation and combating arsenic poisoning.

This study investigates the structural and biochemical role of ArsD, a metallochaperone in E. coli, in enhancing arsenic detoxification by transferring As(III) to the ArsA ATPase, providing new insights into arsenic resistance mechanisms in bacteria.

This study explored the complex regulatory roles of ArsR proteins in Agrobacterium tumefaciens 5A, showing they influence a broad range of cellular functions, including arsenic resistance, metabolism, and iron homeostasis.

This systematic review links probiotics and heavy metals to clinical outcomes, showing faster diarrhea recovery with zinc, fewer H. pylori therapy side effects, improved iron absorption with prebiotics, and early evidence of lower toxic metal burden in pregnancy.

This review outlines the diversity, evolution, and distribution of arsenic resistance genes in prokaryotes, emphasizing their central role in the environmental microbiome, biogeochemical cycling, and potential clinical implications through gene transfer and resistance in pathogens.

This study demonstrates that both a functional host As3mt enzyme and a stable, diverse gut microbiome—especially the presence of Faecalibacterium prausnitzii—are required for full protection against acute arsenic toxicity in mice, highlighting the microbiome as a target for arsenicosis prevention and treatment.

The human gut microbiome and arsenic toxicity are tightly linked: microbes change arsenic speciation and dose, while arsenic reshapes gut ecology, altering risk. Clinicians should integrate microbiome status, nutrition, antibiotics history, and speciation into assessment and management.

In Nepal, arsenic disturbs the gut microbiome, driving sulfate-reducers and depleting commensals; urine arsenic best explains dysbiosis patterns with clear taxa-level signals useful for exposure-aware clinical care.

This study shows that probiotics can mitigate the effects of heavy metal toxicity in farmed fish. By binding metals and reducing oxidative stress, probiotics improve fish health and safety for consumption, offering a sustainable solution for the aquaculture industry.

Lactobacillus plantarum CCFM8246 shows protective effects against copper toxicity in mice by promoting copper excretion, alleviating oxidative stress, and improving liver function and cognitive performance. This suggests its potential for use in therapeutic applications for copper toxicity.