Divine Aleru, Microbiome Signatures Research Coordinator

Intermittent fasting improves weight, insulin sensitivity, and cardiovascular health in postmenopausal women, offering a promising non-pharmacological strategy for managing metabolic disorders.

Dietary intake of (poly)phenol-rich foods modestly improves cardiometabolic risk factors and reduces oxidative stress in postmenopausal women, with gut microbiome variability influencing outcomes.

Ketogenic diets effectively improve metabolic, hormonal, and inflammatory profiles in female endocrine disorders, aiding PCOS, menopause, and hormone-related cancers by promoting weight loss and reducing insulin resistance.

A plant-based diet with soy reduces hot flashes in postmenopausal women, potentially by modulating gut bacteria linked to inflammation and estrogen metabolism.

Menopause disrupts multiple microbiomes, elevating risks for infections, metabolic and cardiovascular diseases, and osteoporosis. Targeted interventions including probiotics, diet, and hormone therapy improve health outcomes.

Menopause alters gut microbiota composition and estrogen metabolism, contributing to symptoms and disease risks. Prebiotic and probiotic interventions show promise for symptom relief and metabolic health improvement.

Mind-body therapies like hypnosis effectively reduce menopausal hot flashes; natural products and whole-system CAM approaches show mixed evidence. More high-quality research is needed.

Estrogen therapy remains the most effective treatment for menopausal symptoms, with transdermal delivery preferred for safety. Non-hormonal options offer moderate relief; emerging therapies like SERMs and androgens show promise but require cautious use.

This review finds insufficient evidence that black cohosh effectively reduces menopausal symptoms. Hormone therapy outperforms black cohosh, which appears safe but needs further study for efficacy and impact on quality of life.

Combining Rhodiola rosea and Actaea racemosa extracts significantly improves menopausal symptoms and quality of life, outperforming black cohosh alone with good safety.

Rhodiola rosea shows promise as a natural selective estrogen receptor modulator, offering neuroprotective, cardiovascular, and bone health benefits for menopausal women with fewer risks than conventional therapies.

This review details the estrogenic activity, neuroprotective effects, and clinical relevance of medicinal plants for menopausal women, highlighting their potential to prevent cognitive decline and neurodegeneration via microbiome-associated mechanisms.

The study examined the metabolic changes that occur during menopause, focusing on how menopause modulates circulating metabolites in midlife women. Researchers specifically analyzed 94 charged metabolites, including amino acids, fatty acids, and other small molecules, to assess how these metabolic changes correlate with the increased risk of chronic diseases, such as cardiovascular […]

This review synthesizes evidence on menopause-related lipid metabolic disorders, emphasizing estrogen deficiency, dietary interventions, and the role of probiotics and microbiome modulation in improving metabolic health among postmenopausal women.

Menopause is linked to significant metabolic shifts, including a proatherogenic lipid profile and altered amino acid levels, which may increase cardiovascular and metabolic disease risks in women. The study highlights the importance of monitoring metabolic health during menopause.

This study reveals significant metabolic changes in postmenopausal women, including a pro-atherogenic lipid profile and increased amino acids linked to cardiovascular and metabolic risk, emphasizing menopause as a key factor in long-term health risks.

This study links urinary heavy metal exposure (arsenic, cadmium, mercury, lead) to altered sex hormone levels in midlife women, with stronger effects during the perimenopausal transition. It suggests that metal exposure may accelerate ovarian aging and impact long-term health outcomes.

This review details how environmental metal exposures influence menopause onset, symptoms, and COVID-19 outcomes, emphasizing the potential for trace mineral supplementation and the need for monitoring heavy metal and micronutrient status in menopausal women.

The study links higher urinary arsenic and lead concentrations to earlier menopause, suggesting that exposure to these metals accelerates ovarian aging. Women with higher environmental risk scores (ERS) experienced menopause earlier, emphasizing the role of metal mixtures in reproductive health.

This review outlines the evaluation and management of osteoporosis in premenopausal women, emphasizing secondary causes, appropriate BMD interpretation, and tailored treatment—highlighting the importance of individualized care and cautious pharmacotherapy in this population.

This review challenges the labeling of hot flashes as mere menopausal symptoms, proposing they signal underlying neurovascular dysregulation linked to chronic disease risk, and calls for new clinical and research approaches.

This study demonstrates significant alterations in gut bacteria, fungi, and metabolites in postmenopausal women with osteoporosis, revealing microbial and metabolic signatures closely linked to bone mineral density and providing a basis for early diagnosis and targeted interventions.

This review elucidates the neuroendocrine and thermoregulatory mechanisms of menopausal hot flashes, evaluating objective measurement and treatment strategies, with a focus on central sympathetic activation and the limited role of the microbiome or estrogen alone in HF etiology.

This study identifies distinct gut microbiome and functional gene signatures associated with osteoporosis and osteopenia in postmenopausal women, highlighting key microbial taxa and metabolic pathways that may influence bone health and serve as potential targets for clinical intervention.