Divine Aleru, Microbiome Signatures Research Coordinator

This review discusses inflammatory markers and therapeutic options in primary dysmenorrhea, focusing on prostaglandins, cytokines, and vasopressin, and evaluates treatments like NSAIDs, acupuncture, and physiotherapy.

This metabolomics study identifies ten urinary biomarkers linked to primary dysmenorrhea, providing insights into the metabolic disruptions that contribute to PD and suggesting potential new therapeutic targets.

This study links dysmenorrhea symptom phenotypes with distinct vaginal microbiome compositions, suggesting that microbiome imbalances contribute to more severe menstrual pain, which could be targeted in new treatments.

This study explores how graphene-based warm uterus acupoint paste (GWUAP) treats primary dysmenorrhea by regulating intestinal microbiota and metabolites, highlighting its potential as a non-drug alternative therapy.

This systematic review highlights the significant association between primary dysmenorrhea and depression, emphasizing the need for integrated care that addresses both physical and mental health in affected women.

A bibliometric analysis of dysmenorrhea research from 1992 to 2022 reveals increasing global interest in its pathogenesis, treatment, and functional connectivity. It emphasizes the role of prostaglandins, nonsteroidal anti-inflammatory drugs, and traditional Chinese medicine in managing the condition.

Primary dysmenorrhea is a common and impactful condition affecting young women. This review explores its pathophysiology, symptoms, and treatment options to improve diagnosis and management in clinical practice.

Primary dysmenorrhea is a common, underdiagnosed condition that causes significant pain and affects women’s daily lives. The study highlights its pathophysiology, diagnostic approach, treatment options, and the need for greater awareness and research into its management.

This study examined the interaction between the vaginal microbiota and mycobiota in patients with vulvovaginal candidiasis (VVC). The research focused on understanding the role of different Candida species, specifically Candida albicans and Candida glabrata, in the pathology of VVC, and how they influence the vaginal bacteriome. The study aimed to identify the […]

This study investigates the link between gut microbiota and postpartum depressive disorder (PPD), identifying specific microbiota changes that correlate with depressive symptoms and hormonal levels. These findings could provide biomarkers for diagnosing and treating PPD.

This study explores the differences in microbiomes across breast tissue, oral, and urinary sites in women with and without breast cancer. Key findings suggest distinct microbiomic patterns in cancerous tissue and the urinary microbiome, providing new insights into the role of microbiota in cancer development.

This study examined the impact of estrogen on oral health and microbiome composition in COVID-19 patients, showing that postmenopausal women and men experience poorer oral health, which correlates with elevated proinflammatory cytokines and lower ACE2 expression, potentially influencing COVID-19 outcomes.

This study explores the impact of vaginal microbiota on IVF outcomes in women with infertility. It highlights how specific bacteria like Lactobacillus iners and Pseudomonas spp. can predict IVF success or failure, offering potential insights for personalized ART treatments.

This pilot study links gut microbiome diversity with breast cancer risk factors and tumor characteristics, particularly in HER2+ tumors and those with early menarche. It suggests microbial alterations in these groups that may influence cancer development and risk.

This study explores the vaginal microbiome and metabolome in women with common genital infections, revealing key microbial shifts and metabolic markers associated with infections like VVC, CT, and BV, highlighting potential diagnostic tools and therapeutic targets.

This study suggests that birth mode may influence the vaginal microbiota, with C-section delivery potentially linked to a less protective microbiome and higher odds of Molecular-BV in adulthood.

This study examined how bacterial vaginosis and HR-HPV infection influence vaginal microbiota diversity and cervical dysplasia in Chinese women, identifying Lactobacillus iners as a key microbial player in HPV-related CIN progression.

This study characterized the fungal communities in the female genital tract of young South African women and identified how fungal composition relates to bacterial vaginosis and other clinical factors.

A longitudinal study in predominantly Black and Hispanic young women found that a molecular BV subtype (CST-IV-A) and a network of specific bacteria increase risk for Chlamydia trachomatis infection and reinfection, underscoring the clinical importance of cervicovaginal microbiome signatures.

Menopausal hot flashes are one of the most common and disruptive symptoms that women experience during the transition to menopause. Characterized by sudden sensations of heat, sweating, and flushing, hot flashes can significantly affect a woman’s quality of life, causing sleep disturbances, mood swings, and even long-term health consequences. Understanding the complex mechanisms behind hot flashes, as well as the role of microbiome-targeted therapies, offers new avenues for improving menopausal health.

This systematic review and meta-analysis found that Salvia officinalis significantly reduces the frequency of hot flashes in postmenopausal women, making it a promising non-hormonal alternative.

This meta-analysis reveals that SSRIs are effective in reducing hot flashes in menopausal women, with escitalopram showing the highest efficacy. These results support SSRIs as a non-hormonal alternative to hormone therapy.

This study demonstrates that MLE4901, an NK3R antagonist, significantly reduces hot flash frequency, severity, and interference in menopausal women, offering a non-hormonal treatment alternative.

The study assessed the effectiveness of the Evia app, a smartphone-based hypnotherapy intervention, in reducing hot flash frequency and severity in menopausal women.