Divine Aleru, Microbiome Signatures Research Coordinator

This review shows that glutathione depletion drives immune dysfunction in HIV by disrupting T-cell balance, gut immunity, and pathogen control, while supplementation restores immune signaling and reduces inflammation.

This review shows that glutathione restores immune balance, limits oxidative stress, and improves host defense against Mycobacterium tuberculosis infection.

This review links oxidative stress, ferroptosis, immune activation, pain, and emerging gut microbiome changes to endometriosis progression and severity.

This study shows that glutathione depletion in hepatic tuberculosis increases oxidative stress, disrupts immune signaling, damages granulomas, and promotes Mycobacterium tuberculosis survival.

This review explains how glutathione deficiency worsens immune dysfunction, oxidative stress, and inflammation during severe COVID-19 and highlights its role in disease severity.

This study shows that glutathione enhances M1-like macrophage activation while controlling oxidative stress through Nrf2-HO-1 signaling, supporting balanced immune defense.

This review explains how macrophage activation, metabolism, and signaling control immune responses in infection, inflammation, and cancer.

This review explains how neutrophils generate reactive oxygen species through NADPH oxidase and how bacteria resist oxidative killing, with clinical relevance for infection susceptibility and inflammation.

This review explains how reactive oxygen species regulate innate immune signaling through controlled protein oxidation, shaping macrophage and neutrophil function in inflammation and disease.

This original research studied how endogenous glutathione (GSH) shapes innate immune signaling in macrophages beyond its antioxidant role. The authors tested whether severe intracellular GSH depletion changes inflammatory gene expression or instead redirects signaling toward antiviral pathways. They focused on toll-like receptor 4 activation using lipopolysaccharide and examined transcriptional responses, redox status, […]

This review explains natural-compounds-glutathione control by polyphenols, terpenoids, and glucosinolates. It shows how these compounds can raise or deplete GSH, shift NRF2-ARE signaling, change GSH enzymes, and alter cancer stress responses in a dose- and context-dependent way.

This review covered glutathione homeostasis by explaining how it protects cells from reactive oxygen species, reactive nitrogen species, and electrophiles, and by mapping the main control points that set GSH levels in tissues. The author described GSH structure as a tripeptide with a reactive cysteine thiol and an unusual γ-glutamyl bond that […]

This review explains glutathione synthesis regulation through cysteine supply, GCL/GS control, and transcriptional networks that include Nrf2, AP-1, and NFκB. It links disease states such as cholestasis, endotoxemia, fibrosis, diabetes, and alcoholism to reduced enzyme expression and depleted GSH.

This review explains glutathione-related enzymes inflammation by detailing how glutathione-dependent enzymes regulate redox balance, detoxification, and inflammatory signaling across tissues exposed to oxidative stress.

This review explains how glutathione-and-microbiome-inflammation fits into redox control, immune sensing, and chronic inflammation. It links GSH depletion with lung disease, atherosclerosis, and severe COVID-19 through ROS, cytokines, NF-κB, and Nrf2 pathways.

Crohn’s disease is a chronic inflammatory condition of the gastrointestinal tract that can cause a wide range of symptoms, including abdominal pain, diarrhea, and fatigue. The exact cause of the disease remains unclear, but it is believed to result from a combination of genetic predisposition and environmental factors. Although there is no cure, ongoing advancements in medical research continue to improve management strategies and quality of life for those affected by Crohn’s disease.

This study demonstrates the promising role of hyperbaric oxygen therapy (HBOT) as an adjunct treatment for perianal fistulas in Crohn’s disease. It shows substantial improvements in fistula healing, disease activity, and inflammatory markers, with sustained effects over 9 months post-treatment.

This review explores the potential role of Mycobacterium avium subspecies paratuberculosis (MAP) in Crohn’s disease and examines the benefits of anti-MAP therapy (AMT) in treating refractory disease. It discusses recent findings, clinical trial outcomes, and the promising use of novel drug formulations targeting MAP.

This review explores phage therapy as a promising treatment for liver diseases linked to gut microbiota imbalances. It highlights key findings on how phages target harmful bacteria, restoring microbiome balance and improving liver function.

This review examines the impact of dietary zinc on gut microbiota and its role in Clostridium difficile infection. Excess zinc is shown to alter microbiota composition and increase disease severity, underscoring the importance of regulating zinc intake in high-risk populations.

The review explores the role of gut microbiota in immune regulation and pathogen resistance, particularly in inflammatory diseases like IBD. It highlights the effects of microbiota dysbiosis and the potential for therapeutic interventions to manage gut inflammation.

This review examines the impact of iron therapy on oxidative stress and the intestinal microbiota in IBD, highlighting the complexities of managing iron deficiency in these patients. It emphasizes the need for careful iron therapy management to avoid exacerbating oxidative stress and microbial imbalance.

This study examines the genome sequences of copper-resistant Enterococcus faecalis strains isolated from copper-fed pigs. It identifies key resistance genes, highlighting the potential for co-transfer of copper and antibiotic resistance, with implications for agricultural practices and pathogen control.

Copper’s dual role as both an antimicrobial and essential micronutrient plays a significant part in the host-pathogen interaction, with pathogens evolving resistance mechanisms while hosts leverage copper to combat infections. This study offers insights into how copper impacts infection biology, potentially informing new therapeutic strategies.