Divine Aleru, Microbiome Signatures Research Coordinator

This review discusses the rising antimicrobial resistance in Listeria species, focusing on their resistance mechanisms to antibiotics, biocides, and heavy metals, and their implications for food safety and public health.

This study explores the persistence of Listeria monocytogenes biofilms in food industries, stressing the need for stronger hygiene protocols to prevent contamination. It highlights genetic factors that contribute to biofilm formation and resistance.

The review examines the persistence of Listeria monocytogenes biofilms in the food industry and evaluates current cleaning methods, offering insights into innovative control strategies.

This study examines pregnancy-associated listeriosis in England and Wales, exploring factors influencing pregnancy outcomes and infant survival, with a focus on maternal symptoms and timing of infection.

The paper reviews Listeria monocytogenes, its global prevalence, risk factors, and clinical management of listeriosis, with a focus on vulnerable populations.

Manganese plays a pivotal role in microbial pathogenesis. As a vital cofactor for enzymes involved in antioxidant defense and metabolism, manganese is essential for pathogens, enabling them to survive within the host. However, when not properly managed, manganese can become toxic to both the host and the pathogen. The host’s immune system, through mechanisms like the secretion of calprotectin, tries to limit microbial access to manganese, creating an ongoing battle between host defenses and microbial survival .

This study examines the relationship between the metal content of human milk and the infant gut microbiota, highlighting metal-induced microbial shifts and their potential impact on infant health and development.

This study investigates the buffer capacity and systems of human whole saliva, revealing the key role of bicarbonate, saliva flow rate, and pH in maintaining oral health. It provides insights into the implications for dental health and saliva analysis.

This study addresses diagnostic challenges for manganese imbalances, providing algorithms for identifying hypermanganesemia and hypomanganesemia, and offering solutions to improve clinical diagnosis, including sample handling and reference range standardization.

This study optimizes electrothermal atomic absorption spectrometry (ETAAS) for detecting manganese in urine and blood samples, demonstrating high sensitivity and precision, and providing insights into the use of chemical modifiers for improved analysis.

This study explores how heavy metals in an ecological restoration area of a manganese mining site promote the diffusion of high-risk antibiotic resistance genes and pathogens through a transmission chain involving mulberry leaves, silkworms, and soil, raising concerns for public health and environmental safety.

This review explores how environmental bacteria acquire co-resistance to heavy metals and antibiotics, revealing complex genetic interactions and co-selection mechanisms.

This study links placental manganese levels, maternal gut microbiota, and preeclampsia risk, highlighting specific bacterial genera and metabolic pathways involved. It suggests that manganese may help mitigate preeclampsia, offering new insights for therapeutic strategies targeting the gut microbiome.

This study shows that manganese exposure triggers neuroinflammation in rats through the NLRP3 inflammasome, but fecal microbiota transplantation can alleviate these effects, suggesting microbiome-based therapies for neurotoxic and neurodegenerative diseases.

This study shows that fecal microbiome transplantation (FMT) can attenuate manganese-induced neurotoxicity by regulating the apelin signaling pathway and autophagy in the brain, offering new therapeutic insights into managing metal-induced neurodegenerative diseases.

This study shows how manganese exposure alters the gut microbiome and metabolic functions in a sex-specific manner in C57BL/6 mice. It highlights changes in neurotransmitter pathways and microbial composition that could impact brain health and suggests the need for sex-specific approaches to understanding metal toxicity.

This study identifies the MntABC manganese transporter as crucial for S. aureus survival after phagocytosis. It helps bacteria recover from oxidative stress by facilitating DNA repair through the NrdEF complex, offering new therapeutic targets to disrupt metal acquisition and combat bacterial infections.

This study reveals how the human immune protein calprotectin (CP) sequesters zinc, facilitating manganese binding to bacterial solute-binding proteins. This interaction prevents zinc toxicity and supports bacterial virulence, offering new insights into metal ion competition between host and pathogen.

This review examines how iron, copper, zinc, and manganese affect gut microbiota composition and function, highlighting their regulatory role in health and disease. It discusses both the effects of metal deficiencies and supplementation on microbial balance and associated health outcomes.

This study maps the metallophore synthesis and uptake potential across the Staphylococcus genus, revealing species-specific production and utilization of metallophores. These findings provide insights into microbial cooperation, competition, and potential therapeutic targets for infections caused by S. aureus and other staphylococcal species.

This study reveals how S. aureus uses staphylopine (StP) to acquire transition metals, with CntA playing a central role in metal recognition and transport. The findings highlight new potential therapeutic targets to disrupt metal acquisition and reduce bacterial virulence.

This study reveals that the ArlRS two-component system in S. aureus enables resistance to host-imposed manganese starvation by modulating metabolism, particularly by promoting amino acid utilization. These findings provide insights into how bacterial metabolic flexibility aids in overcoming nutritional immunity and suggest potential therapeutic targets.

This study reveals that S. aureus uses the Cnt-StP system to acquire zinc during infection, enabling it to compete with the host’s immune defenses. This zinc acquisition pathway is critical for pathogen survival and virulence, offering new targets for antimicrobial therapy.

This review summarizes bacterial Mn sensing and homeostasis mechanisms, highlighting key regulators like MntR and the yybP-ykoY riboswitch. It discusses newly identified Mn exporters and their roles in protecting against Mn toxicity, with implications for antimicrobial strategies targeting bacterial metal regulation.