Divine Aleru, Microbiome Signatures Research Coordinator

This study reveals significant dysbiosis of gut microbiota in women with PCOS, particularly in obese individuals. The altered microbial composition correlates with metabolic and hormonal imbalances, offering potential therapeutic targets for improving PCOS-related conditions.

The study explores how alterations in gut bacteria, fungi, and serum metabolites are linked to polycystic ovary syndrome (PCOS), revealing potential diagnostic markers and the role of hyperandrogenemia in disease development.

This study reveals that low fiber and magnesium intake—not overeating or inactivity—contribute significantly to insulin resistance and hyperandrogenism in PCOS, with strong implications for microbiome-linked interventions.

A 24-week ketogenic diet significantly reduced insulin resistance, free testosterone, and LH/FSH ratio in women with PCOS, improving fertility markers. The dietary intervention may influence gut microbiota, enhancing metabolic and hormonal outcomes.

This study revealed elevated serum copper and zinc, and reduced manganese and lead, in women with PCOS, suggesting trace element dysregulation may fuel oxidative stress and hormonal imbalance. These imbalances may also impact gut microbiota and insulin resistance.

What was reviewed? This overview synthesized evidence from eight systematic reviews and meta-analyses investigating the effects of probiotics, prebiotics, and synbiotics on the management of polycystic ovarian syndrome (PCOS). The reviews collectively evaluated randomized controlled trials (RCTs) focusing on metabolic, hormonal, and inflammatory markers to clarify how microbiota-modulating interventions influence PCOS-related outcomes. The analysis spanned […]

A Mediterranean/low-carb diet significantly improved insulin resistance, androgen levels, and weight in overweight PCOS patients. The findings suggest microbiome-mediated metabolic benefits and support clinical adoption of this dietary model over traditional low-fat diets.

A ketogenic diet restored menstrual cycles and improved pregnancy rates in obese women with PCOS, even without metformin or ovulation induction. Findings suggest KD enhances fertility through metabolic and microbiome-linked pathways beyond weight loss.

Women with PCOS had lower Mediterranean diet adherence and worse metabolic, inflammatory, and hormonal profiles. Poor MD adherence correlated with higher testosterone, CRP, and HOMA-IR, suggesting a microbiome-linked dietary influence on PCOS severity.

What was studied? This randomized, double-blinded, placebo-controlled clinical trial investigated the effects of co-supplementation with vitamin D and probiotics on mental health, hormonal profiles, inflammatory markers, and oxidative stress in women with polycystic ovary syndrome (PCOS). The study tested whether the combination of these two interventions could provide synergistic benefits in a population known to […]

This review highlights how probiotic and synbiotic supplementation improves insulin resistance, inflammation, and androgen levels in obese adolescents with PCOS. Microbiome modulation offers a promising non-pharmacological therapy.

This meta-analysis confirms that women with PCOS consume significantly less dietary fiber than controls, independent of calorie intake. Reduced fiber may worsen PCOS via gut dysbiosis and diminished SCFA production.

A high-fiber diet combined with acarbose improved hormonal, metabolic, and inflammatory markers in women with PCOS by remodeling the gut microbiota. Key microbial shifts included increases in Bifidobacterium and reductions in Bacteroides vulgatus, correlating with decreased insulin resistance and hyperandrogenism.

This study identifies a strong link between gut microbiota dysbiosis and altered serum metabolites in PCOS patients. Specific microbial shifts, including elevated Escherichia-Shigella and reduced Roseburia, correlate with lipid and energy metabolism markers, offering insights into PCOS-related insulin resistance and mood disturbances.

This study links elevated conjugated primary bile acids to hyperandrogenism in PCOS, suggesting bile acid metabolism plays a direct role in endocrine dysfunction and opens new therapeutic perspectives for managing PCOS.

This study links the gut microbiome in PCOS to metabolic traits, identifying microbial shifts tied to insulin resistance and prediabetes. Specific taxa like Ruminococcaceae UCG-002 and Dorea correlate with hormonal and glucose metabolism markers, highlighting the gut microbiome’s role in PCOS-related metabolic health.

This study identified significant bile acid profile changes in PCOS patients and highlighted CDCA and LCA as promising biomarkers, especially when combined with testosterone. The results suggest a bile acid–androgen–microbiome axis in PCOS pathophysiology.

This study reveals elevated primary and conjugated bile acids in follicular fluid of PCOS patients, suggesting a novel ovarian micro-environmental role in ovulation dysfunction and potential links to gut microbiota.

This 5-year study found significantly higher serum copper levels in women with PCOS, correlating with triglycerides and BMI but not IVF outcomes. Copper may reflect metabolic dysfunction and gut-related oxidative stress in PCOS.

This review connects gut and vaginal microbiome dysbiosis with PCOS-related inflammation, metabolic imbalance, and hormone disruption, highlighting bile acids and SCFAs as key mediators and therapeutic targets.

What was studied? This clinical study investigated the serum levels of essential macro- and microelements, specifically magnesium, copper, manganese, nickel, zinc, chromium, selenium, and vanadium, in women diagnosed with polycystic ovary syndrome (PCOS), both with and without concurrent pelvic inflammatory disease (PID). The primary goal was to determine whether the concentrations of these elements differed […]

This study identified elevated erythrocyte nickel in obese women with PCOS and revealed trace element–hormone correlations linked to reproductive dysfunction. These findings point to micronutrient-driven endocrine disruption and potential gut microbiota imbalances in PCOS.

This meta-analysis confirms that serum copper levels are significantly elevated in women with PCOS. Copper may drive hormonal imbalance and oxidative stress, and could influence gut microbiota, highlighting its potential as a biomarker and therapeutic target in PCOS management.

This study found that women with PCOS had elevated cadmium, antimony, lead, and mercury levels, alongside reduced zinc and copper. These imbalances correlated with insulin resistance, oxidative stress, and inflammation, suggesting that metal exposure contributes to PCOS pathogenesis and potentially alters the gut microbiome.