Divine Aleru, Microbiome Signatures Research Coordinator

This review summarizes the essential role of balanced reproductive microbiota, particularly Lactobacillus dominance, in fertility and IVF success, linking microbial dysbiosis to infertility and poorer pregnancy outcomes, and highlighting microbiome evaluation as key to improving reproductive health management.

This study shows chronic endometritis significantly increases pregnancy complications in women with endometriosis-associated infertility. Placenta previa, gestational hypertension, and cesarean sections were notably higher, emphasizing the importance of diagnosing and managing CE effectively for improved reproductive outcomes.

This study demonstrates a causal link between specific gut microbiota and infertility risks, identifying protective and harmful bacterial taxa in both men and women. It highlights the microbiome’s potential role in fertility management through targeted probiotics and lifestyle interventions.

The study confirmed causal links between specific gut microbiota and female reproductive tract inflammation and infertility. Notably, Lachnospiraceae and Ruminococcus increased inflammation risks, while Butyricicoccus provided protection. Faecalibacterium heightened infertility risk, suggesting new targets for microbiome-based diagnostics and interventions.

Vaginal microbiota transplantation (VMT) successfully treats bacterial vaginosis by restoring Lactobacillus dominance, lowering vaginal pH, and inhibiting pathogens through nutritional competition, antimicrobial production, and enhanced epithelial adhesion, promising broad clinical applications for reproductive health.

Bacteriophage therapy presents a promising alternative to antibiotics for bacterial sexually transmitted infections, particularly against antibiotic-resistant strains like N. gonorrhoeae, through targeted bacterial destruction and minimal off-target effects, though significant clinical research and optimization remain essential for widespread application.

Metformin emerges as a promising non-hormonal therapy for endometriosis, showing potent anti-inflammatory, anti-angiogenic, and fertility-enhancing effects, with significant symptom relief in limited clinical testing.

Metformin shows potential in treating endometriosis through anti-inflammatory, anti-angiogenic, anti-proliferative effects, and modulation of the gut microbiome. It could be a safe, effective alternative or adjunctive therapy, particularly in patients contraindicated for hormonal therapies or seeking fertility.

The study found a potent inhibitory effect against Chlamydia trachomatis infection using Lactobacillus brevis combined with lactoferrin, notably reducing bacterial adhesion, invasion, and inflammation. This indicates significant therapeutic potential in preventing chronic complications from genital infections.

This review explores the impact of microbiome imbalances on infertility, with insights into microbial diagnostics and potential treatments to improve fertility outcomes.

This review investigates the potential of Complementary and Alternative Medicine (CAM) in managing Pelvic Inflammatory Disease (PID). Therapies like Chinese Herbal Medicine and acupuncture show promise in improving symptoms and reducing inflammation, making them valuable adjuncts to conventional treatments.

This review highlights the crucial interactions between gut microbiota and microRNAs in pelvic inflammatory disease, revealing novel diagnostic markers and therapeutic targets.

Women with pelvic inflammatory disease have a higher risk of endometrial cancer, especially older and hypertensive women, highlighting the need for vigilant care.

Higher dietary copper intake significantly lowers the risk of pelvic inflammatory disease in U.S. women, highlighting copper’s role in inflammation and reproductive health.

Higher dietary magnesium intake significantly reduces pelvic inflammatory disease risk in U.S. women, especially older adults, highlighting magnesium’s role in inflammation and reproductive health.

Kangfuxiaoyan suppository effectively treats chronic pelvic inflammatory disease by regulating key inflammatory and metabolic pathways, significantly reducing inflammation. Integrated metabolomics and network pharmacology clarify its therapeutic mechanisms, highlighting specific active ingredients and metabolic biomarkers for potential clinical use.

This study shows volatile oil from Prunella vulgaris effectively reduces pelvic inflammation by correcting metabolic disruptions in a rat PID model, highlighting key inflammatory metabolites as biomarkers and suggesting therapeutic potential for herbal treatments in PID management.

This study identifies key differences in the vaginal microbiome of women with PID, emphasizing a significant reduction in Lactobacillus and an increase in polymicrobial infections. The findings underscore the importance of microbiome management in diagnosing and treating PID.

This study identifies microbial differences in women with PID based on IUD use, highlighting a higher presence of anaerobic bacteria in IUD users and an increased risk of PID complications. These findings emphasize the need for careful monitoring of IUD users and further research into the microbiome’s role in PID development.

This study identifies key bacterial pathogens associated with pelvic inflammatory disease (PID) in Abuja, Nigeria, highlighting the effectiveness of Cefotaxime in treatment. The research also stresses the role of socio-demographic factors in PID prevalence and calls for targeted health interventions.

This study identifies key socio-demographic factors associated with PID in women of reproductive age, highlighting the need for better education, healthcare access, and early intervention. It underscores the importance of targeting high-risk groups, including young, uneducated, and economically disadvantaged women, for improved reproductive health outcomes.

This meta-analysis reveals a significant association between pelvic inflammatory disease (PID) and an increased risk of ovarian cancer. The link is particularly strong among Asian women, with implications for early detection and prevention strategies, especially for borderline ovarian tumors.

This nationwide study from Taiwan demonstrates that women with a history of pelvic inflammatory disease (PID) are at a significantly higher risk of developing ovarian cancer. The study highlights the importance of monitoring and early screening for ovarian cancer in women with PID, particularly those aged 40 and above.

This review highlights how vaginal microbiota imbalance, particularly bacterial vaginosis, significantly increases the risk of pelvic inflammatory disease. Advanced molecular methods have identified diverse microbes linked to PID, emphasizing the importance of microbiome health in preventing serious reproductive infections.