Gut microbiota signatures in tissues of the colorectal polyp and normal colorectal mucosa, and faecesOriginal paper
Karen Pendergrass is a microbiome researcher specializing in microbiome-targeted interventions (MBTIs). She systematically analyzes scientific literature to identify microbial patterns, develop hypotheses, and validate interventions. As the founder of the Microbiome Signatures Database, she bridges microbiome research with clinical practice. In 2012, based on her own investigative research, she became the first documented case of FMT for Celiac Disease, four years before the first published case study.
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Colorectal polyps are common precursors of colorectal cancer (CRC) and are influenced by various lifestyle and environmental factors. Increasing evidence highlights the role of gut microbiota in the development of intestinal diseases, including CRC. Previous studies have reported differences between mucosal and faecal microbiota, with certain taxa such as Fusobacterium and Bacteroides fragilis being implicated in disease progression. However, microbiota signatures across different sampling sites in individuals with colorectal polyps remain unclear. This study aimed to characterize and compare the gut microbiota in faecal samples, normal colorectal mucosa, and polyp tissues from patients with colorectal polyps, as well as in healthy individuals. Using 16S rRNA gene sequencing and bioinformatic analysis, the study evaluates differences in microbial composition across these sites. The findings are expected to provide insight into site-specific microbiota variations and contribute to understanding microbial changes involved in the progression from colorectal polyps to colorectal cancer.