Karen Pendergrass, Standards Team

What was studied?The study reviewed the relationship between Müllerian duct anomalies (MDAs) and endometriosis, focusing on their coexistence and the underlying pathophysiological theories that might explain their association. It extensively covered the embryology, genetics, and pathophysiology of MDAs, alongside the American Society for Reproductive Medicine (ASRM) classification of these anomalies. The review also detailed different […]

This study identifies significant gut microbiota alterations in Hashimoto’s thyroiditis, with reduced beneficial microbes and increased pathogens.

What was studied? The study investigated the microbiota in the cervical mucus of women with and without endometriosis using next-generation sequencing (NGS) technologies. It aimed to clarify whether cervical mucus in women with endometriosis is contaminated with bacteria, which could potentially transmigrate into the intrauterine cavity, influencing the pathogenesis of endometriosis. The research explored the […]

What was studied? The research focused on investigating microbial colonization in women’s intrauterine environment and cystic fluid, utilizing a molecular approach to detect bacterial presence. This involved examining variations in bacterial types and their implications in the context of endometriosis and treatment effects. Who was studied? The study included 32 women, evenly divided between those […]

What was studied?The study investigated the gut microbial composition in patients with Graves’ disease (GD) compared to healthy controls. Who was studied?The study involved 27 GD patients and 11 healthy controls, with fecal samples collected for analysis. What were the most important findings? The association between gut microbiota and host homeostasis is pivotal […]

This review explores the microbiota–gut–brain axis, highlighting the role of gut microbiota in barrier integrity and lymphatic transport. It discusses microbial metabolites, vagus nerve signaling, and meningeal lymphatics as critical communication pathways, emphasizing their implications for gastrointestinal and neurological disorders.

What was studied? The study investigated the microbiota distribution across the entire female reproductive tract of endometriosis (EMS) patients and non-EMS women, aiming to identify EMS-specific bacterial species and examine the relationship between flora and disease development. Who was studied? Fifty women undergoing laparoscopic surgery for benign gynecological diseases or pelvic endometriosis at Peking […]

What was studied? The study focused on the relationship between oral-gut dysbiosis and chronic systemic inflammation, particularly in the context of periodontitis and its associated diseases. It reviewed the mechanisms underlying the crosstalk between the microbiome and the host, and explored novel precision medicine approaches aimed at controlling systemic inflammation by modulating the microbiome. The […]

What was studied? The study focused on identifying and comparing the bacterial patterns present in the vaginal fluid, eutopic endometrium, and endometriotic lesions of patients with endometriosis to those found in the vaginal fluid and eutopic endometrium of control patients without the disease. High-throughput DNA sequencing of the 16S rRNA marker gene was utilized to […]

What was studied? The study investigated the relationship between the genital tract microbiota and endometriosis, particularly focusing on how microbiota diversity and specific bacteria like Atopobium might be associated with the disease. Who was studied? 68 participants, from whom 134 samples were collected from the cervical canal, posterior fornix, and uterine cavity for 16s-rRNA […]

Microbial dysbiosis, marked by reduced bacterial load and altered species composition, is linked to breast cancer progression. Enrichment of Methylobacterium radiotolerans in tumors and depletion of Sphingomonas yanoikuyae in normal tissue suggest diagnostic and therapeutic potential for microbiota-based interventions in breast cancer.

This review identifies metalloestrogens as a critical factor in hormone disruption and breast cancer risk.

What Was Reviewed? The systematic review and meta-analysis examined the relationship between exposure to metalloestrogens—specifically arsenic (As), antimony (Sb), chromium (Cr), cadmium (Cd), copper (Cu), selenium (Se), and mercury (Hg)—and the risk of developing gestational diabetes mellitus (GDM). This review aimed to aggregate findings from observational studies to better understand how these metals, which have […]

This study highlights metabolic alterations in endometrial tissue and serum of minimal and mild endometriosis patients, identifying amino acid biomarkers with diagnostic potential. A combined serum panel demonstrated 100% sensitivity and 83% specificity for Stage II diagnosis, offering a promising step toward non-invasive early detection of endometriosis.

What was studied?The meta-analysis focused on the human gut microbiome’s association with various diseases by analyzing 28 published case-control gut microbiome studies covering ten diseases. The researchers aimed to standardize the processing and analysis of these datasets to identify consistent patterns and shifts in the gut microbiome associated with specific diseases or a generalized health-disease […]

Who was studied? The study included forty-nine symptomatic women diagnosed with endometriosis via laparoscopy, who volunteered to participate in the randomized trial. These women were undergoing treatment with long-acting GnRH agonists and were subsequently monitored for up to six years. What were the most important findings? The study’s key findings indicate that long-term use […]

What was studied? The study investigated the antimicrobial effects of essential oils derived from the Colombian plant Lippia origanoides, specifically focusing on two terpenes, thymol and carvacrol, against polymicrobial biofilms of Streptococcus mutans, Lactobacillus rhamnosus, and Candida albicans. The study also assessed the cytotoxic effects of these compounds on human skin keratinocytes (HaCaT) and periodontal […]

Iron overload in endometriosis contributes to oxidative stress, inflammation, and tissue damage, driving lesion persistence and subfertility. Ferroptosis resistance and dysregulated iron metabolism highlight therapeutic opportunities using iron chelators and modulators.

Gut microbiota influences early breast cancer prognosis and treatment side effects, with specific commensals correlating to outcomes. Chemotherapy alters microbiota, favoring beneficial species and improving immune modulation and neuroprotection.

This study revealed novel molecular signatures linking gut microbiota and transcriptome in Hashimoto’s thyroiditis, advancing diagnostic and therapeutic approaches.

What was studied? The study investigated the impact of heavy metal exposure on the composition and function of gut microbiota. Specifically, it looked at how heavy metals such as arsenic, cadmium, lead, and mercury affect the diversity, richness, and metabolism of gut bacteria. Who was studied? The research encompassed various model organisms, including humans, […]

What was studied? The study investigated the relationship between inflammatory markers (IL-6, IL-10, IL-13, and TNF-α), the composition of bacterial flora in peritoneal fluid, and infertility in patients with endometriosis. Who was studied? The participants included 55 patients diagnosed with endometriosis and infertility (observation group) attending a Gynecology Clinic from June 2014 to July […]

What was studied? The study focused on evaluating the antibiofilm, antibacterial, antioxidant, and anticancer activities of the methanolic extract of the marine algae Padina pavonica L. Who was studied? The subjects of the study were various microorganisms including Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, Klebsiella pneumoniae, Bacillus subtilis, Escherichia coli, Pseudomonas fluorescens, and Streptococcus […]

This study identifies stool-based biomarkers for endometriosis diagnosis and highlights the therapeutic potential of 4-hydroxyindole, a microbiota-derived metabolite, in reducing inflammation and lesion progression.