Karen Pendergrass, Standards Team

This study identifies stool-based biomarkers for endometriosis diagnosis and highlights the therapeutic potential of 4-hydroxyindole, a microbiota-derived metabolite, in reducing inflammation and lesion progression.

This study explored oral microbiome-signatures for diagnosing LSCC non-invasively. Using 16S rRNA sequencing and machine learning, key taxa differences were identified, enabling a predictive model with 85.7% accuracy. The findings suggest oral microbiota’s potential as a stable biomarker, revolutionizing early, non-invasive cancer detection.

Metabolomics provides insights into the metabolic underpinnings of IBD and IBS, revealing disease-specific biomarker metabolites linked to gut dysbiosis. These findings pave the way for non-invasive diagnostics and precision medicine.

Endometriosis significantly increases the risk of clear-cell, low-grade serous, and endometrioid ovarian cancers. This study highlights the need for subtype-specific ovarian cancer surveillance and prevention strategies.

This review explores the significant comorbidity between systemic lupus erythematosus (SLE) and endometriosis, emphasizing shared pathological pathways.

This review synthesizes key theories on endometriosis pathogenesis, emphasizing immune, hormonal, and epigenetic interactions in its progression.

The study links endometriosis with a fivefold increased risk of IBS in adolescents, emphasizing the role of acyclic pelvic pain severity and inflammation as shared mechanisms. Early screening for IBS and microbiome-targeted interventions could improve outcomes in this group.

Fusobacterium infection significantly contributes to endometriosis pathogenesis, activating fibroblast inflammation and lesion formation. Antibiotics like metronidazole show promise.

Zinc is an essential trace element vital for cellular functions and microbiome health. It influences immune regulation, pathogen virulence, and disease progression in conditions like IBS and breast cancer. Pathogens exploit zinc for survival, while therapeutic zinc chelation can suppress virulence, rebalance the microbiome, and offer potential treatments for inflammatory and degenerative diseases.

Matrix Metalloproteinases (MMPs) are zinc-dependent enzymes that regulate extracellular matrix remodeling, with critical roles in health, disease, and interactions with the microbiome.

This study examined gut microbiota alterations in Immunoglobulin A Nephropathy (IgAN) and Membranous Nephropathy (MN), identifying unique and shared microbial changes linked to disease pathology. The findings suggest potential biomarkers and therapeutic targets through the gut-kidney axis.

OverviewJoseph F. Petrosino’s editorial highlights the microbiome’s pivotal role in precision medicine, emphasizing its potential to advance personalized diagnostics and therapeutic strategies. The integration of microbiome signatures with other ‘omics’ data, such as genomics and metabolomics, offers a comprehensive understanding of disease mechanisms and tailored treatments. Petrosino draws parallels between microbiome signature research and genomics, […]

OverviewA microbiome specialist is a healthcare or research professional with expertise in the human microbiome—the diverse community of microorganisms that inhabit various body sites, including the gut, skin, oral cavity, and genitourinary tract. Microbiome specialists study how microbial communities interact with human health and disease and apply this knowledge to develop targeted interventions.These professionals often […]

Estrogen receptors (ERs) are specialized proteins that respond to the hormone estrogen, playing a critical role in regulating biological processes such as reproduction, cellular growth, and differentiation.

What was studied?This study investigated the presence of metalloestrogens in ectopic endometrial tissue from women with endometriosis. Metalloestrogens, heavy metals that can mimic estrogen and may contribute to estrogen-dependent diseases, were the focus, particularly regarding their potential role in the persistence and pathology of endometriosis. The researchers specifically analyzed levels of cadmium, nickel, and lead […]

This review identifies metalloestrogens as a critical factor in hormone disruption and breast cancer risk.

Metalloestrogens are metals that activate the estrogen receptor in the absence of estradiol.

What Was Reviewed?The systematic review and meta-analysis examined the relationship between exposure to metalloestrogens—specifically arsenic (As), antimony (Sb), chromium (Cr), cadmium (Cd), copper (Cu), selenium (Se), and mercury (Hg)—and the risk of developing gestational diabetes mellitus (GDM). This review aimed to aggregate findings from observational studies to better understand how these metals, which have estrogenic […]

A study of celiac patients revealed that persistent symptoms during gluten-free eating may stem from nickel allergic contact mucositis. A low-nickel diet significantly improved gastrointestinal and systemic symptoms.

Irritable Bowel Syndrome (IBS) is a common gastrointestinal disorder characterized by symptoms such as abdominal pain, bloating, and altered bowel habits. Recent research has focused on the gut microbiota’s role in IBS, aiming to identify specific microbial signatures associated with the condition.

Study identifying significantly higher zinc and nickel hypersensitivity in IBS patients, suggesting metal-induced immune activation as a contributor to mucosal inflammation and symptom generation.

Clinoptilolite zeolite binds nickel ions, reducing pathogen activity, making it a potential therapy for nickel allergies and nickel-induced microbiome imbalances.

What was reviewed?The review focused on the safety and medical applications of clinoptilolite, a naturally occurring zeolite, for in vivo use. The analysis encompassed the physical and chemical properties of clinoptilolite, its detoxifying capabilities, and its potential therapeutic effects in both human and veterinary medicine. The review also considered various studies on clinoptilolite’s role in […]

Phage therapy uses viruses to target and kill specific bacteria, offering a precise alternative to antibiotics, especially for resistant infections.

Major Microbial Associations (MMAs) are fundamental in understanding disease-microbiome interactions and play a crucial role in advancing microbiome-targeted interventions aimed at treating or preventing diseases through microbial modulation.

Gram-negative bacteria are resilient pathogens with antibiotic resistance, causing infections like UTIs, sepsis, and pneumonia.

Oxidase positivity in an organism refers to the ability of the organism to produce the enzyme cytochrome c oxidase, which is involved in the electron transport chain during aerobic respiration.

Overview Koch’s postulates, formulated by Robert Koch in the late 19th century, were a set of criteria used to establish a causative relationship between a specific microbe and a disease. These postulates became foundational in microbiology, providing a systematic approach for identifying pathogenic microorganisms. The original postulates consist of four criteria:Presence of the Microbe in […]

The study found that 100% of the CD patients who completed the study tested positive for allergic contact mucositis to Nickel.

This study suggests that nickel sensitivity may play a significant role in the etiology of IBS, warranting further exploration and potentially influencing future diagnostic and therapeutic strategies for IBS management.

What was reviewed?The review paper provides a comprehensive overview of the gut microbiota-brain axis (GBA) and its role in various neurological disorders. Specifically, the paper examined the intricate bidirectional communication between the gut microbiota (GM) and the central nervous system (CNS), exploring how dysbiosis (an imbalance in the gut microbiota) contributes to the pathogenesis of […]

Pathways of communication between the microbiota and the brain.

What Was Reviewed?The paper reviews the emerging field of neuromicrobiology, which explores the interactions between the gut microbiome and the brain, particularly focusing on how gut microbiota produce neuroactive metabolites that influence cognitive function and brain health. It addresses the biosynthesis, absorption, and transport of these neuroactive metabolites, including neurotransmitters such as γ-aminobutyric acid (GABA), […]

What Was Reviewed?The study reviewed the effectiveness of partially hydrolyzed guar gum (PHGG), a water-soluble prebiotic dietary fiber, on cognitive function, sleep efficiency, and overall mental health in elderly individuals. The research specifically focused on assessing the impact of PHGG supplementation on cognitive domains such as visual memory and simple attention, sleep quality parameters like […]

TMAO is a metabolite formed when gut bacteria convert dietary nutrients like choline and L-carnitine into trimethylamine (TMA), which is then oxidized in the liver to TMAO. This compound is linked to cardiovascular disease, as it promotes atherosclerosis, thrombosis, and inflammation, highlighting the crucial role of gut microbiota in influencing heart health.

This study shows that kidney function is the key regulator of TMAO levels, linked to cardiovascular risk. Reno-protective therapies, like GLP-1 receptor agonists, may lower TMAO levels, offering new strategies for managing cardiovascular and kidney health.

This review underscores the critical role of gut microbiota and TMAO in heart failure pathophysiology and opens up new avenues for therapeutic interventions targeting the gut–TMAO–HF axis. The findings suggest promising directions for future research and clinical applications aimed at improving HF patient care and outcomes.

This review emphasizes the significant alterations in gut microbiota in severe chronic heart failure (CHF) patients and suggests that gut microbiota modulation could be a promising avenue for therapeutic intervention. The study provides a foundation for future research aimed at leveraging gut microbiota to improve CHF management and patient health.

This review explores the gut-heart axis, highlighting how gut microbiota alterations and metabolites like TMAO and SCFAs contribute to heart failure (HF). It evaluates the gut hypothesis, emphasizing bacterial translocation and inflammation in HF, and discusses potential interventions.

This review in Frontiers in Cellular and Infection Microbiology examines the vaginal microbiome’s role in health and disease, particularly bacterial vaginosis (BV). It highlights the shift from a Lactobacillus-dominant microbiome in health to a dysbiotic state in BV, linked to increased risk of STIs, PID, and preterm birth. It also discusses current diagnostic and treatment limitations, emphasizing advanced molecular techniques and innovative therapies like probiotics and vaginal microbiota transplantation (VMT) for better management and improved reproductive health outcomes.

Parkinson’s disease is increasingly recognized as a systemic disorder involving coordinated disturbances across the gut–brain axis, rather than a condition confined to dopaminergic neurodegeneration alone. Converging evidence implicates gut dysbiosis, altered microbial metabolites, impaired intestinal barrier integrity, and metal dyshomeostasis as upstream drivers of neuroinflammation and alpha-synuclein pathology. These interconnected microbiome, metabolomic, and metallomic signals provide a mechanistic framework for understanding disease initiation, progression, and therapeutic targeting beyond the central nervous system.

What was reviewed?This review article examined the therapeutic potential of minocycline, a second-generation tetracycline antibiotic, as a neuroprotective agent in Parkinson’s disease (PD). The authors synthesized data from 92 selected sources, including preclinical studies, clinical trials, and review articles, to assess the capacity of minocycline to modify disease progression through its anti-inflammatory, anti-apoptotic, and antioxidant […]

The study showed dramatic, sustained improvements in ASD symptoms in dizygotic female twins through a personalized, multidisciplinary approach targeting modifiable lifestyle and environmental factors, including microbiome-targeted interventions. These included dietary changes, gluten-free and casein-free diets, and supplements like omega-3 fatty acids and probiotics to support gut health and overall wellbeing.

Microbiome Targeted Interventions (MBTIs) are cutting-edge treatments that utilize information from Microbiome Signatures to modulate the microbiome, revolutionizing medicine with unparalleled precision and impact.

This study evaluates nickel chelation therapy using DMG against multidrug-resistant Salmonella and Klebsiella. DMG impaired virulence by inhibiting Ni-dependent enzymes, reduced bacterial load in organs, and improved survival in animal models, offering a promising metallomic intervention.

The radiotracer [111In]In-FnBPA5 accumulated in the mouse uterus, with uptake varying according to the estrous cycle, suggesting an increased abundance of relaxed fibronectin during estrogen-dependent phases.

GS2, a gallium complex, inhibits tumor invasion by targeting MMP-14, with implications for anti-metastatic cancer therapy.

What was studied? The study explored the impact of photobiomodulation therapy using different types of light on the major salivary glands and its subsequent effects on caries risk factors in individuals with high risk for dental caries. The therapy modalities tested included polarized polychromatic light, continuous LED light, and pulsed LED light, each aiming to modify […]

This review highlights gallium’s role as an iron mimic disrupting bacterial iron metabolism, effective against multidrug-resistant pathogens. Innovations in gallium delivery, including nanomaterials and synergistic therapies with antibiotics, address bioavailability challenges and enhance its antimicrobial potency.

What was studied? The study focused on evaluating the antibiofilm, antibacterial, antioxidant, and anticancer activities of the methanolic extract of the marine algae Padina pavonica L. Who was studied? The subjects of the study were various microorganisms including Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, Klebsiella pneumoniae, Bacillus subtilis, Escherichia coli, Pseudomonas fluorescens, and Streptococcus agalactiae. Additionally, […]

What was studied?The study investigated the antimicrobial, probiotic, and immunobiological effects of the Henola Cannabis sativae extract and its combinations with specific carriers: polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer, magnesium aluminometasilicate, and hydroxypropyl-β-cyclodextrin.  The study demonstrated that Henola Cannabis sativae extract, particularly when combined with carriers like hydroxypropyl-β-cyclodextrin, exhibits strong antimicrobial activity against various pathogens […]

What was studied? The study focused on terpenes derived from plants as potential antimicrobial agents, particularly their effectiveness against antibiotic-resistant infections. This included an exploration of the diverse mechanisms by which terpenes combat microbial resistance, their bioavailability, and the synergistic effects when combined with other antimicrobials. Who was studied? The research mainly involved microbial organisms that […]

What was studied?The study investigated the antimicrobial effects of essential oils derived from the Colombian plant Lippia origanoides, specifically focusing on two terpenes, thymol and carvacrol, against polymicrobial biofilms of Streptococcus mutans, Lactobacillus rhamnosus, and Candida albicans. The study also assessed the cytotoxic effects of these compounds on human skin keratinocytes (HaCaT) and periodontal ligament […]

Pueraria flower extract (PFE) inhibits endometriotic cell adhesion, migration, and MMP expression, reducing lesions in a mouse model, offering potential for non-hormonal therapies.

The study investigates the role of cholestyramine for refractory iodine-induced hyperthyroidism, showing rapid FT4 reduction in 12 days.

What was studied? The study examined the role of biofilms in chronic infections and evaluated whether current medical approaches are effectively targeting biofilm-related infections. Who was studied? The study focused on clinical observations and laboratory analyses involving patients with chronic infections. It analyzed biofilm samples and treatment outcomes in these patients. What were the most important findings?The […]

The review investigated the biological and medicinal importance of flavonols, particularly their roles in disease prevention and treatment. The focus was on their antioxidative properties and their potential therapeutic utility against diabetes, cancer, cardiovascular diseases, and microbial infections.The key findings highlighted the protective roles of flavonols such as quercetin, myricetin, kaempferol, and fisetin against oxidative […]

What was studied?The study examined the association between urinary lead concentrations and changes in the gut microbiota composition in a population-based sample of adults. The research explored how varying levels of lead exposure could impact microbial diversity, richness, and specific bacterial taxa within the gut. Who was studied?The study population comprised adults from Wisconsin, USA, who […]

What was studied?The study investigated the role of copper in microbial pathogenesis. Specifically, it examined how copper serves as both a necessary nutrient for microbial organisms and a microbial weapon used by hosts against pathogens. The research explored copper’s dual roles, its involvement in various microbial resistance mechanisms, and its interaction with the host’s immune […]

What was studied? The study investigated the impact of heavy metal exposure on the composition and function of gut microbiota. Specifically, it looked at how heavy metals such as arsenic, cadmium, lead, and mercury affect the diversity, richness, and metabolism of gut bacteria. Who was studied? The research encompassed various model organisms, including humans, mice, rats, […]

 What was studied?The study focused on the pathophysiology, genetic variants, and epigenetic abnormalities underlying endometriosis and adenomyosis. It emphasized the mechanisms through which these conditions develop, the somatic mutations and epigenetic changes in endometrial and adenomyotic tissues, and the clinical implications of these findings. The primary genetic alterations studied include mutations in the KRAS gene […]

What was studied?The research focused on examining the effects of PCB 126, a dioxin-like pollutant, on gut health and microbiota as well as metabolic homeostasis in a mouse model predisposed to cardiometabolic diseases. The study investigated how exposure to this pollutant influences the gut microbiome, intestinal and systemic inflammation, metabolic hormones, and the development of […]

What was studied?The study focused on the potential impact of environmental exposure to dioxin-like polychlorinated biphenyls (PCBs) on the development of endometriosis. It specifically reviewed the complexities and challenges of determining the effects of such toxicants on human health, with an emphasis on reproductive tract diseases. Who was studied?The research predominantly referenced studies involving both human […]

What was studied?The retrospective study explored the prevalence of endometriosis in patients with uterine malformations. It specifically investigated the relationship between different types of uterine malformations (obstructive, non-obstructive, and various classifications under the American Fertility Society (AFS)) and the incidence of endometriosis, which is characterized by the presence of endometrial tissue outside the uterus. The […]

What was studied?The study focused on pulmonary endometriosis, a rare condition characterized by the presence of endometrial tissue in the lungs. It analyzed a series of historical and recent cases, dividing them into two distinct groups based on the characteristics of the lung lesions and their association with pregnancy and endometrial glands. The study aimed […]

What was studied?The meta-analysis focused on the human gut microbiome’s association with various diseases by analyzing 28 published case-control gut microbiome studies covering ten diseases. The researchers aimed to standardize the processing and analysis of these datasets to identify consistent patterns and shifts in the gut microbiome associated with specific diseases or a generalized health-disease […]

What was studied?The study reviewed the relationship between Müllerian duct anomalies (MDAs) and endometriosis, focusing on their coexistence and the underlying pathophysiological theories that might explain their association. It extensively covered the embryology, genetics, and pathophysiology of MDAs, alongside the American Society for Reproductive Medicine (ASRM) classification of these anomalies. The review also detailed different […]

What was studied?The study focused on the role of somatic stem cells (SSCs), including endometrial stem cells (EnSCs) and bone marrow-derived mesenchymal stem cells (MSCs), in the pathogenesis of endometriosis. This was conducted through a comprehensive literature review, including in vitro experiments and studies on animal models and human tissue analyses. The research examined the […]

What was studied?The review focused on the role of epigenetic changes in endometriosis, exploring how these modifications influence the disease’s etiopathogenesis, diagnosis, and therapeutic approaches. It reviewed existing evidence up to June 2009, linking epigenetic aberrations such as DNA methylation and histone modification to endometriosis, and discussed the potential of these aberrations in developing non-surgical […]

This study links persistent organic pollutants to metabolic alterations in deep endometriosis, identifying trans-nonachlor and 2-hydroxybutyrate as key markers.

What was studied?The study focused on analyzing the receptive-phase endometrial metabolome profiles among women with infertility and examining their associations with adherence to the Mediterranean Diet (MD). It aimed to identify metabolomic signatures that could influence the intrauterine environment and impact reproductive outcomes. Who was studied?The study involved 45 women of infertile couples, recruited at the […]

The study in question focused on the use of transvaginal photobiomodulation (TV-PBM) as a treatment for chronic pelvic pain (CPP) in women. Here are the details based on the key aspects of the study: What was studied?The research investigated whether transvaginal photobiomodulation could effectively reduce chronic pelvic pain in women. This was a pilot study aiming […]

What was studied?The study reviewed the potential effects of photobiomodulation (PBM) on the vaginal microbiome, particularly exploring theoretical and emerging research on how PBM may influence vaginal health through its interaction with microbial communities. Who was studied?The study itself is a review and does not directly study a group of individuals. Instead, it synthesizes research on […]

What was reviewed?The study reviewed the relationship between the gut microbiota and endometriosis, focusing on how the gut microbiota may influence the pathogenesis, diagnosis, and potential treatment of endometriosis through various mechanisms such as estrogen modulation, immune response, and inflammation. Who was reviewed?The review did not involve specific individuals as subjects of study but instead synthesized […]

What was studied?The study explored the therapeutic mechanisms and future perspectives of Vaginal Microbiota Transplantation (VMT). It focused on transferring healthy vaginal microbiota from a donor to recipients with dysbiotic vaginal microbiomes to restore normal microbial composition and function. Who was studied?The study didn’t involve direct experimentation on individuals. Instead, it reviewed existing research and clinical […]

What was studied?The study focused on the relationship between oral-gut dysbiosis and chronic systemic inflammation, particularly in the context of periodontitis and its associated diseases. It reviewed the mechanisms underlying the crosstalk between the microbiome and the host, and explored novel precision medicine approaches aimed at controlling systemic inflammation by modulating the microbiome. The study […]

What was reviewed?The review evaluated the evidence for clinical effects of various microbiome-targeted interventions (MBTIs) on cardiometabolic traits. The interventions assessed included dietary changes, dietary supplementation, prebiotics, probiotics, synbiotics, and other therapeutic strategies targeting the gut microbiome. The review aimed to understand how these interventions influence cardiometabolic health outcomes and to identify the mechanisms through […]

What was studied?The study investigated whether the induction of endometriosis in mice affects the composition of their gut microbiota. It tested this by transplanting uterine tissue fragments into mice and analyzing changes in the gut microbiota before and after endometriosis induction. Who was studied?Female C57BL/6 wild-type mice and GFP+ transgenic donor mice were used. Uterine tissue […]

This review explores microbiota-targeted interventions for mental health, including probiotics, prebiotics, synbiotics, FMT, and diet. While promising, large-scale trials are needed to refine evidence-based strategies. Microbiota-based therapies may serve as adjuncts for psychiatric care, highlighting the gut-brain axis as a key target for future research.

What was studied?The study investigated the relationship between the genital tract microbiota and endometriosis, particularly focusing on how microbiota diversity and specific bacteria like Atopobium might be associated with the disease. Who was studied?68 participants, from whom 134 samples were collected from the cervical canal, posterior fornix, and uterine cavity for 16s-rRNA sequencing, were included in […]

What was studied?The study examined the gut microbiota in women with endometriosis compared to healthy controls. It aimed to explore differences based on disease localization, symptoms, or treatment and assess the gut microbiota’s potential role in the pathogenesis of endometriosis. Who was studied?66 women diagnosed with endometriosis at Skåne University Hospital were studied alongside 198 matched […]

What was studied?The study investigated the interaction between fecal metabolomics and gut microbiota in mice with endometriosis (EMS), aiming to identify metabolic changes and microbiota diversity associated with the disease. Who was studied?Female C57BL/6J mice, utilized to construct an EMS model, were the subjects of this research, allowing for the examination of fecal metabolites and gut […]

This study examines the role of the vaginal microbiome in distinguishing chronic pelvic pain caused by endometriosis and adenomyosis. Findings highlight specific microbial signatures associated with pain severity, offering potential non-invasive biomarkers for differential diagnosis and targeted therapeutic strategies.

This study identifies microbiota alterations in ovarian endometrioma, showing distinct microbial shifts in peritoneal fluid extracellular vesicles. Enrichment of Pseudomonas and Acinetobacter, alongside depletion of Propionibacterium and Actinomyces, suggests inflammatory contributions to pathogenesis. Findings highlight the diagnostic potential of microbiota-derived EVs in endometrioma management.

What was studied?The study investigated the microbiota distribution across the entire female reproductive tract of endometriosis (EMS) patients and non-EMS women, aiming to identify EMS-specific bacterial species and examine the relationship between flora and disease development. Who was studied?Fifty women undergoing laparoscopic surgery for benign gynecological diseases or pelvic endometriosis at Peking University Shenzhen Hospital were […]

What was studied?The study focused on characterizing the gut and vaginal microbiome profiles of women with endometriosis compared to controls without the disease, exploring the potential of these profiles as less-invasive diagnostic tools for assessing the severity of endometriosis. Who was studied?Fifty-nine women participated in the study, including 35 with endometriosis and 24 control subjects. Rectal […]

Who was studied?The study included forty-nine symptomatic women diagnosed with endometriosis via laparoscopy, who volunteered to participate in the randomized trial. These women were undergoing treatment with long-acting GnRH agonists and were subsequently monitored for up to six years. What were the most important findings?The study’s key findings indicate that long-term use of GnRH agonists results […]

What was studied?The study investigated the role of gut microbiota in endometriosis (EM), focusing on its differences between individuals with stage 3/4 EM and healthy controls and how these differences correlate with serum hormone levels and inflammatory cytokines. Who was studied?The research involved 12 patients diagnosed with stage 3/4 endometriosis and 12 healthy control subjects. The […]

What was studied?The research investigated the impact of antibiotic treatment on the progression of endometriosis, specifically examining how altering the gut microbiota with antibiotics affects the development of endometriotic lesions in a mouse model. Who was studied?Mice subjected to surgically induced endometriosis were studied. These mice were treated with either broad-spectrum antibiotics or metronidazole to assess […]

What was studied?The research focused on investigating the impact of murine endometriosis on gut microbiota composition using high-throughput DNA sequencing to explore how the disease affects intestinal microbial communities. Who was studied?The study subjects were mice. These animals were divided into two groups: one group with induced endometriosis through the intraperitoneal injection of endometrial tissues and […]

What was studied?The research focused on investigating microbial colonization in women’s intrauterine environment and cystic fluid, utilizing a molecular approach to detect bacterial presence. This involved examining variations in bacterial types and their implications in the context of endometriosis and treatment effects.Who was studied?The study included 32 women, evenly divided between those diagnosed with endometriosis […]

What was studied?The study investigated the microbiota in the cervical mucus of women with and without endometriosis using next-generation sequencing (NGS) technologies. It aimed to clarify whether cervical mucus in women with endometriosis is contaminated with bacteria, which could potentially transmigrate into the intrauterine cavity, influencing the pathogenesis of endometriosis. The research explored the bacterial […]

What was studied?The study investigated the relationship between inflammatory markers (IL-6, IL-10, IL-13, and TNF-α), the composition of bacterial flora in peritoneal fluid, and infertility in patients with endometriosis. Who was studied?The participants included 55 patients diagnosed with endometriosis and infertility (observation group) attending a Gynecology Clinic from June 2014 to July 2017 and 30 individuals […]

What was studied?The study focused on identifying and comparing the bacterial patterns present in the vaginal fluid, eutopic endometrium, and endometriotic lesions of patients with endometriosis to those found in the vaginal fluid and eutopic endometrium of control patients without the disease. High-throughput DNA sequencing of the 16S rRNA marker gene was utilized to analyze […]

What was studied?The study aimed to investigate how endometriosis affects the uterine and cervical bacterial communities. Utilizing next-generation amplicon sequencing of the bacterial 16S rRNA gene, the research sought to identify alterations in these microbiomes associated with endometriosis and to determine if specific bacterial taxa within the cervix could help diagnose active endometriosis, potentially avoiding […]

This study reveals Anaerococcus as a predictive marker for endometriosis severity and highlights Lactobacillus crispatus’s lactic acid-mediated modulatory role, offering promise for non-invasive diagnostics.

What was studied?The study focused on exploring the associations between the microbiota of the vaginal, cervical, and gut regions and stage 3–4 endometriosis in women. This research aimed to uncover potential differences in the microbiome composition between women diagnosed with advanced endometriosis and healthy controls, particularly at the genus level of microbial classification. Who was studied?The […]

This study reveals that gut microbiota dysbiosis in immune-mediated inflammatory diseases includes shared enrichment of pro-inflammatory taxa like Streptococcus and Eggerthella, alongside depletion of beneficial genera such as Roseburia. These patterns support a common microbial signature across IMIDs and highlight potential targets for diagnosis and therapeutic intervention.

What was studied?This study explored the gut microbiota of children diagnosed with early-onset pediatric multiple sclerosis (MS) and compared it to controls of similar age and sex. The researchers aimed to identify gut microbial community differences, including taxonomic and functional perturbations, and examined the influence of immunomodulatory drug (IMD) exposure. This study also predicted functional […]

This case-control study investigates the gut microbiota’s role in multiple sclerosis (MS) pathogenesis by comparing the fecal microbiota of relapsing-remitting MS patients to healthy controls. Findings reveal significant microbial dysbiosis in MS patients, highlighting differences in the abundance of specific bacterial genera, supporting the gut microbiota’s involvement in MS etiology.